ZNF20_HUMAN
ID ZNF20_HUMAN Reviewed; 532 AA.
AC P17024; Q8N457; Q9UG41;
DT 01-AUG-1990, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2000, sequence version 2.
DT 03-AUG-2022, entry version 199.
DE RecName: Full=Zinc finger protein 20;
DE AltName: Full=Zinc finger protein KOX13;
GN Name=ZNF20; Synonyms=KOX13;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D.,
RA Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A.,
RA Wiemann S., Schupp I.;
RT "The full-ORF clone resource of the German cDNA consortium.";
RL BMC Genomics 8:399-399(2007).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=B-cell;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 227-282.
RX PubMed=2288909;
RA Thiesen H.-J.;
RT "Multiple genes encoding zinc finger domains are expressed in human T
RT cells.";
RL New Biol. 2:363-374(1990).
CC -!- FUNCTION: May be involved in transcriptional regulation.
CC -!- INTERACTION:
CC P17024; P68133: ACTA1; NbExp=3; IntAct=EBI-717634, EBI-367510;
CC P17024; Q9NZD4: AHSP; NbExp=3; IntAct=EBI-717634, EBI-720250;
CC P17024; P13637: ATP1A3; NbExp=3; IntAct=EBI-717634, EBI-948169;
CC P17024; Q9NX04: C1orf109; NbExp=3; IntAct=EBI-717634, EBI-8643161;
CC P17024; Q9H257-2: CARD9; NbExp=3; IntAct=EBI-717634, EBI-11530605;
CC P17024; Q68D86: CCDC102B; NbExp=6; IntAct=EBI-717634, EBI-10171570;
CC P17024; Q96JN2-2: CCDC136; NbExp=3; IntAct=EBI-717634, EBI-10171416;
CC P17024; O95273: CCNDBP1; NbExp=6; IntAct=EBI-717634, EBI-748961;
CC P17024; Q8NHQ1: CEP70; NbExp=3; IntAct=EBI-717634, EBI-739624;
CC P17024; Q9BSW2: CRACR2A; NbExp=3; IntAct=EBI-717634, EBI-739773;
CC P17024; G5E9A7: DMWD; NbExp=3; IntAct=EBI-717634, EBI-10976677;
CC P17024; A1L4K1: FSD2; NbExp=3; IntAct=EBI-717634, EBI-5661036;
CC P17024; P55040: GEM; NbExp=3; IntAct=EBI-717634, EBI-744104;
CC P17024; P14136: GFAP; NbExp=3; IntAct=EBI-717634, EBI-744302;
CC P17024; A6NEM1: GOLGA6L9; NbExp=3; IntAct=EBI-717634, EBI-5916454;
CC P17024; Q9Y4H4: GPSM3; NbExp=3; IntAct=EBI-717634, EBI-347538;
CC P17024; Q8WXH2: JPH3; NbExp=3; IntAct=EBI-717634, EBI-1055254;
CC P17024; Q9BVG8: KIFC3; NbExp=3; IntAct=EBI-717634, EBI-2125614;
CC P17024; Q9BVG8-5: KIFC3; NbExp=3; IntAct=EBI-717634, EBI-14069005;
CC P17024; Q15323: KRT31; NbExp=3; IntAct=EBI-717634, EBI-948001;
CC P17024; O76015: KRT38; NbExp=3; IntAct=EBI-717634, EBI-1047263;
CC P17024; Q6A162: KRT40; NbExp=3; IntAct=EBI-717634, EBI-10171697;
CC P17024; P60370: KRTAP10-5; NbExp=3; IntAct=EBI-717634, EBI-10172150;
CC P17024; P60409: KRTAP10-7; NbExp=3; IntAct=EBI-717634, EBI-10172290;
CC P17024; P60410: KRTAP10-8; NbExp=6; IntAct=EBI-717634, EBI-10171774;
CC P17024; P60411: KRTAP10-9; NbExp=3; IntAct=EBI-717634, EBI-10172052;
CC P17024; P60328: KRTAP12-3; NbExp=3; IntAct=EBI-717634, EBI-11953334;
