ZN862_HUMAN
ID ZN862_HUMAN Reviewed; 1169 AA.
AC O60290; A0AUL8;
DT 26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 26-FEB-2008, sequence version 2.
DT 03-AUG-2022, entry version 146.
DE RecName: Full=Zinc finger protein 862;
GN Name=ZNF862; Synonyms=KIAA0543;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=12853948; DOI=10.1038/nature01782;
RA Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H.,
RA Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K.,
RA Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A.,
RA Delehaunty K.D., Miner T.L., Nash W.E., Cordes M., Du H., Sun H.,
RA Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A.,
RA Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P.,
RA Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M.,
RA Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S.,
RA Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R.,
RA Strowmatt C., Latreille P., Miller N., Johnson D., Murray J.,
RA Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W.,
RA Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E.,
RA Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A.,
RA Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E.,
RA Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E.,
RA Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A.,
RA Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A.,
RA Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R.,
RA McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H.,
RA Wilson R.K.;
RT "The DNA sequence of human chromosome 7.";
RL Nature 424:157-164(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 59-1169 (ISOFORM 1).
RC TISSUE=Brain;
RX PubMed=9628581; DOI=10.1093/dnares/5.1.31;
RA Nagase T., Ishikawa K., Miyajima N., Tanaka A., Kotani H., Nomura N.,
RA Ohara O.;
RT "Prediction of the coding sequences of unidentified human genes. IX. The
RT complete sequences of 100 new cDNA clones from brain which can code for
RT large proteins in vitro.";
RL DNA Res. 5:31-39(1998).
CC -!- FUNCTION: May be involved in transcriptional regulation. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=O60290-1; Sequence=Displayed;
CC Name=2;
CC IsoId=O60290-2; Sequence=VSP_031702, VSP_031703;
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DR EMBL; AC004877; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC113087; AAI13088.1; -; mRNA.
DR EMBL; AB011115; BAA25469.1; -; mRNA.
DR CCDS; CCDS47741.1; -. [O60290-1]
DR PIR; T00324; T00324.
DR RefSeq; NP_001092690.1; NM_001099220.2. [O60290-1]
DR AlphaFoldDB; O60290; -.
DR BioGRID; 568930; 1.
DR IntAct; O60290; 7.
DR STRING; 9606.ENSP00000223210; -.
DR iPTMnet; O60290; -.
DR PhosphoSitePlus; O60290; -.
DR BioMuta; ZNF862; -.
DR MassIVE; O60290; -.
DR PaxDb; O60290; -.
DR PeptideAtlas; O60290; -.
DR PRIDE; O60290; -.
DR ProteomicsDB; 49317; -. [O60290-1]
DR Antibodypedia; 10495; 29 antibodies from 14 providers.
DR DNASU; 643641; -.
DR Ensembl; ENST00000223210.5; ENSP00000223210.4; ENSG00000106479.11. [O60290-1]
DR GeneID; 643641; -.
DR KEGG; hsa:643641; -.
DR MANE-Select; ENST00000223210.5; ENSP00000223210.4; NM_001099220.3; NP_001092690.1.
DR UCSC; uc010lpn.4; human. [O60290-1]
DR CTD; 643641; -.
DR DisGeNET; 643641; -.
DR GeneCards; ZNF862; -.
DR HGNC; HGNC:34519; ZNF862.
DR HPA; ENSG00000106479; Low tissue specificity.
DR neXtProt; NX_O60290; -.
DR OpenTargets; ENSG00000106479; -.
DR PharmGKB; PA164727781; -.
DR VEuPathDB; HostDB:ENSG00000106479; -.
DR eggNOG; KOG1721; Eukaryota.
DR GeneTree; ENSGT00940000162620; -.
DR HOGENOM; CLU_283080_0_0_1; -.
DR InParanoid; O60290; -.
DR OMA; DQACVGI; -.
DR OrthoDB; 82127at2759; -.
DR PhylomeDB; O60290; -.
DR TreeFam; TF350866; -.
DR PathwayCommons; O60290; -.
DR SignaLink; O60290; -.
DR BioGRID-ORCS; 643641; 9 hits in 1070 CRISPR screens.
DR GenomeRNAi; 643641; -.
DR Pharos; O60290; Tdark.
DR PRO; PR:O60290; -.
DR Proteomes; UP000005640; Chromosome 7.
DR RNAct; O60290; protein.
DR Bgee; ENSG00000106479; Expressed in right uterine tube and 177 other tissues.
DR ExpressionAtlas; O60290; baseline and differential.
DR Genevisible; O60290; HS.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR CDD; cd07765; KRAB_A-box; 2.
