ID   ZNF22_BOVIN             Reviewed;         225 AA.
AC   Q1LZC0;
DT   01-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   30-MAY-2006, sequence version 1.
DT   03-AUG-2022, entry version 94.
DE   RecName: Full=Zinc finger protein 22;
GN   Name=ZNF22;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Ascending colon;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (MAY-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Binds DNA through the consensus sequence 5'-CAATG-3'. May be
CC       involved in transcriptional regulation and may play a role in tooth
CC       formation (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC       family. {ECO:0000305}.
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DR   EMBL; BC116093; AAI16094.1; -; mRNA.
DR   RefSeq; NP_001070576.1; NM_001077108.1.
DR   AlphaFoldDB; Q1LZC0; -.
DR   SMR; Q1LZC0; -.
DR   PRIDE; Q1LZC0; -.
DR   Ensembl; ENSBTAT00000052457; ENSBTAP00000059027; ENSBTAG00000037913.
DR   GeneID; 768051; -.
DR   KEGG; bta:768051; -.
DR   CTD; 7570; -.
DR   VEuPathDB; HostDB:ENSBTAG00000037913; -.
DR   GeneTree; ENSGT01050000244959; -.
DR   InParanoid; Q1LZC0; -.
DR   OMA; QKWGVTI; -.
DR   OrthoDB; 1318335at2759; -.
DR   Proteomes; UP000009136; Chromosome 28.
DR   Bgee; ENSBTAG00000037913; Expressed in oocyte and 106 other tissues.
DR   GO; GO:0005654; C:nucleoplasm; IBA:GO_Central.
DR   GO; GO:0001227; F:DNA-binding transcription repressor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   InterPro; IPR036236; Znf_C2H2_sf.
DR   InterPro; IPR013087; Znf_C2H2_type.
DR   Pfam; PF00096; zf-C2H2; 5.
DR   SMART; SM00355; ZnF_C2H2; 5.
DR   SUPFAM; SSF57667; SSF57667; 3.
DR   PROSITE; PS00028; ZINC_FINGER_C2H2_1; 5.
DR   PROSITE; PS50157; ZINC_FINGER_C2H2_2; 5.
PE   2: Evidence at transcript level;
KW   Acetylation; DNA-binding; Metal-binding; Nucleus; Reference proteome;
KW   Repeat; Transcription; Transcription regulation; Zinc; Zinc-finger.
FT   CHAIN           1..225
FT                   /note="Zinc finger protein 22"
FT                   /id="PRO_0000285815"
FT   ZN_FING         55..77
FT                   /note="C2H2-type 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         83..105
FT                   /note="C2H2-type 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         111..133
FT                   /note="C2H2-type 3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         139..161
FT                   /note="C2H2-type 4"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         167..189
FT                   /note="C2H2-type 5"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   REGION          1..35
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          183..225
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        183..198
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         18
FT                   /note="N6-acetyllysine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9ERU3"
SQ   SEQUENCE   225 AA;  26077 MW;  6FE57A70CE110481 CRC64;
     MRLGKPKGGI SRSSSQGKVY ENQRKTGRQR QRWGMTVRFD SSLRRLRRGL DEKPYKCVEC
     EKSFSQSSTL FQHQKIHTGK KSHKCADCGK SFFQSSNLIQ HRRVHTGEKP YRCDECGERF
     KQSSNLIQHQ RIHTGEKPYQ CDECGRCFSQ SSHLIQHQRT HTGEKPYQCS ECGKCFSQSS
     HLRQHTKVHE EEKPRKTRGR SLRAKTHSLS SWKAGKGRRS AAGLR