CC P17024; Q9BQ66: KRTAP4-12; NbExp=3; IntAct=EBI-717634, EBI-739863;
CC P17024; Q9BYR5: KRTAP4-2; NbExp=3; IntAct=EBI-717634, EBI-10172511;
CC P17024; Q9BYQ4: KRTAP9-2; NbExp=3; IntAct=EBI-717634, EBI-1044640;
CC P17024; P02545: LMNA; NbExp=3; IntAct=EBI-717634, EBI-351935;
CC P17024; Q9BRK4: LZTS2; NbExp=3; IntAct=EBI-717634, EBI-741037;
CC P17024; Q5JR59: MTUS2; NbExp=3; IntAct=EBI-717634, EBI-742948;
CC P17024; Q5JR59-3: MTUS2; NbExp=3; IntAct=EBI-717634, EBI-11522433;
CC P17024; P35240: NF2; NbExp=3; IntAct=EBI-717634, EBI-1014472;
CC P17024; P16284: PECAM1; NbExp=3; IntAct=EBI-717634, EBI-716404;
CC P17024; P20339: RAB5A; NbExp=3; IntAct=EBI-717634, EBI-399437;
CC P17024; Q9BWG6: SCNM1; NbExp=3; IntAct=EBI-717634, EBI-748391;
CC P17024; O94964-4: SOGA1; NbExp=3; IntAct=EBI-717634, EBI-14083835;
CC P17024; Q7Z699: SPRED1; NbExp=3; IntAct=EBI-717634, EBI-5235340;
CC P17024; Q8WW24: TEKT4; NbExp=3; IntAct=EBI-717634, EBI-750487;
CC P17024; Q13077: TRAF1; NbExp=6; IntAct=EBI-717634, EBI-359224;
CC P17024; P36406: TRIM23; NbExp=3; IntAct=EBI-717634, EBI-740098;
CC P17024; Q8N3L3: TXLNB; NbExp=3; IntAct=EBI-717634, EBI-6116822;
CC P17024; P08670: VIM; NbExp=3; IntAct=EBI-717634, EBI-353844;
CC P17024; B2RUY7: VWC2L; NbExp=3; IntAct=EBI-717634, EBI-11747707;
CC P17024; Q96DN2: VWCE; NbExp=3; IntAct=EBI-717634, EBI-2850497;
CC P17024; P54577: YARS1; NbExp=3; IntAct=EBI-717634, EBI-1048893;
CC P17024; Q8TAU3: ZNF417; NbExp=3; IntAct=EBI-717634, EBI-740727;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. {ECO:0000305}.
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DR EMBL; AL080125; CAB45723.2; -; mRNA.
DR EMBL; CH471106; EAW84260.1; -; Genomic_DNA.
DR EMBL; BC036714; AAH36714.3; -; mRNA.
DR EMBL; X52344; CAA36570.1; -; mRNA.
DR CCDS; CCDS45986.1; -.
DR PIR; T12489; T12489.
DR RefSeq; NP_066966.2; NM_021143.3.
DR AlphaFoldDB; P17024; -.
DR SMR; P17024; -.
DR BioGRID; 113399; 42.
DR IntAct; P17024; 52.
DR MINT; P17024; -.
DR STRING; 9606.ENSP00000335437; -.
DR iPTMnet; P17024; -.
DR PhosphoSitePlus; P17024; -.
DR BioMuta; ZNF20; -.
DR DMDM; 12643268; -.
DR MassIVE; P17024; -.
DR MaxQB; P17024; -.
DR PaxDb; P17024; -.
DR PeptideAtlas; P17024; -.
DR PRIDE; P17024; -.
DR ProteomicsDB; 53424; -.
DR Antibodypedia; 6988; 73 antibodies from 18 providers.
DR DNASU; 7568; -.
DR Ensembl; ENST00000334213.10; ENSP00000335437.5; ENSG00000132010.16.
DR GeneID; 7568; -.
DR KEGG; hsa:7568; -.
DR MANE-Select; ENST00000334213.10; ENSP00000335437.5; NM_021143.4; NP_066966.2.
DR UCSC; uc002mtf.3; human.
DR CTD; 7568; -.
DR DisGeNET; 7568; -.
DR GeneCards; ZNF20; -.
DR HGNC; HGNC:12992; ZNF20.
DR HPA; ENSG00000132010; Low tissue specificity.
DR MIM; 194557; gene.
DR neXtProt; NX_P17024; -.
DR PharmGKB; PA37572; -.
