ZNF17_HUMAN
ID ZNF17_HUMAN Reviewed; 662 AA.
AC P17021; B3KXU2; B3KY20; Q8N7M1; Q8N893; Q8TF54;
DT 01-AUG-1990, integrated into UniProtKB/Swiss-Prot.
DT 24-MAR-2009, sequence version 3.
DT 03-AUG-2022, entry version 182.
DE RecName: Full=Zinc finger protein 17;
DE AltName: Full=Zinc finger protein HPF3;
DE AltName: Full=Zinc finger protein KOX10;
GN Name=ZNF17; Synonyms=KIAA1947, KOX10;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 3).
RC TISSUE=Liver, Mesenchymal stem cell, Spleen, and Trachea;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15057824; DOI=10.1038/nature02399;
RA Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E.,
RA Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A.,
RA Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S.,
RA Carrano A.V., Caoile C., Chan Y.M., Christensen M., Cleland C.A.,
RA Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J.,
RA Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M.,
RA Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W.,
RA Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V.,
RA Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D.,
RA McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I.,
RA Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L.,
RA Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A.,
RA She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M.,
RA Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J.,
RA Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA Rubin E.M., Lucas S.M.;
RT "The DNA sequence and biology of human chromosome 19.";
RL Nature 428:529-535(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 55-662 (ISOFORMS 1/2/3).
RC TISSUE=Brain;
RX PubMed=11853319; DOI=10.1093/dnares/8.6.319;
RA Nagase T., Kikuno R., Ohara O.;
RT "Prediction of the coding sequences of unidentified human genes. XXII. The
RT complete sequences of 50 new cDNA clones which code for large proteins.";
RL DNA Res. 8:319-327(2001).
RN [4]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 442-497 (ISOFORMS 1/2/3).
RC TISSUE=Lymphoid tissue;
RX PubMed=2288909;
RA Thiesen H.-J.;
RT "Multiple genes encoding zinc finger domains are expressed in human T
RT cells.";
RL New Biol. 2:363-374(1990).
CC -!- FUNCTION: May be involved in transcriptional regulation.
CC -!- INTERACTION:
CC P17021; Q9NX04: C1orf109; NbExp=3; IntAct=EBI-1105334, EBI-8643161;
CC P17021; Q8NHQ1: CEP70; NbExp=3; IntAct=EBI-1105334, EBI-739624;
CC P17021; A6NEM1: GOLGA6L9; NbExp=3; IntAct=EBI-1105334, EBI-5916454;
CC P17021; Q6A162: KRT40; NbExp=3; IntAct=EBI-1105334, EBI-10171697;
CC P17021; Q5JR59-3: MTUS2; NbExp=3; IntAct=EBI-1105334, EBI-11522433;
CC P17021; Q96CV9: OPTN; NbExp=3; IntAct=EBI-1105334, EBI-748974;
CC P17021; Q9NRD5: PICK1; NbExp=3; IntAct=EBI-1105334, EBI-79165;
CC P17021; Q01105-2: SET; NbExp=3; IntAct=EBI-1105334, EBI-7481343;
CC P17021; P13994: YJU2B; NbExp=3; IntAct=EBI-1105334, EBI-716093;
CC P17021; Q7Z4V0: ZNF438; NbExp=3; IntAct=EBI-1105334, EBI-11962468;
CC P17021; Q96EG3: ZNF837; NbExp=3; IntAct=EBI-1105334, EBI-11962574;
CC P17021; Q9UGI0: ZRANB1; NbExp=3; IntAct=EBI-1105334, EBI-527853;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1;
CC IsoId=P17021-1; Sequence=Displayed;
CC Name=2;
CC IsoId=P17021-2; Sequence=VSP_036651;
CC Name=3;
CC IsoId=P17021-3; Sequence=VSP_036652;
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAC04956.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC Sequence=BAC05252.1; Type=Erroneous termination; Note=Truncated C-terminus.; Evidence={ECO:0000305};
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DR EMBL; AK097123; BAC04956.1; ALT_INIT; mRNA.
