ZNF18_HUMAN
ID ZNF18_HUMAN Reviewed; 549 AA.
AC P17022; Q5QHQ3; Q8IYC4; Q8NAH6;
DT 01-AUG-1990, integrated into UniProtKB/Swiss-Prot.
DT 10-JAN-2006, sequence version 2.
DT 03-AUG-2022, entry version 200.
DE RecName: Full=Zinc finger protein 18;
DE AltName: Full=Heart development-specific gene 1 protein;
DE AltName: Full=Zinc finger protein 535;
DE AltName: Full=Zinc finger protein KOX11;
DE AltName: Full=Zinc finger protein with KRAB and SCAN domains 6;
GN Name=ZNF18; Synonyms=HDSG1, KOX11, ZKSCAN6, ZNF535;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
RX PubMed=16120570;
RA Guo L.L., Shan H.S., Zou X., Ci H.L., Zai Y.G., Li Y.P.;
RT "Molecular cloning and expression analysis of a novel human gene ZNF18.";
RL Yi Chuan 27:523-530(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Prostate;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), AND VARIANTS ARG-210
RP AND ILE-240.
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 436-491 (ISOFORMS 1/2).
RC TISSUE=Lymphoid tissue;
RX PubMed=2288909;
RA Thiesen H.-J.;
RT "Multiple genes encoding zinc finger domains are expressed in human T
RT cells.";
RL New Biol. 2:363-374(1990).
CC -!- FUNCTION: May be involved in transcriptional regulation.
CC -!- INTERACTION:
CC P17022; P24863: CCNC; NbExp=4; IntAct=EBI-8648067, EBI-395261;
CC P17022; Q9UBL6-2: CPNE7; NbExp=3; IntAct=EBI-8648067, EBI-12012272;
CC P17022; Q5I0X7: TTC32; NbExp=3; IntAct=EBI-8648067, EBI-8636434;
CC P17022; Q9NWS9-2: ZNF446; NbExp=3; IntAct=EBI-8648067, EBI-740232;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00187}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=P17022-1; Sequence=Displayed;
CC Name=2;
CC IsoId=P17022-2; Sequence=VSP_016947;
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AY491053; AAS67595.1; -; mRNA.
DR EMBL; AK092656; BAC03939.1; -; mRNA.
DR EMBL; BC036096; AAH36096.1; -; mRNA.
DR EMBL; X52342; CAA36568.1; -; mRNA.
DR CCDS; CCDS32568.1; -. [P17022-1]
DR CCDS; CCDS76957.1; -. [P17022-2]
DR PIR; I37950; S10399.
DR RefSeq; NP_001290210.1; NM_001303281.1. [P17022-1]
DR RefSeq; NP_001290211.1; NM_001303282.1. [P17022-2]
DR RefSeq; NP_653281.2; NM_144680.3. [P17022-1]
DR RefSeq; XP_011522304.1; XM_011524002.2. [P17022-1]
DR RefSeq; XP_016880495.1; XM_017025006.1. [P17022-1]
DR RefSeq; XP_016880496.1; XM_017025007.1. [P17022-1]
DR RefSeq; XP_016880497.1; XM_017025008.1. [P17022-2]
DR RefSeq; XP_016880498.1; XM_017025009.1.
DR RefSeq; XP_016880499.1; XM_017025010.1. [P17022-2]
DR RefSeq; XP_016880500.1; XM_017025011.1. [P17022-2]
DR AlphaFoldDB; P17022; -.
DR SMR; P17022; -.
DR BioGRID; 113397; 12.
DR IntAct; P17022; 11.
DR MINT; P17022; -.
DR STRING; 9606.ENSP00000315664; -.
DR iPTMnet; P17022; -.
DR PhosphoSitePlus; P17022; -.
DR BioMuta; ZNF18; -.
DR DMDM; 85681864; -.
DR EPD; P17022; -.
DR jPOST; P17022; -.
DR MassIVE; P17022; -.
DR PaxDb; P17022; -.
DR PeptideAtlas; P17022; -.
DR PRIDE; P17022; -.
DR ProteomicsDB; 53420; -. [P17022-1]
DR ProteomicsDB; 53421; -. [P17022-2]
DR ABCD; P17022; 1 sequenced antibody.
DR Antibodypedia; 1806; 165 antibodies from 28 providers.
DR DNASU; 7566; -.
DR Ensembl; ENST00000322748.7; ENSP00000315664.3; ENSG00000154957.14. [P17022-1]
DR Ensembl; ENST00000454073.7; ENSP00000391376.3; ENSG00000154957.14. [P17022-2]
DR Ensembl; ENST00000580306.7; ENSP00000463471.1; ENSG00000154957.14. [P17022-1]
DR Ensembl; ENST00000580613.5; ENSP00000462296.3; ENSG00000154957.14. [P17022-1]
DR GeneID; 7566; -.
DR KEGG; hsa:7566; -.
DR MANE-Select; ENST00000580306.7; ENSP00000463471.1; NM_001303281.2; NP_001290210.1.
DR UCSC; uc002gng.1; human. [P17022-1]
DR CTD; 7566; -.
DR DisGeNET; 7566; -.
