ZN875_HUMAN
ID ZN875_HUMAN Reviewed; 659 AA.
AC P10072; A8MRS7; Q6PJD0; Q9BSW9; Q9UM09;
DT 01-JUL-1989, integrated into UniProtKB/Swiss-Prot.
DT 25-NOV-2008, sequence version 4.
DT 03-AUG-2022, entry version 199.
DE RecName: Full=Zinc finger protein 875 {ECO:0000305};
DE AltName: Full=Krueppel-related zinc finger protein 1;
DE AltName: Full=Protein HKR1;
GN Name=ZNF875 {ECO:0000312|HGNC:HGNC:4928};
GN Synonyms=HKR1 {ECO:0000312|HGNC:HGNC:4928};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), AND VARIANT ILE-513.
RX PubMed=9813242; DOI=10.1016/s0378-1119(98)00464-8;
RA Oguri T., Katoh O., Takahashi T., Isobe T., Kuramoto K., Hirata S.,
RA Yamakido M., Watanabe H.;
RT "The Kruppel-type zinc finger family gene, HKR1, is induced in lung cancer
RT by exposure to platinum drugs.";
RL Gene 222:61-67(1998).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15057824; DOI=10.1038/nature02399;
RA Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E.,
RA Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A.,
RA Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S.,
RA Carrano A.V., Caoile C., Chan Y.M., Christensen M., Cleland C.A.,
RA Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J.,
RA Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M.,
RA Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W.,
RA Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V.,
RA Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D.,
RA McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I.,
RA Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L.,
RA Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A.,
RA She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M.,
RA Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J.,
RA Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA Rubin E.M., Lucas S.M.;
RT "The DNA sequence and biology of human chromosome 19.";
RL Nature 428:529-535(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), AND VARIANT ILE-513.
RC TISSUE=Ovary;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 276-499.
RX PubMed=2850480; DOI=10.1128/mcb.8.8.3104-3113.1988;
RA Ruppert J.M., Kinzler K.W., Wong A.J., Bigner S.H., Kao F.T., Law M.L.,
RA Seuanez H.N., O'Brien S.J., Vogelstein B.;
RT "The GLI-Kruppel family of human genes.";
RL Mol. Cell. Biol. 8:3104-3113(1988).
CC -!- FUNCTION: May be involved in transcriptional regulation.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=P10072-1; Sequence=Displayed;
CC Name=2;
CC IsoId=P10072-2; Sequence=VSP_035755;
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAA86058.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AB013897; BAA86058.1; ALT_INIT; mRNA.
DR EMBL; AC016590; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471126; EAW56722.1; -; Genomic_DNA.
DR EMBL; BC004513; AAH04513.2; -; mRNA.
DR EMBL; BC017256; AAH17256.1; -; mRNA.
DR EMBL; M20675; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS12502.1; -. [P10072-1]
DR CCDS; CCDS82338.1; -. [P10072-2]
DR PIR; C31201; C31201.
DR RefSeq; NP_001316692.1; NM_001329763.1. [P10072-2]
DR RefSeq; NP_001316693.1; NM_001329764.1. [P10072-2]
DR RefSeq; NP_861451.1; NM_181786.3. [P10072-1]
DR RefSeq; XP_016882167.1; XM_017026678.1.
DR AlphaFoldDB; P10072; -.
DR SMR; P10072; -.
DR BioGRID; 129883; 3.
DR IntAct; P10072; 1.
DR STRING; 9606.ENSP00000315505; -.
DR iPTMnet; P10072; -.
DR PhosphoSitePlus; P10072; -.
DR BioMuta; HKR1; -.
DR DMDM; 215274257; -.
DR MassIVE; P10072; -.
DR PaxDb; P10072; -.
DR PeptideAtlas; P10072; -.
DR PRIDE; P10072; -.
DR ProteomicsDB; 52558; -. [P10072-1]
DR ProteomicsDB; 52559; -. [P10072-2]
DR Antibodypedia; 29891; 188 antibodies from 24 providers.
DR DNASU; 284459; -.
DR Ensembl; ENST00000324411.8; ENSP00000315505.3; ENSG00000181666.19. [P10072-1]
DR Ensembl; ENST00000392153.8; ENSP00000375994.3; ENSG00000181666.19. [P10072-2]
DR GeneID; 284459; -.
DR KEGG; hsa:284459; -.
DR MANE-Select; ENST00000392153.8; ENSP00000375994.3; NM_001353803.2; NP_001340732.1. [P10072-2]
DR UCSC; uc002ogb.5; human. [P10072-1]
DR CTD; 284459; -.
DR DisGeNET; 284459; -.
DR GeneCards; ZNF875; -.
DR HGNC; HGNC:4928; ZNF875.
DR HPA; ENSG00000181666; Tissue enhanced (retina).
DR MIM; 165250; gene.
DR neXtProt; NX_P10072; -.
DR OpenTargets; ENSG00000181666; -.
DR PharmGKB; PA29306; -.
DR VEuPathDB; HostDB:ENSG00000181666; -.
DR eggNOG; KOG1721; Eukaryota.
DR GeneTree; ENSGT00940000163548; -.
DR HOGENOM; CLU_002678_44_5_1; -.
