ZN860_HUMAN
ID ZN860_HUMAN Reviewed; 632 AA.
AC A6NHJ4; B4DFA4;
DT 23-SEP-2008, integrated into UniProtKB/Swiss-Prot.
DT 25-NOV-2008, sequence version 3.
DT 03-AUG-2022, entry version 129.
DE RecName: Full=Zinc finger protein 860;
GN Name=ZNF860;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Cerebellum;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16641997; DOI=10.1038/nature04728;
RA Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J.,
RA Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P.,
RA Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A.,
RA Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L.,
RA Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G.,
RA Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W.,
RA Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M.,
RA Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P.,
RA Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H.,
RA Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J.,
RA Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W.,
RA Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B.,
RA Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O.,
RA Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B.,
RA Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H.,
RA Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J.,
RA Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X.,
RA Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R.,
RA Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.;
RT "The DNA sequence, annotation and analysis of human chromosome 3.";
RL Nature 440:1194-1198(2006).
RN [3]
RP SUMOYLATION [LARGE SCALE ANALYSIS] AT LYS-220, AND IDENTIFICATION BY MASS
RP SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=28112733; DOI=10.1038/nsmb.3366;
RA Hendriks I.A., Lyon D., Young C., Jensen L.J., Vertegaal A.C.,
RA Nielsen M.L.;
RT "Site-specific mapping of the human SUMO proteome reveals co-modification
RT with phosphorylation.";
RL Nat. Struct. Mol. Biol. 24:325-336(2017).
CC -!- FUNCTION: May be involved in transcriptional regulation. {ECO:0000250}.
CC -!- INTERACTION:
CC A6NHJ4; Q8NHQ1: CEP70; NbExp=3; IntAct=EBI-17263060, EBI-739624;
CC A6NHJ4; P60411: KRTAP10-9; NbExp=3; IntAct=EBI-17263060, EBI-10172052;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. {ECO:0000305}.
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DR EMBL; AK294003; BAG57365.1; -; mRNA.
DR EMBL; AC108485; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS46784.1; -.
DR RefSeq; NP_001131146.2; NM_001137674.2.
DR RefSeq; XP_016861788.1; XM_017006299.1.
DR AlphaFoldDB; A6NHJ4; -.
DR SMR; A6NHJ4; -.
DR BioGRID; 131322; 5.
DR IntAct; A6NHJ4; 2.
DR STRING; 9606.ENSP00000373274; -.
DR iPTMnet; A6NHJ4; -.
DR PhosphoSitePlus; A6NHJ4; -.
DR BioMuta; ZNF860; -.
DR jPOST; A6NHJ4; -.
DR MassIVE; A6NHJ4; -.
DR MaxQB; A6NHJ4; -.
DR PaxDb; A6NHJ4; -.
DR PeptideAtlas; A6NHJ4; -.
DR PRIDE; A6NHJ4; -.
DR ProteomicsDB; 1202; -.
DR Antibodypedia; 57012; 64 antibodies from 14 providers.
DR DNASU; 344787; -.
DR Ensembl; ENST00000360311.5; ENSP00000373274.3; ENSG00000197385.6.
DR GeneID; 344787; -.
DR KEGG; hsa:344787; -.
DR MANE-Select; ENST00000360311.5; ENSP00000373274.3; NM_001137674.3; NP_001131146.2.
DR UCSC; uc011axg.3; human.
DR CTD; 344787; -.
DR DisGeNET; 344787; -.
DR GeneCards; ZNF860; -.
DR HGNC; HGNC:34513; ZNF860.
DR HPA; ENSG00000197385; Tissue enhanced (lymphoid).
DR neXtProt; NX_A6NHJ4; -.
DR OpenTargets; ENSG00000197385; -.
DR PharmGKB; PA164727773; -.
DR VEuPathDB; HostDB:ENSG00000197385; -.
DR eggNOG; KOG1721; Eukaryota.
DR GeneTree; ENSGT00940000154397; -.
DR HOGENOM; CLU_002678_44_5_1; -.
DR InParanoid; A6NHJ4; -.
DR OMA; NYRNLHS; -.
DR OrthoDB; 1318335at2759; -.
DR PhylomeDB; A6NHJ4; -.
DR TreeFam; TF341892; -.
