ZN850_HUMAN
ID ZN850_HUMAN Reviewed; 1090 AA.
AC A8MQ14;
DT 29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 08-MAR-2011, sequence version 2.
DT 03-AUG-2022, entry version 114.
DE RecName: Full=Zinc finger protein 850;
GN Name=ZNF850;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15057824; DOI=10.1038/nature02399;
RA Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E.,
RA Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A.,
RA Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S.,
RA Carrano A.V., Caoile C., Chan Y.M., Christensen M., Cleland C.A.,
RA Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J.,
RA Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M.,
RA Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W.,
RA Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V.,
RA Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D.,
RA McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I.,
RA Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L.,
RA Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A.,
RA She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M.,
RA Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J.,
RA Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA Rubin E.M., Lucas S.M.;
RT "The DNA sequence and biology of human chromosome 19.";
RL Nature 428:529-535(2004).
CC -!- FUNCTION: May be involved in transcriptional regulation. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AC020928; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS59379.1; -.
DR RefSeq; NP_001180481.1; NM_001193552.1.
DR AlphaFoldDB; A8MQ14; -.
DR SMR; A8MQ14; -.
DR BioGRID; 131203; 5.
DR IntAct; A8MQ14; 3.
DR STRING; 9606.ENSP00000464976; -.
DR iPTMnet; A8MQ14; -.
DR PhosphoSitePlus; A8MQ14; -.
DR BioMuta; ZNF850; -.
DR EPD; A8MQ14; -.
DR jPOST; A8MQ14; -.
DR MassIVE; A8MQ14; -.
DR PaxDb; A8MQ14; -.
DR PeptideAtlas; A8MQ14; -.
DR PRIDE; A8MQ14; -.
DR ProteomicsDB; 1933; -.
DR Antibodypedia; 71746; 4 antibodies from 4 providers.
DR Ensembl; ENST00000591344.2; ENSP00000464976.1; ENSG00000267041.6.
DR GeneID; 342892; -.
DR KEGG; hsa:342892; -.
DR MANE-Select; ENST00000591344.2; ENSP00000464976.1; NM_001193552.2; NP_001180481.1.
DR UCSC; uc010efc.4; human.
DR CTD; 342892; -.
DR GeneCards; ZNF850; -.
DR HGNC; HGNC:27994; ZNF850.
DR HPA; ENSG00000267041; Tissue enhanced (bone).
DR neXtProt; NX_A8MQ14; -.
DR OpenTargets; ENSG00000267041; -.
DR VEuPathDB; HostDB:ENSG00000267041; -.
DR eggNOG; KOG1721; Eukaryota.
DR GeneTree; ENSGT01030000234576; -.
DR HOGENOM; CLU_002678_17_1_1; -.
DR InParanoid; A8MQ14; -.
DR OMA; AFCSRTT; -.
DR OrthoDB; 1318335at2759; -.
DR PhylomeDB; A8MQ14; -.
DR PathwayCommons; A8MQ14; -.
DR SignaLink; A8MQ14; -.
DR BioGRID-ORCS; 342892; 12 hits in 1043 CRISPR screens.
DR ChiTaRS; ZNF850; human.
DR GenomeRNAi; 342892; -.
DR Pharos; A8MQ14; Tdark.
DR PRO; PR:A8MQ14; -.
DR Proteomes; UP000005640; Chromosome 19.
DR RNAct; A8MQ14; protein.
DR Bgee; ENSG00000267041; Expressed in oocyte and 120 other tissues.
DR ExpressionAtlas; A8MQ14; baseline and differential.
DR Genevisible; A8MQ14; HS.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd07765; KRAB_A-box; 1.
DR InterPro; IPR001909; KRAB.
DR InterPro; IPR036051; KRAB_dom_sf.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF01352; KRAB; 1.
DR Pfam; PF00096; zf-C2H2; 28.
DR SMART; SM00349; KRAB; 1.
DR SMART; SM00355; ZnF_C2H2; 30.
DR SUPFAM; SSF109640; SSF109640; 1.
DR SUPFAM; SSF57667; SSF57667; 19.
DR PROSITE; PS50805; KRAB; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 29.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 32.
