ZN844_HUMAN
ID ZN844_HUMAN Reviewed; 666 AA.
AC Q08AG5; Q5JPI8;
DT 02-SEP-2008, integrated into UniProtKB/Swiss-Prot.
DT 31-OCT-2006, sequence version 1.
DT 03-AUG-2022, entry version 136.
DE RecName: Full=Zinc finger protein 844;
GN Name=ZNF844;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Trachea;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Lymph node;
RX PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D.,
RA Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A.,
RA Wiemann S., Schupp I.;
RT "The full-ORF clone resource of the German cDNA consortium.";
RL BMC Genomics 8:399-399(2007).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: May be involved in transcriptional regulation. {ECO:0000250}.
CC -!- INTERACTION:
CC Q08AG5; Q9NP86: CABP5; NbExp=3; IntAct=EBI-10225757, EBI-10311131;
CC Q08AG5; A6NEM1: GOLGA6L9; NbExp=3; IntAct=EBI-10225757, EBI-5916454;
CC Q08AG5; Q96ED9-2: HOOK2; NbExp=3; IntAct=EBI-10225757, EBI-10961706;
CC Q08AG5; O75031: HSF2BP; NbExp=3; IntAct=EBI-10225757, EBI-7116203;
CC Q08AG5; Q6A162: KRT40; NbExp=6; IntAct=EBI-10225757, EBI-10171697;
CC Q08AG5; P60409: KRTAP10-7; NbExp=3; IntAct=EBI-10225757, EBI-10172290;
CC Q08AG5; P60411: KRTAP10-9; NbExp=3; IntAct=EBI-10225757, EBI-10172052;
CC Q08AG5; Q99750: MDFI; NbExp=6; IntAct=EBI-10225757, EBI-724076;
CC Q08AG5; Q14696: MESD; NbExp=3; IntAct=EBI-10225757, EBI-6165891;
CC Q08AG5; Q5JR59: MTUS2; NbExp=3; IntAct=EBI-10225757, EBI-742948;
CC Q08AG5; Q9GZM8: NDEL1; NbExp=6; IntAct=EBI-10225757, EBI-928842;
CC Q08AG5; Q13077: TRAF1; NbExp=3; IntAct=EBI-10225757, EBI-359224;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. {ECO:0000305}.
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DR EMBL; AK098117; BAG53579.1; -; mRNA.
DR EMBL; AL832297; CAI46141.1; -; mRNA.
DR EMBL; CH471106; EAW84257.1; -; Genomic_DNA.
DR EMBL; BC125186; AAI25187.1; -; mRNA.
DR CCDS; CCDS45985.1; -.
DR RefSeq; NP_001129973.1; NM_001136501.2.
DR AlphaFoldDB; Q08AG5; -.
DR SMR; Q08AG5; -.
DR BioGRID; 129858; 12.
DR IntAct; Q08AG5; 12.
DR STRING; 9606.ENSP00000392024; -.
DR iPTMnet; Q08AG5; -.
DR PhosphoSitePlus; Q08AG5; -.
DR BioMuta; ZNF844; -.
DR DMDM; 121939996; -.
DR EPD; Q08AG5; -.
DR jPOST; Q08AG5; -.
DR MassIVE; Q08AG5; -.
DR MaxQB; Q08AG5; -.
DR PaxDb; Q08AG5; -.
DR PeptideAtlas; Q08AG5; -.
DR PRIDE; Q08AG5; -.
DR Antibodypedia; 49319; 40 antibodies from 11 providers.
DR DNASU; 284391; -.
DR Ensembl; ENST00000439326.8; ENSP00000392024.3; ENSG00000223547.10.
DR GeneID; 284391; -.
DR KEGG; hsa:284391; -.
DR MANE-Select; ENST00000439326.8; ENSP00000392024.3; NM_001136501.3; NP_001129973.1.
DR UCSC; uc002mtb.3; human.
DR CTD; 284391; -.
DR GeneCards; ZNF844; -.
DR HGNC; HGNC:25932; ZNF844.
DR HPA; ENSG00000223547; Low tissue specificity.
DR neXtProt; NX_Q08AG5; -.
DR OpenTargets; ENSG00000223547; -.
DR PharmGKB; PA162410862; -.
DR VEuPathDB; HostDB:ENSG00000223547; -.
DR eggNOG; KOG1721; Eukaryota.
DR GeneTree; ENSGT00950000182755; -.
DR HOGENOM; CLU_002678_61_0_1; -.
DR InParanoid; Q08AG5; -.
DR OMA; NVRYVGK; -.
DR PhylomeDB; Q08AG5; -.
DR TreeFam; TF338854; -.
DR PathwayCommons; Q08AG5; -.
DR SignaLink; Q08AG5; -.
DR BioGRID-ORCS; 284391; 21 hits in 1089 CRISPR screens.
