ZN839_HUMAN
ID ZN839_HUMAN Reviewed; 811 AA.
AC A8K0R7; B3KSD2; Q53FH5; Q6GPI5; Q86TU1; Q9BQ86; Q9NUU3;
DT 08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 04-DEC-2007, sequence version 1.
DT 03-AUG-2022, entry version 113.
DE RecName: Full=Zinc finger protein 839;
DE AltName: Full=Renal carcinoma antigen NY-REN-50;
GN Name=ZNF839; Synonyms=C14orf131;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Amygdala, Placenta, and Testis;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=12508121; DOI=10.1038/nature01348;
RA Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C.,
RA Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A.,
RA Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H.,
RA Du H., Pepin K., Artiguenave F., Robert C., Cruaud C., Bruels T.,
RA Jaillon O., Friedlander L., Samson G., Brottier P., Cure S., Segurens B.,
RA Aniere F., Samain S., Crespeau H., Abbasi N., Aiach N., Boscus D.,
RA Dickhoff R., Dors M., Dubois I., Friedman C., Gouyvenoux M., James R.,
RA Madan A., Mairey-Estrada B., Mangenot S., Martins N., Menard M., Oztas S.,
RA Ratcliffe A., Shaffer T., Trask B., Vacherie B., Bellemere C., Belser C.,
RA Besnard-Gonnet M., Bartol-Mavel D., Boutard M., Briez-Silla S.,
RA Combette S., Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C.,
RA Muselet D., Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P.,
RA Trybou A., Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M.,
RA Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V.,
RA Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., Verdier J.,
RA Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., Matsuda F.,
RA Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., Quetier F.,
RA Waterston R., Hood L., Weissenbach J.;
RT "The DNA sequence and analysis of human chromosome 14.";
RL Nature 421:601-607(2003).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-340 (ISOFORM 3).
RC TISSUE=Neuroblastoma;
RA Li W.B., Gruber C., Jessee J., Polayes D.;
RT "Full-length cDNA libraries and normalization.";
RL Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 288-811 (ISOFORM 2).
RC TISSUE=Lung, and PNS;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 414-811.
RC TISSUE=Thymus;
RA Suzuki Y., Sugano S., Totoki Y., Toyoda A., Takeda T., Sakaki Y.,
RA Tanaka A., Yokoyama S.;
RL Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1;
CC IsoId=A8K0R7-1; Sequence=Displayed;
CC Name=2;
CC IsoId=A8K0R7-2; Sequence=VSP_032760;
CC Name=3;
CC IsoId=A8K0R7-5; Sequence=VSP_040648;
CC -!- SEQUENCE CAUTION:
CC Sequence=BAA92026.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC Sequence=CAD62594.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AK001994; BAA92026.1; ALT_INIT; mRNA.
DR EMBL; AK289632; BAF82321.1; -; mRNA.
DR EMBL; AK093342; BAG52694.1; -; mRNA.
DR EMBL; AL137229; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL352978; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BX248266; CAD62594.1; ALT_INIT; mRNA.
DR EMBL; BC073137; AAH73137.2; -; mRNA.
DR EMBL; AK223312; BAD97032.1; -; mRNA.
DR CCDS; CCDS45164.1; -. [A8K0R7-5]
DR CCDS; CCDS58336.1; -. [A8K0R7-1]
DR RefSeq; NP_001254756.1; NM_001267827.1. [A8K0R7-1]
DR RefSeq; NP_001254757.1; NM_001267828.1. [A8K0R7-1]
DR RefSeq; NP_060805.3; NM_018335.4. [A8K0R7-5]
DR RefSeq; XP_011535250.1; XM_011536948.2. [A8K0R7-1]
DR AlphaFoldDB; A8K0R7; -.
DR BioGRID; 120893; 7.
DR IntAct; A8K0R7; 3.
DR GlyGen; A8K0R7; 1 site, 1 O-linked glycan (1 site).
DR iPTMnet; A8K0R7; -.
DR PhosphoSitePlus; A8K0R7; -.
DR BioMuta; ZNF839; -.
DR EPD; A8K0R7; -.
DR jPOST; A8K0R7; -.
DR MassIVE; A8K0R7; -.
DR MaxQB; A8K0R7; -.
DR PaxDb; A8K0R7; -.
DR PeptideAtlas; A8K0R7; -.
DR PRIDE; A8K0R7; -.
DR ProteomicsDB; 1838; -. [A8K0R7-1]
DR ProteomicsDB; 1839; -. [A8K0R7-2]
DR ProteomicsDB; 1840; -. [A8K0R7-5]
DR Antibodypedia; 27811; 79 antibodies from 22 providers.
DR DNASU; 55778; -.
DR Ensembl; ENST00000442396.7; ENSP00000399863.2; ENSG00000022976.16. [A8K0R7-5]
DR Ensembl; ENST00000558850.5; ENSP00000453363.1; ENSG00000022976.16. [A8K0R7-1]
DR Ensembl; ENST00000559185.5; ENSP00000453109.1; ENSG00000022976.16. [A8K0R7-1]
DR GeneID; 55778; -.
DR KEGG; hsa:55778; -.
DR MANE-Select; ENST00000442396.7; ENSP00000399863.2; NM_018335.6; NP_060805.3. [A8K0R7-5]
DR UCSC; uc001ylo.4; human. [A8K0R7-1]
DR CTD; 55778; -.
DR DisGeNET; 55778; -.
DR GeneCards; ZNF839; -.
DR HGNC; HGNC:20345; ZNF839.
DR HPA; ENSG00000022976; Low tissue specificity.
