ZN821_HUMAN
ID ZN821_HUMAN Reviewed; 412 AA.
AC O75541; A6NK48; B4DKK4; D3DWS3;
DT 05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 16-MAY-2012, sequence version 3.
DT 03-AUG-2022, entry version 181.
DE RecName: Full=Zinc finger protein 821;
GN Name=ZNF821;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Brain;
RA Yu W., Gibbs R.A.;
RL Submitted (JUN-1998) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Colon;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15616553; DOI=10.1038/nature03187;
RA Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G.,
RA Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E.,
RA Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J., Buckingham J.M.,
RA Callen D.F., Campbell C.S., Campbell M.L., Campbell E.W., Caoile C.,
RA Challacombe J.F., Chasteen L.A., Chertkov O., Chi H.C., Christensen M.,
RA Clark L.M., Cohn J.D., Denys M., Detter J.C., Dickson M.,
RA Dimitrijevic-Bussod M., Escobar J., Fawcett J.J., Flowers D., Fotopulos D.,
RA Glavina T., Gomez M., Gonzales E., Goodstein D., Goodwin L.A., Grady D.L.,
RA Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E.,
RA Huang W., Israni S., Jett J., Jewett P.B., Kadner K., Kimball H.,
RA Kobayashi A., Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y.,
RA Lowry S., Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J.,
RA Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D.,
RA Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., Rash S.,
RA Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., Salamov A.,
RA Saunders E.H., Scott D., Shough T., Stallings R.L., Stalvey M.,
RA Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H.,
RA Torney D.C., Tran-Gyamfi M., Tsai M., Ulanovsky L.E., Ustaszewska A.,
RA Vo N., White P.S., Williams A.L., Wills P.L., Wu J.-R., Wu K., Yang J.,
RA DeJong P., Bruce D., Doggett N.A., Deaven L., Schmutz J., Grimwood J.,
RA Richardson P., Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M.,
RA Myers R.M., Rubin E.M., Pennacchio L.A.;
RT "The sequence and analysis of duplication-rich human chromosome 16.";
RL Nature 432:988-994(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Uterus;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: May be involved in transcriptional regulation.
CC -!- INTERACTION:
CC O75541; Q96GN5: CDCA7L; NbExp=3; IntAct=EBI-740865, EBI-5278764;
CC O75541; Q9P1W9: PIM2; NbExp=3; IntAct=EBI-740865, EBI-720425;
CC O75541-2; Q92997: DVL3; NbExp=3; IntAct=EBI-14544035, EBI-739789;
CC O75541-2; Q59EK9-3: RUNDC3A; NbExp=3; IntAct=EBI-14544035, EBI-11957366;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=O75541-1; Sequence=Displayed;
CC Name=2;
CC IsoId=O75541-2; Sequence=VSP_030933;
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. {ECO:0000305}.
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DR EMBL; AF070588; AAC28648.1; -; mRNA.
DR EMBL; AK296603; BAG59216.1; -; mRNA.
DR EMBL; AC009127; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC010653; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471166; EAW59211.1; -; Genomic_DNA.
DR EMBL; CH471166; EAW59213.1; -; Genomic_DNA.
DR EMBL; CH471166; EAW59214.1; -; Genomic_DNA.
DR EMBL; CH471166; EAW59219.1; -; Genomic_DNA.
DR EMBL; BC012116; AAH12116.1; -; mRNA.
DR CCDS; CCDS32481.1; -. [O75541-2]
DR CCDS; CCDS56006.1; -. [O75541-1]
DR RefSeq; NP_001188481.1; NM_001201552.1. [O75541-1]
DR RefSeq; NP_001188482.1; NM_001201553.1. [O75541-1]
DR RefSeq; NP_001188483.1; NM_001201554.1.
DR RefSeq; NP_001188485.1; NM_001201556.1.
DR RefSeq; NP_060000.1; NM_017530.2.
DR RefSeq; XP_005256090.1; XM_005256033.2.
DR RefSeq; XP_006721296.1; XM_006721233.1.
DR RefSeq; XP_011521513.1; XM_011523211.2. [O75541-1]
DR RefSeq; XP_016878898.1; XM_017023409.1.
DR RefSeq; XP_016878899.1; XM_017023410.1. [O75541-1]
DR RefSeq; XP_016878900.1; XM_017023411.1. [O75541-1]
DR RefSeq; XP_016878901.1; XM_017023412.1. [O75541-1]
DR RefSeq; XP_016878903.1; XM_017023414.1.
DR AlphaFoldDB; O75541; -.
DR SMR; O75541; -.
DR BioGRID; 120720; 11.
