ZN845_HUMAN
ID ZN845_HUMAN Reviewed; 970 AA.
AC Q96IR2;
DT 02-SEP-2008, integrated into UniProtKB/Swiss-Prot.
DT 18-MAY-2010, sequence version 3.
DT 03-AUG-2022, entry version 161.
DE RecName: Full=Zinc finger protein 845;
GN Name=ZNF845;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15057824; DOI=10.1038/nature02399;
RA Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E.,
RA Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A.,
RA Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S.,
RA Carrano A.V., Caoile C., Chan Y.M., Christensen M., Cleland C.A.,
RA Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J.,
RA Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M.,
RA Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W.,
RA Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V.,
RA Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D.,
RA McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I.,
RA Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L.,
RA Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A.,
RA She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M.,
RA Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J.,
RA Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA Rubin E.M., Lucas S.M.;
RT "The DNA sequence and biology of human chromosome 19.";
RL Nature 428:529-535(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 334-970.
RC TISSUE=Eye;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP SUMOYLATION [LARGE SCALE ANALYSIS] AT LYS-205, AND IDENTIFICATION BY MASS
RP SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=28112733; DOI=10.1038/nsmb.3366;
RA Hendriks I.A., Lyon D., Young C., Jensen L.J., Vertegaal A.C.,
RA Nielsen M.L.;
RT "Site-specific mapping of the human SUMO proteome reveals co-modification
RT with phosphorylation.";
RL Nat. Struct. Mol. Biol. 24:325-336(2017).
CC -!- FUNCTION: May be involved in transcriptional regulation. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. {ECO:0000305}.
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DR EMBL; AK295079; BAG58121.1; -; mRNA.
DR EMBL; AC010467; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC007307; AAH07307.1; -; mRNA.
DR CCDS; CCDS46170.1; -.
DR RefSeq; NP_001308451.1; NM_001321522.1.
DR RefSeq; NP_001308452.1; NM_001321523.1.
DR RefSeq; NP_001308453.1; NM_001321524.1.
DR RefSeq; NP_612383.1; NM_138374.2.
DR AlphaFoldDB; Q96IR2; -.
DR SMR; Q96IR2; -.
DR BioGRID; 124863; 33.
DR IntAct; Q96IR2; 5.
DR STRING; 9606.ENSP00000388311; -.
DR iPTMnet; Q96IR2; -.
DR PhosphoSitePlus; Q96IR2; -.
DR BioMuta; ZNF845; -.
DR DMDM; 296453067; -.
DR EPD; Q96IR2; -.
DR jPOST; Q96IR2; -.
DR MassIVE; Q96IR2; -.
DR MaxQB; Q96IR2; -.
DR PaxDb; Q96IR2; -.
DR PeptideAtlas; Q96IR2; -.
DR PRIDE; Q96IR2; -.
DR ProteomicsDB; 76846; -.
DR Antibodypedia; 32690; 73 antibodies from 14 providers.
DR DNASU; 91664; -.
DR Ensembl; ENST00000458035.3; ENSP00000388311.1; ENSG00000213799.13.
DR Ensembl; ENST00000595091.6; ENSP00000470005.1; ENSG00000213799.13.
DR GeneID; 91664; -.
DR KEGG; hsa:91664; -.
DR MANE-Select; ENST00000458035.3; ENSP00000388311.1; NM_138374.3; NP_612383.1.
DR UCSC; uc010ydv.1; human.
DR CTD; 91664; -.
DR GeneCards; ZNF845; -.
DR HGNC; HGNC:25112; ZNF845.
DR HPA; ENSG00000213799; Low tissue specificity.
DR neXtProt; NX_Q96IR2; -.
DR OpenTargets; ENSG00000213799; -.
DR PharmGKB; PA162410863; -.
DR VEuPathDB; HostDB:ENSG00000213799; -.
DR eggNOG; KOG1721; Eukaryota.
DR GeneTree; ENSGT00940000155274; -.
DR HOGENOM; CLU_002678_17_0_1; -.
DR InParanoid; Q96IR2; -.
DR OMA; CHTREKS; -.
DR OrthoDB; 1318335at2759; -.
DR PhylomeDB; Q96IR2; -.
DR TreeFam; TF343410; -.
DR PathwayCommons; Q96IR2; -.
DR SignaLink; Q96IR2; -.
DR BioGRID-ORCS; 91664; 12 hits in 1027 CRISPR screens.
DR ChiTaRS; ZNF845; human.
DR GenomeRNAi; 91664; -.
DR Pharos; Q96IR2; Tdark.
DR PRO; PR:Q96IR2; -.
DR Proteomes; UP000005640; Chromosome 19.
DR RNAct; Q96IR2; protein.
DR Bgee; ENSG00000213799; Expressed in thymus and 112 other tissues.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd07765; KRAB_A-box; 1.
DR InterPro; IPR001909; KRAB.
DR InterPro; IPR036051; KRAB_dom_sf.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF01352; KRAB; 1.
DR Pfam; PF00096; zf-C2H2; 24.
DR SMART; SM00349; KRAB; 1.
