ZNF18_MOUSE
ID ZNF18_MOUSE Reviewed; 556 AA.
AC Q810A1; Q9D972;
DT 10-JAN-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2003, sequence version 1.
DT 03-AUG-2022, entry version 146.
DE RecName: Full=Zinc finger protein 18;
DE AltName: Full=Zinc finger protein 535;
DE AltName: Full=Zinc finger protein with KRAB and SCAN domains 6;
GN Name=Znf18; Synonyms=Zfp535, Zkscan6;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Testis;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Fetal brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: May be involved in transcriptional regulation.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00187}.
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. {ECO:0000305}.
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DR EMBL; AK007308; BAB24947.1; -; mRNA.
DR EMBL; AL596025; CAI24583.1; -; Genomic_DNA.
DR EMBL; BC043075; AAH43075.1; -; mRNA.
DR CCDS; CCDS24845.1; -.
DR RefSeq; NP_001289303.1; NM_001302374.1.
DR RefSeq; NP_001289304.1; NM_001302375.1.
DR RefSeq; NP_080383.2; NM_026107.3.
DR RefSeq; XP_006533780.1; XM_006533717.3.
DR AlphaFoldDB; Q810A1; -.
DR SMR; Q810A1; -.
DR STRING; 10090.ENSMUSP00000018491; -.
DR iPTMnet; Q810A1; -.
DR PhosphoSitePlus; Q810A1; -.
DR PaxDb; Q810A1; -.
DR PRIDE; Q810A1; -.
DR ProteomicsDB; 275039; -.
DR Antibodypedia; 1806; 165 antibodies from 28 providers.
DR DNASU; 52712; -.
DR Ensembl; ENSMUST00000018491; ENSMUSP00000018491; ENSMUSG00000018347.
DR Ensembl; ENSMUST00000071465; ENSMUSP00000071406; ENSMUSG00000018347.
DR GeneID; 52712; -.
DR KEGG; mmu:52712; -.
DR UCSC; uc007jld.2; mouse.
DR CTD; 52712; -.
DR MGI; MGI:1289293; Zkscan6.
DR VEuPathDB; HostDB:ENSMUSG00000018347; -.
DR eggNOG; KOG1721; Eukaryota.
DR GeneTree; ENSGT00940000161617; -.
DR HOGENOM; CLU_002678_49_10_1; -.
DR InParanoid; Q810A1; -.
DR OMA; DEPGCFE; -.
DR OrthoDB; 1318335at2759; -.
DR PhylomeDB; Q810A1; -.
DR TreeFam; TF337489; -.
DR Reactome; R-MMU-212436; Generic Transcription Pathway.
DR BioGRID-ORCS; 52712; 3 hits in 72 CRISPR screens.
DR ChiTaRS; Zkscan6; mouse.
DR PRO; PR:Q810A1; -.
DR Proteomes; UP000000589; Chromosome 11.
DR RNAct; Q810A1; protein.
DR Bgee; ENSMUSG00000018347; Expressed in primary oocyte and 244 other tissues.
DR Genevisible; Q810A1; MM.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd07765; KRAB_A-box; 1.
DR CDD; cd07936; SCAN; 1.
DR Gene3D; 1.10.4020.10; -; 1.
DR InterPro; IPR001909; KRAB.
DR InterPro; IPR036051; KRAB_dom_sf.
DR InterPro; IPR003309; SCAN_dom.
DR InterPro; IPR038269; SCAN_sf.
DR InterPro; IPR027764; Zfp18.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR PANTHER; PTHR23226:SF190; PTHR23226:SF190; 1.
DR Pfam; PF01352; KRAB; 1.
DR Pfam; PF02023; SCAN; 1.
DR Pfam; PF00096; zf-C2H2; 5.
DR SMART; SM00349; KRAB; 1.
DR SMART; SM00431; SCAN; 1.
DR SMART; SM00355; ZnF_C2H2; 5.
DR SUPFAM; SSF109640; SSF109640; 1.
DR SUPFAM; SSF57667; SSF57667; 3.
DR PROSITE; PS50805; KRAB; 1.
DR PROSITE; PS50804; SCAN_BOX; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 5.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 5.
PE 2: Evidence at transcript level;
KW DNA-binding; Metal-binding; Nucleus; Reference proteome; Repeat;
KW Transcription; Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1..556
FT /note="Zinc finger protein 18"
FT /id="PRO_0000047341"
FT DOMAIN 41..123
FT /note="SCAN box"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00187"
FT DOMAIN 218..291
FT /note="KRAB"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00119"
FT ZN_FING 415..437
FT /note="C2H2-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 443..465
FT /note="C2H2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 471..493
FT /note="C2H2-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 499..521
FT /note="C2H2-type 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 527..549
FT /note="C2H2-type 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT REGION 169..195
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 169..183
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 207
FT /note="A -> D (in Ref. 1; BAB24947)"
FT /evidence="ECO:0000305"
FT CONFLICT 373
FT /note="S -> P (in Ref. 1; BAB24947)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 556 AA; 62929 MW; A0034301B498AF50 CRC64;
MPVDLGQALG PLPFLAKAED ATFSASDATQ QRELANPETA RQLFRQFRYQ VLSGPQETLR
QLRKLCFQWL RPEVHTKEQI LELLMLEQFL TILPGEIQMW VRKQCPGSGQ EAVTLVESLK
GEPQKLWHWI STQVLGQEIP FEKENLTHCP GDKLEPALEV EPSLEVAPQD LPLQNSSSAT
GELLSHGVKE ESDMEPELAL AASQLPARPE ERPVRDQELG TAVLPPLQEE QWRHLDSTQK
EQYWDLMLET YGKMVSGVAG ISNSKPDLTN LAEYGEELVG LHLHGAEKMA RLPCKEDRQE
NDKENLNLEN HRDQGCLDVF CQASGEAPPQ TALSDFFGES EPHRFGGDSV PEALENHQGE
GTGAHLFPYE RGSGKQPGQH IQSSSLGELT ALWLEEKREA SQKGQARSPM AQKLPTCREC
GKTFYRNSQL VFHQRTHTGE TYFHCHICKK AFLRSSDFVK HQRTHTGEKP CKCDYCGKGF
SDFSGLRHHE KIHTGEKPYK CPLCEKSFIQ RSNFNRHQRV HTGEKPYKCT HCGKQFSWSS
SLDKHQRSHL GKMPCP
