ZN821_MOUSE
ID ZN821_MOUSE Reviewed; 413 AA.
AC Q6PD05; E9Q0F1; Q3UWR1;
DT 05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 27-JUL-2011, sequence version 2.
DT 03-AUG-2022, entry version 136.
DE RecName: Full=Zinc finger protein 821;
GN Name=Znf821; Synonyms=Zfp821;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-404.
RC STRAIN=C57BL/6J;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
CC -!- FUNCTION: May be involved in transcriptional regulation.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. {ECO:0000305}.
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DR EMBL; AC132138; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC059014; AAH59014.1; -; mRNA.
DR EMBL; AK136168; BAE22853.1; -; mRNA.
DR CCDS; CCDS40473.1; -.
DR RefSeq; NP_001161418.1; NM_001167946.2.
DR RefSeq; NP_001273322.1; NM_001286393.1.
DR RefSeq; NP_083744.2; NM_029468.3.
DR RefSeq; XP_011246835.1; XM_011248533.2.
DR RefSeq; XP_011246836.1; XM_011248534.2.
DR RefSeq; XP_011246837.1; XM_011248535.1.
DR RefSeq; XP_011246838.1; XM_011248536.2.
DR RefSeq; XP_017168486.1; XM_017312997.1.
DR AlphaFoldDB; Q6PD05; -.
DR SMR; Q6PD05; -.
DR BioGRID; 217810; 1.
DR STRING; 10090.ENSMUSP00000034163; -.
DR iPTMnet; Q6PD05; -.
DR PhosphoSitePlus; Q6PD05; -.
DR PaxDb; Q6PD05; -.
DR PRIDE; Q6PD05; -.
DR Antibodypedia; 16662; 96 antibodies from 22 providers.
DR DNASU; 75871; -.
DR Ensembl; ENSMUST00000034163; ENSMUSP00000034163; ENSMUSG00000031728.
DR Ensembl; ENSMUST00000212000; ENSMUSP00000148348; ENSMUSG00000031728.
DR GeneID; 75871; -.
DR KEGG; mmu:75871; -.
DR UCSC; uc009njb.1; mouse.
DR CTD; 75871; -.
DR MGI; MGI:1923121; Zfp821.
DR VEuPathDB; HostDB:ENSMUSG00000031728; -.
DR eggNOG; KOG1721; Eukaryota.
DR GeneTree; ENSGT00940000159421; -.
DR HOGENOM; CLU_048218_0_0_1; -.
DR InParanoid; Q6PD05; -.
DR OMA; NPPVYPA; -.
DR OrthoDB; 901424at2759; -.
DR PhylomeDB; Q6PD05; -.
DR TreeFam; TF326851; -.
DR BioGRID-ORCS; 75871; 1 hit in 71 CRISPR screens.
DR ChiTaRS; Zfp821; mouse.
DR PRO; PR:Q6PD05; -.
DR Proteomes; UP000000589; Chromosome 8.
DR RNAct; Q6PD05; protein.
DR Bgee; ENSMUSG00000031728; Expressed in saccule of membranous labyrinth and 184 other tissues.
DR ExpressionAtlas; Q6PD05; baseline and differential.
DR Genevisible; Q6PD05; MM.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:1990837; F:sequence-specific double-stranded DNA binding; ISO:MGI.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR SMART; SM00355; ZnF_C2H2; 2.
DR SUPFAM; SSF57667; SSF57667; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 2.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 1.
PE 2: Evidence at transcript level;
KW Coiled coil; DNA-binding; Metal-binding; Nucleus; Reference proteome;
KW Repeat; Transcription; Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1..413
FT /note="Zinc finger protein 821"
FT /id="PRO_0000317290"
FT ZN_FING 117..141
FT /note="C2H2-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 151..173
FT /note="C2H2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT REGION 26..83
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 279..320
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 260..367
FT /evidence="ECO:0000255"
FT COMPBIAS 39..53
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 67..83
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 215
FT /note="G -> V (in Ref. 3; BAE22853)"
FT /evidence="ECO:0000305"
FT CONFLICT 271
FT /note="R -> T (in Ref. 2; AAH59014)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 413 AA; 46828 MW; 088D0A40B89455FC CRC64;
MSRRKQTNPN KVHWDQVFAG LEEQARQAMM KTDFPGDLGS QRQAIQQLRD QDSSSSDSEG
DEEETTQDEV SSHTSEEDGG VVKVEKELET AEAPVSSGDA LAEREVTENL NSDPLLQLCQ
CPLCQLDCGS REQLIAHVYQ HTAAVVSAKS YMCPVCGRAL SSPGSLGRHL LIHSEDQRSN
CAVCGARFTS HATFNSEKLP QVLNMESVPQ VHSEGPSSAE GKDIACSPPV YPAGILLVCN
NCAAYRKLLE TQTPSVRKWA LRRQNEPLEV RLQRLERERT AKKSRRDNET PEEREVRRMR
DREAKRLQRM QETDEQRARR LQRDREAMRL KRANETPEKR QARLIREREA KRLKRRLEKM
DMMLRAQFGQ DPSAMAALAA EMNFFQLPVS GVELDSQLLG KMAFEEQNNS SLH
