ZNF19_HUMAN
ID ZNF19_HUMAN Reviewed; 458 AA.
AC P17023; A8K895; Q86Y66; Q8NDE2; Q96M79; Q96NE5;
DT 01-AUG-1990, integrated into UniProtKB/Swiss-Prot.
DT 24-MAR-2009, sequence version 4.
DT 03-AUG-2022, entry version 203.
DE RecName: Full=Zinc finger protein 19;
DE AltName: Full=Zinc finger protein KOX12;
GN Name=ZNF19; Synonyms=KOX12;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), AND VARIANTS
RP HIS-218 AND GLN-224.
RC TISSUE=Lung, and Testis;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15616553; DOI=10.1038/nature03187;
RA Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G.,
RA Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E.,
RA Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J., Buckingham J.M.,
RA Callen D.F., Campbell C.S., Campbell M.L., Campbell E.W., Caoile C.,
RA Challacombe J.F., Chasteen L.A., Chertkov O., Chi H.C., Christensen M.,
RA Clark L.M., Cohn J.D., Denys M., Detter J.C., Dickson M.,
RA Dimitrijevic-Bussod M., Escobar J., Fawcett J.J., Flowers D., Fotopulos D.,
RA Glavina T., Gomez M., Gonzales E., Goodstein D., Goodwin L.A., Grady D.L.,
RA Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E.,
RA Huang W., Israni S., Jett J., Jewett P.B., Kadner K., Kimball H.,
RA Kobayashi A., Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y.,
RA Lowry S., Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J.,
RA Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D.,
RA Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., Rash S.,
RA Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., Salamov A.,
RA Saunders E.H., Scott D., Shough T., Stallings R.L., Stalvey M.,
RA Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H.,
RA Torney D.C., Tran-Gyamfi M., Tsai M., Ulanovsky L.E., Ustaszewska A.,
RA Vo N., White P.S., Williams A.L., Wills P.L., Wu J.-R., Wu K., Yang J.,
RA DeJong P., Bruce D., Doggett N.A., Deaven L., Schmutz J., Grimwood J.,
RA Richardson P., Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M.,
RA Myers R.M., Rubin E.M., Pennacchio L.A.;
RT "The sequence and analysis of duplication-rich human chromosome 16.";
RL Nature 432:988-994(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), AND VARIANT HIS-218.
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 120-458 (ISOFORMS 1/2), AND
RP VARIANT HIS-218.
RC TISSUE=Brain;
RX PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D.,
RA Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A.,
RA Wiemann S., Schupp I.;
RT "The full-ORF clone resource of the German cDNA consortium.";
RL BMC Genomics 8:399-399(2007).
RN [5]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 270-334 (ISOFORMS 1/2).
RC TISSUE=Placenta;
RX PubMed=1946370; DOI=10.1073/pnas.88.21.9563;
RA Bray P.L., Lichter P., Thiesen H.-J., Ward D.C., Dawid I.B.;
RT "Characterization and mapping of human genes encoding zinc finger
RT proteins.";
RL Proc. Natl. Acad. Sci. U.S.A. 88:9563-9567(1991).
RN [6]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 273-328 (ISOFORMS 1/2).
RC TISSUE=Lymphoid tissue;
RX PubMed=2288909;
RA Thiesen H.-J.;
RT "Multiple genes encoding zinc finger domains are expressed in human T
RT cells.";
RL New Biol. 2:363-374(1990).
CC -!- FUNCTION: May be involved in transcriptional regulation.
