ZN835_HUMAN
ID ZN835_HUMAN Reviewed; 537 AA.
AC Q9Y2P0; B7Z5Y0; G3V1S0;
DT 26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 05-SEP-2012, sequence version 2.
DT 03-AUG-2022, entry version 164.
DE RecName: Full=Zinc finger protein 835;
GN Name=ZNF835;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANTS LYS-29 AND ALA-88.
RC TISSUE=Fetal brain, and Teratocarcinoma;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15057824; DOI=10.1038/nature02399;
RA Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E.,
RA Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A.,
RA Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S.,
RA Carrano A.V., Caoile C., Chan Y.M., Christensen M., Cleland C.A.,
RA Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J.,
RA Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M.,
RA Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W.,
RA Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V.,
RA Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D.,
RA McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I.,
RA Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L.,
RA Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A.,
RA She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M.,
RA Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J.,
RA Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA Rubin E.M., Lucas S.M.;
RT "The DNA sequence and biology of human chromosome 19.";
RL Nature 428:529-535(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: May be involved in transcriptional regulation.
CC -!- INTERACTION:
CC Q9Y2P0; Q9BUH8: BEGAIN; NbExp=3; IntAct=EBI-5667516, EBI-742722;
CC Q9Y2P0; Q13895: BYSL; NbExp=3; IntAct=EBI-5667516, EBI-358049;
CC Q9Y2P0; Q9NP86: CABP5; NbExp=3; IntAct=EBI-5667516, EBI-10311131;
CC Q9Y2P0; Q2TAC2-2: CCDC57; NbExp=3; IntAct=EBI-5667516, EBI-10961624;
CC Q9Y2P0; Q16204: CCDC6; NbExp=3; IntAct=EBI-5667516, EBI-1045350;
CC Q9Y2P0; O95273: CCNDBP1; NbExp=3; IntAct=EBI-5667516, EBI-748961;
CC Q9Y2P0; Q86X02: CDR2L; NbExp=3; IntAct=EBI-5667516, EBI-11063830;
CC Q9Y2P0; Q8NHQ1: CEP70; NbExp=3; IntAct=EBI-5667516, EBI-739624;
CC Q9Y2P0; Q96Q77: CIB3; NbExp=3; IntAct=EBI-5667516, EBI-10292696;
CC Q9Y2P0; P49761: CLK3; NbExp=5; IntAct=EBI-5667516, EBI-745579;
CC Q9Y2P0; A8MQ03: CYSRT1; NbExp=3; IntAct=EBI-5667516, EBI-3867333;
CC Q9Y2P0; Q05D60: DEUP1; NbExp=3; IntAct=EBI-5667516, EBI-748597;
CC Q9Y2P0; A1L4K1: FSD2; NbExp=3; IntAct=EBI-5667516, EBI-5661036;
CC Q9Y2P0; Q08379: GOLGA2; NbExp=3; IntAct=EBI-5667516, EBI-618309;
