ZN878_HUMAN
ID ZN878_HUMAN Reviewed; 531 AA.
AC C9JN71;
DT 18-MAY-2010, integrated into UniProtKB/Swiss-Prot.
DT 08-MAR-2011, sequence version 2.
DT 03-AUG-2022, entry version 102.
DE RecName: Full=Zinc finger protein 878;
GN Name=ZNF878;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15057824; DOI=10.1038/nature02399;
RA Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E.,
RA Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A.,
RA Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S.,
RA Carrano A.V., Caoile C., Chan Y.M., Christensen M., Cleland C.A.,
RA Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J.,
RA Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M.,
RA Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W.,
RA Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V.,
RA Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D.,
RA McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I.,
RA Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L.,
RA Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A.,
RA She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M.,
RA Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J.,
RA Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA Rubin E.M., Lucas S.M.;
RT "The DNA sequence and biology of human chromosome 19.";
RL Nature 428:529-535(2004).
CC -!- FUNCTION: May be involved in transcriptional regulation. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. {ECO:0000305}.
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DR EMBL; AC022415; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS45984.2; -.
DR RefSeq; NP_001073873.2; NM_001080404.2.
DR AlphaFoldDB; C9JN71; -.
DR SMR; C9JN71; -.
DR BioGRID; 610144; 1.
DR IntAct; C9JN71; 2.
DR STRING; 9606.ENSP00000447931; -.
DR iPTMnet; C9JN71; -.
DR PhosphoSitePlus; C9JN71; -.
DR BioMuta; ZNF878; -.
DR EPD; C9JN71; -.
DR jPOST; C9JN71; -.
DR MassIVE; C9JN71; -.
DR PaxDb; C9JN71; -.
DR PeptideAtlas; C9JN71; -.
DR PRIDE; C9JN71; -.
DR ProteomicsDB; 10937; -.
DR Antibodypedia; 62880; 4 antibodies from 4 providers.
DR DNASU; 729747; -.
DR Ensembl; ENST00000547628.2; ENSP00000447931.1; ENSG00000257446.4.
DR GeneID; 729747; -.
DR KEGG; hsa:729747; -.
DR MANE-Select; ENST00000547628.2; ENSP00000447931.1; NM_001080404.3; NP_001073873.2.
DR UCSC; uc021upl.2; human.
DR CTD; 729747; -.
DR GeneCards; ZNF878; -.
DR HGNC; HGNC:37246; ZNF878.
DR HPA; ENSG00000257446; Low tissue specificity.
DR neXtProt; NX_C9JN71; -.
DR OpenTargets; ENSG00000257446; -.
DR PharmGKB; PA165395055; -.
DR VEuPathDB; HostDB:ENSG00000257446; -.
DR eggNOG; KOG1721; Eukaryota.
DR GeneTree; ENSGT00950000182755; -.
DR HOGENOM; CLU_002678_44_17_1; -.
DR InParanoid; C9JN71; -.
DR OMA; ISFQTHM; -.
DR OrthoDB; 1318335at2759; -.
DR PhylomeDB; C9JN71; -.
DR TreeFam; TF338854; -.
DR PathwayCommons; C9JN71; -.
DR SignaLink; C9JN71; -.
DR BioGRID-ORCS; 729747; 15 hits in 1050 CRISPR screens.
DR GenomeRNAi; 729747; -.
DR Pharos; C9JN71; Tdark.
DR PRO; PR:C9JN71; -.
DR Proteomes; UP000005640; Chromosome 19.
DR RNAct; C9JN71; protein.
DR Bgee; ENSG00000257446; Expressed in placenta and 90 other tissues.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000977; F:RNA polymerase II transcription regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd07765; KRAB_A-box; 1.
DR InterPro; IPR001909; KRAB.
DR InterPro; IPR036051; KRAB_dom_sf.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF01352; KRAB; 1.
DR Pfam; PF00096; zf-C2H2; 12.
DR SMART; SM00349; KRAB; 1.
DR SMART; SM00355; ZnF_C2H2; 14.
DR SUPFAM; SSF109640; SSF109640; 1.
DR SUPFAM; SSF57667; SSF57667; 8.
DR PROSITE; PS50805; KRAB; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 14.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 15.
PE 3: Inferred from homology;
KW Metal-binding; Nucleus; Reference proteome; Repeat; Transcription;
KW Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1..531
FT /note="Zinc finger protein 878"
FT /id="PRO_0000393952"
FT DOMAIN 4..90
FT /note="KRAB"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00119"
FT ZN_FING 122..137
FT /note="C2H2-type 1; degenerate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 143..165
FT /note="C2H2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 171..193
FT /note="C2H2-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 199..221
FT /note="C2H2-type 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 227..249
FT /note="C2H2-type 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 255..277
FT /note="C2H2-type 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 283..305
FT /note="C2H2-type 7"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 311..333
FT /note="C2H2-type 8"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 339..361
FT /note="C2H2-type 9"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 367..389
FT /note="C2H2-type 10"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 395..417
FT /note="C2H2-type 11"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 423..445
FT /note="C2H2-type 12"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 451..473
FT /note="C2H2-type 13"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 479..501
FT /note="C2H2-type 14"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 507..529
FT /note="C2H2-type 15"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
SQ SEQUENCE 531 AA; 61540 MW; 5E11E87B22256BF5 CRC64;
MDSVAFEDVA VNFTQEEWAL LDPSQKNLYR EVMQETLRNL TSIGKKWNNQ YIEDEHQNPR
RNLRRLIGER LSESKESHQH GEVLTQVPDD TLKKKTPGVQ SYESSVCGEI GIGLSSLNRH
LRAFSYSSSL AIHGRTHTGE KPYECKECGK AFRFPSSVRR HERIHSAKKP YECKQCGKAF
SFPSSVRRHE RIHSAKKPYE CKQCGKALSY LVSFQTHMRM HTGERPHKCN ICGKAFFSPS
SLKRHEKSHT GEKRYKCKQC DKAFNCPSSF QYHERTHSGE KPYECTQCRK AFRSVKYLRV
HERKHTGEKP YECKLCGKGF ISSTSFRYHE KTHTGEKPYE CKKCVKAFSF VKDLRIHERT
HTGEKPFECK QCGKTFTSSN SFHYHERTHT GEKPYECKQC GKAFRSASVL QKHIRTHTGE
KPYGCKQCGK VFRVASQLKM HERTHTGEKP YECKQCGKAF ISSNSIRYHK RTHTGEKPYK
CKQCGKAFIS SNSFLYHERI HTGEKPYECK QCGKAFRSAS ILQKHVRTHA G
