ZN879_HUMAN
ID ZN879_HUMAN Reviewed; 563 AA.
AC B4DU55;
DT 18-MAY-2010, integrated into UniProtKB/Swiss-Prot.
DT 18-MAY-2010, sequence version 2.
DT 03-AUG-2022, entry version 110.
DE RecName: Full=Zinc finger protein 879;
GN Name=ZNF879;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Prostate;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15372022; DOI=10.1038/nature02919;
RA Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S.,
RA Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M.,
RA She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S.,
RA Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M.,
RA Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M.,
RA Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T.,
RA Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A.,
RA Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R.,
RA Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L.,
RA Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N.,
RA Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J.,
RA Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A.,
RA Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M.;
RT "The DNA sequence and comparative analysis of human chromosome 5.";
RL Nature 431:268-274(2004).
CC -!- FUNCTION: May be involved in transcriptional regulation.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. {ECO:0000305}.
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DR EMBL; AK300504; BAG62217.1; -; mRNA.
DR EMBL; AC104117; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS47352.1; -.
DR RefSeq; NP_001129588.1; NM_001136116.1.
DR RefSeq; XP_005265965.1; XM_005265908.3.
DR RefSeq; XP_011532852.1; XM_011534550.2.
DR RefSeq; XP_011532853.1; XM_011534551.2.
DR AlphaFoldDB; B4DU55; -.
DR SMR; B4DU55; -.
DR BioGRID; 131351; 1.
DR STRING; 9606.ENSP00000414887; -.
DR iPTMnet; B4DU55; -.
DR PhosphoSitePlus; B4DU55; -.
DR BioMuta; ZNF879; -.
DR EPD; B4DU55; -.
DR jPOST; B4DU55; -.
DR MassIVE; B4DU55; -.
DR PaxDb; B4DU55; -.
DR PeptideAtlas; B4DU55; -.
DR PRIDE; B4DU55; -.
DR Antibodypedia; 29464; 40 antibodies from 10 providers.
DR DNASU; 345462; -.
DR Ensembl; ENST00000444149.7; ENSP00000414887.2; ENSG00000234284.7.
DR GeneID; 345462; -.
DR KEGG; hsa:345462; -.
DR MANE-Select; ENST00000444149.7; ENSP00000414887.2; NM_001136116.3; NP_001129588.1.
DR UCSC; uc003mjt.5; human.
DR CTD; 345462; -.
DR GeneCards; ZNF879; -.
DR HGNC; HGNC:37273; ZNF879.
DR HPA; ENSG00000234284; Low tissue specificity.
DR neXtProt; NX_B4DU55; -.
DR OpenTargets; ENSG00000234284; -.
DR PharmGKB; PA165660603; -.
DR VEuPathDB; HostDB:ENSG00000234284; -.
DR eggNOG; KOG1721; Eukaryota.
DR GeneTree; ENSGT00940000162816; -.
DR HOGENOM; CLU_002678_57_1_1; -.
DR InParanoid; B4DU55; -.
DR OMA; TIKNTYM; -.
DR OrthoDB; 1318335at2759; -.
DR PhylomeDB; B4DU55; -.
DR TreeFam; TF350823; -.
DR PathwayCommons; B4DU55; -.
DR SignaLink; B4DU55; -.
DR BioGRID-ORCS; 345462; 3 hits in 1081 CRISPR screens.
DR ChiTaRS; ZNF879; human.
DR GenomeRNAi; 345462; -.
DR Pharos; B4DU55; Tdark.
DR PRO; PR:B4DU55; -.
DR Proteomes; UP000005640; Chromosome 5.
DR RNAct; B4DU55; protein.
DR Bgee; ENSG00000234284; Expressed in pancreatic ductal cell and 134 other tissues.
DR ExpressionAtlas; B4DU55; baseline and differential.
DR Genevisible; B4DU55; HS.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd07765; KRAB_A-box; 1.
DR InterPro; IPR001909; KRAB.
DR InterPro; IPR036051; KRAB_dom_sf.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF01352; KRAB; 1.
DR Pfam; PF00096; zf-C2H2; 11.
DR SMART; SM00349; KRAB; 1.
DR SMART; SM00355; ZnF_C2H2; 13.
DR SUPFAM; SSF109640; SSF109640; 1.
DR SUPFAM; SSF57667; SSF57667; 7.
DR PROSITE; PS50805; KRAB; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 13.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 13.
PE 2: Evidence at transcript level;
KW DNA-binding; Metal-binding; Nucleus; Reference proteome; Repeat;
KW Transcription; Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1..563
FT /note="Zinc finger protein 879"
FT /id="PRO_0000393967"
FT DOMAIN 14..85
FT /note="KRAB"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00119"
FT ZN_FING 204..226
FT /note="C2H2-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 232..254
FT /note="C2H2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 260..282
FT /note="C2H2-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 288..310
FT /note="C2H2-type 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 316..338
FT /note="C2H2-type 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 344..366
FT /note="C2H2-type 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 372..394
FT /note="C2H2-type 7"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 400..422
FT /note="C2H2-type 8"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 428..450
FT /note="C2H2-type 9"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 456..478
FT /note="C2H2-type 10"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 484..506
FT /note="C2H2-type 11"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 512..534
FT /note="C2H2-type 12"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 540..562
FT /note="C2H2-type 13"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT CONFLICT 238
FT /note="R -> G (in Ref. 1; BAG62217)"
FT /evidence="ECO:0000305"
FT CONFLICT 267
FT /note="K -> N (in Ref. 1; BAG62217)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 563 AA; 64577 MW; 0BF85BAA4B4D5CF4 CRC64;
MARRLLPAHV QESVTFRDVA VFFSQDEWLH LDSAQRALYR EVMLENYSIL VSLGILFSKP
KVISQLEQGE DPWMVESGVP QGAHLGWESL FGTIVSKEEN QEVMKKLIID GTFDFKLEKT
YINEDKLEKQ QGKKNRLFSK VLVTIKKVYM KERSFKGVEF GKNLGLKSSL IRKPRIVSRG
RRPRSQQYSV LFKQLGVNTV RKCYKCNICG KIFLHSSSLS KHQRIHTGEK LYKCKECRKA
FSQSSSLTQH LRVHTGEKPY ICSECGKAFS FTTSLIGHQR MHTGERPYKC KECGKTFKGS
SSLNNHQRIH TGEKPYKCNE CGRAFSQCSS LIQHHRIHTG EKPYECTQCG KAFTSISRLS
RHHRIHTGEK PFHCNECGKV FSYHSALIIH QRIHTGEKPY ACKECGKAFS QSSALIQHQR
IHTGEKPYKC NECGKAFSWI SRLNIHHRIH TGEKPYNCKE CGKAFSSHSG VNTHRKIHTG
EKPYKCNDCE KAFNQSSALI QHQRIHTGEK PYNCKVCGKA FRQSSSLMTH MRIHTGEKPY
KCKECGKAFS QSSSLTNHQR THN
