ZN829_HUMAN
ID ZN829_HUMAN Reviewed; 432 AA.
AC Q3KNS6; A0A075B6T0; Q3KNS7; Q6ZNN0; Q7Z657;
DT 20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT 08-NOV-2005, sequence version 1.
DT 03-AUG-2022, entry version 149.
DE RecName: Full=Zinc finger protein 829;
GN Name=ZNF829;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Liver;
RX PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D.,
RA Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A.,
RA Wiemann S., Schupp I.;
RT "The full-ORF clone resource of the German cDNA consortium.";
RL BMC Genomics 8:399-399(2007).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-182 (ISOFORM 1).
RC TISSUE=Testis;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15057824; DOI=10.1038/nature02399;
RA Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E.,
RA Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A.,
RA Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S.,
RA Carrano A.V., Caoile C., Chan Y.M., Christensen M., Cleland C.A.,
RA Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J.,
RA Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M.,
RA Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W.,
RA Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V.,
RA Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D.,
RA McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I.,
RA Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L.,
RA Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A.,
RA She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M.,
RA Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J.,
RA Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA Rubin E.M., Lucas S.M.;
RT "The DNA sequence and biology of human chromosome 19.";
RL Nature 428:529-535(2004).
CC -!- FUNCTION: May be involved in transcriptional regulation.
CC -!- INTERACTION:
CC Q3KNS6-3; Q9H257-2: CARD9; NbExp=3; IntAct=EBI-18036029, EBI-11530605;
CC Q3KNS6-3; P55212: CASP6; NbExp=3; IntAct=EBI-18036029, EBI-718729;
CC Q3KNS6-3; P28329-3: CHAT; NbExp=3; IntAct=EBI-18036029, EBI-25837549;
CC Q3KNS6-3; G5E9A7: DMWD; NbExp=3; IntAct=EBI-18036029, EBI-10976677;
CC Q3KNS6-3; O75190: DNAJB6; NbExp=3; IntAct=EBI-18036029, EBI-1053164;
CC Q3KNS6-3; Q01658: DR1; NbExp=3; IntAct=EBI-18036029, EBI-750300;
CC Q3KNS6-3; P41091: EIF2S3; NbExp=3; IntAct=EBI-18036029, EBI-1054228;
CC Q3KNS6-3; O75460-2: ERN1; NbExp=3; IntAct=EBI-18036029, EBI-25852368;
CC Q3KNS6-3; Q96EF6: FBXO17; NbExp=3; IntAct=EBI-18036029, EBI-2510157;
CC Q3KNS6-3; P22607: FGFR3; NbExp=3; IntAct=EBI-18036029, EBI-348399;
CC Q3KNS6-3; Q0VDC6: FKBP1A; NbExp=3; IntAct=EBI-18036029, EBI-10226858;
CC Q3KNS6-3; Q14957: GRIN2C; NbExp=3; IntAct=EBI-18036029, EBI-8285963;
CC Q3KNS6-3; P06396: GSN; NbExp=3; IntAct=EBI-18036029, EBI-351506;
CC Q3KNS6-3; Q00403: GTF2B; NbExp=3; IntAct=EBI-18036029, EBI-389564;
CC Q3KNS6-3; Q9Y5Q9: GTF3C3; NbExp=3; IntAct=EBI-18036029, EBI-1054873;
CC Q3KNS6-3; P54652: HSPA2; NbExp=3; IntAct=EBI-18036029, EBI-356991;
CC Q3KNS6-3; P42858: HTT; NbExp=6; IntAct=EBI-18036029, EBI-466029;
CC Q3KNS6-3; O60333-2: KIF1B; NbExp=3; IntAct=EBI-18036029, EBI-10975473;
