ZN837_HUMAN
ID ZN837_HUMAN Reviewed; 531 AA.
AC Q96EG3;
DT 26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 19-SEP-2006, sequence version 2.
DT 03-AUG-2022, entry version 155.
DE RecName: Full=Zinc finger protein 837;
GN Name=ZNF837;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=B-cell;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: May be involved in transcriptional regulation. {ECO:0000250}.
CC -!- INTERACTION:
CC Q96EG3; Q8TBE0: BAHD1; NbExp=3; IntAct=EBI-11962574, EBI-742750;
CC Q96EG3; Q9BUH8: BEGAIN; NbExp=3; IntAct=EBI-11962574, EBI-742722;
CC Q96EG3; Q9BWT7: CARD10; NbExp=3; IntAct=EBI-11962574, EBI-3866279;
CC Q96EG3; Q8NEC5: CATSPER1; NbExp=3; IntAct=EBI-11962574, EBI-744545;
CC Q96EG3; Q86Z20: CCDC125; NbExp=3; IntAct=EBI-11962574, EBI-11977221;
CC Q96EG3; O95273: CCNDBP1; NbExp=3; IntAct=EBI-11962574, EBI-748961;
CC Q96EG3; Q16543: CDC37; NbExp=3; IntAct=EBI-11962574, EBI-295634;
CC Q96EG3; Q9UKJ5: CHIC2; NbExp=3; IntAct=EBI-11962574, EBI-741528;
CC Q96EG3; P49760: CLK2; NbExp=3; IntAct=EBI-11962574, EBI-750020;
CC Q96EG3; A8MQ03: CYSRT1; NbExp=3; IntAct=EBI-11962574, EBI-3867333;
CC Q96EG3; Q6P158: DHX57; NbExp=3; IntAct=EBI-11962574, EBI-1051531;
CC Q96EG3; Q92997: DVL3; NbExp=3; IntAct=EBI-11962574, EBI-739789;
CC Q96EG3; O95967: EFEMP2; NbExp=3; IntAct=EBI-11962574, EBI-743414;
CC Q96EG3; Q96KQ7: EHMT2; NbExp=3; IntAct=EBI-11962574, EBI-744366;
CC Q96EG3; A1L4K1: FSD2; NbExp=3; IntAct=EBI-11962574, EBI-5661036;
CC Q96EG3; A6NEM1: GOLGA6L9; NbExp=3; IntAct=EBI-11962574, EBI-5916454;
CC Q96EG3; Q9NWQ4-1: GPATCH2L; NbExp=3; IntAct=EBI-11962574, EBI-11959863;
CC Q96EG3; A0A024R8L2: hCG_1987119; NbExp=3; IntAct=EBI-11962574, EBI-14103818;
CC Q96EG3; P49639: HOXA1; NbExp=5; IntAct=EBI-11962574, EBI-740785;
CC Q96EG3; Q5VWX1: KHDRBS2; NbExp=3; IntAct=EBI-11962574, EBI-742808;
CC Q96EG3; Q07627: KRTAP1-1; NbExp=3; IntAct=EBI-11962574, EBI-11959885;
CC Q96EG3; Q8IUG1: KRTAP1-3; NbExp=3; IntAct=EBI-11962574, EBI-11749135;
CC Q96EG3; P60409: KRTAP10-7; NbExp=3; IntAct=EBI-11962574, EBI-10172290;
CC Q96EG3; P60410: KRTAP10-8; NbExp=3; IntAct=EBI-11962574, EBI-10171774;
CC Q96EG3; P60411: KRTAP10-9; NbExp=3; IntAct=EBI-11962574, EBI-10172052;
CC Q96EG3; P60328: KRTAP12-3; NbExp=3; IntAct=EBI-11962574, EBI-11953334;