DR EMBL; AK098183; BAC05252.1; ALT_SEQ; mRNA.
DR EMBL; AK127948; BAG54604.1; -; mRNA.
DR EMBL; AK128471; BAG54682.1; -; mRNA.
DR EMBL; AC003002; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AB075827; BAB85533.1; -; mRNA.
DR EMBL; X52341; CAA36567.1; -; mRNA.
DR CCDS; CCDS42636.1; -. [P17021-1]
DR CCDS; CCDS82405.1; -. [P17021-2]
DR PIR; I37949; S10398.
DR RefSeq; NP_001317546.1; NM_001330617.1. [P17021-2]
DR RefSeq; NP_008890.2; NM_006959.2. [P17021-1]
DR AlphaFoldDB; P17021; -.
DR SMR; P17021; -.
DR BioGRID; 113396; 40.
DR IntAct; P17021; 13.
DR iPTMnet; P17021; -.
DR PhosphoSitePlus; P17021; -.
DR BioMuta; ZNF17; -.
DR DMDM; 229485310; -.
DR MassIVE; P17021; -.
DR MaxQB; P17021; -.
DR PaxDb; P17021; -.
DR PeptideAtlas; P17021; -.
DR PRIDE; P17021; -.
DR ProteomicsDB; 53417; -. [P17021-1]
DR ProteomicsDB; 53418; -. [P17021-2]
DR ProteomicsDB; 53419; -. [P17021-3]
DR Antibodypedia; 9873; 45 antibodies from 12 providers.
DR DNASU; 7565; -.
DR Ensembl; ENST00000307658.12; ENSP00000302455.7; ENSG00000186272.13. [P17021-2]
DR Ensembl; ENST00000601808.1; ENSP00000471905.1; ENSG00000186272.13. [P17021-1]
DR GeneID; 7565; -.
DR KEGG; hsa:7565; -.
DR MANE-Select; ENST00000307658.12; ENSP00000302455.7; NM_001330617.2; NP_001317546.1. [P17021-2]
DR UCSC; uc002qoo.2; human. [P17021-1]
DR CTD; 7565; -.
DR GeneCards; ZNF17; -.
DR HGNC; HGNC:12958; ZNF17.
DR HPA; ENSG00000186272; Low tissue specificity.
DR MIM; 619254; gene.
DR neXtProt; NX_P17021; -.
DR PharmGKB; PA37540; -.
DR VEuPathDB; HostDB:ENSG00000186272; -.
DR eggNOG; KOG1721; Eukaryota.
DR GeneTree; ENSGT00940000164515; -.
DR HOGENOM; CLU_002678_17_1_1; -.
DR InParanoid; P17021; -.
DR OMA; LCCESRK; -.
DR OrthoDB; 1318335at2759; -.
DR PhylomeDB; P17021; -.
DR TreeFam; TF339848; -.
DR PathwayCommons; P17021; -.
DR Reactome; R-HSA-212436; Generic Transcription Pathway.
DR SignaLink; P17021; -.
DR BioGRID-ORCS; 7565; 8 hits in 1100 CRISPR screens.
DR GenomeRNAi; 7565; -.
DR Pharos; P17021; Tdark.
DR PRO; PR:P17021; -.
DR Proteomes; UP000005640; Chromosome 19.
DR RNAct; P17021; protein.
DR Bgee; ENSG00000186272; Expressed in corpus callosum and 106 other tissues.
DR ExpressionAtlas; P17021; baseline and differential.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd07765; KRAB_A-box; 1.
DR InterPro; IPR001909; KRAB.
DR InterPro; IPR036051; KRAB_dom_sf.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF01352; KRAB; 1.
DR Pfam; PF00096; zf-C2H2; 14.
DR SMART; SM00349; KRAB; 1.
DR SMART; SM00355; ZnF_C2H2; 18.