DR IntAct; O75541; 9.
DR MINT; O75541; -.
DR STRING; 9606.ENSP00000398089; -.
DR GlyGen; O75541; 1 site, 1 N-linked glycan (1 site).
DR iPTMnet; O75541; -.
DR PhosphoSitePlus; O75541; -.
DR BioMuta; ZNF821; -.
DR MassIVE; O75541; -.
DR PaxDb; O75541; -.
DR PeptideAtlas; O75541; -.
DR PRIDE; O75541; -.
DR ProteomicsDB; 50075; -. [O75541-1]
DR ProteomicsDB; 50076; -. [O75541-2]
DR Antibodypedia; 16662; 96 antibodies from 22 providers.
DR DNASU; 55565; -.
DR Ensembl; ENST00000425432.6; ENSP00000398089.1; ENSG00000102984.15. [O75541-1]
DR Ensembl; ENST00000565601.5; ENSP00000455648.1; ENSG00000102984.15. [O75541-1]
DR GeneID; 55565; -.
DR KEGG; hsa:55565; -.
DR MANE-Select; ENST00000425432.6; ENSP00000398089.1; NM_001201552.2; NP_001188481.1.
DR UCSC; uc002fbf.4; human. [O75541-1]
DR CTD; 55565; -.
DR DisGeNET; 55565; -.
DR GeneCards; ZNF821; -.
DR HGNC; HGNC:28043; ZNF821.
DR HPA; ENSG00000102984; Tissue enhanced (testis).
DR neXtProt; NX_O75541; -.
DR OpenTargets; ENSG00000102984; -.
DR PharmGKB; PA162410689; -.
DR VEuPathDB; HostDB:ENSG00000102984; -.
DR eggNOG; KOG1721; Eukaryota.
DR GeneTree; ENSGT00940000159421; -.
DR InParanoid; O75541; -.
DR OMA; NPPVYPA; -.
DR OrthoDB; 901424at2759; -.
DR PhylomeDB; O75541; -.
DR TreeFam; TF326851; -.
DR PathwayCommons; O75541; -.
DR SignaLink; O75541; -.
DR BioGRID-ORCS; 55565; 8 hits in 1098 CRISPR screens.
DR ChiTaRS; ZNF821; human.
DR GenomeRNAi; 55565; -.
DR Pharos; O75541; Tdark.
DR PRO; PR:O75541; -.
DR Proteomes; UP000005640; Chromosome 16.
DR RNAct; O75541; protein.
DR Bgee; ENSG00000102984; Expressed in cortical plate and 112 other tissues.
DR ExpressionAtlas; O75541; baseline and differential.
DR Genevisible; O75541; HS.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:1990837; F:sequence-specific double-stranded DNA binding; IDA:ARUK-UCL.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR SMART; SM00355; ZnF_C2H2; 2.
DR SUPFAM; SSF57667; SSF57667; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 2.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Coiled coil; DNA-binding; Metal-binding; Nucleus;
KW Reference proteome; Repeat; Transcription; Transcription regulation; Zinc;
KW Zinc-finger.
FT CHAIN 1..412
FT /note="Zinc finger protein 821"
FT /id="PRO_0000317289"
FT ZN_FING 116..140
FT /note="C2H2-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 150..172
FT /note="C2H2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT REGION 26..83
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 278..319
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 257..366
FT /evidence="ECO:0000255"
FT COMPBIAS 39..53
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 67..83
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 16..57
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334, ECO:0000303|Ref.1"
FT /id="VSP_030933"
SQ SEQUENCE 412 AA; 46794 MW; B3C953147F1C4E5C CRC64;
MSRRKQTNPN KVHWDQVFAG LEEQARQAMM KTDFPGDLGS QRQAIQQLRD QDSSSSDSEG
DEEETTQDEV SSHTSEEDGG VVKVEKELEN TEQPVGGNEV VEHEVTGNLN SDPLLELCQC
PLCQLDCGSR EQLIAHVYQH TAAVVSAKSY MCPVCGRALS SPGSLGRHLL IHSEDQRSNC
AVCGARFTSH ATFNSEKLPE VLNMESLPTV HNEGPSSAEG KDIAFSPPVY PAGILLVCNN
CAAYRKLLEA QTPSVRKWAL RRQNEPLEVR LQRLERERTA KKSRRDNETP EEREVRRMRD
REAKRLQRMQ ETDEQRARRL QRDREAMRLK RANETPEKRQ ARLIREREAK RLKRRLEKMD
MMLRAQFGQD PSAMAALAAE MNFFQLPVSG VELDSQLLGK MAFEEQNSSS LH
