ZN841_HUMAN
ID ZN841_HUMAN Reviewed; 808 AA.
AC Q6ZN19; B9EG58; Q6ZN82; Q6ZP71; Q8N9U7;
DT 20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 156.
DE RecName: Full=Zinc finger protein 841;
GN Name=ZNF841;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC TISSUE=Kidney, and Testis;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15057824; DOI=10.1038/nature02399;
RA Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E.,
RA Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A.,
RA Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S.,
RA Carrano A.V., Caoile C., Chan Y.M., Christensen M., Cleland C.A.,
RA Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J.,
RA Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M.,
RA Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W.,
RA Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V.,
RA Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D.,
RA McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I.,
RA Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L.,
RA Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A.,
RA She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M.,
RA Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J.,
RA Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA Rubin E.M., Lucas S.M.;
RT "The DNA sequence and biology of human chromosome 19.";
RL Nature 428:529-535(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
RC TISSUE=Heart, and Lung;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP SUMOYLATION [LARGE SCALE ANALYSIS] AT LYS-137; LYS-554; LYS-579 AND
RP LYS-791, AND IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=28112733; DOI=10.1038/nsmb.3366;
RA Hendriks I.A., Lyon D., Young C., Jensen L.J., Vertegaal A.C.,
RA Nielsen M.L.;
RT "Site-specific mapping of the human SUMO proteome reveals co-modification
RT with phosphorylation.";
RL Nat. Struct. Mol. Biol. 24:325-336(2017).
CC -!- FUNCTION: May be involved in transcriptional regulation. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1;
CC IsoId=Q6ZN19-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q6ZN19-2; Sequence=VSP_033755;
CC Name=3;
CC IsoId=Q6ZN19-3; Sequence=VSP_040752;
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAC04190.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC Sequence=BAD18493.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AK093512; BAC04190.1; ALT_INIT; mRNA.
DR EMBL; AK129938; BAC85253.1; -; mRNA.
DR EMBL; AK131334; BAD18493.1; ALT_INIT; mRNA.
DR EMBL; AK131409; BAD18556.1; -; mRNA.
DR EMBL; AC011468; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC136254; AAI36255.1; -; mRNA.
DR CCDS; CCDS46161.1; -. [Q6ZN19-3]
DR CCDS; CCDS82388.1; -. [Q6ZN19-1]
DR RefSeq; NP_001129971.1; NM_001136499.1. [Q6ZN19-3]
DR RefSeq; NP_001308278.1; NM_001321349.1. [Q6ZN19-1]
DR RefSeq; XP_016882145.1; XM_017026656.1.
DR RefSeq; XP_016882146.1; XM_017026657.1.
DR AlphaFoldDB; Q6ZN19; -.
DR SMR; Q6ZN19; -.
DR BioGRID; 129850; 2.
DR IntAct; Q6ZN19; 1.
DR STRING; 9606.ENSP00000470746; -.
DR iPTMnet; Q6ZN19; -.
DR PhosphoSitePlus; Q6ZN19; -.
DR BioMuta; ZNF841; -.
DR DMDM; 74758703; -.
DR EPD; Q6ZN19; -.
DR jPOST; Q6ZN19; -.
DR MassIVE; Q6ZN19; -.
DR MaxQB; Q6ZN19; -.
DR PaxDb; Q6ZN19; -.
DR PeptideAtlas; Q6ZN19; -.
DR PRIDE; Q6ZN19; -.
DR ProteomicsDB; 67964; -. [Q6ZN19-1]
DR ProteomicsDB; 67965; -. [Q6ZN19-2]
DR ProteomicsDB; 67966; -. [Q6ZN19-3]
DR Antibodypedia; 66958; 58 antibodies from 12 providers.
DR DNASU; 284371; -.
DR Ensembl; ENST00000389534.8; ENSP00000374185.4; ENSG00000197608.12. [Q6ZN19-3]
DR Ensembl; ENST00000426391.6; ENSP00000415453.2; ENSG00000197608.12. [Q6ZN19-1]
DR Ensembl; ENST00000594295.5; ENSP00000470746.1; ENSG00000197608.12. [Q6ZN19-3]
DR Ensembl; ENST00000594440.6; ENSP00000470100.2; ENSG00000197608.12. [Q6ZN19-3]
DR GeneID; 284371; -.
DR KEGG; hsa:284371; -.
DR MANE-Select; ENST00000594440.6; ENSP00000470100.2; NM_001136499.2; NP_001129971.1. [Q6ZN19-3]
DR UCSC; uc002pyl.1; human. [Q6ZN19-1]
DR CTD; 284371; -.
DR DisGeNET; 284371; -.
DR GeneCards; ZNF841; -.
DR HGNC; HGNC:27611; ZNF841.
DR HPA; ENSG00000197608; Low tissue specificity.
DR neXtProt; NX_Q6ZN19; -.
DR OpenTargets; ENSG00000197608; -.
DR PharmGKB; PA162410839; -.
DR VEuPathDB; HostDB:ENSG00000197608; -.
DR eggNOG; KOG1721; Eukaryota.
DR GeneTree; ENSGT00940000164553; -.
DR HOGENOM; CLU_002678_17_0_1; -.
DR InParanoid; Q6ZN19; -.
DR OMA; TVMLEGH; -.
DR PhylomeDB; Q6ZN19; -.
DR TreeFam; TF343410; -.
