ZN865_MOUSE
ID ZN865_MOUSE Reviewed; 1058 AA.
AC Q3U3I9; D3Z3M5;
DT 08-FEB-2011, integrated into UniProtKB/Swiss-Prot.
DT 11-OCT-2005, sequence version 1.
DT 03-AUG-2022, entry version 120.
DE RecName: Full=Zinc finger protein 865;
GN Name=Znf865; Synonyms=Zfp865;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=NOD;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
CC -!- FUNCTION: May be involved in transcriptional regulation. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AK154737; BAE32797.1; -; mRNA.
DR EMBL; AC157563; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS20753.1; -.
DR RefSeq; NP_001028555.1; NM_001033383.2.
DR RefSeq; XP_006540122.1; XM_006540059.2.
DR RefSeq; XP_006540123.1; XM_006540060.1.
DR AlphaFoldDB; Q3U3I9; -.
DR SMR; Q3U3I9; -.
DR STRING; 10090.ENSMUSP00000075601; -.
DR iPTMnet; Q3U3I9; -.
DR PhosphoSitePlus; Q3U3I9; -.
DR EPD; Q3U3I9; -.
DR jPOST; Q3U3I9; -.
DR MaxQB; Q3U3I9; -.
DR PaxDb; Q3U3I9; -.
DR PeptideAtlas; Q3U3I9; -.
DR PRIDE; Q3U3I9; -.
DR ProteomicsDB; 302146; -.
DR Antibodypedia; 69405; 41 antibodies from 12 providers.
DR Ensembl; ENSMUST00000076251; ENSMUSP00000075601; ENSMUSG00000074405.
DR GeneID; 319748; -.
DR KEGG; mmu:319748; -.
DR UCSC; uc009ezk.1; mouse.
DR CTD; 319748; -.
DR MGI; MGI:2442656; Zfp865.
DR VEuPathDB; HostDB:ENSMUSG00000074405; -.
DR eggNOG; KOG1721; Eukaryota.
DR GeneTree; ENSGT00530000064557; -.
DR HOGENOM; CLU_010472_0_0_1; -.
DR InParanoid; Q3U3I9; -.
DR OMA; PTPQWGI; -.
DR OrthoDB; 1318335at2759; -.
DR PhylomeDB; Q3U3I9; -.
DR TreeFam; TF350857; -.
DR BioGRID-ORCS; 319748; 3 hits in 74 CRISPR screens.
DR ChiTaRS; Zfp865; mouse.
DR PRO; PR:Q3U3I9; -.
DR Proteomes; UP000000589; Chromosome 7.
DR RNAct; Q3U3I9; protein.
DR Bgee; ENSMUSG00000074405; Expressed in embryonic brain and 93 other tissues.
DR ExpressionAtlas; Q3U3I9; baseline and differential.
DR Genevisible; Q3U3I9; MM.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF00096; zf-C2H2; 10.
DR SMART; SM00355; ZnF_C2H2; 20.
DR SUPFAM; SSF57667; SSF57667; 11.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 20.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 20.
PE 2: Evidence at transcript level;
KW DNA-binding; Isopeptide bond; Metal-binding; Nucleus; Reference proteome;
KW Repeat; Transcription; Transcription regulation; Ubl conjugation; Zinc;
KW Zinc-finger.
FT CHAIN 1..1058
FT /note="Zinc finger protein 865"
FT /id="PRO_0000404595"
FT ZN_FING 220..242
FT /note="C2H2-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 248..270
FT /note="C2H2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 350..372
FT /note="C2H2-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 378..400
FT /note="C2H2-type 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 407..429
FT /note="C2H2-type 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 439..461
FT /note="C2H2-type 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 546..568
FT /note="C2H2-type 7"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 574..596
FT /note="C2H2-type 8"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 602..624
FT /note="C2H2-type 9"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 664..686
FT /note="C2H2-type 10"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 692..714
FT /note="C2H2-type 11"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 791..813
FT /note="C2H2-type 12"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 819..841
FT /note="C2H2-type 13"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 847..869
FT /note="C2H2-type 14"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 875..897
FT /note="C2H2-type 15"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 903..925
FT /note="C2H2-type 16"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 931..953
FT /note="C2H2-type 17"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 959..981
FT /note="C2H2-type 18"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 988..1010
FT /note="C2H2-type 19"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 1016..1038
FT /note="C2H2-type 20"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT REGION 1..24
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 58..134
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 156..201
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 269..342
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 459..486
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 721..743
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 59..81
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 87..118
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 294..330
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 725..743
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CROSSLNK 801
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0000250|UniProtKB:P0CJ78"
FT CROSSLNK 1039
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0000250|UniProtKB:P0CJ78"
SQ SEQUENCE 1058 AA; 111676 MW; 4A9158A4AFD3AC71 CRC64;
MEANQAGSGA GGGGSSGIGG EDGVHFQSYP FDFLEFLNHQ RFEPMELYGE HAKAVAALPC
TPGPPPQPPP QPPPPQYDYP PQSSFKPKAE APSSSSSSSS SSSSSSSSSS SSSQAKKMDP
PLPPTFGAPP PPLFDAAFPA PQWGIVDLSG HQHLFGNLKR GGPTPGPGVA SGLGTPTGTP
GPLTTPSQTP PGPAVGAACD PTKDDKGYFR RLKYLMERRF PCGVCQKSFK QSSHLVQHML
VHSGERPYEC GICGRTYNHV SSLIRHRRCH KDVPPTPTGG TPQPGPALPS LGLPVSTASA
TASSDPAAVS SGPSATPATP ATSTDGNTTP AAPPGVAMPP SATTGGDGPF ACSLCWKVFK
KPSHLHQHQI IHTGEKPFSC SVCSKSFNRR ESLKRHVKTH SADLLRLPCG ICGKVFRDAS
YLLKHQAAHA AAGTPRPVYP CDLCGKTYSA PQSLLRHKAA HAPPVATEPA KDGAASVPQP
PPPFPPGPYL LPADPSTTDE KATAAAAAVV YGAVPVPLLS AHPLLLGGAG NGGAGGPGAG
GPSKTFCCGI CGRAFGRRET LKRHERIHTG EKPHQCPVCG KRFRESFHLS KHHVVHTRER
PYKCELCGKV FGYPQSLTRH RQVHRLQLPC ALAGATGLAT GQGTTGACGP GAAGTSGGPA
DLSYACSDCG EHFPDLFHVM SHKEAHMSEK PYGCDACGKT FGFIENLMWH KLVHQAAPER
LLAPTPSGPQ SSDGGSSGGG TDASSVLDNG LAGEVGTAVA ALAGVSGGSE DAGGATVAGS
GGGTSSGAER FSCATCGQSF KHFLGLVTHK YVHLVRRTLG CGLCGQSFAG AYDLLLHRRS
HRQKRGFRCP VCGKRFWEAA LLMRHQRCHT EQRPYRCGVC GRGFLRSWYL RQHRVVHTGE
RAFKCGVCAK HFAQSSSLAE HRRLHAVARP QRCGACGKTF RYRSNLLEHQ RLHLGERAYR
CEHCGKGFFY LSSVLRHQRA HEPPRPELRC PACLKAFKDP GYFRKHLAAH QGGRPFRCSS
CGEGFANTYG LKKHRLMHKA EGLGMPGTGG SALAGKDP
