ID   ZN821_BOVIN             Reviewed;         412 AA.
AC   Q32KS7;
DT   05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   06-DEC-2005, sequence version 1.
DT   03-AUG-2022, entry version 114.
DE   RecName: Full=Zinc finger protein 821;
GN   Name=ZNF821;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Crossbred X Angus; TISSUE=Liver;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (NOV-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May be involved in transcriptional regulation.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC       family. {ECO:0000305}.
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DR   EMBL; BC109947; AAI09948.1; -; mRNA.
DR   RefSeq; NP_001033241.1; NM_001038152.2.
DR   RefSeq; XP_005218695.1; XM_005218638.3.
DR   RefSeq; XP_005218696.1; XM_005218639.3.
DR   RefSeq; XP_015331243.1; XM_015475757.1.
DR   RefSeq; XP_015331244.1; XM_015475758.1.
DR   AlphaFoldDB; Q32KS7; -.
DR   STRING; 9913.ENSBTAP00000032245; -.
DR   PaxDb; Q32KS7; -.
DR   PRIDE; Q32KS7; -.
DR   Ensembl; ENSBTAT00000032310; ENSBTAP00000032245; ENSBTAG00000021438.
DR   Ensembl; ENSBTAT00000070098; ENSBTAP00000063939; ENSBTAG00000021438.
DR   GeneID; 532668; -.
DR   KEGG; bta:532668; -.
DR   CTD; 55565; -.
DR   VEuPathDB; HostDB:ENSBTAG00000021438; -.
DR   VGNC; VGNC:37353; ZNF821.
DR   eggNOG; KOG1721; Eukaryota.
DR   GeneTree; ENSGT00940000159421; -.
DR   HOGENOM; CLU_048218_0_0_1; -.
DR   InParanoid; Q32KS7; -.
DR   OMA; NPPVYPA; -.
DR   OrthoDB; 901424at2759; -.
DR   TreeFam; TF326851; -.
DR   Proteomes; UP000009136; Chromosome 18.
DR   Bgee; ENSBTAG00000021438; Expressed in spermatocyte and 103 other tissues.
DR   ExpressionAtlas; Q32KS7; baseline and differential.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IBA:GO_Central.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   InterPro; IPR036236; Znf_C2H2_sf.
DR   InterPro; IPR013087; Znf_C2H2_type.
DR   SMART; SM00355; ZnF_C2H2; 2.
DR   SUPFAM; SSF57667; SSF57667; 1.
DR   PROSITE; PS00028; ZINC_FINGER_C2H2_1; 2.
DR   PROSITE; PS50157; ZINC_FINGER_C2H2_2; 1.
PE   2: Evidence at transcript level;
KW   Coiled coil; DNA-binding; Metal-binding; Nucleus; Reference proteome;
KW   Repeat; Transcription; Transcription regulation; Zinc; Zinc-finger.
FT   CHAIN           1..412
FT                   /note="Zinc finger protein 821"
FT                   /id="PRO_0000317288"
FT   ZN_FING         116..140
FT                   /note="C2H2-type 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         150..172
FT                   /note="C2H2-type 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   REGION          26..83
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          278..319
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          257..366
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        39..53
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        67..83
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   412 AA;  46723 MW;  758DD8361323E7E6 CRC64;
     MSRRKQTNPN KVHWDQVFAG LEEQARQAMM KTDFPGDLGS QRQAIQQLRD QDSSSSDSEG
     DEEETTQDEV SSHTSEEDGG VVKVEKELEN AEQPVGGKKV VEHEVTENLH SDPLLGLCQC
     PLCQLDCGSR EQLIAHVYQH TAAVVSAKSY MCPVCGRALS SPGSLGRHLL IHSEDQRSNC
     AVCGARFTSH ATFNSEKLPE VLNVESLPPA HSEGPSSAEG KDIAFTPPVY PAGILLVCNN
     CAAYRKLLEA QTPSVRKWAL RRQNEPLEVR LQRLERERTA KKSRRDNETP EEREVRRMRD
     REAKRLQRMQ ETDEQRARRL QRDREAMRLK RANETPEKRQ ARLIREREAK RLKRRLEKMD
     MMLRAQFGQD PSAMAALAAE MNFFQLPVSG VELDSQLLGK MAFEEQNSSS LH