CC Q96EG3; Q9BYQ6: KRTAP4-11; NbExp=3; IntAct=EBI-11962574, EBI-10302392;
CC Q96EG3; Q9BQ66: KRTAP4-12; NbExp=3; IntAct=EBI-11962574, EBI-739863;
CC Q96EG3; Q9BYR2: KRTAP4-5; NbExp=3; IntAct=EBI-11962574, EBI-11993254;
CC Q96EG3; P26371: KRTAP5-9; NbExp=3; IntAct=EBI-11962574, EBI-3958099;
CC Q96EG3; Q99750: MDFI; NbExp=3; IntAct=EBI-11962574, EBI-724076;
CC Q96EG3; Q5JR59-3: MTUS2; NbExp=3; IntAct=EBI-11962574, EBI-11522433;
CC Q96EG3; P0DPK4: NOTCH2NLC; NbExp=3; IntAct=EBI-11962574, EBI-22310682;
CC Q96EG3; Q92824-2: PCSK5; NbExp=3; IntAct=EBI-11962574, EBI-11956269;
CC Q96EG3; Q5T6S3: PHF19; NbExp=3; IntAct=EBI-11962574, EBI-2339674;
CC Q96EG3; Q03181-2: PPARD; NbExp=3; IntAct=EBI-11962574, EBI-10223258;
CC Q96EG3; O75864: PPP1R37; NbExp=3; IntAct=EBI-11962574, EBI-5235692;
CC Q96EG3; Q8WWY3: PRPF31; NbExp=3; IntAct=EBI-11962574, EBI-1567797;
CC Q96EG3; Q15415: RBMY1J; NbExp=3; IntAct=EBI-11962574, EBI-8642021;
CC Q96EG3; Q6UXX9-2: RSPO2; NbExp=3; IntAct=EBI-11962574, EBI-12009390;
CC Q96EG3; Q7Z698: SPRED2; NbExp=6; IntAct=EBI-11962574, EBI-7082156;
CC Q96EG3; O43609: SPRY1; NbExp=3; IntAct=EBI-11962574, EBI-3866665;
CC Q96EG3; Q8N8B7-2: TCEANC; NbExp=3; IntAct=EBI-11962574, EBI-11955057;
CC Q96EG3; Q63HR2: TNS2; NbExp=3; IntAct=EBI-11962574, EBI-949753;
CC Q96EG3; Q8WV44: TRIM41; NbExp=3; IntAct=EBI-11962574, EBI-725997;
CC Q96EG3; Q8IZ69: TRMT2A; NbExp=3; IntAct=EBI-11962574, EBI-2515774;
CC Q96EG3; Q7KZS0: UBE2I; NbExp=3; IntAct=EBI-11962574, EBI-10180829;
CC Q96EG3; Q6EMK4: VASN; NbExp=3; IntAct=EBI-11962574, EBI-10249550;
CC Q96EG3; Q2TAL6: VWC2; NbExp=3; IntAct=EBI-11962574, EBI-11957238;
CC Q96EG3; O43167: ZBTB24; NbExp=3; IntAct=EBI-11962574, EBI-744471;
CC Q96EG3; P10074: ZBTB48; NbExp=3; IntAct=EBI-11962574, EBI-744864;
CC Q96EG3; Q96BR9: ZBTB8A; NbExp=3; IntAct=EBI-11962574, EBI-742740;
CC Q96EG3; P58317: ZNF121; NbExp=3; IntAct=EBI-11962574, EBI-1228269;
CC Q96EG3; Q15973: ZNF124; NbExp=6; IntAct=EBI-11962574, EBI-2555767;
CC Q96EG3; P49910: ZNF165; NbExp=3; IntAct=EBI-11962574, EBI-741694;
CC Q96EG3; P17021: ZNF17; NbExp=3; IntAct=EBI-11962574, EBI-1105334;
CC Q96EG3; O95125: ZNF202; NbExp=3; IntAct=EBI-11962574, EBI-751960;
CC Q96EG3; P15622-3: ZNF250; NbExp=3; IntAct=EBI-11962574, EBI-10177272;
CC Q96EG3; Q9NSD4: ZNF275; NbExp=3; IntAct=EBI-11962574, EBI-17263125;