CC Q9Y2P0; A6NEM1: GOLGA6L9; NbExp=3; IntAct=EBI-5667516, EBI-5916454;
CC Q9Y2P0; Q9HD26-2: GOPC; NbExp=3; IntAct=EBI-5667516, EBI-11102276;
CC Q9Y2P0; Q4V328: GRIPAP1; NbExp=3; IntAct=EBI-5667516, EBI-717919;
CC Q9Y2P0; Q96NT3-2: GUCD1; NbExp=3; IntAct=EBI-5667516, EBI-11978177;
CC Q9Y2P0; P54257: HAP1; NbExp=3; IntAct=EBI-5667516, EBI-712814;
CC Q9Y2P0; Q96ED9-2: HOOK2; NbExp=3; IntAct=EBI-5667516, EBI-10961706;
CC Q9Y2P0; Q4VB01: HOXB1; NbExp=3; IntAct=EBI-5667516, EBI-17494170;
CC Q9Y2P0; O75031: HSF2BP; NbExp=3; IntAct=EBI-5667516, EBI-7116203;
CC Q9Y2P0; Q9Y6K9: IKBKG; NbExp=3; IntAct=EBI-5667516, EBI-81279;
CC Q9Y2P0; Q14005-2: IL16; NbExp=3; IntAct=EBI-5667516, EBI-17178971;
CC Q9Y2P0; Q9BVG8-5: KIFC3; NbExp=3; IntAct=EBI-5667516, EBI-14069005;
CC Q9Y2P0; Q15323: KRT31; NbExp=3; IntAct=EBI-5667516, EBI-948001;
CC Q9Y2P0; P60328: KRTAP12-3; NbExp=3; IntAct=EBI-5667516, EBI-11953334;
CC Q9Y2P0; Q9BYR2: KRTAP4-5; NbExp=3; IntAct=EBI-5667516, EBI-11993254;
CC Q9Y2P0; O95751: LDOC1; NbExp=3; IntAct=EBI-5667516, EBI-740738;
CC Q9Y2P0; Q96A72: MAGOHB; NbExp=3; IntAct=EBI-5667516, EBI-746778;
CC Q9Y2P0; Q13064: MKRN3; NbExp=3; IntAct=EBI-5667516, EBI-2340269;
CC Q9Y2P0; P13349: MYF5; NbExp=3; IntAct=EBI-5667516, EBI-17491620;
CC Q9Y2P0; Q9H4L5: OSBPL3; NbExp=3; IntAct=EBI-5667516, EBI-1051317;
CC Q9Y2P0; O15160: POLR1C; NbExp=3; IntAct=EBI-5667516, EBI-1055079;
CC Q9Y2P0; Q9GZV8: PRDM14; NbExp=3; IntAct=EBI-5667516, EBI-3957793;
CC Q9Y2P0; Q6NUQ1: RINT1; NbExp=3; IntAct=EBI-5667516, EBI-726876;
CC Q9Y2P0; Q5TA31: RNF187; NbExp=3; IntAct=EBI-5667516, EBI-6868977;
CC Q9Y2P0; Q59EK9-3: RUNDC3A; NbExp=3; IntAct=EBI-5667516, EBI-11957366;
CC Q9Y2P0; Q9BZQ2: SHCBP1L; NbExp=3; IntAct=EBI-5667516, EBI-10818532;
CC Q9Y2P0; Q9NUL5-4: SHFL; NbExp=3; IntAct=EBI-5667516, EBI-11955083;
CC Q9Y2P0; Q9UM82: SPATA2; NbExp=3; IntAct=EBI-5667516, EBI-744066;
CC Q9Y2P0; Q96FJ0: STAMBPL1; NbExp=3; IntAct=EBI-5667516, EBI-745021;
CC Q9Y2P0; Q16623: STX1A; NbExp=3; IntAct=EBI-5667516, EBI-712466;
CC Q9Y2P0; Q9BXU0: TEX12; NbExp=3; IntAct=EBI-5667516, EBI-12090309;
CC Q9Y2P0; Q08117-2: TLE5; NbExp=3; IntAct=EBI-5667516, EBI-11741437;
CC Q9Y2P0; Q9BUZ4: TRAF4; NbExp=3; IntAct=EBI-5667516, EBI-3650647;
CC Q9Y2P0; P36406: TRIM23; NbExp=3; IntAct=EBI-5667516, EBI-740098;
CC Q9Y2P0; Q8WV44: TRIM41; NbExp=6; IntAct=EBI-5667516, EBI-725997;
CC Q9Y2P0; Q9H2G4: TSPYL2; NbExp=3; IntAct=EBI-5667516, EBI-947459;
CC Q9Y2P0; P42681: TXK; NbExp=3; IntAct=EBI-5667516, EBI-7877438;
CC Q9Y2P0; P26368-2: U2AF2; NbExp=3; IntAct=EBI-5667516, EBI-11097439;