DR InParanoid; P10072; -.
DR OMA; FGAIKYE; -.
DR OrthoDB; 1318335at2759; -.
DR PhylomeDB; P10072; -.
DR TreeFam; TF338096; -.
DR PathwayCommons; P10072; -.
DR Reactome; R-HSA-212436; Generic Transcription Pathway.
DR SignaLink; P10072; -.
DR BioGRID-ORCS; 284459; 13 hits in 1100 CRISPR screens.
DR ChiTaRS; HKR1; human.
DR GeneWiki; HKR1; -.
DR GenomeRNAi; 284459; -.
DR Pharos; P10072; Tbio.
DR PRO; PR:P10072; -.
DR Proteomes; UP000005640; Chromosome 19.
DR RNAct; P10072; protein.
DR Bgee; ENSG00000181666; Expressed in pancreatic ductal cell and 173 other tissues.
DR ExpressionAtlas; P10072; baseline and differential.
DR Genevisible; P10072; HS.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0001227; F:DNA-binding transcription repressor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000977; F:RNA polymerase II transcription regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd07765; KRAB_A-box; 1.
DR InterPro; IPR001909; KRAB.
DR InterPro; IPR036051; KRAB_dom_sf.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF01352; KRAB; 1.
DR Pfam; PF00096; zf-C2H2; 12.
DR SMART; SM00349; KRAB; 1.
DR SMART; SM00355; ZnF_C2H2; 13.
DR SUPFAM; SSF109640; SSF109640; 1.
DR SUPFAM; SSF57667; SSF57667; 8.
DR PROSITE; PS50805; KRAB; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 13.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 13.
PE 2: Evidence at transcript level;
KW Alternative splicing; DNA-binding; Metal-binding; Nucleus;
KW Reference proteome; Repeat; Transcription; Transcription regulation; Zinc;
KW Zinc-finger.
FT CHAIN 1..659
FT /note="Zinc finger protein 875"
FT /id="PRO_0000047270"
FT DOMAIN 33..104
FT /note="KRAB"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00119"
FT ZN_FING 301..323
FT /note="C2H2-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 329..351
FT /note="C2H2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 357..379
FT /note="C2H2-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 385..407
FT /note="C2H2-type 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 413..435
FT /note="C2H2-type 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 441..463
FT /note="C2H2-type 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 469..491
FT /note="C2H2-type 7"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 497..519
FT /note="C2H2-type 8"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 525..547
FT /note="C2H2-type 9"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 553..575
FT /note="C2H2-type 10"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 579..601
FT /note="C2H2-type 11"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 607..629
FT /note="C2H2-type 12"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 635..657
FT /note="C2H2-type 13"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT REGION 191..229
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 191..215
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 1..30
FT /note="MRVNHTVSTMLPTCMVHRQTMSCSGAGGIT -> MATGLLRAKKE (in
FT isoform 2)"
FT /evidence="ECO:0000305"
FT /id="VSP_035755"
FT VARIANT 448
FT /note="R -> H (in dbSNP:rs2921563)"
FT /id="VAR_047404"
FT VARIANT 513
FT /note="S -> I (in dbSNP:rs3745765)"
FT /evidence="ECO:0000269|PubMed:15489334,
FT ECO:0000269|PubMed:9813242"
FT /id="VAR_047405"
FT VARIANT 628
FT /note="T -> I (in dbSNP:rs3745764)"
FT /id="VAR_047406"
SQ SEQUENCE 659 AA; 75128 MW; 36D48F8EA3A6D80A CRC64;
MRVNHTVSTM LPTCMVHRQT MSCSGAGGIT AFVAFRDVAV YFTQEEWRLL SPAQRTLHRE
VMLETYNHLV SLEIPSSKPK LIAQLERGEA PWREERKCPL DLCPESKPEI QLSPSCPLIF
SSQQALSQHV WLSHLSQLFS SLWAGNPLHL GKHYPEDQKQ QQDPFCFSGK AEWIQEGEDS
RLLFGRVSKN GTSKALSSPP EEQQPAQSKE DNTVVDIGSS PERRADLEET DKVLHGLEVS
GFGEIKYEEF GPGFIKESNL LSLQKTQTGE TPYMYTEWGD SFGSMSVLIK NPRTHSGGKP
YVCRECGRGF TWKSNLITHQ RTHSGEKPYV CKDCGRGFTW KSNLFTHQRT HSGLKPYVCK
ECGQSFSLKS NLITHQRAHT GEKPYVCREC GRGFRQHSHL VRHKRTHSGE KPYICRECEQ
GFSQKSHLIR HLRTHTGEKP YVCTECGRHF SWKSNLKTHQ RTHSGVKPYV CLECGQCFSL
KSNLNKHQRS HTGEKPFVCT ECGRGFTRKS TLSTHQRTHS GEKPFVCAEC GRGFNDKSTL
ISHQRTHSGE KPFMCRECGR RFRQKPNLFR HKRAHSGAFV CRECGQGFCA KLTLIKHQRA
HAGGKPHVCR ECGQGFSRQS HLIRHQRTHS GEKPYICRKC GRGFSRKSNL IRHQRTHSG