DR GeneCards; ZNF18; -.
DR HGNC; HGNC:12969; ZNF18.
DR HPA; ENSG00000154957; Low tissue specificity.
DR MIM; 194524; gene.
DR neXtProt; NX_P17022; -.
DR OpenTargets; ENSG00000154957; -.
DR PharmGKB; PA37551; -.
DR VEuPathDB; HostDB:ENSG00000154957; -.
DR eggNOG; KOG1721; Eukaryota.
DR GeneTree; ENSGT00940000161617; -.
DR HOGENOM; CLU_002678_49_8_1; -.
DR InParanoid; P17022; -.
DR OMA; DEPGCFE; -.
DR OrthoDB; 1318335at2759; -.
DR PhylomeDB; P17022; -.
DR TreeFam; TF337489; -.
DR PathwayCommons; P17022; -.
DR Reactome; R-HSA-212436; Generic Transcription Pathway.
DR SignaLink; P17022; -.
DR BioGRID-ORCS; 7566; 7 hits in 1098 CRISPR screens.
DR ChiTaRS; ZNF18; human.
DR GenomeRNAi; 7566; -.
DR Pharos; P17022; Tdark.
DR PRO; PR:P17022; -.
DR Proteomes; UP000005640; Chromosome 17.
DR RNAct; P17022; protein.
DR Bgee; ENSG00000154957; Expressed in blood and 97 other tissues.
DR ExpressionAtlas; P17022; baseline and differential.
DR Genevisible; P17022; HS.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd07765; KRAB_A-box; 1.
DR CDD; cd07936; SCAN; 1.
DR Gene3D; 1.10.4020.10; -; 1.
DR InterPro; IPR001909; KRAB.
DR InterPro; IPR036051; KRAB_dom_sf.
DR InterPro; IPR003309; SCAN_dom.
DR InterPro; IPR038269; SCAN_sf.
DR InterPro; IPR027764; Zfp18.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR PANTHER; PTHR23226:SF190; PTHR23226:SF190; 1.
DR Pfam; PF01352; KRAB; 1.
DR Pfam; PF02023; SCAN; 1.
DR Pfam; PF00096; zf-C2H2; 5.
DR SMART; SM00349; KRAB; 1.
DR SMART; SM00431; SCAN; 1.
DR SMART; SM00355; ZnF_C2H2; 5.
DR SUPFAM; SSF109640; SSF109640; 1.
DR SUPFAM; SSF57667; SSF57667; 3.
DR PROSITE; PS50805; KRAB; 1.
DR PROSITE; PS50804; SCAN_BOX; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 5.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 5.
PE 1: Evidence at protein level;
KW Alternative splicing; DNA-binding; Metal-binding; Nucleus;
KW Reference proteome; Repeat; Transcription; Transcription regulation; Zinc;
KW Zinc-finger.
FT CHAIN 1..549
FT /note="Zinc finger protein 18"
FT /id="PRO_0000047340"
FT DOMAIN 41..123
FT /note="SCAN box"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00187"
FT DOMAIN 211..283
FT /note="KRAB"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00119"
FT ZN_FING 408..430
FT /note="C2H2-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 436..458
FT /note="C2H2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 464..486
FT /note="C2H2-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 492..514
FT /note="C2H2-type 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 520..542
FT /note="C2H2-type 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT VAR_SEQ 251
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:16120570"
FT /id="VSP_016947"
FT VARIANT 210
FT /note="Q -> R (in dbSNP:rs17857095)"
FT /evidence="ECO:0000269|PubMed:15489334"
FT /id="VAR_024835"
FT VARIANT 240
FT /note="M -> I (in dbSNP:rs17853545)"
FT /evidence="ECO:0000269|PubMed:15489334"
FT /id="VAR_024836"
SQ SEQUENCE 549 AA; 62288 MW; 5468BA67A459174D CRC64;
MPVDLGQALG LLPSLAKAED SQFSESDAAL QEELSSPETA RQLFRQFRYQ VMSGPHETLK
QLRKLCFQWL QPEVHTKEQI LEILMLEQFL TILPGEIQMW VRKQCPGSGE EAVTLVESLK
GDPQRLWQWI SIQVLGQDIL SEKMESPSCQ VGEVEPHLEV VPQELGLENS SSGPGELLSH
IVKEESDTEA ELALAASQPA RLEERLIRDQ DLGASLLPAA PQEQWRQLDS TQKEQYWDLM
LETYGKMVSG AGISHPKSDL TNSIEFGEEL AGIYLHVNEK IPRPTCIGDR QENDKENLNL
ENHRDQELLH ASCQASGEVP SQASLRGFFT EDEPGCFGEG ENLPEALQNI QDEGTGEQLS
PQERISEKQL GQHLPNPHSG EMSTMWLEEK RETSQKGQPR APMAQKLPTC RECGKTFYRN
SQLIFHQRTH TGETYFQCTI CKKAFLRSSD FVKHQRTHTG EKPCKCDYCG KGFSDFSGLR
HHEKIHTGEK PYKCPICEKS FIQRSNFNRH QRVHTGEKPY KCSHCGKSFS WSSSLDKHQR
SHLGKKPFQ