DR PathwayCommons; A6NHJ4; -.
DR Reactome; R-HSA-212436; Generic Transcription Pathway.
DR SignaLink; A6NHJ4; -.
DR BioGRID-ORCS; 344787; 11 hits in 1040 CRISPR screens.
DR GenomeRNAi; 344787; -.
DR Pharos; A6NHJ4; Tdark.
DR PRO; PR:A6NHJ4; -.
DR Proteomes; UP000005640; Chromosome 3.
DR RNAct; A6NHJ4; protein.
DR Bgee; ENSG00000197385; Expressed in cortical plate and 94 other tissues.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd07765; KRAB_A-box; 1.
DR InterPro; IPR001909; KRAB.
DR InterPro; IPR036051; KRAB_dom_sf.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF01352; KRAB; 1.
DR Pfam; PF00096; zf-C2H2; 10.
DR SMART; SM00349; KRAB; 1.
DR SMART; SM00355; ZnF_C2H2; 12.
DR SUPFAM; SSF109640; SSF109640; 1.
DR SUPFAM; SSF57667; SSF57667; 8.
DR PROSITE; PS50805; KRAB; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 12.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 14.
PE 1: Evidence at protein level;
KW DNA-binding; Isopeptide bond; Metal-binding; Nucleus; Reference proteome;
KW Repeat; Transcription; Transcription regulation; Ubl conjugation; Zinc;
KW Zinc-finger.
FT CHAIN 1..632
FT /note="Zinc finger protein 860"
FT /id="PRO_0000350815"
FT DOMAIN 24..99
FT /note="KRAB"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00119"
FT ZN_FING 230..252
FT /note="C2H2-type 1; degenerate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 258..280
FT /note="C2H2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 286..308
FT /note="C2H2-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 314..336
FT /note="C2H2-type 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 342..364
FT /note="C2H2-type 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 370..392
FT /note="C2H2-type 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 398..420
FT /note="C2H2-type 7"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 426..448
FT /note="C2H2-type 8"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 454..476
FT /note="C2H2-type 9"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 482..504
FT /note="C2H2-type 10"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 510..532
FT /note="C2H2-type 11"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 538..560
FT /note="C2H2-type 12"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 566..588
FT /note="C2H2-type 13; degenerate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 594..616
FT /note="C2H2-type 14"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT CROSSLNK 220
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0007744|PubMed:28112733"
FT CONFLICT 547
FT /note="F -> Y (in Ref. 1; BAG57365)"
FT /evidence="ECO:0000305"
FT CONFLICT 586
FT /note="R -> K (in Ref. 1; BAG57365)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 632 AA; 73757 MW; 54F37E8AC0386171 CRC64;
MLREEAAQKR KEKEPGMALP QGHLTFRDVA IEFSLEEWKC LDPTQRALYR AMMLENYRNL
HSVDISSKCM MKKFSSTAQG NTEVDTGTLE RHESHHIGDF CFQKIGKDIH DFEFQWQEDK
RNSHEATMTQ IKKLTGSTDR YDRRHPGNKP IKDQLGLSFH SHLPELHIFQ TKGKVGNQVE
KSINDASSVL TSQRISSRPK IHISNNYENN FFHSSLLTLK QEVHIREKSF QCNESGKAFN
CSSLLRKHQI IYLGGKQYKC DVCGKVFNQK RYLACHHRCH TGEKPYKCNE CGKVFNQQSN
LASHHRLHTG EKPYKCEECD KVFSRKSNLE RHRRIHTGEK PYKCKVCEKA FRRDSHLTQH
TRIHTGEKPY KCNECGKAFS GQSTLIHHQA IHGIGKLYKC NDCHKVFSNA TTIANHWRIH
NEERSYKCNK CGKFFRRRSY LVVHWRTHTG EKPYKCNECG KTFHHNSALV IHKAIHTGEK
PYKCNECGKT FRHNSALVIH KAIHTGEKPY KCNECGKVFN QQATLARHHR LHTGEKPYKC
EECDTVFSRK SHHETHKRIH TGEKPYKCDD FDEAFSQASS YAKQRRIHMG EKHHKCDDCG
KAFTSHSHRI RHQRIHTGQK SYKCHKRGKV FS