DR neXtProt; NX_A8K0R7; -.
DR OpenTargets; ENSG00000022976; -.
DR PharmGKB; PA162410800; -.
DR VEuPathDB; HostDB:ENSG00000022976; -.
DR eggNOG; ENOG502RIPD; Eukaryota.
DR GeneTree; ENSGT00390000002751; -.
DR HOGENOM; CLU_012723_0_0_1; -.
DR InParanoid; A8K0R7; -.
DR OMA; ATIQPQT; -.
DR OrthoDB; 861724at2759; -.
DR PhylomeDB; A8K0R7; -.
DR TreeFam; TF328610; -.
DR PathwayCommons; A8K0R7; -.
DR Reactome; R-HSA-212436; Generic Transcription Pathway.
DR SignaLink; A8K0R7; -.
DR BioGRID-ORCS; 55778; 27 hits in 1078 CRISPR screens.
DR GenomeRNAi; 55778; -.
DR Pharos; A8K0R7; Tdark.
DR PRO; PR:A8K0R7; -.
DR Proteomes; UP000005640; Chromosome 14.
DR RNAct; A8K0R7; protein.
DR Bgee; ENSG00000022976; Expressed in left testis and 178 other tissues.
DR ExpressionAtlas; A8K0R7; baseline and differential.
DR Genevisible; A8K0R7; HS.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR InterPro; IPR031885; DUF4764.
DR InterPro; IPR039946; ZN839.
DR InterPro; IPR013087; Znf_C2H2_type.
DR PANTHER; PTHR16116; PTHR16116; 1.
DR Pfam; PF15961; DUF4764; 1.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Metal-binding; Reference proteome; Zinc; Zinc-finger.
FT CHAIN 1..811
FT /note="Zinc finger protein 839"
FT /id="PRO_0000328721"
FT ZN_FING 197..222
FT /note="C2H2-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT REGION 329..349
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 455..555
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 612..654
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 455..501
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 533..555
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 1
FT /note="M -> MADAEPEAGGGSEDGGGGGGPAPPGQSGSVARVAPLGPEQLRQVLEQ
FT VTKAQPPPPPPPFVLRDAARRLRDAAQQAALQRGRGTEPPRLPRLLPPQQLEAICVKVT
FT SGETKGQERPM (in isoform 3)"
FT /evidence="ECO:0000303|Ref.3"
FT /id="VSP_040648"
FT VAR_SEQ 527
FT /note="G -> GEG (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_032760"
FT VARIANT 314
FT /note="A -> T (in dbSNP:rs1543540)"
FT /id="VAR_057456"
FT VARIANT 531
FT /note="P -> S (in dbSNP:rs9464)"
FT /id="VAR_042468"
FT VARIANT 693
FT /note="V -> M (in dbSNP:rs28646161)"
FT /id="VAR_042469"
FT VARIANT 731
FT /note="F -> L (in dbSNP:rs1053019)"
FT /id="VAR_042470"
FT CONFLICT 411
FT /note="M -> L (in Ref. 4; AAH73137)"
FT /evidence="ECO:0000305"
FT CONFLICT 418
FT /note="D -> G (in Ref. 5; BAD97032)"
FT /evidence="ECO:0000305"
FT CONFLICT 479
FT /note="K -> E (in Ref. 1; BAG52694)"
FT /evidence="ECO:0000305"
FT CONFLICT 590
FT /note="Y -> C (in Ref. 1; BAA92026)"
FT /evidence="ECO:0000305"
FT CONFLICT 771
FT /note="K -> R (in Ref. 5; BAD97032)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 811 AA; 87484 MW; 58E2C46E98154976 CRC64;
MLLPTTIQPQ TARKSQLPRG NSCLVGLHIA SPQLLRVQPL VRTEPQSCFL SDLCQPPAQG
FVQRPLPALQ VVPAKRVPAP KAPDEQGSML TPLSASDPLA VTSLSSSSAH PFISNLHTRH
TEKLKKSLKV KTRSGRVSRP PKYKAKDYKF IKTEDLADGH LSDSDDYSEL CVEEDEDQRE
RHALFDLSSC SLRPKSFKCQ TCEKSYIGKG GLARHFKLNP GHGQLDPEMV LSEKASGSTL
RGCTEERTLS LTSLGLSMPA DPCEGGARSC LVTESARGGL QNGQSVDVEE TLPSEPENGA
LLRSERYQGP RRRACSETLA ESRTAVLQQR RAAQLPGGPA AAGEQRASPS KARLKEFLQQ
CDREDLVELA LPQLAQVVTV YEFLLMKVEK DHLAKPFFPA IYKEFEELHK MVKKMCQDYL
SSSGLCSQET LEINNDKVAE SLGITEFLRK KEIHPDNLGP KHLSRDMDGE QLEGASSEKR
EREAAEEGLA SVKRPRREAL SNDTTESLAA NSRGREKPRP LHALAAGFSP PVNVTVSPRS
EESHTTTVSG GNGSVFQAGP QLQALANLEA RRGSIGAALS SRDVSGLPVY AQSGEPRRLT
QAQVAAFPGE NALEHSSDQD TWDSLRSPGF CSPLSSGGGA ESLPPGGPGH AEAGHLGKVC
DFHLNHQQPS PTSVLPTEVA APPLEKILSV DSVAVDCAYR TVPKPGPQPG PHGSLLTEGC
LRSLSGDLNR FPCGMEVHSG QRELESVVAV GEAMAFEISN GSHELLSQGQ KQIFIQTSDG
LILSPPGTIV SQEEDIVTVT DAEGRACGWA R
