ZN846_HUMAN
ID ZN846_HUMAN Reviewed; 533 AA.
AC Q147U1; A8K0H1; B3KUP1;
DT 29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 29-APR-2008, sequence version 2.
DT 03-AUG-2022, entry version 127.
DE RecName: Full=Zinc finger protein 846;
GN Name=ZNF846;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Cerebellum, and Testis;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15057824; DOI=10.1038/nature02399;
RA Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E.,
RA Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A.,
RA Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S.,
RA Carrano A.V., Caoile C., Chan Y.M., Christensen M., Cleland C.A.,
RA Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J.,
RA Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M.,
RA Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W.,
RA Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V.,
RA Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D.,
RA McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I.,
RA Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L.,
RA Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A.,
RA She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M.,
RA Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J.,
RA Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA Rubin E.M., Lucas S.M.;
RT "The DNA sequence and biology of human chromosome 19.";
RL Nature 428:529-535(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma;
RX PubMed=18669648; DOI=10.1073/pnas.0805139105;
RA Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,
RA Elledge S.J., Gygi S.P.;
RT "A quantitative atlas of mitotic phosphorylation.";
RL Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
CC -!- FUNCTION: May be involved in transcriptional regulation. {ECO:0000250}.
CC -!- INTERACTION:
CC Q147U1; P60409: KRTAP10-7; NbExp=3; IntAct=EBI-10234020, EBI-10172290;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q147U1-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q147U1-3; Sequence=VSP_033362, VSP_033363;
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AK097652; BAG53503.1; -; mRNA.
DR EMBL; AK289536; BAF82225.1; -; mRNA.
DR EMBL; AC008752; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC118576; AAI18577.2; -; mRNA.
DR CCDS; CCDS42496.1; -. [Q147U1-1]
DR RefSeq; NP_001071092.1; NM_001077624.1. [Q147U1-1]
DR RefSeq; XP_005259829.1; XM_005259772.3.
DR RefSeq; XP_011526019.1; XM_011527717.2.
DR AlphaFoldDB; Q147U1; -.
DR SMR; Q147U1; -.
DR BioGRID; 127839; 2.
DR IntAct; Q147U1; 3.
DR STRING; 9606.ENSP00000380999; -.
DR iPTMnet; Q147U1; -.
DR PhosphoSitePlus; Q147U1; -.
DR BioMuta; ZNF846; -.
DR DMDM; 187671939; -.
DR jPOST; Q147U1; -.
DR MassIVE; Q147U1; -.
DR MaxQB; Q147U1; -.
DR PaxDb; Q147U1; -.
DR PeptideAtlas; Q147U1; -.
DR PRIDE; Q147U1; -.
DR ProteomicsDB; 60181; -. [Q147U1-1]
DR ProteomicsDB; 60182; -. [Q147U1-3]
DR Antibodypedia; 25081; 39 antibodies from 15 providers.
DR DNASU; 162993; -.
DR Ensembl; ENST00000397902.6; ENSP00000380999.1; ENSG00000196605.7. [Q147U1-1]
DR Ensembl; ENST00000588267.5; ENSP00000465467.1; ENSG00000196605.7. [Q147U1-3]
DR Ensembl; ENST00000592859.1; ENSP00000467891.1; ENSG00000196605.7. [Q147U1-3]
DR GeneID; 162993; -.
DR KEGG; hsa:162993; -.
DR MANE-Select; ENST00000397902.7; ENSP00000380999.1; NM_001077624.3; NP_001071092.1.
DR UCSC; uc002mmb.2; human. [Q147U1-1]
DR CTD; 162993; -.
DR DisGeNET; 162993; -.
DR GeneCards; ZNF846; -.
DR HGNC; HGNC:27260; ZNF846.
DR HPA; ENSG00000196605; Low tissue specificity.
DR neXtProt; NX_Q147U1; -.
DR OpenTargets; ENSG00000196605; -.
DR PharmGKB; PA162410876; -.
DR VEuPathDB; HostDB:ENSG00000196605; -.
DR eggNOG; KOG1721; Eukaryota.
DR GeneTree; ENSGT00940000163958; -.
DR HOGENOM; CLU_002678_2_1_1; -.
DR InParanoid; Q147U1; -.
DR OMA; RYSTCLN; -.
DR OrthoDB; 1318335at2759; -.
