ZN816_HUMAN
ID ZN816_HUMAN Reviewed; 651 AA.
AC Q0VGE8; A8K7H5; Q3KR39; Q659B3;
DT 10-JUL-2007, integrated into UniProtKB/Swiss-Prot.
DT 02-MAR-2010, sequence version 2.
DT 03-AUG-2022, entry version 131.
DE RecName: Full=Zinc finger protein 816;
GN Name=ZNF816; Synonyms=ZNF816A;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Small intestine;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15057824; DOI=10.1038/nature02399;
RA Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E.,
RA Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A.,
RA Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S.,
RA Carrano A.V., Caoile C., Chan Y.M., Christensen M., Cleland C.A.,
RA Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J.,
RA Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M.,
RA Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W.,
RA Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V.,
RA Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D.,
RA McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I.,
RA Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L.,
RA Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A.,
RA She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M.,
RA Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J.,
RA Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA Rubin E.M., Lucas S.M.;
RT "The DNA sequence and biology of human chromosome 19.";
RL Nature 428:529-535(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANTS ASN-80 AND LEU-162.
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 380-651.
RC TISSUE=Testis;
RX PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D.,
RA Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A.,
RA Wiemann S., Schupp I.;
RT "The full-ORF clone resource of the German cDNA consortium.";
RL BMC Genomics 8:399-399(2007).
CC -!- FUNCTION: May be involved in transcriptional regulation.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. {ECO:0000305}.
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DR EMBL; AK291990; BAF84679.1; -; mRNA.
DR EMBL; AC010487; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC010328; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471135; EAW72106.1; -; Genomic_DNA.
DR EMBL; BC105739; AAI05740.1; -; mRNA.
DR EMBL; BC105740; AAI05741.1; -; mRNA.
DR EMBL; BC105930; AAI05931.1; -; mRNA.
DR EMBL; AL713804; CAH56373.1; -; mRNA.
DR CCDS; CCDS33096.1; -.
DR RefSeq; NP_001026835.1; NM_001031665.2.
DR RefSeq; NP_001189385.1; NM_001202456.1.
DR RefSeq; NP_001189386.1; NM_001202457.1.
DR AlphaFoldDB; Q0VGE8; -.
DR SMR; Q0VGE8; -.
DR BioGRID; 125933; 49.
DR IntAct; Q0VGE8; 14.
DR STRING; 9606.ENSP00000350295; -.
DR iPTMnet; Q0VGE8; -.
DR PhosphoSitePlus; Q0VGE8; -.
DR BioMuta; ZNF816; -.
DR DMDM; 290457609; -.
DR jPOST; Q0VGE8; -.
DR MassIVE; Q0VGE8; -.
DR MaxQB; Q0VGE8; -.
DR PaxDb; Q0VGE8; -.
DR PeptideAtlas; Q0VGE8; -.
DR PRIDE; Q0VGE8; -.
DR ProteomicsDB; 58844; -.
DR Antibodypedia; 46251; 57 antibodies from 13 providers.
DR DNASU; 125893; -.
DR Ensembl; ENST00000357666.8; ENSP00000350295.4; ENSG00000180257.14.
DR Ensembl; ENST00000444460.7; ENSP00000403266.2; ENSG00000180257.14.
DR GeneID; 125893; -.
DR KEGG; hsa:125893; -.
DR MANE-Select; ENST00000444460.7; ENSP00000403266.2; NM_001202457.3; NP_001189386.1.
DR UCSC; uc002qal.3; human.
DR CTD; 125893; -.
DR DisGeNET; 125893; -.
DR GeneCards; ZNF816; -.
DR HGNC; HGNC:26995; ZNF816.
DR HPA; ENSG00000180257; Low tissue specificity.
DR neXtProt; NX_Q0VGE8; -.
DR OpenTargets; ENSG00000180257; -.
DR PharmGKB; PA165394953; -.
DR VEuPathDB; HostDB:ENSG00000180257; -.
DR eggNOG; KOG1721; Eukaryota.
DR GeneTree; ENSGT00940000154397; -.
DR HOGENOM; CLU_002678_44_5_1; -.
DR InParanoid; Q0VGE8; -.
DR OMA; SHEHSNT; -.
DR OrthoDB; 1318335at2759; -.
DR PhylomeDB; Q0VGE8; -.
DR TreeFam; TF341892; -.
DR PathwayCommons; Q0VGE8; -.