DR VEuPathDB; HostDB:ENSG00000132010; -.
DR eggNOG; KOG1721; Eukaryota.
DR GeneTree; ENSGT00940000164761; -.
DR HOGENOM; CLU_002678_44_3_1; -.
DR InParanoid; P17024; -.
DR OMA; QSHDEAC; -.
DR OrthoDB; 1318335at2759; -.
DR PhylomeDB; P17024; -.
DR TreeFam; TF338854; -.
DR PathwayCommons; P17024; -.
DR Reactome; R-HSA-212436; Generic Transcription Pathway.
DR SignaLink; P17024; -.
DR BioGRID-ORCS; 7568; 16 hits in 1087 CRISPR screens.
DR GenomeRNAi; 7568; -.
DR Pharos; P17024; Tdark.
DR PRO; PR:P17024; -.
DR Proteomes; UP000005640; Chromosome 19.
DR RNAct; P17024; protein.
DR Bgee; ENSG00000132010; Expressed in sural nerve and 100 other tissues.
DR ExpressionAtlas; P17024; baseline and differential.
DR Genevisible; P17024; HS.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0001227; F:DNA-binding transcription repressor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000977; F:RNA polymerase II transcription regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd07765; KRAB_A-box; 1.
DR InterPro; IPR001909; KRAB.
DR InterPro; IPR036051; KRAB_dom_sf.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF01352; KRAB; 1.
DR Pfam; PF00096; zf-C2H2; 5.
DR SMART; SM00349; KRAB; 1.
DR SMART; SM00355; ZnF_C2H2; 14.
DR SUPFAM; SSF109640; SSF109640; 1.
DR SUPFAM; SSF57667; SSF57667; 8.
DR PROSITE; PS50805; KRAB; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 11.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 15.
PE 1: Evidence at protein level;
KW DNA-binding; Metal-binding; Nucleus; Reference proteome; Repeat;
KW Transcription; Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1..532
FT /note="Zinc finger protein 20"
FT /id="PRO_0000047344"
FT DOMAIN 7..78
FT /note="KRAB"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00119"
FT ZN_FING 103..130
FT /note="C2H2-type 1; atypical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 143..165
FT /note="C2H2-type 2; degenerate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 171..193
FT /note="C2H2-type 3; degenerate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 199..221
FT /note="C2H2-type 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 227..249
FT /note="C2H2-type 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 255..277
FT /note="C2H2-type 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 283..305
FT /note="C2H2-type 7"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 311..333
FT /note="C2H2-type 8"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 339..361
FT /note="C2H2-type 9"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 367..389
FT /note="C2H2-type 10"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 395..417
FT /note="C2H2-type 11"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 423..445
FT /note="C2H2-type 12"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 451..473
FT /note="C2H2-type 13"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 479..500
FT /note="C2H2-type 14"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 506..528
FT /note="C2H2-type 15"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
SQ SEQUENCE 532 AA; 61567 MW; C92473E875FCAA42 CRC64;
MMFQDSVAFE DVAVSFTQEE WALLDPSQKN LYRDVMQETF KNLTSVGKTW KVQNIEDEYK
NPRRNLSLMR EKLCESKESH HCGESFNQIA DDMLNRKTLP GITPCESSVC GEVGTGHSSL
NTHIRADTGH KSSEYQEYGE NPYRNKECKK AFSYLDSFQS HDKACTKEKP YDGKECTETF
ISHSCIQRHR VMHSGDGPYK CKFCGKAFYF LNLCLIHERI HTGVKPYKCK QCGKAFTRST
TLPVHERTHT GVNADECKEC GNAFSFPSEI RRHKRSHTGE KPYECKQCGK VFISFSSIQY
HKMTHTGEKP YECKQCGKAF RCGSHLQKHG RTHTGEKPYE CRQCGKAFRC TSDLQRHEKT
HTEDKPYGCK QCGKGFRCAS QLQIHERTHS GEKPHECKEC GKVFKYFSSL RIHERTHTGE
KPHECKQCGK AFRYFSSLHI HERTHTGDKP YECKVCGKAF TCSSSIRYHE RTHTGEKPYE
CKHCGKAFIS NYIRYHERTH TGEKPYQCKQ CGKAFIRASS CREHERTHTI NR