DR PhylomeDB; Q147U1; -.
DR TreeFam; TF341817; -.
DR PathwayCommons; Q147U1; -.
DR SignaLink; Q147U1; -.
DR BioGRID-ORCS; 162993; 7 hits in 1098 CRISPR screens.
DR ChiTaRS; ZNF846; human.
DR GenomeRNAi; 162993; -.
DR Pharos; Q147U1; Tdark.
DR PRO; PR:Q147U1; -.
DR Proteomes; UP000005640; Chromosome 19.
DR RNAct; Q147U1; protein.
DR Bgee; ENSG00000196605; Expressed in left testis and 142 other tissues.
DR ExpressionAtlas; Q147U1; baseline and differential.
DR Genevisible; Q147U1; HS.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0001227; F:DNA-binding transcription repressor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000977; F:RNA polymerase II transcription regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd07765; KRAB_A-box; 1.
DR InterPro; IPR001909; KRAB.
DR InterPro; IPR036051; KRAB_dom_sf.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF01352; KRAB; 1.
DR Pfam; PF00096; zf-C2H2; 10.
DR SMART; SM00349; KRAB; 1.
DR SMART; SM00355; ZnF_C2H2; 12.
DR SUPFAM; SSF109640; SSF109640; 1.
DR SUPFAM; SSF57667; SSF57667; 8.
DR PROSITE; PS50805; KRAB; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 11.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 12.
PE 1: Evidence at protein level;
KW Alternative splicing; DNA-binding; Metal-binding; Nucleus;
KW Reference proteome; Repeat; Transcription; Transcription regulation; Zinc;
KW Zinc-finger.
FT CHAIN 1..533
FT /note="Zinc finger protein 846"
FT /id="PRO_0000332245"
FT DOMAIN 8..80
FT /note="KRAB"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00119"
FT ZN_FING 114..136
FT /note="C2H2-type 1; degenerate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 170..192
FT /note="C2H2-type 2; degenerate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 198..220
FT /note="C2H2-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 226..248
FT /note="C2H2-type 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 254..276
FT /note="C2H2-type 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 282..304
FT /note="C2H2-type 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 310..332
FT /note="C2H2-type 7"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 338..360
FT /note="C2H2-type 8"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 366..388
FT /note="C2H2-type 9"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 394..416
FT /note="C2H2-type 10"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 422..444
FT /note="C2H2-type 11"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 450..472
FT /note="C2H2-type 12"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 478..500
FT /note="C2H2-type 13"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 506..528
FT /note="C2H2-type 14; degenerate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT VAR_SEQ 1..129
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_033362"
FT VAR_SEQ 340..533
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_033363"
FT VARIANT 450
FT /note="C -> Y (in dbSNP:rs10414485)"
FT /id="VAR_052911"
FT VARIANT 492
FT /note="Y -> C (in dbSNP:rs10420364)"
FT /id="VAR_052912"
SQ SEQUENCE 533 AA; 60552 MW; 08BE40F6CA55405F CRC64;
MDSSQHLVTF EDVAVDFTQE EWTLLDQAQR DLYRDVMLEN YKNLIILAGS ELFKRSLMSG
LEQMEELRTG VTGVLQELDL QLKTKGSPLL QDISAERSPN GVQLERSNTA EKLYDSNHSG
KVFNEHPFLM THMITHIGEK TSEDNQSGKA LRKNFPHSFY KKSHAEGKMP KCVKHEKAFN
QFPNLTRQNK THTQEKLCEC KDCWRTFLNQ SSLKLHIRSH NGDKHYVCKE CGKAFSNSSH
LIGHGRIHSG EKPYVCKECG KAFTQSTGLK LHIRTHSGEK PYKCKECGKA FTHSSYLTDH
TRIHSGKKPY VCMECGKAFT RSTGLILHMR IHTGEKPYEC KECGKAFIHS SYLTKHVRIH
SGEKLYLCKA CGKAFTRSSG LVLHMRTHTG EKPYECKECG KAFNNSSMLS QHVRIHTGEK
PYECKECGKA FTQSSGLSTH LRTHTGEKAC ECKECGKAFA RSTNLNMHMR THTGEKPYAC
KECGKAFRYS TYLNVHTRTH TGAKPYECKK CGKNFTQSSA LAKHLRTKAC EKT