PE 3: Inferred from homology;
KW DNA-binding; Metal-binding; Nucleus; Reference proteome; Repeat;
KW Transcription; Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1..1090
FT /note="Zinc finger protein 850"
FT /id="PRO_0000332269"
FT DOMAIN 7..78
FT /note="KRAB"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00119"
FT ZN_FING 197..219
FT /note="C2H2-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 225..247
FT /note="C2H2-type 2; degenerate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 253..275
FT /note="C2H2-type 3; degenerate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 281..303
FT /note="C2H2-type 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 309..331
FT /note="C2H2-type 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 337..359
FT /note="C2H2-type 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 365..387
FT /note="C2H2-type 7"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 393..415
FT /note="C2H2-type 8"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 421..443
FT /note="C2H2-type 9"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 449..471
FT /note="C2H2-type 10"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 477..499
FT /note="C2H2-type 11"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 505..527
FT /note="C2H2-type 12"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 533..555
FT /note="C2H2-type 13"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 561..583
FT /note="C2H2-type 14"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 589..611
FT /note="C2H2-type 15"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 617..639
FT /note="C2H2-type 16"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 645..667
FT /note="C2H2-type 17"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 673..695
FT /note="C2H2-type 18"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 701..723
FT /note="C2H2-type 19"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 729..751
FT /note="C2H2-type 20; degenerate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 757..779
FT /note="C2H2-type 21"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 785..807
FT /note="C2H2-type 22"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 813..835
FT /note="C2H2-type 23"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 841..863
FT /note="C2H2-type 24"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 869..891
FT /note="C2H2-type 25"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 897..919
FT /note="C2H2-type 26"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 925..947
FT /note="C2H2-type 27"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 953..975
FT /note="C2H2-type 28"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 981..1003
FT /note="C2H2-type 29"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 1009..1031
FT /note="C2H2-type 30"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 1037..1059
FT /note="C2H2-type 31"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 1065..1087
FT /note="C2H2-type 32"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
SQ SEQUENCE 1090 AA; 125431 MW; 6A02205E3BFB8F30 CRC64;
MNMEGLVMFQ DLSIDFSQEE WECLDAAQKD LYRDVMMENY SSLVSLGLSI PKPDVISLLE
QGKEPWMVSR DVLGGWCRDS EFRCKTKDSC LPKEIYEVTS SQWVRMEKCH SLVGSSVRDD
WECKGQFQHQ DINQERYLEK AIMTYETTPT FCLQTSLTLH HRIHPGEKLY KSTECMAFKY
GSELTQQQET HTGEKLYKCK ECGKAFHHFS YLVKHQRIHT GEKPCACKEY GKAFISGSHL
IQHQKMYTDE RPHECQESVK AFRPSAHLIQ HWRIHTGDKP YECKECGKSF TSGSTLNQHQ
QIHTGEKPYH CKQCGKSFTV GSTLIRHQQI HTGEKPYDCK ECGKSFASGS ALIRHQRIHT
GEKPYDCKEC GKSFTFHSAL IRHQRIHTGE KPYDCKECGK SFTFRSGLIG HQAIHTGEKP
YDCKECGKSF TAGSTLIQHQ RIHTGEKPYD CKECGKSFAS GSALLQHQRI HTGEKPYCCK
ECGKSFTFRS TRNRHQRIHT GEKPYNCKEC GKSFASGSAL LQHQRIHTGE KPYHCKECGK
SFTFRSGLIG HQAVHTGEKP YDCKECGKSF TSRSALIQHQ RIHTGEKPYH CKECGKSFTV
GSTLLQHQQI HTGEKPYDCK ECGKAFRLRL RLTQHQQIHT GEKPYQCQEC GKAFVSVSGL
TQHHRIHTGE KPYECPDCGK AFRQRTYLNQ HRRIHTGEKP YECKECGKSF TFCSGLIQHQ
QNHTDEKPYD GKECGKSFTS HSTLIQHQQI HTGEKPYDCK ECGKSFTSHS TLIQHQQIHT
GEKLYDCKEC GKSFTSHSTL IQHQPLHTGE KPYHCKECGK SFTLRSALIQ HRPVHTGEKR
YSCKECGKSF TSRSTLIEHQ RIHTGEKPYH CKECGKSFAF RSAIIQHRRI HTGEKPYDCK
ECGKAFRRRS KLTQHQRIHT GEKPYRCHEC GKAFVRFSGL TKHHSIHTGE KPYECKTCGK
SFRQRTHLTL HQRIHTGDRP YECKECGKSF TCGSELIRHQ RTHTGEKPYD CKECGKAFRC
PSQLSQHKRI HTGEKTYQCP ECGKAFFYAS GLSRHQSVHT GEKPYECKTC GKAFKQLTQL
TRHQRIHDLT