DR SMART; SM00355; ZnF_C2H2; 27.
DR SUPFAM; SSF109640; SSF109640; 1.
DR SUPFAM; SSF57667; SSF57667; 16.
DR PROSITE; PS50805; KRAB; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 26.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 27.
PE 1: Evidence at protein level;
KW DNA-binding; Isopeptide bond; Metal-binding; Nucleus; Reference proteome;
KW Repeat; Transcription; Transcription regulation; Ubl conjugation; Zinc;
KW Zinc-finger.
FT CHAIN 1..970
FT /note="Zinc finger protein 845"
FT /id="PRO_0000349878"
FT DOMAIN 8..81
FT /note="KRAB"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00119"
FT ZN_FING 215..237
FT /note="C2H2-type 1; degenerate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 243..265
FT /note="C2H2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 271..293
FT /note="C2H2-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 299..321
FT /note="C2H2-type 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 327..349
FT /note="C2H2-type 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 355..377
FT /note="C2H2-type 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 383..405
FT /note="C2H2-type 7"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 411..433
FT /note="C2H2-type 8"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 439..461
FT /note="C2H2-type 9"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 467..489
FT /note="C2H2-type 10"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 495..517
FT /note="C2H2-type 11"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 523..545
FT /note="C2H2-type 12"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 551..573
FT /note="C2H2-type 13"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 579..601
FT /note="C2H2-type 14"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 607..629
FT /note="C2H2-type 15"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 635..657
FT /note="C2H2-type 16"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 663..685
FT /note="C2H2-type 17"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 691..713
FT /note="C2H2-type 18"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 719..741
FT /note="C2H2-type 19"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 747..769
FT /note="C2H2-type 20"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 775..797
FT /note="C2H2-type 21"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 803..825
FT /note="C2H2-type 22"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 831..853
FT /note="C2H2-type 23"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 859..881
FT /note="C2H2-type 24"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 887..909
FT /note="C2H2-type 25"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 915..937
FT /note="C2H2-type 26"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 943..965
FT /note="C2H2-type 27"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT CROSSLNK 205
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0007744|PubMed:28112733"
FT CONFLICT 348
FT /note="L -> F (in Ref. 3; AAH07307)"
FT /evidence="ECO:0000305"
FT CONFLICT 537
FT /note="S -> F (in Ref. 1; BAG58121)"
FT /evidence="ECO:0000305"
FT CONFLICT 662..745
FT /note="Missing (in Ref. 1; BAG58121)"
FT /evidence="ECO:0000305"
FT CONFLICT 807
FT /note="E -> D (in Ref. 3; AAH07307)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 970 AA; 113133 MW; 3ED3FDDF5893B5CF CRC64;
MALSQGLLTF RDVAIEFSQE EWKCLDPAQR TLYRDVMLEN YRNLVSLDIS SKCMMKEFSS
TAQGNTEVIH TGTLQRHERH HIGDFCFQEM EKDIHDFEFQ WKEDERNSHE APMTEIKQLT
GSTNRHDQRH AGNKPIKDQL GSSFHSHLPE LHMFQTEGKI GNQVEKSINS ASLVSTSQRI
SCRPKTHISK NYGNNFLNSS LLTQKQEVHM REKSFQCNES GKAFNYSSVL RKHQIIHLGA
KQYKCDVCGK VFNQKRYLAC HRRCHTGKKP YKCNDCGKTF SQELTLTCHH RLHTGEKHYK
CSECGKTFSR NSALVIHKAI HTGEKSYKCN ECGKTFSQTS YLVYHRRLHT GEKPYKCEEC
DKAFSFKSNL ERHRKIHTGE KPYKCNECSR TFSRKSSLTR HRRLHTGEKP YKCNDCGKTF
SQMSSLVYHR RLHTGEKPYK CEECDEAFSF KSNLERHRRI HTGEKPYKCN DCGKTFSQTS
SLVYHRRLHT GEKPYKCEEC DEAFSFKSNL ERHRIIHTGE KLYKCNECGK TFSRKSSLTR
HCRLHTGEKP YQCNECGKAF RGQSALIYHQ AIHGIGKLYK CNDCHQVFSN ATTIANHWRI
HNEERSYKCN RCGKFFRHRS YLAVHWRTHS GEKPYKCEEC DEAFSFKSNL QRHRRIHTGE
KPYRCNECGK TFSRKSYLTC HRRLHTGEKP YKCNECGKTF GRNSALIIHK AIHTGEKPYK
CNECGKAFSQ KSSLTCHLRL HTGEKPYKCE ECDKVFSRKS SLEKHRRIHT GEKPYKCKVC
DKAFGRDSHL AQHTRIHTGE KPYKCNECGK NFRHNSALVI HKAIHSGEKP YKCNECGKTF
RHNSALEIHK AIHTGEKPYK CSECGKVFNR KANLSRHHRL HTGEKPYKCN KCGKVFNQQA
HLACHHRIHT GEKPYKCNEC GKTFRHNSVL VIHKTIHTGE KPYKCNECGK VFNRKAKLAR
HHRIHTGKKH