CC Q3KNS6-3; Q969R5: L3MBTL2; NbExp=3; IntAct=EBI-18036029, EBI-739909;
CC Q3KNS6-3; P13473-2: LAMP2; NbExp=3; IntAct=EBI-18036029, EBI-21591415;
CC Q3KNS6-3; O14561: NDUFAB1; NbExp=3; IntAct=EBI-18036029, EBI-1246261;
CC Q3KNS6-3; P07196: NEFL; NbExp=3; IntAct=EBI-18036029, EBI-475646;
CC Q3KNS6-3; P50897: PPT1; NbExp=3; IntAct=EBI-18036029, EBI-1237011;
CC Q3KNS6-3; O75400-2: PRPF40A; NbExp=3; IntAct=EBI-18036029, EBI-5280197;
CC Q3KNS6-3; P60891: PRPS1; NbExp=3; IntAct=EBI-18036029, EBI-749195;
CC Q3KNS6-3; P62826: RAN; NbExp=3; IntAct=EBI-18036029, EBI-286642;
CC Q3KNS6-3; Q9BWG6: SCNM1; NbExp=3; IntAct=EBI-18036029, EBI-748391;
CC Q3KNS6-3; Q9Y371: SH3GLB1; NbExp=3; IntAct=EBI-18036029, EBI-2623095;
CC Q3KNS6-3; Q7Z699: SPRED1; NbExp=3; IntAct=EBI-18036029, EBI-5235340;
CC Q3KNS6-3; Q9UKI8: TLK1; NbExp=3; IntAct=EBI-18036029, EBI-740492;
CC Q3KNS6-3; Q9UMX0: UBQLN1; NbExp=3; IntAct=EBI-18036029, EBI-741480;
CC Q3KNS6-3; O76024: WFS1; NbExp=3; IntAct=EBI-18036029, EBI-720609;
CC Q3KNS6-3; Q9BW85: YJU2; NbExp=3; IntAct=EBI-18036029, EBI-10300345;
CC Q3KNS6-3; Q96SQ5: ZNF587; NbExp=3; IntAct=EBI-18036029, EBI-6427977;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1;
CC IsoId=Q3KNS6-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q3KNS6-2; Sequence=VSP_033769, VSP_033770;
CC Name=3;
CC IsoId=Q3KNS6-3; Sequence=VSP_057606;
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=CAD98083.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR EMBL; BX538288; CAD98083.1; ALT_INIT; mRNA.
DR EMBL; BC107131; AAI07132.1; -; mRNA.
DR EMBL; BC107132; AAI07133.1; -; mRNA.
DR EMBL; AK130969; BAC85471.1; -; mRNA.
DR EMBL; AC008733; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; KC877740; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS42557.1; -. [Q3KNS6-1]
DR CCDS; CCDS59380.1; -. [Q3KNS6-3]
DR RefSeq; NP_001032309.2; NM_001037232.3. [Q3KNS6-1]
DR RefSeq; NP_001165450.1; NM_001171979.1. [Q3KNS6-3]
DR RefSeq; XP_005258933.1; XM_005258876.4. [Q3KNS6-1]
DR RefSeq; XP_011525235.1; XM_011526933.2. [Q3KNS6-1]
DR AlphaFoldDB; Q3KNS6; -.
DR SMR; Q3KNS6; -.
DR BioGRID; 131934; 20.
DR IntAct; Q3KNS6; 41.
DR MINT; Q3KNS6; -.
DR STRING; 9606.ENSP00000428679; -.
DR iPTMnet; Q3KNS6; -.
DR PhosphoSitePlus; Q3KNS6; -.
DR BioMuta; ZNF829; -.
DR DMDM; 121947691; -.
DR EPD; Q3KNS6; -.
DR jPOST; Q3KNS6; -.
DR MassIVE; Q3KNS6; -.
DR MaxQB; Q3KNS6; -.
DR PaxDb; Q3KNS6; -.
DR PeptideAtlas; Q3KNS6; -.
DR PRIDE; Q3KNS6; -.
DR ProteomicsDB; 61696; -. [Q3KNS6-1]
DR ProteomicsDB; 61697; -. [Q3KNS6-2]
DR Antibodypedia; 59032; 120 antibodies from 16 providers.
DR DNASU; 374899; -.
DR Ensembl; ENST00000391711.8; ENSP00000429266.1; ENSG00000185869.15. [Q3KNS6-1]
DR Ensembl; ENST00000520965.5; ENSP00000428679.2; ENSG00000185869.15. [Q3KNS6-3]
DR GeneID; 374899; -.
DR KEGG; hsa:374899; -.
DR MANE-Select; ENST00000391711.8; ENSP00000429266.1; NM_001037232.4; NP_001032309.2.
DR UCSC; uc002ofa.3; human. [Q3KNS6-1]
DR UCSC; uc021utr.1; human.
DR CTD; 374899; -.
DR DisGeNET; 374899; -.
DR GeneCards; ZNF829; -.
DR HGNC; HGNC:34032; ZNF829.
