ZN852_HUMAN
ID ZN852_HUMAN Reviewed; 543 AA.
AC Q6ZMS4; B4DLD7;
DT 29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2014, sequence version 4.
DT 03-AUG-2022, entry version 138.
DE RecName: Full=Zinc finger protein 852;
GN Name=ZNF852;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Tongue;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16641997; DOI=10.1038/nature04728;
RA Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J.,
RA Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P.,
RA Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A.,
RA Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L.,
RA Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G.,
RA Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W.,
RA Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M.,
RA Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P.,
RA Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H.,
RA Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J.,
RA Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W.,
RA Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B.,
RA Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O.,
RA Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B.,
RA Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H.,
RA Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J.,
RA Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X.,
RA Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R.,
RA Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.;
RT "The DNA sequence, annotation and analysis of human chromosome 3.";
RL Nature 440:1194-1198(2006).
RN [3]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-145, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Erythroleukemia;
RX PubMed=23186163; DOI=10.1021/pr300630k;
RA Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J.,
RA Mohammed S.;
RT "Toward a comprehensive characterization of a human cancer cell
RT phosphoproteome.";
RL J. Proteome Res. 12:260-271(2013).
CC -!- FUNCTION: May be involved in transcriptional regulation. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAG59499.1; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; AK296954; BAG59499.1; ALT_FRAME; mRNA.
DR EMBL; AC099669; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; NP_001274278.1; NM_001287349.1.
DR AlphaFoldDB; Q6ZMS4; -.
DR SMR; Q6ZMS4; -.
DR BioGRID; 130087; 8.
DR IntAct; Q6ZMS4; 4.
DR STRING; 9606.ENSP00000389841; -.
DR iPTMnet; Q6ZMS4; -.
DR PhosphoSitePlus; Q6ZMS4; -.
DR BioMuta; ZNF852; -.
DR DMDM; 298286894; -.
DR EPD; Q6ZMS4; -.
DR jPOST; Q6ZMS4; -.
DR MassIVE; Q6ZMS4; -.
DR MaxQB; Q6ZMS4; -.
DR PaxDb; Q6ZMS4; -.
DR PeptideAtlas; Q6ZMS4; -.
DR PRIDE; Q6ZMS4; -.
DR ProteomicsDB; 67908; -.
DR Antibodypedia; 62713; 28 antibodies from 6 providers.
DR DNASU; 285346; -.
DR Ensembl; ENST00000436261.6; ENSP00000389841.2; ENSG00000178917.17.
DR Ensembl; ENST00000628759.2; ENSP00000487256.1; ENSG00000281626.4.
DR GeneID; 285346; -.
DR KEGG; hsa:285346; -.
DR UCSC; uc062iux.1; human.
DR CTD; 285346; -.
DR GeneCards; ZNF852; -.
DR HGNC; HGNC:27713; ZNF852.
DR HPA; ENSG00000178917; Low tissue specificity.
DR neXtProt; NX_Q6ZMS4; -.
DR VEuPathDB; HostDB:ENSG00000178917; -.
DR eggNOG; KOG1721; Eukaryota.
DR HOGENOM; CLU_002678_44_5_1; -.
DR InParanoid; Q6ZMS4; -.
DR OMA; WFSETES; -.
DR OrthoDB; 1318335at2759; -.
DR PhylomeDB; Q6ZMS4; -.
DR TreeFam; TF350837; -.
DR PathwayCommons; Q6ZMS4; -.
DR SignaLink; Q6ZMS4; -.
DR BioGRID-ORCS; 285346; 5 hits in 269 CRISPR screens.
DR GenomeRNAi; 285346; -.
DR Pharos; Q6ZMS4; Tdark.
DR PRO; PR:Q6ZMS4; -.
DR Proteomes; UP000005640; Chromosome 3.
DR RNAct; Q6ZMS4; protein.
DR Bgee; ENSG00000178917; Expressed in colonic epithelium and 109 other tissues.
DR ExpressionAtlas; Q6ZMS4; baseline and differential.
DR Genevisible; Q6ZMS4; HS.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd07765; KRAB_A-box; 1.
DR InterPro; IPR001909; KRAB.
DR InterPro; IPR036051; KRAB_dom_sf.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF01352; KRAB; 1.
DR Pfam; PF00096; zf-C2H2; 12.
DR SMART; SM00349; KRAB; 1.
DR SMART; SM00355; ZnF_C2H2; 12.
DR SUPFAM; SSF109640; SSF109640; 1.
DR SUPFAM; SSF57667; SSF57667; 7.
DR PROSITE; PS50805; KRAB; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 12.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 12.
PE 1: Evidence at protein level;
KW Metal-binding; Nucleus; Phosphoprotein; Reference proteome; Repeat; Zinc;
KW Zinc-finger.
FT CHAIN 1..543
FT /note="Zinc finger protein 852"
FT /id="PRO_0000332125"
FT DOMAIN 8..82
FT /note="KRAB"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00119"
FT ZN_FING 159..181
FT /note="C2H2-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 187..209
FT /note="C2H2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 215..237
FT /note="C2H2-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 243..265
FT /note="C2H2-type 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 271..293
FT /note="C2H2-type 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 299..321
FT /note="C2H2-type 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 327..349
FT /note="C2H2-type 7"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 355..377
FT /note="C2H2-type 8"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 383..405
FT /note="C2H2-type 9"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 411..433
FT /note="C2H2-type 10"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 439..461
FT /note="C2H2-type 11"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 467..489
FT /note="C2H2-type 12"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT MOD_RES 145
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:23186163"
FT CONFLICT 158
FT /note="S -> P (in Ref. 1; BAG59499)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 543 AA; 62084 MW; 4DE82359226B9414 CRC64;
MVRPQDTVAY EDLSEDYTQK KWKGLALSQR ALHWNMMLEN DRSMASLGRN MMESSELTPK
QEIFKGSESS NSTSGGLFGV VPGGTETGDV CEDTFKELEG QPSNEEGSRL ESDFLEIIDE
DKKKSTKDRY EEYKEVEEHP PLSSSPVEHE GVLKGQKSYR CDECGKAFYW SSHLIGHRRI
HTGEKPYECN ECGKTFRQTS QLIVHLRTHT GEKPYECSEC GKAYRHSSHL IQHQRLHNGE
KPYKCNECAK AFNQSSKLFD HQRTHTGEKP YECKECGAAF SRSKNLVRHQ FLHTGKKPYK
CNECGRAFCS NRNLIDHQRT HTGEKPYKCN ECGKAFSRSK CLIRHQSLHT GEKPYKCSEC
GKAFNQISQL VEHERIHTGE KPFKCSECGK AFGLSKCLIR HQRLHTSEKP YKCNECGKSF
NQNSYLIIHQ RIHTGEKPYE CNECGKVFSY NSSLMVHQRT HTGEKPYKCN SCGKAFSDSS
QLTVHQRVHT GEKNLMNVLS VGKPLVSVPL LITTSELMLE RSPQVWLGHL LKAWFSETDS
KDL