CC -!- INTERACTION:
CC P17023; Q9BXS5: AP1M1; NbExp=3; IntAct=EBI-12884200, EBI-541426;
CC P17023; Q8N5M1: ATPAF2; NbExp=3; IntAct=EBI-12884200, EBI-1166928;
CC P17023; Q9P287: BCCIP; NbExp=3; IntAct=EBI-12884200, EBI-711154;
CC P17023; Q9BXY8: BEX2; NbExp=3; IntAct=EBI-12884200, EBI-745073;
CC P17023; Q9H257-2: CARD9; NbExp=3; IntAct=EBI-12884200, EBI-11530605;
CC P17023; Q86X02: CDR2L; NbExp=3; IntAct=EBI-12884200, EBI-11063830;
CC P17023; Q96Q77: CIB3; NbExp=3; IntAct=EBI-12884200, EBI-10292696;
CC P17023; Q9BW66: CINP; NbExp=3; IntAct=EBI-12884200, EBI-739784;
CC P17023; P67870: CSNK2B; NbExp=3; IntAct=EBI-12884200, EBI-348169;
CC P17023; Q9UI47-2: CTNNA3; NbExp=3; IntAct=EBI-12884200, EBI-11962928;
CC P17023; Q6L9T8: FAM72D; NbExp=3; IntAct=EBI-12884200, EBI-18397873;
CC P17023; P14136: GFAP; NbExp=3; IntAct=EBI-12884200, EBI-744302;
CC P17023; Q9NSC5: HOMER3; NbExp=3; IntAct=EBI-12884200, EBI-748420;
CC P17023; P42858: HTT; NbExp=3; IntAct=EBI-12884200, EBI-466029;
CC P17023; Q8WXH2: JPH3; NbExp=3; IntAct=EBI-12884200, EBI-1055254;
CC P17023; P25800: LMO1; NbExp=3; IntAct=EBI-12884200, EBI-8639312;
CC P17023; P25791-3: LMO2; NbExp=3; IntAct=EBI-12884200, EBI-11959475;
CC P17023; Q96A72: MAGOHB; NbExp=3; IntAct=EBI-12884200, EBI-746778;
CC P17023; O14561: NDUFAB1; NbExp=3; IntAct=EBI-12884200, EBI-1246261;
CC P17023; P19404: NDUFV2; NbExp=3; IntAct=EBI-12884200, EBI-713665;
CC P17023; Q9BRQ3: NUDT22; NbExp=3; IntAct=EBI-12884200, EBI-10297093;
CC P17023; P40937: RFC5; NbExp=5; IntAct=EBI-12884200, EBI-712376;
CC P17023; Q9BWG6: SCNM1; NbExp=3; IntAct=EBI-12884200, EBI-748391;
CC P17023; Q5MJ10: SPANXN2; NbExp=3; IntAct=EBI-12884200, EBI-12023934;
CC P17023; O75558: STX11; NbExp=3; IntAct=EBI-12884200, EBI-714135;
CC P17023; Q8TAU3: ZNF417; NbExp=3; IntAct=EBI-12884200, EBI-740727;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=P17023-1; Sequence=Displayed;
CC Name=2;
CC IsoId=P17023-2; Sequence=VSP_036733;
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAA36814.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AK055567; BAB70957.1; -; mRNA.
DR EMBL; AK057330; BAB71430.1; -; mRNA.
DR EMBL; AK292260; BAF84949.1; -; mRNA.
DR EMBL; AC010547; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC047091; AAH47091.1; -; mRNA.
DR EMBL; AL834237; CAD38915.1; -; mRNA.
DR EMBL; M77171; AAA36814.1; ALT_INIT; Genomic_DNA.
DR EMBL; X52343; CAA36569.1; -; mRNA.
DR CCDS; CCDS10901.1; -. [P17023-1]
DR PIR; B56409; B56409.
DR RefSeq; NP_008892.2; NM_006961.3. [P17023-1]
DR AlphaFoldDB; P17023; -.
DR SMR; P17023; -.
DR BioGRID; 113398; 30.
DR IntAct; P17023; 29.
DR STRING; 9606.ENSP00000288177; -.
DR iPTMnet; P17023; -.
DR PhosphoSitePlus; P17023; -.
DR BioMuta; ZNF19; -.
DR DMDM; 229485313; -.
DR jPOST; P17023; -.
DR MassIVE; P17023; -.
DR MaxQB; P17023; -.
DR PaxDb; P17023; -.
DR PeptideAtlas; P17023; -.
DR PRIDE; P17023; -.
DR ProteomicsDB; 53422; -. [P17023-1]
DR ProteomicsDB; 53423; -. [P17023-2]
DR Antibodypedia; 16592; 172 antibodies from 21 providers.
DR DNASU; 7567; -.
DR Ensembl; ENST00000288177.10; ENSP00000288177.5; ENSG00000157429.16. [P17023-1]
DR Ensembl; ENST00000564230.5; ENSP00000458105.1; ENSG00000157429.16. [P17023-1]
DR GeneID; 7567; -.
DR KEGG; hsa:7567; -.
DR MANE-Select; ENST00000288177.10; ENSP00000288177.5; NM_006961.4; NP_008892.2.
DR UCSC; uc002fam.2; human. [P17023-1]
DR CTD; 7567; -.
DR DisGeNET; 7567; -.
DR GeneCards; ZNF19; -.
DR HGNC; HGNC:12981; ZNF19.
DR HPA; ENSG00000157429; Low tissue specificity.
DR MIM; 194525; gene.
DR neXtProt; NX_P17023; -.
DR OpenTargets; ENSG00000157429; -.
DR PharmGKB; PA37562; -.
DR VEuPathDB; HostDB:ENSG00000157429; -.
