ZN880_HUMAN
ID ZN880_HUMAN Reviewed; 577 AA.
AC Q6PDB4; B4DNA6;
DT 18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT 18-MAR-2008, sequence version 2.
DT 03-AUG-2022, entry version 132.
DE RecName: Full=Zinc finger protein 880;
GN Name=ZNF880;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Heart;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15057824; DOI=10.1038/nature02399;
RA Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E.,
RA Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A.,
RA Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S.,
RA Carrano A.V., Caoile C., Chan Y.M., Christensen M., Cleland C.A.,
RA Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J.,
RA Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M.,
RA Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W.,
RA Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V.,
RA Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D.,
RA McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I.,
RA Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L.,
RA Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A.,
RA She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M.,
RA Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J.,
RA Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA Rubin E.M., Lucas S.M.;
RT "The DNA sequence and biology of human chromosome 19.";
RL Nature 428:529-535(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Heart;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q6PDB4-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q6PDB4-2; Sequence=VSP_032509, VSP_032510;
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DR EMBL; AK297834; BAG60168.1; -; mRNA.
DR EMBL; AC010320; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC010332; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC058819; AAH58819.1; -; mRNA.
DR CCDS; CCDS46164.1; -. [Q6PDB4-1]
DR RefSeq; NP_001138906.1; NM_001145434.1. [Q6PDB4-1]
DR RefSeq; XP_016882301.1; XM_017026812.1. [Q6PDB4-1]
DR AlphaFoldDB; Q6PDB4; -.
DR SMR; Q6PDB4; -.
DR STRING; 9606.ENSP00000406318; -.
DR iPTMnet; Q6PDB4; -.
DR PhosphoSitePlus; Q6PDB4; -.
DR BioMuta; ZNF880; -.
DR DMDM; 172046155; -.
DR jPOST; Q6PDB4; -.
DR MassIVE; Q6PDB4; -.
DR PaxDb; Q6PDB4; -.
DR PeptideAtlas; Q6PDB4; -.
DR PRIDE; Q6PDB4; -.
DR ProteomicsDB; 67075; -. [Q6PDB4-1]
DR Antibodypedia; 52850; 9 antibodies from 5 providers.
DR DNASU; 400713; -.
DR Ensembl; ENST00000344085.9; ENSP00000343625.5; ENSG00000221923.9. [Q6PDB4-2]
DR Ensembl; ENST00000422689.3; ENSP00000406318.2; ENSG00000221923.9. [Q6PDB4-1]
DR GeneID; 400713; -.
DR KEGG; hsa:400713; -.
DR MANE-Select; ENST00000422689.3; ENSP00000406318.2; NM_001145434.2; NP_001138906.1.
DR UCSC; uc002pzc.4; human. [Q6PDB4-1]
DR CTD; 400713; -.
DR DisGeNET; 400713; -.
DR GeneCards; ZNF880; -.
DR HGNC; HGNC:37249; ZNF880.
DR HPA; ENSG00000221923; Low tissue specificity.
DR neXtProt; NX_Q6PDB4; -.
DR OpenTargets; ENSG00000221923; -.
DR PharmGKB; PA165395098; -.
DR VEuPathDB; HostDB:ENSG00000221923; -.
DR eggNOG; KOG1721; Eukaryota.
DR GeneTree; ENSGT00940000163013; -.
DR HOGENOM; CLU_002678_69_11_1; -.
DR InParanoid; Q6PDB4; -.
DR OMA; NHHRMHT; -.
DR OrthoDB; 1318335at2759; -.
DR PhylomeDB; Q6PDB4; -.
DR TreeFam; TF341892; -.
DR PathwayCommons; Q6PDB4; -.
DR BioGRID-ORCS; 400713; 14 hits in 1057 CRISPR screens.
DR ChiTaRS; ZNF880; human.
DR GenomeRNAi; 400713; -.
DR Pharos; Q6PDB4; Tdark.
DR PRO; PR:Q6PDB4; -.
DR Proteomes; UP000005640; Chromosome 19.
DR RNAct; Q6PDB4; protein.
DR Bgee; ENSG00000221923; Expressed in buccal mucosa cell and 165 other tissues.
DR ExpressionAtlas; Q6PDB4; baseline and differential.
DR Genevisible; Q6PDB4; HS.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd07765; KRAB_A-box; 1.
DR InterPro; IPR001909; KRAB.
DR InterPro; IPR036051; KRAB_dom_sf.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF01352; KRAB; 1.
DR Pfam; PF00096; zf-C2H2; 12.
DR SMART; SM00349; KRAB; 1.
DR SMART; SM00355; ZnF_C2H2; 13.
DR SUPFAM; SSF109640; SSF109640; 1.
DR SUPFAM; SSF57667; SSF57667; 8.
DR PROSITE; PS50805; KRAB; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 13.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 14.
PE 2: Evidence at transcript level;
KW Alternative splicing; Metal-binding; Reference proteome; Repeat; Zinc;
KW Zinc-finger.
FT CHAIN 1..577
FT /note="Zinc finger protein 880"
FT /id="PRO_0000326033"
FT DOMAIN 7..78
FT /note="KRAB"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00119"
FT ZN_FING 184..206
FT /note="C2H2-type 1; degenerate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 212..234
FT /note="C2H2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 240..262
FT /note="C2H2-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 268..290
FT /note="C2H2-type 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 296..318
FT /note="C2H2-type 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 324..346
FT /note="C2H2-type 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 352..374
FT /note="C2H2-type 7"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 380..402
FT /note="C2H2-type 8"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 408..430
FT /note="C2H2-type 9"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 436..458
FT /note="C2H2-type 10"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 464..486
FT /note="C2H2-type 11"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 492..514
FT /note="C2H2-type 12"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 520..542
FT /note="C2H2-type 13"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 548..570
FT /note="C2H2-type 14"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT VAR_SEQ 80..98
FT /note="GRECIKGVNAESSSKLGSN -> SCSVTQAVVEWQSSVAIVA (in
FT isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_032509"
FT VAR_SEQ 99..577
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_032510"
SQ SEQUENCE 577 AA; 66762 MW; 6258532D56C8A03E CRC64;
MLRRGHLAFR DVAIEFPQEE WKCLDPAQRT LYREVMVENY RNLVFLGICL PDLSVISMLE
QRRDPRNLQS EVKIANNPGG RECIKGVNAE SSSKLGSNAG NKSLKNQLGL TFQLHLSELQ
LFQAERNISG CKHVEKPINN SLVSPLQKIY SSVKSHILNK YRNDFDDSPF LPQEQKAQIR
EKPCECNEHG KAFRVSSRLA NNQVIHTADN PYKCNECDKV FSNSSNLVQH QRIHTGEKPY
KCHECGKLFN RISLLARHQR IHTGEKPYKC HECGKVFTQN SHLANHHRIH TGEKPYKCNE
CGKVFNRNAH LARHQKIHSG EKPYKCKECG KAFSGGSGLT AHLVIHTGEK LYKCNKCGKV
FNRNAHLTRH QRIHTGEKPY ECKECGKVFR HKFCLTNHHR MHTGEQPYKC NECGKAFRDC
SGLTAHLLIH TGEKPYKCKE CAKVFRHRLS LSNHQRFHTG EKPYRCDECG KDFTRNSNLA
NHHRIHTGEK PYKCSECHKV FSHNSHLARH RQIHTGEKSY KCNECGKVFS HKLYLKKHER
IHTGEKPYRC HECGKDFTRN SNLANHHRIH TGEKPYR