DR SUPFAM; SSF109640; SSF109640; 1.
DR SUPFAM; SSF57667; SSF57667; 9.
DR PROSITE; PS50805; KRAB; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 18.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 17.
PE 1: Evidence at protein level;
KW Alternative splicing; DNA-binding; Metal-binding; Nucleus;
KW Reference proteome; Repeat; Transcription; Transcription regulation; Zinc;
KW Zinc-finger.
FT CHAIN 1..662
FT /note="Zinc finger protein 17"
FT /id="PRO_0000047339"
FT DOMAIN 8..101
FT /note="KRAB"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00119"
FT ZN_FING 190..212
FT /note="C2H2-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 218..240
FT /note="C2H2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 246..268
FT /note="C2H2-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 274..296
FT /note="C2H2-type 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 302..324
FT /note="C2H2-type 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 358..380
FT /note="C2H2-type 7"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 386..408
FT /note="C2H2-type 8"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 414..436
FT /note="C2H2-type 9"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 442..464
FT /note="C2H2-type 10"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 470..492
FT /note="C2H2-type 11"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 498..520
FT /note="C2H2-type 12"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 526..548
FT /note="C2H2-type 13"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 554..576
FT /note="C2H2-type 14"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 582..604
FT /note="C2H2-type 15"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 610..632
FT /note="C2H2-type 16"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 638..660
FT /note="C2H2-type 17"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT VAR_SEQ 1..47
FT /note="MNLTEDYMVFEDVAIHFSQEEWGILNDVQRHLHSDVMLENFALLSSV -> M
FT GLPLPSKVIMHFMSISVL (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_036652"
FT VAR_SEQ 1..5
FT /note="MNLTE -> MLMDAGQ (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_036651"
FT VARIANT 148
FT /note="T -> K (in dbSNP:rs2014827)"
FT /id="VAR_057382"
FT CONFLICT 96
FT /note="I -> T (in Ref. 1; BAC05252)"
FT /evidence="ECO:0000305"
FT CONFLICT 394
FT /note="F -> S (in Ref. 1; BAG54604)"
FT /evidence="ECO:0000305"
FT CONFLICT 552
FT /note="R -> G (in Ref. 1; BAG54682)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 662 AA; 77204 MW; DB91A427566145E0 CRC64;
MNLTEDYMVF EDVAIHFSQE EWGILNDVQR HLHSDVMLEN FALLSSVGCW HGAKDEEAPS
KQCVSVGVSQ VTTLKPALST QKAQPCETCS SLLKDILHLA EHDGTHPKRT AKLYLHQKEH
LREKLTRSDE GRPSFVNDSV HLAKRNLTCM QGGKDFTGDS DLQQQALHSG WKPHRDTHGV
EAFQSGQNNY SCTQCGKDFC HQHTLFEHQK IHTEERPYEC SECGKLFRYN SDLIKHQRNH
TGERPYKCSE CGKAFSLKYN VVQHQKIHTG ERPYECSECG KAFLRKSHLL QHQRIHTRPR
PYVCSECGKA FLTQAHLVGH QKIHTGERPY GCNECGKYFM YSSALIRHQK VHTGERPFYC
CECGKFFMDS CTLIIHQRVH TGEKPYECNE CGKFFRYRST LIRHQKVHTG EKPYECSECG
KFFMDTSTLI IHQRVHTGEK PYECNKCGKF FRYCFTLNRH QRVHSGERPY ECSECGKFFV
DSCTLKSHQR VHTGERPFEC SICGKSFRCR STLDTHQRIH TGERPYECSE CGKFFRHNSN
HIRHRRNHFG ERSFECTECG RVFSQNSHLI RHQKVHTRER TYKCSKCGKF FMDSSTLISH
ERVHTGEKPY ECSECGKVFR YNSSLIKHRR IHTGERPYQC SECGRVFNQN SHLIQHQKVH
TR
