ZN836_HUMAN
ID ZN836_HUMAN Reviewed; 936 AA.
AC Q6ZNA1;
DT 26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 26-FEB-2008, sequence version 2.
DT 03-AUG-2022, entry version 150.
DE RecName: Full=Zinc finger protein 836;
GN Name=ZNF836;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15057824; DOI=10.1038/nature02399;
RA Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E.,
RA Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A.,
RA Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S.,
RA Carrano A.V., Caoile C., Chan Y.M., Christensen M., Cleland C.A.,
RA Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J.,
RA Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M.,
RA Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W.,
RA Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V.,
RA Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D.,
RA McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I.,
RA Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L.,
RA Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A.,
RA She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M.,
RA Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J.,
RA Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA Rubin E.M., Lucas S.M.;
RT "The DNA sequence and biology of human chromosome 19.";
RL Nature 428:529-535(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-891, AND VARIANTS ILE-219 AND
RP SER-809.
RC TISSUE=Brain;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
CC -!- FUNCTION: May be involved in transcriptional regulation.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. {ECO:0000305}.
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DR EMBL; AC010320; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC011468; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AK131308; BAD18474.1; -; mRNA.
DR CCDS; CCDS46162.1; -.
DR RefSeq; NP_001096127.1; NM_001102657.1.
DR RefSeq; XP_011524860.1; XM_011526558.2.
DR RefSeq; XP_011524861.1; XM_011526559.2.
DR AlphaFoldDB; Q6ZNA1; -.
DR SMR; Q6ZNA1; -.
DR BioGRID; 127831; 3.
DR IntAct; Q6ZNA1; 1.
DR STRING; 9606.ENSP00000470239; -.
DR iPTMnet; Q6ZNA1; -.
DR PhosphoSitePlus; Q6ZNA1; -.
DR BioMuta; ZNF836; -.
DR DMDM; 172046146; -.
DR EPD; Q6ZNA1; -.
DR jPOST; Q6ZNA1; -.
DR MassIVE; Q6ZNA1; -.
DR MaxQB; Q6ZNA1; -.
DR PaxDb; Q6ZNA1; -.
DR PeptideAtlas; Q6ZNA1; -.
DR PRIDE; Q6ZNA1; -.
DR ProteomicsDB; 68001; -.
DR Antibodypedia; 56947; 56 antibodies from 9 providers.
DR DNASU; 162962; -.
DR Ensembl; ENST00000597252.5; ENSP00000470239.1; ENSG00000196267.14.
DR Ensembl; ENST00000682614.1; ENSP00000507838.1; ENSG00000196267.14.
DR GeneID; 162962; -.
DR KEGG; hsa:162962; -.
DR MANE-Select; ENST00000682614.1; ENSP00000507838.1; NM_001102657.3; NP_001096127.1.
DR UCSC; uc010ydi.3; human.
DR CTD; 162962; -.
DR GeneCards; ZNF836; -.
DR HGNC; HGNC:34333; ZNF836.
DR HPA; ENSG00000196267; Tissue enhanced (adrenal).
DR neXtProt; NX_Q6ZNA1; -.
DR OpenTargets; ENSG00000196267; -.
DR PharmGKB; PA162410788; -.
DR VEuPathDB; HostDB:ENSG00000196267; -.
DR eggNOG; KOG1721; Eukaryota.
DR GeneTree; ENSGT00940000164568; -.
DR HOGENOM; CLU_002678_17_1_1; -.
DR InParanoid; Q6ZNA1; -.
DR OMA; MLERHEC; -.
DR OrthoDB; 1318335at2759; -.
DR PhylomeDB; Q6ZNA1; -.
DR TreeFam; TF343410; -.
DR PathwayCommons; Q6ZNA1; -.
DR SignaLink; Q6ZNA1; -.
DR BioGRID-ORCS; 162962; 6 hits in 1081 CRISPR screens.
DR ChiTaRS; ZNF836; human.
DR GenomeRNAi; 162962; -.
DR Pharos; Q6ZNA1; Tdark.
DR PRO; PR:Q6ZNA1; -.
DR Proteomes; UP000005640; Chromosome 19.
DR RNAct; Q6ZNA1; protein.
DR Bgee; ENSG00000196267; Expressed in buccal mucosa cell and 106 other tissues.
DR ExpressionAtlas; Q6ZNA1; baseline and differential.
DR Genevisible; Q6ZNA1; HS.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd07765; KRAB_A-box; 1.
DR InterPro; IPR001909; KRAB.
DR InterPro; IPR036051; KRAB_dom_sf.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF01352; KRAB; 1.
DR Pfam; PF00096; zf-C2H2; 22.
DR SMART; SM00349; KRAB; 1.
DR SMART; SM00355; ZnF_C2H2; 24.
DR SUPFAM; SSF109640; SSF109640; 1.
DR SUPFAM; SSF57667; SSF57667; 13.
