ZNF14_HUMAN
ID ZNF14_HUMAN Reviewed; 642 AA.
AC P17017; B9EGA4; Q9ULZ5;
DT 01-AUG-1990, integrated into UniProtKB/Swiss-Prot.
DT 30-NOV-2010, sequence version 3.
DT 03-AUG-2022, entry version 195.
DE RecName: Full=Zinc finger protein 14;
DE AltName: Full=Gonadotropin-inducible ovary transcription repressor 4;
DE Short=GIOT-4;
DE AltName: Full=Zinc finger protein KOX6;
GN Name=ZNF14; Synonyms=GIOT4, KOX6;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND VARIANT SER-274.
RC TISSUE=Ovary;
RA Okada T., Mizutani T., Miyamoto K.;
RT "Identification and characterization of novel zinc finger proteins in the
RT human ovary.";
RL Submitted (DEC-1998) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15057824; DOI=10.1038/nature02399;
RA Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E.,
RA Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A.,
RA Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S.,
RA Carrano A.V., Caoile C., Chan Y.M., Christensen M., Cleland C.A.,
RA Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J.,
RA Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M.,
RA Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W.,
RA Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V.,
RA Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D.,
RA McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I.,
RA Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L.,
RA Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A.,
RA She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M.,
RA Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J.,
RA Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA Rubin E.M., Lucas S.M.;
RT "The DNA sequence and biology of human chromosome 19.";
RL Nature 428:529-535(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Lung;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 391-446.
RC TISSUE=Lymphoid tissue;
RX PubMed=2288909;
RA Thiesen H.-J.;
RT "Multiple genes encoding zinc finger domains are expressed in human T
RT cells.";
RL New Biol. 2:363-374(1990).
CC -!- FUNCTION: May be involved in transcriptional regulation.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. {ECO:0000305}.
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DR EMBL; AB021644; BAA86990.1; -; mRNA.
DR EMBL; AC011458; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471106; EAW84858.1; -; Genomic_DNA.
DR EMBL; BC136323; AAI36324.1; -; mRNA.
DR EMBL; X52337; CAA36563.1; -; mRNA.
DR CCDS; CCDS12409.1; -.
DR PIR; I37974; I37974.
DR RefSeq; NP_066358.2; NM_021030.2.
DR AlphaFoldDB; P17017; -.
DR SMR; P17017; -.
DR BioGRID; 113393; 6.
DR STRING; 9606.ENSP00000340514; -.
DR iPTMnet; P17017; -.
DR PhosphoSitePlus; P17017; -.
DR BioMuta; ZNF14; -.
DR DMDM; 313104250; -.
DR EPD; P17017; -.
DR jPOST; P17017; -.
DR MassIVE; P17017; -.
DR MaxQB; P17017; -.
DR PaxDb; P17017; -.
DR PeptideAtlas; P17017; -.
DR PRIDE; P17017; -.
DR ProteomicsDB; 53414; -.
DR Antibodypedia; 28563; 52 antibodies from 17 providers.
DR DNASU; 7561; -.
DR Ensembl; ENST00000344099.4; ENSP00000340514.2; ENSG00000105708.9.
DR GeneID; 7561; -.
DR KEGG; hsa:7561; -.
DR MANE-Select; ENST00000344099.4; ENSP00000340514.2; NM_021030.3; NP_066358.2.
DR UCSC; uc002nnk.2; human.
DR CTD; 7561; -.
DR DisGeNET; 7561; -.
DR GeneCards; ZNF14; -.
DR HGNC; HGNC:12924; ZNF14.
DR HPA; ENSG00000105708; Low tissue specificity.
DR MIM; 194556; gene.
DR neXtProt; NX_P17017; -.
DR OpenTargets; ENSG00000105708; -.
DR PharmGKB; PA37511; -.
DR VEuPathDB; HostDB:ENSG00000105708; -.
DR eggNOG; KOG1721; Eukaryota.
DR GeneTree; ENSGT00950000182755; -.
DR HOGENOM; CLU_002678_44_3_1; -.
DR InParanoid; P17017; -.
DR OMA; CHMVERL; -.
DR OrthoDB; 1318335at2759; -.
DR PhylomeDB; P17017; -.
DR TreeFam; TF343410; -.
DR PathwayCommons; P17017; -.
DR Reactome; R-HSA-212436; Generic Transcription Pathway.