DR HPA; ENSG00000185869; Tissue enriched (testis).
DR neXtProt; NX_Q3KNS6; -.
DR OpenTargets; ENSG00000185869; -.
DR PharmGKB; PA162410750; -.
DR VEuPathDB; HostDB:ENSG00000185869; -.
DR eggNOG; KOG1721; Eukaryota.
DR GeneTree; ENSGT00940000156284; -.
DR HOGENOM; CLU_002678_0_9_1; -.
DR InParanoid; Q3KNS6; -.
DR OrthoDB; 1318335at2759; -.
DR PhylomeDB; Q3KNS6; -.
DR TreeFam; TF337055; -.
DR PathwayCommons; Q3KNS6; -.
DR SignaLink; Q3KNS6; -.
DR BioGRID-ORCS; 374899; 10 hits in 1076 CRISPR screens.
DR ChiTaRS; ZNF829; human.
DR GenomeRNAi; 374899; -.
DR Pharos; Q3KNS6; Tdark.
DR PRO; PR:Q3KNS6; -.
DR Proteomes; UP000005640; Chromosome 19.
DR RNAct; Q3KNS6; protein.
DR Bgee; ENSG00000185869; Expressed in sperm and 142 other tissues.
DR Genevisible; Q3KNS6; HS.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd07765; KRAB_A-box; 1.
DR InterPro; IPR001909; KRAB.
DR InterPro; IPR036051; KRAB_dom_sf.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF01352; KRAB; 1.
DR Pfam; PF00096; zf-C2H2; 9.
DR SMART; SM00349; KRAB; 1.
DR SMART; SM00355; ZnF_C2H2; 9.
DR SUPFAM; SSF109640; SSF109640; 1.
DR SUPFAM; SSF57667; SSF57667; 6.
DR PROSITE; PS50805; KRAB; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 9.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 10.
PE 1: Evidence at protein level;
KW Alternative splicing; DNA-binding; Metal-binding; Nucleus;
KW Reference proteome; Repeat; Transcription; Transcription regulation; Zinc;
KW Zinc-finger.
FT CHAIN 1..432
FT /note="Zinc finger protein 829"
FT /id="PRO_0000335808"
FT DOMAIN 35..106
FT /note="KRAB"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00119"
FT ZN_FING 156..178
FT /note="C2H2-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 184..206
FT /note="C2H2-type 2; degenerate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 212..234
FT /note="C2H2-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 240..262
FT /note="C2H2-type 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 268..290
FT /note="C2H2-type 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 296..318
FT /note="C2H2-type 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 324..346
FT /note="C2H2-type 7"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 352..374
FT /note="C2H2-type 8"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 380..402
FT /note="C2H2-type 9"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 408..430
FT /note="C2H2-type 10"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT VAR_SEQ 1..184
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_033769"
FT VAR_SEQ 1
FT /note="M -> MTGKGLGEDTEDRWGAGALGPCGRSGLKGGGCVWEAEAGGSRGQEIE
FT TILANMETSLRSGQIPTLDSSEHNLSPEPLELDRM (in isoform 3)"
FT /id="VSP_057606"
FT VAR_SEQ 185..186
FT /note="ES -> MN (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_033770"
SQ SEQUENCE 432 AA; 50142 MW; 123E60C5564D53AD CRC64;
MPHSPLISIP HVWCHPEEEE RMHDELLQAV SKGPVMFRDV SIDFSQEEWE CLDADQMNLY
KEVMLENFSN LVSVGLSNSK PAVISLLEQG KEPWMVDREL TRGLCSDLES MCETKILSLK
KRHFSQVIIT REDMSTFIQP TFLIPPQKTM SEEKPWECKI CGKTFNQNSQ FIQHQRIHFG
EKHYESKEYG KSFSRGSLVT RHQRIHTGKK PYECKECGKA FSCSSYFSQH QRIHTGEKPY
ECKECGKAFK YCSNLNDHQR IHTGEKPYEC KVCGKAFTKS SQLFLHLRIH TGEKPYECKE
CGKAFTQHSR LIQHQRMHTG EKPYECKQCG KAFNSASTLT NHHRIHAGEK LYECEECRKA
FIQSSELIQH QRIHTDEKPY ECNECGKAFN KGSNLTRHQR IHTGEKPYDC KECGKAFGSR
SDLIRHEGIH TG
