ZN843_HUMAN
ID ZN843_HUMAN Reviewed; 348 AA.
AC Q8N446; A8K4U8;
DT 22-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 1.
DT 03-AUG-2022, entry version 152.
DE RecName: Full=Zinc finger protein 843;
GN Name=ZNF843;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Teratocarcinoma;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Ovary;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- INTERACTION:
CC Q8N446; Q16543: CDC37; NbExp=2; IntAct=EBI-6428016, EBI-295634;
CC Q8N446; A8MQ03: CYSRT1; NbExp=3; IntAct=EBI-6428016, EBI-3867333;
CC Q8N446; P49639: HOXA1; NbExp=3; IntAct=EBI-6428016, EBI-740785;
CC Q8N446; Q3LI66: KRTAP6-2; NbExp=3; IntAct=EBI-6428016, EBI-11962084;
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DR EMBL; AK291063; BAF83752.1; -; mRNA.
DR EMBL; BC036762; AAH36762.1; -; mRNA.
DR CCDS; CCDS45471.1; -.
DR RefSeq; NP_001129981.1; NM_001136509.1.
DR AlphaFoldDB; Q8N446; -.
DR BioGRID; 129710; 13.
DR IntAct; Q8N446; 10.
DR iPTMnet; Q8N446; -.
DR PhosphoSitePlus; Q8N446; -.
DR BioMuta; ZNF843; -.
DR DMDM; 74759868; -.
DR MassIVE; Q8N446; -.
DR PaxDb; Q8N446; -.
DR PeptideAtlas; Q8N446; -.
DR PRIDE; Q8N446; -.
DR Antibodypedia; 7194; 131 antibodies from 19 providers.
DR DNASU; 283933; -.
DR Ensembl; ENST00000315678.10; ENSP00000322899.5; ENSG00000176723.10.
DR Ensembl; ENST00000618063.1; ENSP00000483573.1; ENSG00000176723.10.
DR GeneID; 283933; -.
DR KEGG; hsa:283933; -.
DR MANE-Select; ENST00000315678.10; ENSP00000322899.5; NM_001136509.3; NP_001129981.1.
DR UCSC; uc010vfm.2; human.
DR CTD; 283933; -.
DR GeneCards; ZNF843; -.
DR HGNC; HGNC:28710; ZNF843.
DR HPA; ENSG00000176723; Low tissue specificity.
DR neXtProt; NX_Q8N446; -.
DR OpenTargets; ENSG00000176723; -.
DR PharmGKB; PA162410853; -.
DR VEuPathDB; HostDB:ENSG00000176723; -.
DR eggNOG; KOG1721; Eukaryota.
DR GeneTree; ENSGT00530000067643; -.
DR HOGENOM; CLU_796827_0_0_1; -.
DR InParanoid; Q8N446; -.
DR OrthoDB; 1318335at2759; -.
DR PhylomeDB; Q8N446; -.
DR PathwayCommons; Q8N446; -.
DR SignaLink; Q8N446; -.
DR BioGRID-ORCS; 283933; 9 hits in 1070 CRISPR screens.
DR ChiTaRS; ZNF843; human.
DR GenomeRNAi; 283933; -.
DR Pharos; Q8N446; Tdark.
DR PRO; PR:Q8N446; -.
DR Proteomes; UP000005640; Chromosome 16.
DR RNAct; Q8N446; protein.
DR Bgee; ENSG00000176723; Expressed in secondary oocyte and 125 other tissues.
DR ExpressionAtlas; Q8N446; baseline and differential.
DR Genevisible; Q8N446; HS.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR SUPFAM; SSF57667; SSF57667; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 1.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 2.
PE 1: Evidence at protein level;
KW Metal-binding; Reference proteome; Repeat; Zinc; Zinc-finger.
FT CHAIN 1..348
FT /note="Zinc finger protein 843"
FT /id="PRO_0000343750"
FT ZN_FING 33..55
FT /note="C2H2-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 145..167
FT /note="C2H2-type 2; degenerate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT REGION 184..203
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 256..329
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 184..200
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 284
FT /note="Q -> L (in Ref. 1; BAF83752)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 348 AA; 37065 MW; 34BC7ED6E61438A7 CRC64;
MRSLPFALTV ESVSARAPTC CSTGRFTQGR QPCKCKACGR GFTQSASLLQ HWRVHSDWRE
TLSLSPVRQD LLWPLQPHQA PASPLGRSHS SAGVRQGFSG QLCCWLTKEH TLAEALRLSP
VPAGFWGPVE ADRPPANSHR RVCPFCCCSC GDSVNEKTSL SQRVLPHPGE KTCRGGSVES
VSLAPSSVAP DSTSGLRPCG SPGSFLQHLP PSTLLPRPPF LYPGPPLSLQ PLVPSGLPAV
PAVPLGGLEV AQVPPATQPA AQQEGAMGPR SCASAGRDSR EAVQAPGYPE PARKASQHRA
AGPLGEARAR LQRQCRAPPP PSNPHWRGAL PVFPVWKASS RRSNLARH
