ZNF22_HUMAN
ID ZNF22_HUMAN Reviewed; 224 AA.
AC P17026; Q5T741; Q96FM4;
DT 01-AUG-1990, integrated into UniProtKB/Swiss-Prot.
DT 02-MAY-2002, sequence version 3.
DT 03-AUG-2022, entry version 203.
DE RecName: Full=Zinc finger protein 22;
DE AltName: Full=Zinc finger protein KOX15;
DE AltName: Full=Zinc finger protein Krox-26;
GN Name=ZNF22; Synonyms=KOX15, KROX26;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=1421376;
RA Wu B.Y., Hanley E.W., Turka L.A., Nabel G.J.;
RT "Isolation of a cDNA clone encoding a zinc finger protein highly expressed
RT in T-leukemia lines.";
RL Blood 80:2571-2576(1992).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RX PubMed=14630903; DOI=10.1177/154405910308201213;
RA Gao Y., Kobayashi H., Ganss B.;
RT "The human KROX-26/ZNF22 gene is expressed at sites of tooth formation and
RT maps to the locus for permanent tooth agenesis (He-Zhao deficiency).";
RL J. Dent. Res. 82:1002-1007(2003).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S.,
RA Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y.,
RA Phelan M., Farmer A.;
RT "Cloning of human full-length CDSs in BD Creator(TM) system donor vector.";
RL Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15164054; DOI=10.1038/nature02462;
RA Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L.,
RA Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K.,
RA Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L.,
RA Taylor A., Battles J., Bird C.P., Ainscough R., Almeida J.P.,
RA Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J.,
RA Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y.,
RA Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P.,
RA Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N.,
RA Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A.,
RA Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C.,
RA Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D.,
RA Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C.,
RA Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K.,
RA Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A.,
RA Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S.,
RA McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S.,
RA Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V.,
RA Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A.,
RA Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M.,
RA Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A.,
RA Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P.,
RA Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y.,
RA Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D.,
RA Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.;
RT "The DNA sequence and comparative analysis of human chromosome 10.";
RL Nature 429:375-381(2004).
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [7]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Blood, Brain, and Colon;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [8]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 132-224.
RC TISSUE=Placenta;
RX PubMed=1946370; DOI=10.1073/pnas.88.21.9563;
RA Bray P.L., Lichter P., Thiesen H.-J., Ward D.C., Dawid I.B.;
RT "Characterization and mapping of human genes encoding zinc finger
RT proteins.";
RL Proc. Natl. Acad. Sci. U.S.A. 88:9563-9567(1991).
RN [9]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 139-194.
RC TISSUE=Lymphoid tissue;
RX PubMed=2288909;
RA Thiesen H.-J.;
RT "Multiple genes encoding zinc finger domains are expressed in human T
RT cells.";
RL New Biol. 2:363-374(1990).
RN [10]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-49, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Liver;
RX PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014;
RA Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L.,
RA Ye M., Zou H.;
RT "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver
RT phosphoproteome.";
RL J. Proteomics 96:253-262(2014).
RN [11]
RP VARIANT [LARGE SCALE ANALYSIS] LEU-129.
RX PubMed=16959974; DOI=10.1126/science.1133427;
RA Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D.,
RA Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P.,
RA Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V.,
RA Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H.,
RA Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W.,
RA Velculescu V.E.;
RT "The consensus coding sequences of human breast and colorectal cancers.";
RL Science 314:268-274(2006).
CC -!- FUNCTION: Binds DNA through the consensus sequence 5'-CAATG-3'. May be
CC involved in transcriptional regulation and may play a role in tooth
CC formation (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC -!- TISSUE SPECIFICITY: In the embryo, expressed in developing craniofacial
CC structures including dental epithelium of maxillary molar tooth organs,
CC tongue epithelium and muscle, and craniofacial bone osteoblasts. In the
CC adult, expressed in mesoderm-derived tissues such as skeletal muscle,
CC heart, kidney and liver. Intermediate expression in spleen, thymus and
CC brain. Low levels in endoderm-derived tissues such as intestine and
CC colon. {ECO:0000269|PubMed:14630903}.
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. {ECO:0000305}.
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DR EMBL; S50223; AAB24264.2; -; mRNA.
DR EMBL; AY137767; AAN15804.1; -; Genomic_DNA.
DR EMBL; BT009806; AAP88808.1; -; mRNA.
DR EMBL; AK291508; BAF84197.1; -; mRNA.
DR EMBL; AL353801; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471160; EAW86632.1; -; Genomic_DNA.
DR EMBL; BC010642; AAH10642.1; -; mRNA.
DR EMBL; BC041139; AAH41139.1; -; mRNA.
DR EMBL; BC053687; AAH53687.1; -; mRNA.
DR EMBL; M77172; AAA36815.1; -; Genomic_DNA.
DR EMBL; X52346; CAA36572.1; -; mRNA.
DR CCDS; CCDS7211.1; -.
DR PIR; A48927; A48927.
DR RefSeq; NP_008894.2; NM_006963.4.
DR AlphaFoldDB; P17026; -.
DR SMR; P17026; -.
DR BioGRID; 113401; 110.
DR IntAct; P17026; 25.
DR MINT; P17026; -.
DR STRING; 9606.ENSP00000298299; -.
