ZN840_HUMAN
ID ZN840_HUMAN Reviewed; 716 AA.
AC A6NDX5; Q6KAL7;
DT 29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 16-DEC-2008, sequence version 5.
DT 25-MAY-2022, entry version 98.
DE RecName: Full=Putative zinc finger protein 840;
DE AltName: Full=Zinc finger protein 840 pseudogene;
GN Name=ZNF840P; Synonyms=C20orf157, ZNF840;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=11780052; DOI=10.1038/414865a;
RA Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R.,
RA Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L.,
RA Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P.,
RA Bird C.P., Blakey S.E., Bridgeman A.M., Brown A.J., Buck D., Burrill W.D.,
RA Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G.,
RA Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E.,
RA Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D.,
RA Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P.,
RA Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E.,
RA Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J.,
RA Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D.,
RA Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S.,
RA Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D.,
RA Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A.,
RA Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T.,
RA Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I.,
RA Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M.,
RA Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D.,
RA Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M.,
RA Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A.,
RA Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L.,
RA Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L.,
RA Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.;
RT "The DNA sequence and comparative analysis of human chromosome 20.";
RL Nature 414:865-871(2001).
CC -!- FUNCTION: May be involved in transcriptional regulation. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. {ECO:0000305}.
CC -!- CAUTION: Could be the product of a pseudogene. {ECO:0000305}.
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DR EMBL; AL031686; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A6NDX5; -.
DR SMR; A6NDX5; -.
DR IntAct; A6NDX5; 1.
DR iPTMnet; A6NDX5; -.
DR PhosphoSitePlus; A6NDX5; -.
DR BioMuta; HGNC:34344; -.
DR MassIVE; A6NDX5; -.
DR PeptideAtlas; A6NDX5; -.
DR PRIDE; A6NDX5; -.
DR ProteomicsDB; 939; -.
DR GeneCards; ZNF840P; -.
DR HGNC; HGNC:34344; ZNF840P.
DR neXtProt; NX_A6NDX5; -.
DR InParanoid; A6NDX5; -.
DR PhylomeDB; A6NDX5; -.
DR PathwayCommons; A6NDX5; -.
DR Reactome; R-HSA-212436; Generic Transcription Pathway.
DR SignaLink; A6NDX5; -.
DR Pharos; A6NDX5; Tdark.
DR Proteomes; UP000005640; Unplaced.
DR RNAct; A6NDX5; protein.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd07765; KRAB_A-box; 1.
DR InterPro; IPR001909; KRAB.
DR InterPro; IPR036051; KRAB_dom_sf.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF01352; KRAB; 1.
DR Pfam; PF00096; zf-C2H2; 13.
DR SMART; SM00349; KRAB; 1.
DR SMART; SM00355; ZnF_C2H2; 18.
DR SUPFAM; SSF109640; SSF109640; 1.
DR SUPFAM; SSF57667; SSF57667; 10.
DR PROSITE; PS50805; KRAB; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 18.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 18.
PE 5: Uncertain;
KW DNA-binding; Metal-binding; Nucleus; Reference proteome; Repeat;
KW Transcription; Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1..716
FT /note="Putative zinc finger protein 840"
FT /id="PRO_0000332148"
FT DOMAIN 42..113
FT /note="KRAB"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00119"
FT ZN_FING 151..173
FT /note="C2H2-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 207..229
FT /note="C2H2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 235..257
FT /note="C2H2-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 277..299
FT /note="C2H2-type 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 305..327
FT /note="C2H2-type 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 333..355
FT /note="C2H2-type 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 361..383
FT /note="C2H2-type 7"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 389..411
FT /note="C2H2-type 8"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 417..439
FT /note="C2H2-type 9"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 445..467
FT /note="C2H2-type 10"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 473..495
FT /note="C2H2-type 11"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 501..523
FT /note="C2H2-type 12"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 549..571
FT /note="C2H2-type 13"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 577..599
FT /note="C2H2-type 14"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 605..627
FT /note="C2H2-type 15"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 633..655
FT /note="C2H2-type 16"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 661..683
FT /note="C2H2-type 17"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 689..711
FT /note="C2H2-type 18"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT REGION 515..548
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VARIANT 181
FT /note="Y -> C (in dbSNP:rs3752261)"
FT /id="VAR_048027"
SQ SEQUENCE 716 AA; 83235 MW; 32A5D13B52610D4B CRC64;
MSLMGHGKVE MLLYAVPLLK APNCLSSSMQ LPHGGGRHQE LVRFRDVAVV FSPEEWDHLT
PEQRNLYKDV MLDNCKYLAS LGNWTYKAHV MSSLKQGKEP WMMEREVTGD PCPACQPALA
TFRALNESGN AFRQSFHHGE YRTHRTFVQH YECDDCGMAF GHVSQLTGHQ KIHKVGETHE
YGENTRGFRH RSSFTMLQRI CTLYKHFECN QCGETFNRPS KVIQHQSMHS GLKPYKCDVC
QKAFRFLSSL SIHQRFHVGN RVNLTRHQKT HTQRKPFSCN FCGKTFHRFS EKTQHLLIHT
RKKYYTCNYC KKEFNPYSKF ILHQRTHTGE KPHKCDVCEK SFKSISNLNK HQKTHTGEKP
FSCNECKKTF AQRTDLARHQ QIHTGKKSFI CSSCKKTFVR LSDLTQHKGT HTGERPYQCT
TCEKAFKYRS NFTKHQKTHS IGRPFACNEC GKTYRLNWEL NQHKKIHTGE KPYECGECGK
RFNNNSNLNK HKKIHTGEKH FVCNQCGKAF SLNSKLSRHQ RTHNKKENSS KSVSNLNKHQ
KTHAGEKPFP CNECKKAFAQ RMDLARHQQI HTGRKPFICS SCKKTFVRLS DLTQHKGTHT
GERPYQCTTC EKAFKYQSNF TKHQKTHSIG RPFTCNECGK TFRLNWKLNQ HKKIHTGEKP
YECGECGKCF NNNSNLSKHK KIHTGEKHFV CNQCGKAFSL NSKLSRHQIT HNKKKP
