ZN853_HUMAN
ID ZN853_HUMAN Reviewed; 659 AA.
AC P0CG23;
DT 15-JUN-2010, integrated into UniProtKB/Swiss-Prot.
DT 15-JUN-2010, sequence version 1.
DT 03-AUG-2022, entry version 91.
DE RecName: Full=Zinc finger protein 853;
GN Name=ZNF853;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=12853948; DOI=10.1038/nature01782;
RA Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H.,
RA Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K.,
RA Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A.,
RA Delehaunty K.D., Miner T.L., Nash W.E., Cordes M., Du H., Sun H.,
RA Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A.,
RA Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P.,
RA Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M.,
RA Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S.,
RA Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R.,
RA Strowmatt C., Latreille P., Miller N., Johnson D., Murray J.,
RA Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W.,
RA Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E.,
RA Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A.,
RA Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E.,
RA Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E.,
RA Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A.,
RA Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A.,
RA Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R.,
RA McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H.,
RA Wilson R.K.;
RT "The DNA sequence of human chromosome 7.";
RL Nature 424:157-164(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 26-101, AND VARIANT ARG-30.
RA Stevens M., Wei C., Gross S.S., McPherson J., Brent M.R.;
RT "Exhaustive RT-PCR and sequencing of all novel TWINSCAN predictions in
RT human.";
RL Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; AC073343; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; DT932678; -; NOT_ANNOTATED_CDS; mRNA.
DR CCDS; CCDS59048.1; -.
DR RefSeq; NP_060030.1; NM_017560.1.
DR AlphaFoldDB; P0CG23; -.
DR SMR; P0CG23; -.
DR BioGRID; 120130; 1.
DR STRING; 9606.ENSP00000455585; -.
DR iPTMnet; P0CG23; -.
DR PhosphoSitePlus; P0CG23; -.
DR BioMuta; ZNF853; -.
DR DMDM; 298351896; -.
DR MassIVE; P0CG23; -.
DR MaxQB; P0CG23; -.
DR PaxDb; P0CG23; -.
DR PeptideAtlas; P0CG23; -.
DR PRIDE; P0CG23; -.
DR ProteomicsDB; 52457; -.
DR Antibodypedia; 57952; 62 antibodies from 13 providers.
DR Ensembl; ENST00000457543.4; ENSP00000455585.1; ENSG00000236609.4.
DR GeneID; 54753; -.
DR KEGG; hsa:54753; -.
DR MANE-Select; ENST00000457543.4; ENSP00000455585.1; NM_017560.3; NP_060030.1.
DR UCSC; uc011jwz.3; human.
DR CTD; 54753; -.
DR DisGeNET; 54753; -.
DR GeneCards; ZNF853; -.
DR HGNC; HGNC:21767; ZNF853.
DR HPA; ENSG00000236609; Low tissue specificity.
DR neXtProt; NX_P0CG23; -.
DR OpenTargets; ENSG00000236609; -.
DR PharmGKB; PA162410913; -.
DR VEuPathDB; HostDB:ENSG00000236609; -.
DR eggNOG; KOG1721; Eukaryota.
DR GeneTree; ENSGT00940000156663; -.
DR HOGENOM; CLU_022660_0_0_1; -.
DR InParanoid; P0CG23; -.
DR OMA; QPQCEIC; -.
DR OrthoDB; 1318335at2759; -.
DR TreeFam; TF319691; -.
DR PathwayCommons; P0CG23; -.
DR BioGRID-ORCS; 54753; 10 hits in 1072 CRISPR screens.
DR ChiTaRS; ZNF853; human.
DR GenomeRNAi; 54753; -.
DR Pharos; P0CG23; Tdark.
DR PRO; PR:P0CG23; -.
DR Proteomes; UP000005640; Chromosome 7.
DR RNAct; P0CG23; protein.
DR Bgee; ENSG00000236609; Expressed in hypothalamus and 126 other tissues.
DR Genevisible; P0CG23; HS.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF00096; zf-C2H2; 5.
DR SMART; SM00355; ZnF_C2H2; 5.
DR SUPFAM; SSF57667; SSF57667; 3.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 5.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 5.
PE 2: Evidence at transcript level;
KW Metal-binding; Reference proteome; Repeat; Zinc; Zinc-finger.
FT CHAIN 1..659
FT /note="Zinc finger protein 853"
FT /id="PRO_0000395112"
FT ZN_FING 485..507
FT /note="C2H2-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 513..535
FT /note="C2H2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 541..563
FT /note="C2H2-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 569..591
FT /note="C2H2-type 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 597..620
FT /note="C2H2-type 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT REGION 29..144
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 638..659
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 86..137
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VARIANT 8
FT /note="G -> R (in dbSNP:rs2243563)"
FT /id="VAR_063279"
FT VARIANT 30
FT /note="Q -> R (in dbSNP:rs1806552)"
FT /evidence="ECO:0000269|Ref.2"
FT /id="VAR_063280"
FT VARIANT 212
FT /note="Q -> E (in dbSNP:rs11971880)"
FT /id="VAR_063281"
SQ SEQUENCE 659 AA; 74878 MW; 172677BFF65DEFB1 CRC64;
MLHQPTPGNR GLTARMEVGP ATETFVLELQ CLEDGGPGPD TLSGGSGGSE SQEEEEPQER
NSSPQRPAVS APVGASEIAE ETRPGQRELQ LQQLEQQPEP QQQPQHEQLQ QPQPHLELQQ
QPQQDGQQQL SQLQQEKHQS VHHQELKPEL QLMHQQQQLQ PQQVQEQQRL QQQQEQLQTQ
QAQEQQVLQQ QEQLQQQVQE QQLLQQQQEQ LQQQQLLQQQ EQLQQQQFQQ QQEQLQQQQQ
LLLLQQQGQL QQQLLQQQQA QLQQQLLEQQ QAQLQQQLLL QQQEQLQQQQ QQQLLQQQQE
QLQQQQLQPP PLEPEEEEEV ELELMPVDLG SEQELEQQRQ ELERQQELER QQEQRQLQLK
LQEELQQLEQ QLEQQQQQLE QQEVQLELTP VELGAQQQEV QLELTPVQPE LQLELVPAAG
GGGAAVPGAP AAVVVAPPGY VVVQELMVLP AVAAPAVVAI PGPAGSAALT PARQRRRRRA
RDRPTICGEC GKGFSRSTDL VRHQATHTGE RPHRCGECGK GFSQHSNLVT HQRIHTGEKP
YACSYCAKRF SESSALVQHQ RTHTGERPYA CGDCGKRFSV SSNLLRHRRT HSGERPYVCE
DCGERFRHKV QIRRHERQLH GAGRSRGLGL LRASRPAALG GPARAEQAAT ATAPADKAL