DR InterPro; IPR025398; DUF4371.
DR InterPro; IPR008906; HATC_C_dom.
DR InterPro; IPR001909; KRAB.
DR InterPro; IPR036051; KRAB_dom_sf.
DR InterPro; IPR012337; RNaseH-like_sf.
DR InterPro; IPR006580; Znf_TTF.
DR Pfam; PF05699; Dimer_Tnp_hAT; 1.
DR Pfam; PF14291; DUF4371; 1.
DR Pfam; PF01352; KRAB; 2.
DR SMART; SM00349; KRAB; 2.
DR SMART; SM00597; ZnF_TTF; 2.
DR SUPFAM; SSF109640; SSF109640; 2.
DR SUPFAM; SSF53098; SSF53098; 2.
DR PROSITE; PS50805; KRAB; 2.
PE 2: Evidence at transcript level;
KW Alternative splicing; Metal-binding; Nucleus; Reference proteome; Repeat;
KW Transcription; Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1..1169
FT /note="Zinc finger protein 862"
FT /id="PRO_0000320644"
FT DOMAIN 11..77
FT /note="KRAB 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00119"
FT DOMAIN 333..404
FT /note="KRAB 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00119"
FT ZN_FING 135..218
FT /note="TTF-type 1"
FT ZN_FING 461..544
FT /note="TTF-type 2"
FT VAR_SEQ 1..915
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_031702"
FT VAR_SEQ 916..923
FT /note="RFQADRER -> MGRRWCEW (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_031703"
FT VARIANT 178
FT /note="I -> T (in dbSNP:rs3735328)"
FT /id="VAR_039248"
SQ SEQUENCE 1169 AA; 131654 MW; 76367C6AE1E3C60A CRC64;
MEPRESGKAP VTFDDITVYL LQEEWVLLSQ QQKELCGSNK LVAPLGPTVA NPELFRKFGR
GPEPWLGSVQ GQRSLLEHHP GKKQMGYMGE MEVQGPTRES GQSLPPQKKA YLSHLSTGSG
HIEGDWAGRN RKLLKPRSIQ KSWFVQFPWL IMNEEQTALF CSACREYPSI RDKRSRLIEG
YTGPFKVETL KYHAKSKAHM FCVNALAARD PIWAARFRSI RDPPGDVLAS PEPLFTADCP
IFYPPGPLGG FDSMAELLPS SRAELEDPGG DGAIPAMYLD CISDLRQKEI TDGIHSSSDI
NILYNDAVES CIQDPSAEGL SEEVPVVFEE LPVVFEDVAV YFTREEWGML DKRQKELYRD
VMRMNYELLA SLGPAAAKPD LISKLERRAA PWIKDPNGPK WGKGRPPGNK KMVAVREADT
QASAADSALL PGSPVEARAS CCSSSICEEG DGPRRIKRTY RPRSIQRSWF GQFPWLVIDP
KETKLFCSAC IERPNLHDKS SRLVRGYTGP FKVETLKYHE VSKAHRLCVN TVEIKEDTPH
TALVPEISSD LMANMEHFFN AAYSIAYHSR PLNDFEKILQ LLQSTGTVIL GKYRNRTACT
QFIKYISETL KREILEDVRN SPCVSVLLDS STDASEQACV GIYIRYFKQM EVKESYITLA
PLYSETADGY FETIVSALDE LDIPFRKPGW VVGLGTDGSA MLSCRGGLVE KFQEVIPQLL
PVHCVAHRLH LAVVDACGSI DLVKKCDRHI RTVFKFYQSS NKRLNELQEG AAPLEQEIIR
LKDLNAVRWV ASRRRTLHAL LVSWPALARH LQRVAEAGGQ IGHRAKGMLK LMRGFHFVKF
CHFLLDFLSI YRPLSEVCQK EIVLITEVNA TLGRAYVALE SLRHQAGPKE EEFNASFKDG
RLHGICLDKL EVAEQRFQAD RERTVLTGIE YLQQRFDADR PPQLKNMEVF DTMAWPSGIE
LASFGNDDIL NLARYFECSL PTGYSEEALL EEWLGLKTIA QHLPFSMLCK NALAQHCRFP
LLSKLMAVVV CVPISTSCCE RGFKAMNRIR TDERTKLSNE VLNMLMMTAV NGVAVTEYDP
QPAIQHWYLT SSGRRFSHVY TCAQVPARSP ASARLRKEEM GALYVEEPRT QKPPILPSRE
AAEVLKDCIM EPPERLLYPH TSQEAPGMS