DR SignaLink; Q0VGE8; -.
DR BioGRID-ORCS; 125893; 9 hits in 1045 CRISPR screens.
DR GenomeRNAi; 125893; -.
DR Pharos; Q0VGE8; Tdark.
DR PRO; PR:Q0VGE8; -.
DR Proteomes; UP000005640; Chromosome 19.
DR RNAct; Q0VGE8; protein.
DR Bgee; ENSG00000180257; Expressed in buccal mucosa cell and 103 other tissues.
DR ExpressionAtlas; Q0VGE8; baseline and differential.
DR Genevisible; Q0VGE8; HS.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd07765; KRAB_A-box; 1.
DR InterPro; IPR001909; KRAB.
DR InterPro; IPR036051; KRAB_dom_sf.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF01352; KRAB; 1.
DR Pfam; PF00096; zf-C2H2; 14.
DR SMART; SM00349; KRAB; 1.
DR SMART; SM00355; ZnF_C2H2; 15.
DR SUPFAM; SSF109640; SSF109640; 1.
DR SUPFAM; SSF57667; SSF57667; 8.
DR PROSITE; PS50805; KRAB; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 15.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 15.
PE 2: Evidence at transcript level;
KW DNA-binding; Metal-binding; Nucleus; Reference proteome; Repeat;
KW Transcription; Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1..651
FT /note="Zinc finger protein 816"
FT /id="PRO_0000294362"
FT DOMAIN 24..98
FT /note="KRAB"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00119"
FT ZN_FING 227..251
FT /note="C2H2-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 257..279
FT /note="C2H2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 285..307
FT /note="C2H2-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 313..335
FT /note="C2H2-type 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 341..363
FT /note="C2H2-type 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 369..391
FT /note="C2H2-type 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 397..419
FT /note="C2H2-type 7"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 425..447
FT /note="C2H2-type 8"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 453..475
FT /note="C2H2-type 9"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 481..503
FT /note="C2H2-type 10"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 509..531
FT /note="C2H2-type 11"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 537..559
FT /note="C2H2-type 12"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 565..587
FT /note="C2H2-type 13"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 593..615
FT /note="C2H2-type 14"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 621..643
FT /note="C2H2-type 15"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT VARIANT 80
FT /note="I -> N (in dbSNP:rs12459008)"
FT /evidence="ECO:0000269|PubMed:15489334"
FT /id="VAR_033165"
FT VARIANT 162
FT /note="S -> L (in dbSNP:rs11084210)"
FT /evidence="ECO:0000269|PubMed:15489334"
FT /id="VAR_033166"
FT CONFLICT 184
FT /note="I -> IS (in Ref. 4; AAI05741)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 651 AA; 75725 MW; 833956CE190312A3 CRC64;
MLREEATKKS KEKEPGMALP QGRLTFRDVA IEFSLEEWKC LNPAQRALYR AVMLENYRNL
EFVDSSLKSM MEFSSTRHSI TGEVIHTGTL QRHKSHHIGD FCFPEMKKDI HHFEFQWQEV
ERNGHEAPMT KIKKLTGSTD RSDHRHAGNK PIKDQLGLSF HSHLPELHMF QTKGKISNQL
DKSIGASSAS ESQRISCRLK THISNKYGKN FLHSSFTQIQ EICMREKPCQ SNECGKAFNY
SSLLRRHHIT HSREREYKCD VCGKIFNQKQ YIVYHHRCHT GEKTYKCNEC GKTFTQMSSL
VCHRRLHTGE KPYKCNECGK TFSEKSSLRC HRRLHTGEKP YKCNECGKTF GRNSALVIHK
AIHTGEKPYK CNECGKTFSQ KSSLQCHHIL HTGEKPYKCE ECDNVYIRRS HLERHRKIHT
GEGSYKCKVC DKVFRSDSYL AEHQRVHTGE KPYKCNKCGR SFSRKSSLQY HHTLHTGEKP
YTCNECGKVF SRRENLARHH RLHAGEKPYK CEECDKVFSR RSHLERHRRI HTGEKPYKCK
VCDKAFRSDS CLANHTRVHT GEKPYKCNKC AKVFNQKGIL AQHQRVHTGE KPYKCNECGK
VFNQKASLAK HQRVHTAEKP YKCNECGKAF TGQSTLIHHQ AIHGCRETLQ M
