ZN891_HUMAN
ID ZN891_HUMAN Reviewed; 544 AA.
AC A8MT65;
DT 02-SEP-2008, integrated into UniProtKB/Swiss-Prot.
DT 02-SEP-2008, sequence version 2.
DT 03-AUG-2022, entry version 113.
DE RecName: Full=Zinc finger protein 891;
GN Name=ZNF891;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16541075; DOI=10.1038/nature04569;
RA Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y.,
RA Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C.,
RA Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C.,
RA Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R.,
RA Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E.,
RA Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y.,
RA Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G.,
RA Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H.,
RA Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S.,
RA Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M.,
RA Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H.,
RA Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q.,
RA Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V.,
RA Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E.,
RA Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K.,
RA Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D.,
RA Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R.,
RA David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E.,
RA D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N.,
RA Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N.,
RA Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R.,
RA Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S.,
RA LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H.,
RA Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P.,
RA Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G.,
RA Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E.,
RA Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S.,
RA Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O.,
RA Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J.,
RA Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A.,
RA Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M.,
RA Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I.,
RA Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A.,
RA Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y.,
RA Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A.,
RA Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F.,
RA Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L.,
RA Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G.,
RA Gibbs R.A.;
RT "The finished DNA sequence of human chromosome 12.";
RL Nature 440:346-351(2006).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-305.
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: May be involved in transcriptional regulation. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BC017932; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305};
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DR EMBL; AC026786; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC017932; -; NOT_ANNOTATED_CDS; mRNA.
DR CCDS; CCDS59238.1; -.
DR RefSeq; NP_001264220.1; NM_001277291.1.
DR RefSeq; XP_016874155.1; XM_017018666.1.
DR RefSeq; XP_016874156.1; XM_017018667.1.
DR RefSeq; XP_016874157.1; XM_017018668.1.
DR AlphaFoldDB; A8MT65; -.
DR SMR; A8MT65; -.
DR BioGRID; 136313; 3.
DR IntAct; A8MT65; 2.
DR iPTMnet; A8MT65; -.
DR PhosphoSitePlus; A8MT65; -.
DR BioMuta; ZNF891; -.
DR jPOST; A8MT65; -.
DR MassIVE; A8MT65; -.
DR MaxQB; A8MT65; -.
DR PaxDb; A8MT65; -.
DR PeptideAtlas; A8MT65; -.
DR PRIDE; A8MT65; -.
DR ProteomicsDB; 1996; -.
DR Antibodypedia; 49266; 15 antibodies from 6 providers.
DR DNASU; 101060200; -.
DR Ensembl; ENST00000537226.3; ENSP00000437590.1; ENSG00000214029.6.
DR GeneID; 101060200; -.
DR KEGG; hsa:101060200; -.
DR MANE-Select; ENST00000537226.3; ENSP00000437590.1; NM_001277291.2; NP_001264220.1.
DR UCSC; uc031qkm.2; human.
DR CTD; 101060200; -.
DR DisGeNET; 101060200; -.
DR GeneCards; ZNF891; -.
DR HGNC; HGNC:38709; ZNF891.
DR HPA; ENSG00000214029; Low tissue specificity.
DR neXtProt; NX_A8MT65; -.
DR OpenTargets; ENSG00000214029; -.
DR VEuPathDB; HostDB:ENSG00000214029; -.
DR eggNOG; KOG1721; Eukaryota.
DR GeneTree; ENSGT00940000164587; -.
DR HOGENOM; CLU_002678_0_2_1; -.
DR InParanoid; A8MT65; -.
DR OMA; WHLQRNQ; -.
DR OrthoDB; 1318335at2759; -.
DR PhylomeDB; A8MT65; -.
DR TreeFam; TF337055; -.
DR PathwayCommons; A8MT65; -.
DR SignaLink; A8MT65; -.
DR BioGRID-ORCS; 101060200; 7 hits in 1062 CRISPR screens.
DR ChiTaRS; ZNF891; human.
DR GenomeRNAi; 101060200; -.
DR Pharos; A8MT65; Tdark.
DR PRO; PR:A8MT65; -.
DR Proteomes; UP000005640; Chromosome 12.
DR RNAct; A8MT65; protein.
DR Bgee; ENSG00000214029; Expressed in calcaneal tendon and 135 other tissues.
DR ExpressionAtlas; A8MT65; baseline and differential.
DR Genevisible; A8MT65; HS.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0001227; F:DNA-binding transcription repressor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000977; F:RNA polymerase II transcription regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd07765; KRAB_A-box; 1.
DR InterPro; IPR001909; KRAB.
DR InterPro; IPR036051; KRAB_dom_sf.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF01352; KRAB; 1.
DR Pfam; PF00096; zf-C2H2; 5.
DR SMART; SM00349; KRAB; 1.
DR SMART; SM00355; ZnF_C2H2; 8.
DR SUPFAM; SSF109640; SSF109640; 1.
DR SUPFAM; SSF57667; SSF57667; 4.
DR PROSITE; PS50805; KRAB; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 7.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 8.
PE 2: Evidence at transcript level;
KW DNA-binding; Metal-binding; Nucleus; Reference proteome; Repeat;
KW Transcription; Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1..544
FT /note="Zinc finger protein 891"
FT /id="PRO_0000349185"
FT DOMAIN 43..113
FT /note="KRAB"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00119"
FT ZN_FING 320..342
FT /note="C2H2-type 1; degenerate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 348..370
FT /note="C2H2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 376..398
FT /note="C2H2-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 404..426
FT /note="C2H2-type 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 432..454
FT /note="C2H2-type 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 460..482
FT /note="C2H2-type 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 488..510
FT /note="C2H2-type 7"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 516..538
FT /note="C2H2-type 8"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
SQ SEQUENCE 544 AA; 63592 MW; B8639429E306B007 CRC64;
MAVMDLSSPW ALTKQDSACF HLRNAEEERM IAVFLTTWLQ EPMTFKDVAV EFTQEEWMML
DSAQRSLYRD VMLENYRNLT SVEYQLYRLT VISPLDQEEI RNMKKRIPQA ICPDQKIQPK
TKESTVQKIL WEEPSNAVKM IKLTMHNWSS TLREDWECHK IRKQHKIPGG HWRQMIYAPK
KTVPQELFRD YHELEENSKL GSKLIFSQSI FTSKHCQKCY SEIGCLKHNS IINNYVKNSI
SEKLYESHEC DTTLWHFQRN QTVQKEYTYS KHGMHFTHNM FPVPNNLHMA QNACECNKDE
TLCHQSSLKK QGQTHTEKKH ECNQCGKAFK RISNLTLYKK SHMGEKQYEC KECGKVFNDS
STLRRHVRTH TGEKPYECNQ CGKAFSQKTS LKAHMRTHTG EKPYECNQCG KSFGTSSYLI
VHKRIHTGEK LYECSECGKA FNTSSHLKVH KKIHTGENVY ECSDCGKVFS GVSSLRMHIR
THTGEKPYEC KECRKAFSVS SSLRRHVRIH TGEKPYECIQ CGKAFSQSSS LIIHKRIHTE
RETL