DR eggNOG; KOG1721; Eukaryota.
DR GeneTree; ENSGT00940000163278; -.
DR HOGENOM; CLU_002678_44_0_1; -.
DR InParanoid; P17023; -.
DR OMA; PTVKNTR; -.
DR OrthoDB; 1318335at2759; -.
DR PhylomeDB; P17023; -.
DR TreeFam; TF350808; -.
DR PathwayCommons; P17023; -.
DR Reactome; R-HSA-212436; Generic Transcription Pathway.
DR SignaLink; P17023; -.
DR BioGRID-ORCS; 7567; 8 hits in 1082 CRISPR screens.
DR ChiTaRS; ZNF19; human.
DR GeneWiki; ZNF19; -.
DR GenomeRNAi; 7567; -.
DR Pharos; P17023; Tdark.
DR PRO; PR:P17023; -.
DR Proteomes; UP000005640; Chromosome 16.
DR RNAct; P17023; protein.
DR Bgee; ENSG00000157429; Expressed in right uterine tube and 123 other tissues.
DR ExpressionAtlas; P17023; baseline and differential.
DR Genevisible; P17023; HS.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0001227; F:DNA-binding transcription repressor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000977; F:RNA polymerase II transcription regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd07765; KRAB_A-box; 1.
DR InterPro; IPR001909; KRAB.
DR InterPro; IPR036051; KRAB_dom_sf.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF01352; KRAB; 1.
DR Pfam; PF00096; zf-C2H2; 9.
DR SMART; SM00349; KRAB; 1.
DR SMART; SM00355; ZnF_C2H2; 9.
DR SUPFAM; SSF109640; SSF109640; 1.
DR SUPFAM; SSF57667; SSF57667; 5.
DR PROSITE; PS50805; KRAB; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 9.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 10.
PE 1: Evidence at protein level;
KW Alternative splicing; DNA-binding; Metal-binding; Nucleus;
KW Reference proteome; Repeat; Transcription; Transcription regulation; Zinc;
KW Zinc-finger.
FT CHAIN 1..458
FT /note="Zinc finger protein 19"
FT /id="PRO_0000047343"
FT DOMAIN 14..85
FT /note="KRAB"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00119"
FT ZN_FING 161..183
FT /note="C2H2-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 189..211
FT /note="C2H2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 217..239
FT /note="C2H2-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 245..267
FT /note="C2H2-type 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 273..295
FT /note="C2H2-type 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 301..323
FT /note="C2H2-type 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 329..351
FT /note="C2H2-type 7"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 357..379
FT /note="C2H2-type 8"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 385..407
FT /note="C2H2-type 9"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 413..433
FT /note="C2H2-type 10; atypical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT VAR_SEQ 1..12
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_036733"
FT VARIANT 218
FT /note="Q -> H (in dbSNP:rs8050871)"
FT /evidence="ECO:0000269|PubMed:14702039,
FT ECO:0000269|PubMed:15489334, ECO:0000269|PubMed:17974005"
FT /id="VAR_054792"
FT VARIANT 224
FT /note="R -> Q (in dbSNP:rs10500557)"
FT /evidence="ECO:0000269|PubMed:14702039"
FT /id="VAR_054793"
FT CONFLICT 34
FT /note="A -> V (in Ref. 3; AAH47091)"
FT /evidence="ECO:0000305"
FT CONFLICT 120
FT /note="L -> V (in Ref. 4; CAD38915)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 458 AA; 52449 MW; C53350D55D969A0C CRC64;
MAAMPLKAQY QEMVTFEDVA VHFTKTEWTG LSPAQRALYR SVMLENFGNL TALGYPVPKP
ALISLLERGD MAWGLEAQDD PPAERTKNVC KDVETNIDSE STLIQGISEE RDGMMSHGQL
KSVPQRTDFP ETRNVEKHQD IPTVKNIQGK VPRIPCARKP FICEECGKSF SYFSYYARHQ
RIHTGEKPFE CSECGKAFNG NSSLIRHQRI HTGERPYQCE ECGRAFNDNA NLIRHQRIHS
GDRPYYCTEC GNSFTSSSEF VIHQRIHTGE KPYECNECGK AFVGNSPLLR HQKIHTGEKP
YECNECGKSF GRTSHLSQHQ RIHTGEKPYS CKVCGQAFNF HTKLTRHQRI HSEEKPFDCV
DCGKAFSAQE QLKRHLRIHT QESSYVCDEC GKALTSKRNL HQHQRIHTGE KPYECSKYEK
AFGTSSQLGH LEHVYSGEKP VLDICRFGLP EFFTPFYW