CC Q9Y2P0; P13994: YJU2B; NbExp=3; IntAct=EBI-5667516, EBI-716093;
CC Q9Y2P0; P58317: ZNF121; NbExp=3; IntAct=EBI-5667516, EBI-1228269;
CC Q9Y2P0; O95125: ZNF202; NbExp=3; IntAct=EBI-5667516, EBI-751960;
CC Q9Y2P0; Q6P1L6: ZNF343; NbExp=3; IntAct=EBI-5667516, EBI-10252492;
CC Q9Y2P0; Q6ZNH5: ZNF497; NbExp=3; IntAct=EBI-5667516, EBI-10486136;
CC Q9Y2P0; Q96C55: ZNF524; NbExp=3; IntAct=EBI-5667516, EBI-10283126;
CC Q9Y2P0; Q8TF50: ZNF526; NbExp=3; IntAct=EBI-5667516, EBI-11035148;
CC Q9Y2P0; Q9H707: ZNF552; NbExp=3; IntAct=EBI-5667516, EBI-2555731;
CC Q9Y2P0; Q7Z3I7: ZNF572; NbExp=3; IntAct=EBI-5667516, EBI-10172590;
CC Q9Y2P0; Q9UEG4: ZNF629; NbExp=3; IntAct=EBI-5667516, EBI-9977294;
CC Q9Y2P0; Q9NQZ8: ZNF71; NbExp=3; IntAct=EBI-5667516, EBI-7138235;
CC Q9Y2P0; Q9H5H4: ZNF768; NbExp=3; IntAct=EBI-5667516, EBI-1210580;
CC Q9Y2P0; Q3KQV3: ZNF792; NbExp=3; IntAct=EBI-5667516, EBI-10240849;
CC Q9Y2P0; Q96EG3: ZNF837; NbExp=3; IntAct=EBI-5667516, EBI-11962574;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAD23609.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AK023017; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; AK299565; BAH13066.1; -; mRNA.
DR EMBL; AC007228; AAD23609.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CH471135; EAW72470.1; -; Genomic_DNA.
DR CCDS; CCDS56105.1; -.
DR RefSeq; NP_001005850.2; NM_001005850.2.
DR RefSeq; XP_005259439.1; XM_005259382.2.
DR RefSeq; XP_005259440.1; XM_005259383.3.
DR AlphaFoldDB; Q9Y2P0; -.
DR SMR; Q9Y2P0; -.
DR BioGRID; 124722; 68.
DR IntAct; Q9Y2P0; 67.
DR STRING; 9606.ENSP00000444747; -.
DR iPTMnet; Q9Y2P0; -.
DR PhosphoSitePlus; Q9Y2P0; -.
DR BioMuta; ZNF835; -.
DR DMDM; 403314387; -.
DR jPOST; Q9Y2P0; -.
DR MassIVE; Q9Y2P0; -.
DR PaxDb; Q9Y2P0; -.
DR PeptideAtlas; Q9Y2P0; -.
DR PRIDE; Q9Y2P0; -.
DR ProteomicsDB; 32421; -.
DR ProteomicsDB; 85852; -.
DR Antibodypedia; 33227; 111 antibodies from 17 providers.
DR DNASU; 90485; -.
DR Ensembl; ENST00000537055.4; ENSP00000444747.1; ENSG00000127903.14.
DR GeneID; 90485; -.
DR KEGG; hsa:90485; -.
DR MANE-Select; ENST00000537055.4; ENSP00000444747.1; NM_001005850.3; NP_001005850.2.
DR UCSC; uc010ygn.3; human.
DR CTD; 90485; -.
DR GeneCards; ZNF835; -.
DR HGNC; HGNC:34332; ZNF835.
DR HPA; ENSG00000127903; Low tissue specificity.
DR neXtProt; NX_Q9Y2P0; -.
DR OpenTargets; ENSG00000127903; -.
DR PharmGKB; PA162410787; -.
DR VEuPathDB; HostDB:ENSG00000127903; -.
DR eggNOG; KOG1721; Eukaryota.
DR GeneTree; ENSGT00940000165608; -.
DR HOGENOM; CLU_002678_44_17_1; -.