CC Q96EG3; Q96PQ6: ZNF317; NbExp=3; IntAct=EBI-11962574, EBI-1210473;
CC Q96EG3; Q9Y3S2: ZNF330; NbExp=6; IntAct=EBI-11962574, EBI-373456;
CC Q96EG3; Q9H9D4: ZNF408; NbExp=3; IntAct=EBI-11962574, EBI-347633;
CC Q96EG3; Q8TAU3: ZNF417; NbExp=6; IntAct=EBI-11962574, EBI-740727;
CC Q96EG3; Q8WTR7: ZNF473; NbExp=3; IntAct=EBI-11962574, EBI-751409;
CC Q96EG3; Q6ZNH5: ZNF497; NbExp=3; IntAct=EBI-11962574, EBI-10486136;
CC Q96EG3; Q96C55: ZNF524; NbExp=3; IntAct=EBI-11962574, EBI-10283126;
CC Q96EG3; Q8TF50: ZNF526; NbExp=3; IntAct=EBI-11962574, EBI-11035148;
CC Q96EG3; Q9H707: ZNF552; NbExp=6; IntAct=EBI-11962574, EBI-2555731;
CC Q96EG3; Q96SQ5: ZNF587; NbExp=3; IntAct=EBI-11962574, EBI-6427977;
CC Q96EG3; Q9UID6: ZNF639; NbExp=3; IntAct=EBI-11962574, EBI-947476;
CC Q96EG3; Q5T619: ZNF648; NbExp=3; IntAct=EBI-11962574, EBI-11985915;
CC Q96EG3; Q8N720: ZNF655; NbExp=3; IntAct=EBI-11962574, EBI-625509;
CC Q96EG3; Q96H86: ZNF764; NbExp=3; IntAct=EBI-11962574, EBI-745775;
CC Q96EG3; Q3KQV3: ZNF792; NbExp=3; IntAct=EBI-11962574, EBI-10240849;
CC Q96EG3; Q9Y2P0: ZNF835; NbExp=3; IntAct=EBI-11962574, EBI-5667516;
CC Q96EG3; Q96EG3: ZNF837; NbExp=3; IntAct=EBI-11962574, EBI-11962574;
CC Q96EG3; Q9UGI0: ZRANB1; NbExp=3; IntAct=EBI-11962574, EBI-527853;
CC Q96EG3; Q9Y5A6: ZSCAN21; NbExp=3; IntAct=EBI-11962574, EBI-10281938;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. {ECO:0000305}.
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DR EMBL; BC012365; AAH12365.2; -; mRNA.
DR CCDS; CCDS46216.1; -.
DR RefSeq; NP_612475.1; NM_138466.1.
DR RefSeq; XP_016881731.1; XM_017026242.1.
DR AlphaFoldDB; Q96EG3; -.
DR SMR; Q96EG3; -.
DR BioGRID; 125504; 79.
DR IntAct; Q96EG3; 78.
DR STRING; 9606.ENSP00000405699; -.
DR iPTMnet; Q96EG3; -.
DR PhosphoSitePlus; Q96EG3; -.
DR BioMuta; ZNF837; -.
DR DMDM; 121946273; -.
DR jPOST; Q96EG3; -.
DR MassIVE; Q96EG3; -.
DR MaxQB; Q96EG3; -.
DR PaxDb; Q96EG3; -.
DR PeptideAtlas; Q96EG3; -.
DR PRIDE; Q96EG3; -.
DR ProteomicsDB; 76406; -.
DR Antibodypedia; 33337; 28 antibodies from 12 providers.
DR DNASU; 116412; -.
DR Ensembl; ENST00000427624.2; ENSP00000405699.1; ENSG00000152475.7.
DR Ensembl; ENST00000597582.2; ENSP00000471478.1; ENSG00000152475.7.
DR GeneID; 116412; -.
DR KEGG; hsa:116412; -.
DR MANE-Select; ENST00000597582.2; ENSP00000471478.1; NM_138466.2; NP_612475.1.
