ID   ZNF18_RAT               Reviewed;         556 AA.
AC   Q642B9;
DT   10-JAN-2006, integrated into UniProtKB/Swiss-Prot.
DT   25-OCT-2004, sequence version 1.
DT   03-AUG-2022, entry version 128.
DE   RecName: Full=Zinc finger protein 18;
DE   AltName: Full=Zinc finger protein 535;
GN   Name=Znf18; Synonyms=Zfp18, Zfp535;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Kidney;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: May be involved in transcriptional regulation.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00187}.
CC   -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC       family. {ECO:0000305}.
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DR   EMBL; BC081874; AAH81874.1; -; mRNA.
DR   RefSeq; NP_001012008.1; NM_001012008.1.
DR   RefSeq; XP_006246757.1; XM_006246695.3.
DR   AlphaFoldDB; Q642B9; -.
DR   SMR; Q642B9; -.
DR   STRING; 10116.ENSRNOP00000005518; -.
DR   PaxDb; Q642B9; -.
DR   GeneID; 303226; -.
DR   KEGG; rno:303226; -.
DR   UCSC; RGD:1305130; rat.
DR   CTD; 303226; -.
DR   RGD; 1305130; Zfp18.
DR   VEuPathDB; HostDB:ENSRNOG00000003981; -.
DR   eggNOG; KOG1721; Eukaryota.
DR   HOGENOM; CLU_002678_49_10_1; -.
DR   InParanoid; Q642B9; -.
DR   OMA; DEPGCFE; -.
DR   OrthoDB; 1318335at2759; -.
DR   PhylomeDB; Q642B9; -.
DR   TreeFam; TF337489; -.
DR   Reactome; R-RNO-212436; Generic Transcription Pathway.
DR   PRO; PR:Q642B9; -.
DR   Proteomes; UP000002494; Chromosome 10.
DR   Bgee; ENSRNOG00000003981; Expressed in thymus and 19 other tissues.
DR   Genevisible; Q642B9; RN.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   CDD; cd07765; KRAB_A-box; 1.
DR   CDD; cd07936; SCAN; 1.
DR   Gene3D; 1.10.4020.10; -; 1.
DR   InterPro; IPR001909; KRAB.
DR   InterPro; IPR036051; KRAB_dom_sf.
DR   InterPro; IPR003309; SCAN_dom.
DR   InterPro; IPR038269; SCAN_sf.
DR   InterPro; IPR027764; Zfp18.
DR   InterPro; IPR036236; Znf_C2H2_sf.
DR   InterPro; IPR013087; Znf_C2H2_type.
DR   PANTHER; PTHR23226:SF190; PTHR23226:SF190; 1.
DR   Pfam; PF01352; KRAB; 1.
DR   Pfam; PF02023; SCAN; 1.
DR   Pfam; PF00096; zf-C2H2; 4.
DR   SMART; SM00349; KRAB; 1.
DR   SMART; SM00431; SCAN; 1.
DR   SMART; SM00355; ZnF_C2H2; 5.
DR   SUPFAM; SSF109640; SSF109640; 1.
DR   SUPFAM; SSF57667; SSF57667; 3.
DR   PROSITE; PS50805; KRAB; 1.
DR   PROSITE; PS50804; SCAN_BOX; 1.
DR   PROSITE; PS00028; ZINC_FINGER_C2H2_1; 5.
DR   PROSITE; PS50157; ZINC_FINGER_C2H2_2; 5.
PE   2: Evidence at transcript level;
KW   DNA-binding; Metal-binding; Nucleus; Reference proteome; Repeat;
KW   Transcription; Transcription regulation; Zinc; Zinc-finger.
FT   CHAIN           1..556
FT                   /note="Zinc finger protein 18"
FT                   /id="PRO_0000047342"
FT   DOMAIN          41..123
FT                   /note="SCAN box"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00187"
FT   DOMAIN          218..291
FT                   /note="KRAB"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00119"
FT   ZN_FING         415..437
FT                   /note="C2H2-type 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         443..465
FT                   /note="C2H2-type 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         471..493
FT                   /note="C2H2-type 3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         499..521
FT                   /note="C2H2-type 4"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         527..549
FT                   /note="C2H2-type 5"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   REGION          169..195
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   556 AA;  62947 MW;  81BE49E124CC8200 CRC64;
     MPVNLGQALG LLPFLAKAED ATFSGSDVIQ QRELANPETA RQLFRQFRYQ VMSGPQETLR
     QLRKLCFQWL RPEVHTKEQI LEILMLEQFL TILPGEIQMW VRKQCPGSGE EAVTLVESLK
     GDPQKLWQWI SIQVLGQEIP FEKENSARCR GDKVEPALEA EPTVEVVPQD LPLQNTSSAP
     GELLSHGVKE ESDLEPELAL AASQLPARPE ERPTRDQEVG TALLPSLQEE QWRHLDSTQK
     EQYWDLMLET YGKMVSGVAG ISNSKPDLTN MAEYGEELVG LHLHSAEKMA RAPCKEDRQE
     NDKENLNLEN HRDQGCLDVF DQAPGEAPPQ TALSDFFGES EPHHFGGESV PEALENLQGE
     GTGAHLFPHE RGSGKQLGQH IQSSSSGELS ALWLEEKREA SQKGQARAPM AQKLPTCREC
     GKTFYRNSQL VFHQRTHTGE TYFHCRICKK AFLRSSDFVK HQRTHTGEKP CKCDYCGKGF
     SDFSGLRHHE KIHTGEKPYK CPICEKSFIQ RSNFNRHQRV HTGEKPYKCT HCGKRFSWSS
     SLDKHQRSHL GKKPCP