DR PathwayCommons; Q6ZN19; -.
DR SignaLink; Q6ZN19; -.
DR BioGRID-ORCS; 284371; 8 hits in 1091 CRISPR screens.
DR ChiTaRS; ZNF841; human.
DR GenomeRNAi; 284371; -.
DR Pharos; Q6ZN19; Tdark.
DR PRO; PR:Q6ZN19; -.
DR Proteomes; UP000005640; Chromosome 19.
DR RNAct; Q6ZN19; protein.
DR Bgee; ENSG00000197608; Expressed in calcaneal tendon and 101 other tissues.
DR ExpressionAtlas; Q6ZN19; baseline and differential.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF00096; zf-C2H2; 19.
DR SMART; SM00355; ZnF_C2H2; 22.
DR SUPFAM; SSF57667; SSF57667; 12.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 20.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 23.
PE 1: Evidence at protein level;
KW Alternative splicing; DNA-binding; Isopeptide bond; Metal-binding; Nucleus;
KW Reference proteome; Repeat; Transcription; Transcription regulation;
KW Ubl conjugation; Zinc; Zinc-finger.
FT CHAIN 1..808
FT /note="Zinc finger protein 841"
FT /id="PRO_0000334677"
FT ZN_FING 145..167
FT /note="C2H2-type 1; degenerate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 173..195
FT /note="C2H2-type 2; degenerate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 201..223
FT /note="C2H2-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 229..251
FT /note="C2H2-type 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 257..279
FT /note="C2H2-type 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 285..307
FT /note="C2H2-type 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 313..335
FT /note="C2H2-type 7"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 341..363
FT /note="C2H2-type 8"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 369..391
FT /note="C2H2-type 9"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 397..419
FT /note="C2H2-type 10"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 425..447
FT /note="C2H2-type 11"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 453..475
FT /note="C2H2-type 12"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 481..503
FT /note="C2H2-type 13"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 509..531
FT /note="C2H2-type 14"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 537..559
FT /note="C2H2-type 15"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 565..587
FT /note="C2H2-type 16; degenerate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 593..615
FT /note="C2H2-type 17"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 621..643
FT /note="C2H2-type 18"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 649..671
FT /note="C2H2-type 19"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 677..699
FT /note="C2H2-type 20"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 705..727
FT /note="C2H2-type 21"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 733..755
FT /note="C2H2-type 22"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 761..783
FT /note="C2H2-type 23"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT CROSSLNK 137
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0007744|PubMed:28112733"
FT CROSSLNK 554
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0007744|PubMed:28112733"
FT CROSSLNK 579
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0007744|PubMed:28112733"
FT CROSSLNK 791
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0007744|PubMed:28112733"
FT VAR_SEQ 1
FT /note="M -> MALPQGSLTFRDVAVEFSQEEWKCLDPVQKALYRDVMLENYRNLGFL
FT GLCLPDLNIISMLEQGKEPWTVVSQVKIARNPNCGECMKGVITGISPKCVIKELPPIQN
FT SNTGEKFQAVM (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_040752"
FT VAR_SEQ 340..647
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_033755"
FT CONFLICT 748
FT /note="L -> P (in Ref. 1; BAC04190)"
FT /evidence="ECO:0000305"
FT CONFLICT 778
FT /note="K -> N (in Ref. 1; BAC85253)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 808 AA; 93148 MW; BD06B2DEE9F14BCE CRC64;
MLEGHESYDT ENFYFREIRK NLQEVDFQWK DGEINYKEGP MTHKNNLTGQ RVRHSQGDVE
NKHMENQLIL RFQSGLGELQ KFQTAEKIYG CNQIERTVNN CFLASPLQRI FPGVQTNISR
KYGNDFLQLS LPTQDEKTHI REKPYIGNEC GKAFRVSSSL INHQMIHTTE KPYRCNESGK
AFHRGSLLTV HQIVHTRGKP YQCDVCGRIF RQNSDLVNHR RSHTGDKPYI CNECGKSFSK
SSHLAVHQRI HTGEKPYKCN RCGKCFSQSS SLATHQTVHT GDKPYKCNEC GKTFKRNSSL
TAHHIIHAGK KPYTCDVCGK VFYQNSQLVR HQIIHTGETP YKCNECGKVF FQRSRLAGHR
RIHTGEKPYK CNECGKVFSQ HSHLAVHQRV HTGEKPYKCN ECGKAFNWGS LLTVHQRIHT
GEKPYKCNVC GKVFNYGGYL SVHMRCHTGE KPLHCNKCGM VFTYYSCLAR HQRMHTGEKP
YKCNVCGKVF IDSGNLSIHR RSHTGEKPFQ CNECGKVFSY YSCLARHRKI HTGEKPYKCN
DCGKAYTQRS SLTKHLVIHT GENPYHCNEF GEAFIQSSKL ARYHRNPTGE KPHKCSECGR
TFSHKTSLVY HQRRHTGEMP YKCIECGKVF NSTTTLARHR RIHTGEKPYK CNECGKVFRY
RSGLARHWSI HTGEKPYKCN ECGKAFRVRS ILLNHQMMHT GEKPYKCNEC GKAFIERSNL
VYHQRNHTGE KPYKCMECGK AFGRRSCLTK HQRIHSSEKP YKCNECGKSY ISRSGLTKHQ
IKHAGENLTT KLNVERPLDV VLTSGIPK