DR ChiTaRS; ZNF844; human.
DR GenomeRNAi; 284391; -.
DR Pharos; Q08AG5; Tdark.
DR PRO; PR:Q08AG5; -.
DR Proteomes; UP000005640; Chromosome 19.
DR RNAct; Q08AG5; protein.
DR Bgee; ENSG00000223547; Expressed in kidney epithelium and 175 other tissues.
DR ExpressionAtlas; Q08AG5; baseline and differential.
DR Genevisible; Q08AG5; HS.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000977; F:RNA polymerase II transcription regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd07765; KRAB_A-box; 1.
DR InterPro; IPR001909; KRAB.
DR InterPro; IPR036051; KRAB_dom_sf.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF01352; KRAB; 1.
DR Pfam; PF00096; zf-C2H2; 2.
DR SMART; SM00349; KRAB; 1.
DR SMART; SM00355; ZnF_C2H2; 8.
DR SUPFAM; SSF109640; SSF109640; 1.
DR SUPFAM; SSF57667; SSF57667; 5.
DR PROSITE; PS50805; KRAB; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 6.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 8.
PE 1: Evidence at protein level;
KW DNA-binding; Metal-binding; Nucleus; Reference proteome; Repeat;
KW Transcription; Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1..666
FT /note="Zinc finger protein 844"
FT /id="PRO_0000349877"
FT DOMAIN 4..86
FT /note="KRAB"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00119"
FT ZN_FING 101..125
FT /note="C2H2-type 1; degenerate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 141..163
FT /note="C2H2-type 2; degenerate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 169..191
FT /note="C2H2-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 197..219
FT /note="C2H2-type 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 225..247
FT /note="C2H2-type 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 253..275
FT /note="C2H2-type 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 281..303
FT /note="C2H2-type 7"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 309..331
FT /note="C2H2-type 8"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 337..358
FT /note="C2H2-type 9"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT REGION 73..101
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 80..101
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VARIANT 113
FT /note="V -> M (in dbSNP:rs12611158)"
FT /id="VAR_059941"
FT VARIANT 146
FT /note="R -> H (in dbSNP:rs10422576)"
FT /id="VAR_059942"
FT VARIANT 226
FT /note="K -> E (in dbSNP:rs7259684)"
FT /id="VAR_059943"
FT VARIANT 276
FT /note="T -> A (in dbSNP:rs7259845)"
FT /id="VAR_059944"
FT VARIANT 308
FT /note="A -> P (in dbSNP:rs6511763)"
FT /id="VAR_059945"
FT VARIANT 329
FT /note="V -> A (in dbSNP:rs8102258)"
FT /id="VAR_059946"
FT VARIANT 584
FT /note="M -> L (in dbSNP:rs1438694)"
FT /id="VAR_059947"
FT VARIANT 642
FT /note="I -> M (in dbSNP:rs10426017)"
FT /id="VAR_059948"
FT VARIANT 658
FT /note="V -> I (in dbSNP:rs55703333)"
FT /id="VAR_061980"
FT CONFLICT 177
FT /note="T -> A (in Ref. 2; CAI46141)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 666 AA; 76934 MW; AB7CEEBC7A2083D8 CRC64;
MDLVAFEDVA VNFTQEEWSL LDPSQKNLYR EVMQETLRNL ASIGEKWKDQ NIEDQYKNPR
NNLRSLLGER VDENTEENHC GETSSQIPDD TLNKKTSPGV KSCESSVCGE VFVGHSSLNR
HIRADTAHKP SEYQEYGQEP YKCQQRKKAF RCHPSFQMQE KAHTGEKLYD CKECGKTFIS
HSSIQRHMIM HNGDGTYKCK FCGKACPCLS IYLIHERVHT GEKPYKCKQC GKAFSYSTSL
QIHERTHTGE KPYECKECGK AFGSPNSLYE HRRTHTGEKP YECKQCGKAF RWFHSFQIHE
RTHSEEKAYE CTKCGKAFKC PSYLCRHEVT HSGKKPCECK QCGKALSYLN FQRHMKMHTR
MRPYKCKTVE KPLILPVRFE DMKELTLERN LMNASTVVKP SIVPVPFTIM KGLTLERNPM
NVSSVVKPSF LPLPFDIMKG LTLERNRMSV SNVGKPSDLP HTFKCMEGLT LKRNPMNVSS
VVKPSFFPLP FDIMKGLTLE RNPMSVSNVG KPSHLPHTFK CMKGLTLESN CMNLNNVKKP
LDLSETFKFM KRHTLERNPI RNMEKHSTIS LPFKYMQQCT EDRMPMNVKS VTKHSYLPRS
FEYMQEHTLE RNPMNVRNAE KRSIIFLLCV YTKGCTLERN HINVRIVGKH SVCLVPFVDI
KGLTLE