DR InParanoid; Q9Y2P0; -.
DR OMA; PKKPWKC; -.
DR OrthoDB; 1318335at2759; -.
DR PhylomeDB; Q9Y2P0; -.
DR TreeFam; TF341817; -.
DR PathwayCommons; Q9Y2P0; -.
DR SignaLink; Q9Y2P0; -.
DR BioGRID-ORCS; 90485; 14 hits in 1068 CRISPR screens.
DR ChiTaRS; ZNF835; human.
DR GenomeRNAi; 90485; -.
DR Pharos; Q9Y2P0; Tdark.
DR PRO; PR:Q9Y2P0; -.
DR Proteomes; UP000005640; Chromosome 19.
DR RNAct; Q9Y2P0; protein.
DR Bgee; ENSG00000127903; Expressed in buccal mucosa cell and 106 other tissues.
DR ExpressionAtlas; Q9Y2P0; baseline and differential.
DR Genevisible; Q9Y2P0; HS.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF00096; zf-C2H2; 14.
DR SMART; SM00355; ZnF_C2H2; 14.
DR SUPFAM; SSF57667; SSF57667; 9.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 14.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 14.
PE 1: Evidence at protein level;
KW DNA-binding; Metal-binding; Nucleus; Reference proteome; Repeat;
KW Transcription; Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1..537
FT /note="Zinc finger protein 835"
FT /id="PRO_0000319111"
FT ZN_FING 110..132
FT /note="C2H2-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 138..160
FT /note="C2H2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 166..188
FT /note="C2H2-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 194..216
FT /note="C2H2-type 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 222..244
FT /note="C2H2-type 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 250..272
FT /note="C2H2-type 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 278..300
FT /note="C2H2-type 7"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 306..328
FT /note="C2H2-type 8"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 334..356
FT /note="C2H2-type 9"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 362..384
FT /note="C2H2-type 10"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 390..412
FT /note="C2H2-type 11"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 418..440
FT /note="C2H2-type 12"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 446..468
FT /note="C2H2-type 13"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 474..496
FT /note="C2H2-type 14"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT REGION 12..109
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 497..537
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 63..85
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 86..108
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 510..524
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VARIANT 29
FT /note="E -> K (in dbSNP:rs12462469)"
FT /evidence="ECO:0000269|PubMed:14702039"
FT /id="VAR_061977"
FT VARIANT 88
FT /note="E -> A (in dbSNP:rs12460400)"
FT /evidence="ECO:0000269|PubMed:14702039"
FT /id="VAR_061978"
FT CONFLICT 156
FT /note="H -> R (in Ref. 1; BAH13066)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 537 AA; 59631 MW; 99746C9E4D456DAB CRC64;
MEGLLSVALQ GAELEGNWKH EGQVEDLQEN QESCPEPEAV ACKGDPAGDS MQERDEFSRI
PRTISSPAAT QASVPDDSSS RRCSAPGESP KERHPDSRQR ERGGGPKKPW KCGDCGKAFS
YCSAFILHQR IHTGEKPFAC PECGKAFSQS VHLTLHQRTH TGEKPYACHE CGKAFSQGSY
LASHWRTHTG EKPHRCADCG KAFTRVTHLT QHRRVHTGER PYACAQCAKA FRNRSSLIEH
QRIHTGEKPY ECSACAKAFR FSSALIRHQR IHTEEKPYRC GQCAKAFAQI AHLTQHRRVH
TGEKPYTCQD CGALFSQSAS LAEHRRIHTG EKPYACGQCA KAFTQVSHLT QHQRTHTGER
PYPCHDCGKR FSNRSHLLQH RLVHTGERPY RCLQCGAAFS HVSSLIEHQK IHTGERPYKC
GECGKAFSQG SSLALHQRTH TGERPYTCPE CGKAFSNRSY LIQHHIVHTG EKPYECSGCG
KAFSFSSALI RHQRTHADSS GRLCPAPTPD STPGLSQGGE TCQQGCPGRN PRGPAED