DR iPTMnet; P17026; -.
DR PhosphoSitePlus; P17026; -.
DR BioMuta; ZNF22; -.
DR DMDM; 20455530; -.
DR EPD; P17026; -.
DR jPOST; P17026; -.
DR MassIVE; P17026; -.
DR PaxDb; P17026; -.
DR PeptideAtlas; P17026; -.
DR PRIDE; P17026; -.
DR ProteomicsDB; 53427; -.
DR Antibodypedia; 13486; 72 antibodies from 19 providers.
DR DNASU; 7570; -.
DR Ensembl; ENST00000298299.4; ENSP00000298299.3; ENSG00000165512.5.
DR GeneID; 7570; -.
DR KEGG; hsa:7570; -.
DR MANE-Select; ENST00000298299.4; ENSP00000298299.3; NM_006963.5; NP_008894.2.
DR UCSC; uc001jbw.4; human.
DR CTD; 7570; -.
DR DisGeNET; 7570; -.
DR GeneCards; ZNF22; -.
DR HGNC; HGNC:13012; ZNF22.
DR HPA; ENSG00000165512; Low tissue specificity.
DR MIM; 194529; gene.
DR neXtProt; NX_P17026; -.
DR OpenTargets; ENSG00000165512; -.
DR PharmGKB; PA37591; -.
DR VEuPathDB; HostDB:ENSG00000165512; -.
DR eggNOG; KOG1721; Eukaryota.
DR GeneTree; ENSGT01050000244959; -.
DR HOGENOM; CLU_002678_21_0_1; -.
DR InParanoid; P17026; -.
DR OMA; QKWGVTI; -.
DR OrthoDB; 1318335at2759; -.
DR PhylomeDB; P17026; -.
DR TreeFam; TF350836; -.
DR PathwayCommons; P17026; -.
DR SignaLink; P17026; -.
DR BioGRID-ORCS; 7570; 14 hits in 1107 CRISPR screens.
DR ChiTaRS; ZNF22; human.
DR GeneWiki; ZNF22; -.
DR GenomeRNAi; 7570; -.
DR Pharos; P17026; Tbio.
DR PRO; PR:P17026; -.
DR Proteomes; UP000005640; Chromosome 10.
DR RNAct; P17026; protein.
DR Bgee; ENSG00000165512; Expressed in ventricular zone and 206 other tissues.
DR ExpressionAtlas; P17026; baseline and differential.
DR Genevisible; P17026; HS.
DR GO; GO:0005654; C:nucleoplasm; IDA:HPA.
DR GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR GO; GO:0003677; F:DNA binding; ISS:UniProtKB.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0000977; F:RNA polymerase II transcription regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0008270; F:zinc ion binding; TAS:ProtInc.
DR GO; GO:0042476; P:odontogenesis; NAS:UniProtKB.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; NAS:UniProtKB.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF00096; zf-C2H2; 5.
DR SMART; SM00355; ZnF_C2H2; 5.
DR SUPFAM; SSF57667; SSF57667; 3.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 5.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 5.
PE 1: Evidence at protein level;
KW Acetylation; DNA-binding; Metal-binding; Nucleus; Phosphoprotein;
KW Reference proteome; Repeat; Transcription; Transcription regulation; Zinc;
KW Zinc-finger.
FT CHAIN 1..224
FT /note="Zinc finger protein 22"
FT /id="PRO_0000047348"
FT ZN_FING 55..77
FT /note="C2H2-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 83..105
FT /note="C2H2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 111..133
FT /note="C2H2-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 139..161
FT /note="C2H2-type 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 167..189
FT /note="C2H2-type 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT REGION 1..34
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 18
FT /note="N6-acetyllysine"
FT /evidence="ECO:0000250|UniProtKB:Q9ERU3"
FT MOD_RES 23
FT /note="N6-acetyllysine"
FT /evidence="ECO:0000250|UniProtKB:Q9ERU3"
FT MOD_RES 49
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:24275569"
FT VARIANT 65
FT /note="S -> G (in dbSNP:rs3740093)"
FT /id="VAR_052747"
FT VARIANT 129
FT /note="H -> L (in a breast cancer sample; somatic
FT mutation)"
FT /evidence="ECO:0000269|PubMed:16959974"
FT /id="VAR_035566"
FT CONFLICT 31
FT /note="Q -> E (in Ref. 1; AAB24264)"
FT /evidence="ECO:0000305"
FT CONFLICT 216..224
FT /note="GRKSVAGLR -> EGSLWLVSVKYRAF (in Ref. 1; AAB24264)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 224 AA; 25915 MW; 61BE158D2CEAEE19 CRC64;
MRLAKPKAGI SRSSSQGKAY ENKRKTGRQR QKWGMTIRFD SSFSRLRRSL DDKPYKCTEC
EKSFSQSSTL FQHQKIHTGK KSHKCADCGK SFFQSSNLIQ HRRIHTGEKP YKCDECGESF
KQSSNLIQHQ RIHTGEKPYQ CDECGRCFSQ SSHLIQHQRT HTGEKPYQCS ECGKCFSQSS
HLRQHMKVHK EEKPRKTRGK NIRVKTHLPS WKAGTGRKSV AGLR