DR UCSC; uc002qsl.5; human.
DR CTD; 116412; -.
DR GeneCards; ZNF837; -.
DR HGNC; HGNC:25164; ZNF837.
DR HPA; ENSG00000152475; Low tissue specificity.
DR neXtProt; NX_Q96EG3; -.
DR OpenTargets; ENSG00000152475; -.
DR PharmGKB; PA162410789; -.
DR VEuPathDB; HostDB:ENSG00000152475; -.
DR eggNOG; KOG1721; Eukaryota.
DR GeneTree; ENSGT00940000165357; -.
DR HOGENOM; CLU_002678_84_0_1; -.
DR InParanoid; Q96EG3; -.
DR OMA; CPPCGDC; -.
DR OrthoDB; 1318335at2759; -.
DR PhylomeDB; Q96EG3; -.
DR TreeFam; TF337005; -.
DR PathwayCommons; Q96EG3; -.
DR SignaLink; Q96EG3; -.
DR BioGRID-ORCS; 116412; 18 hits in 1098 CRISPR screens.
DR GenomeRNAi; 116412; -.
DR Pharos; Q96EG3; Tdark.
DR PRO; PR:Q96EG3; -.
DR Proteomes; UP000005640; Chromosome 19.
DR RNAct; Q96EG3; protein.
DR Bgee; ENSG00000152475; Expressed in right uterine tube and 87 other tissues.
DR Genevisible; Q96EG3; HS.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0042802; F:identical protein binding; IPI:IntAct.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF00096; zf-C2H2; 7.
DR SMART; SM00355; ZnF_C2H2; 8.
DR SUPFAM; SSF57667; SSF57667; 4.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 8.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 8.
PE 1: Evidence at protein level;
KW DNA-binding; Metal-binding; Nucleus; Reference proteome; Repeat;
KW Transcription; Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1..531
FT /note="Zinc finger protein 837"
FT /id="PRO_0000321906"
FT ZN_FING 271..293
FT /note="C2H2-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 299..321
FT /note="C2H2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 363..385
FT /note="C2H2-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 391..413
FT /note="C2H2-type 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 419..441
FT /note="C2H2-type 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 447..469
FT /note="C2H2-type 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 475..497
FT /note="C2H2-type 7"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 503..525
FT /note="C2H2-type 8"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT REGION 1..101
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 21..45
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VARIANT 153
FT /note="Q -> R (in dbSNP:rs7256940)"
FT /id="VAR_039373"
FT VARIANT 242
FT /note="A -> T (in dbSNP:rs7255596)"
FT /id="VAR_061979"
SQ SEQUENCE 531 AA; 58078 MW; 40329D17EDD39737 CRC64;
MEAPAQKAGQ GGLPKADAQG ASGAREKRPE EPRPLEEDRA GSRPTQKGDL RGAAGGRTTP
PGGGSRGCSL GVSPGPGTRH SAGTRPLVRE PCGPTSSQNP ELVIPEGLQA REGPCRSPAR
GGDCSRNSCL AWHRGAPAGE TPPVCDPCPE RIQNHPRTQL CEVHTDCWPC QPGTGAPTCP
RTPKPTSRGR NPLVEQPRAC ACGEAFAWRA LRIPQERLQA TEEPRPCARC GKRFRPNQQQ
QAGKSPPVCP ECGQTSRPRP IVPDPPAQRL YACDECGKAF TRTSSLLQHQ RIHTGERPYE
CAECGKAFVR CSGLYRHQKT HSAERHRRGP VLARRAFRLG CPPCGDYSER SPRRGSGAGE
KPYECADCAK AFGLFSHLVE HRRVHTGEKP YACPECGKAF NQRSNLSRHQ RTHSSAKPYA
CPLCEKAFKG RSGLVQHQRA HTGERPYGCS ECGKTFRGCS ELRQHERLHS GEKPYICRDC
GKAFVRNCSL VRHLRTHTGE RPYACGDCGR AFSQRSNLNE HRKRHGGRAA P