DR BioGRID-ORCS; 7561; 84 hits in 1063 CRISPR screens.
DR ChiTaRS; ZNF14; human.
DR GenomeRNAi; 7561; -.
DR Pharos; P17017; Tdark.
DR PRO; PR:P17017; -.
DR Proteomes; UP000005640; Chromosome 19.
DR RNAct; P17017; protein.
DR Bgee; ENSG00000105708; Expressed in secondary oocyte and 193 other tissues.
DR Genevisible; P17017; HS.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000977; F:RNA polymerase II transcription regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd07765; KRAB_A-box; 1.
DR InterPro; IPR001909; KRAB.
DR InterPro; IPR036051; KRAB_dom_sf.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF01352; KRAB; 1.
DR Pfam; PF00096; zf-C2H2; 12.
DR SMART; SM00349; KRAB; 1.
DR SMART; SM00355; ZnF_C2H2; 18.
DR SUPFAM; SSF109640; SSF109640; 1.
DR SUPFAM; SSF57667; SSF57667; 11.
DR PROSITE; PS50805; KRAB; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 17.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 19.
PE 2: Evidence at transcript level;
KW DNA-binding; Metal-binding; Nucleus; Reference proteome; Repeat;
KW Transcription; Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1..642
FT /note="Zinc finger protein 14"
FT /id="PRO_0000047337"
FT DOMAIN 4..76
FT /note="KRAB"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00119"
FT ZN_FING 103..125
FT /note="C2H2-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 141..163
FT /note="C2H2-type 2; degenerate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 169..191
FT /note="C2H2-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 197..217
FT /note="C2H2-type 4; atypical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 223..245
FT /note="C2H2-type 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 251..273
FT /note="C2H2-type 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 279..301
FT /note="C2H2-type 7"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 307..329
FT /note="C2H2-type 8"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 335..357
FT /note="C2H2-type 9"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 363..385
FT /note="C2H2-type 10"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 391..413
FT /note="C2H2-type 11"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 419..441
FT /note="C2H2-type 12"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 447..469
FT /note="C2H2-type 13"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 475..497
FT /note="C2H2-type 14"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 503..525
FT /note="C2H2-type 15"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 531..553
FT /note="C2H2-type 16"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 559..581
FT /note="C2H2-type 17"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 587..609
FT /note="C2H2-type 18"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 615..637
FT /note="C2H2-type 19"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT VARIANT 274
FT /note="T -> S (in dbSNP:rs12973901)"
FT /evidence="ECO:0000269|Ref.1"
FT /id="VAR_054791"
FT VARIANT 379
FT /note="R -> Q (in dbSNP:rs3752153)"
FT /id="VAR_057381"
SQ SEQUENCE 642 AA; 75353 MW; 806374FBDC480CE3 CRC64;
MDSVSFEDVA VNFTLEEWAL LDSSQKKLYE DVMQETFKNL VCLGKKWEDQ DIEDDHRNQG
KNRRCHMVER LCESRRGSKC GETTSQMPNV NINKETFTGA KPHECSFCGR DFIHHSSLNR
HMRSHTGQKP NEYQEYEKQP CKCKAVGKTF SYHHCFRKHE RTHTGVKPYE CKQCGKAFIY
YQPFQRHERT HAGQKPYECK QCGKTFIYYQ SFQKHAHTGK KPYECKQCGK AFICYQSFQR
HKRTHTGEKP YECKQCGKAF SCPTYFRTHE RTHTGEKPYK CKECGKAFSF LSSFRRHKRT
HSGEKPYECK ECGKAFFYSA SFRAHVIIHT GARPYKCKEC GKAFNSSNSC RVHERTHIGE
KPYECKRCGK SFSWSISLRL HERTHTGEKP YECKQCHKTF SFSSSLREHE TTHTGEKPYE
CKQCGKTFSF SSSLQRHERT HNAEKPYECK QCGKAFRCSS YFRIHERSHT GEKPYECKQC
GKVFIRSSSF RLHERTHTGE KPYECKLCGK TFSFSSSLRE HEKIHTGNKP FECKQCGKAF
LRSSQIRLHE RTHTGEKPYQ CKQCGKAFIS SSKFRMHERT HTGEKPYRCK QCGKAFRFSS
SVRIHERSHT GEKPYECKQC GKAFISSSHF RLHERTHMGE KV