DR PROSITE; PS50805; KRAB; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 24.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 25.
PE 2: Evidence at transcript level;
KW DNA-binding; Metal-binding; Nucleus; Reference proteome; Repeat;
KW Transcription; Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1..936
FT /note="Zinc finger protein 836"
FT /id="PRO_0000319434"
FT DOMAIN 8..83
FT /note="KRAB"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00119"
FT ZN_FING 218..240
FT /note="C2H2-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 246..268
FT /note="C2H2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 274..296
FT /note="C2H2-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 302..324
FT /note="C2H2-type 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 330..352
FT /note="C2H2-type 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 358..380
FT /note="C2H2-type 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 386..408
FT /note="C2H2-type 7"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 414..436
FT /note="C2H2-type 8"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 442..464
FT /note="C2H2-type 9"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 470..492
FT /note="C2H2-type 10"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 498..520
FT /note="C2H2-type 11"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 526..548
FT /note="C2H2-type 12"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 554..576
FT /note="C2H2-type 13"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 582..604
FT /note="C2H2-type 14"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 610..632
FT /note="C2H2-type 15"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 638..660
FT /note="C2H2-type 16"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 666..688
FT /note="C2H2-type 17"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 694..716
FT /note="C2H2-type 18; degenerate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 722..744
FT /note="C2H2-type 19"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 750..772
FT /note="C2H2-type 20"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 778..800
FT /note="C2H2-type 21"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 806..828
FT /note="C2H2-type 22"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 834..856
FT /note="C2H2-type 23"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 862..884
FT /note="C2H2-type 24"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 890..912
FT /note="C2H2-type 25"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT VARIANT 219
FT /note="M -> I (in dbSNP:rs1366245)"
FT /evidence="ECO:0000269|PubMed:14702039"
FT /id="VAR_039001"
FT VARIANT 809
FT /note="N -> S (in dbSNP:rs8113504)"
FT /evidence="ECO:0000269|PubMed:14702039"
FT /id="VAR_039002"
FT CONFLICT 434
FT /note="I -> V (in Ref. 2; BAD18474)"
FT /evidence="ECO:0000305"
FT CONFLICT 463
FT /note="S -> G (in Ref. 2; BAD18474)"
FT /evidence="ECO:0000305"
FT CONFLICT 576
FT /note="H -> R (in Ref. 2; BAD18474)"
FT /evidence="ECO:0000305"
FT CONFLICT 661
FT /note="T -> A (in Ref. 2; BAD18474)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 936 AA; 107717 MW; 6C7FC8B639550732 CRC64;
MALTQGPLTF RDVAIEFSQE EWKSLDPVQK ALYWDVMLEN YRNLVFLGIL PKCMTKELPP
IGNSNTGEKC QTVTLERHEC YDVENFYLRE IQKNLQDLEF QWKDGEINYK EVPMTYKNNL
NGKRGQHSQE DVENKCIENQ LTLSFQSRLT ELQKFQTEGK IYECNQSEKT VNNSSLVSPL
QRILPSVQTN ISKKYENEFL QLSLPTQLEK THIREKPYMC KGCGKAFRVS SSLINHQMVH
TTEKPYKCNE CGKAFHRGSL LTIHQIVHTR GKPYQCGVCG KIFRQNSDLV NHRRSHTGEK
PYKCNECGKS FSQSYNLAIH QRIHTGEKPY KCNECGKTFK QGSCLTTHQI IHTGEKPYQC
DICGKVFRQN SNLVNHQRIH TGEKPYKCNI CGKSFSQSSN LATHQTVHSG NKPYKCDECG
KTFKRSSSLT THQIIHTGEK PYTCDVCDKV FSQRSQLARH QRSHTGEKPY KCNECGKVFS
QTSHLVGHRR IHTGEKPYKC DKCGKAFKQG SLLTRHKIIH TREKRYQCGE CGKVFSENSC
LVRHLRIHTG EQPYKCNVCG KVFNYSGNLS IHKRIHTGEK PFQCNECGTV FRNYSCLARH
LRIHTGQKPY KCNVCGKVFN DSGNLSNHKR IHTGEKPFQC NECGKVFSYY SCLARHRKIH
TGEKPYKCND CGKAYTQRSS LTKHLIIHTG EKPYNCNEFG GAFIQSSKLA RYHRNPTGEK
PHKCSHCGRT FSHITGLTYH QRRHTGEMPY KCIECGQVFN STSNLARHRR IHTGEKPYKC
NECGKVFRHQ STLARHRSIH TGEKPYVCNE CGKAFRVRSI LVNHQKMHTG DKPYKCNECG
KAFIERSKLV YHQRNHTGEK PYKCIECGKA FGRFSCLNKH QMIHSGEKPY KCNECGKSFI
SRSGLTKHQT KHTAESLKTK FNVEKPLDVL LTSGFK
