ID   ZNF19_BOVIN             Reviewed;         453 AA.
AC   A3KN36;
DT   24-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT   03-APR-2007, sequence version 1.
DT   03-AUG-2022, entry version 111.
DE   RecName: Full=Zinc finger protein 19;
GN   Name=ZNF19;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Fetal muscle;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (FEB-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May be involved in transcriptional regulation. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC       family. {ECO:0000305}.
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DR   EMBL; BC133549; AAI33550.1; -; mRNA.
DR   RefSeq; NP_001076929.1; NM_001083460.2.
DR   AlphaFoldDB; A3KN36; -.
DR   SMR; A3KN36; -.
DR   PRIDE; A3KN36; -.
DR   Ensembl; ENSBTAT00000071499; ENSBTAP00000069685; ENSBTAG00000032018.
DR   Ensembl; ENSBTAT00000086530; ENSBTAP00000058560; ENSBTAG00000032018.
DR   GeneID; 532079; -.
DR   KEGG; bta:532079; -.
DR   CTD; 7567; -.
DR   VEuPathDB; HostDB:ENSBTAG00000032018; -.
DR   GeneTree; ENSGT00940000163278; -.
DR   HOGENOM; CLU_002678_57_1_1; -.
DR   InParanoid; A3KN36; -.
DR   OMA; PTVKNTR; -.
DR   OrthoDB; 1318335at2759; -.
DR   Reactome; R-BTA-212436; Generic Transcription Pathway.
DR   Proteomes; UP000009136; Chromosome 18.
DR   Bgee; ENSBTAG00000032018; Expressed in caput epididymis and 103 other tissues.
DR   ExpressionAtlas; A3KN36; baseline.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0001227; F:DNA-binding transcription repressor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0000977; F:RNA polymerase II transcription regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   CDD; cd07765; KRAB_A-box; 1.
DR   InterPro; IPR001909; KRAB.
DR   InterPro; IPR036051; KRAB_dom_sf.
DR   InterPro; IPR036236; Znf_C2H2_sf.
DR   InterPro; IPR013087; Znf_C2H2_type.
DR   Pfam; PF01352; KRAB; 1.
DR   Pfam; PF00096; zf-C2H2; 9.
DR   SMART; SM00349; KRAB; 1.
DR   SMART; SM00355; ZnF_C2H2; 9.
DR   SUPFAM; SSF109640; SSF109640; 1.
DR   SUPFAM; SSF57667; SSF57667; 6.
DR   PROSITE; PS50805; KRAB; 1.
DR   PROSITE; PS00028; ZINC_FINGER_C2H2_1; 9.
DR   PROSITE; PS50157; ZINC_FINGER_C2H2_2; 9.
PE   2: Evidence at transcript level;
KW   DNA-binding; Metal-binding; Nucleus; Reference proteome; Repeat;
KW   Transcription; Transcription regulation; Zinc; Zinc-finger.
FT   CHAIN           1..453
FT                   /note="Zinc finger protein 19"
FT                   /id="PRO_0000367589"
FT   DOMAIN          14..85
FT                   /note="KRAB"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00119"
FT   ZN_FING         161..183
FT                   /note="C2H2-type 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         189..211
FT                   /note="C2H2-type 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         217..239
FT                   /note="C2H2-type 3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         245..267
FT                   /note="C2H2-type 4"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         273..295
FT                   /note="C2H2-type 5"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         301..323
FT                   /note="C2H2-type 6"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         329..351
FT                   /note="C2H2-type 7"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         357..379
FT                   /note="C2H2-type 8"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         383..405
FT                   /note="C2H2-type 9"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
SQ   SEQUENCE   453 AA;  52478 MW;  ED11E3D8AF8A3200 CRC64;
     MAVMPLKVWH QEVVTFEDVA VYFTRTEWAG LSPAQRALYR SVMLEIYRSL TSLGYPVPKP
     ALISLLERGD LPVGLETQDN PPAQGTRDIY KNSRTHMDSE LTPTWGISEE RDLMMSHGPQ
     KNVLNKSSFL ETCELEQHQE IPTVKNIRGK VLRIHYDRKP FRCEECGKCF SYFSYYVRHQ
     RIHTGEKPFE CNECGKAFNG NSSLIRHQRI HTGEKPYQCE ECGRAFNDNA NLIRHQRIHS
     GDRPYLCREC GNGFTSSSEF IIHQRIHTGE KPYECNECGK AFVGNSPLLR HQKIHTGEKP
     YECNECGKSF GRTSHLSQHQ RIHTGEKPYS CTICGQAFNF HTKLTRHQRV HSEVKPFDCI
     CCGKVFSTQA QLKRHLRIHI QETSCDECGK VFTSKRNLLQ HQRVHTRKKP REYVKYEKTF
     RTSSQLDCAH PGEKPVLDVG CFGLPEFFTP FYW