ID   ZNF22_PONAB             Reviewed;         224 AA.
AC   Q5R4X5;
DT   01-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   21-DEC-2004, sequence version 1.
DT   03-AUG-2022, entry version 113.
DE   RecName: Full=Zinc finger protein 22;
GN   Name=ZNF22;
OS   Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pongo.
OX   NCBI_TaxID=9601;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain cortex;
RG   The German cDNA consortium;
RL   Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Binds DNA through the consensus sequence 5'-CAATG-3'. May be
CC       involved in transcriptional regulation and may play a role in tooth
CC       formation (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC       family. {ECO:0000305}.
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DR   EMBL; CR861114; CAH93191.1; -; mRNA.
DR   RefSeq; NP_001126877.1; NM_001133405.1.
DR   RefSeq; XP_009243604.1; XM_009245329.1.
DR   AlphaFoldDB; Q5R4X5; -.
DR   SMR; Q5R4X5; -.
DR   STRING; 9601.ENSPPYP00000002601; -.
DR   Ensembl; ENSPPYT00000002679; ENSPPYP00000002601; ENSPPYG00000002226.
DR   GeneID; 100173890; -.
DR   KEGG; pon:100173890; -.
DR   CTD; 7570; -.
DR   eggNOG; KOG1721; Eukaryota.
DR   GeneTree; ENSGT01050000244959; -.
DR   HOGENOM; CLU_002678_21_0_1; -.
DR   InParanoid; Q5R4X5; -.
DR   OMA; QKWGVTI; -.
DR   OrthoDB; 1318335at2759; -.
DR   TreeFam; TF350836; -.
DR   Proteomes; UP000001595; Chromosome 10.
DR   GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   InterPro; IPR036236; Znf_C2H2_sf.
DR   InterPro; IPR013087; Znf_C2H2_type.
DR   Pfam; PF00096; zf-C2H2; 5.
DR   SMART; SM00355; ZnF_C2H2; 5.
DR   SUPFAM; SSF57667; SSF57667; 3.
DR   PROSITE; PS00028; ZINC_FINGER_C2H2_1; 5.
DR   PROSITE; PS50157; ZINC_FINGER_C2H2_2; 5.
PE   2: Evidence at transcript level;
KW   Acetylation; DNA-binding; Metal-binding; Nucleus; Phosphoprotein;
KW   Reference proteome; Repeat; Transcription; Transcription regulation; Zinc;
KW   Zinc-finger.
FT   CHAIN           1..224
FT                   /note="Zinc finger protein 22"
FT                   /id="PRO_0000285816"
FT   ZN_FING         55..77
FT                   /note="C2H2-type 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         83..105
FT                   /note="C2H2-type 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         111..133
FT                   /note="C2H2-type 3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         139..161
FT                   /note="C2H2-type 4"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         167..189
FT                   /note="C2H2-type 5"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   REGION          1..34
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         18
FT                   /note="N6-acetyllysine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9ERU3"
FT   MOD_RES         23
FT                   /note="N6-acetyllysine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9ERU3"
FT   MOD_RES         49
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:P17026"
SQ   SEQUENCE   224 AA;  25915 MW;  61BE158D2CEAEE19 CRC64;
     MRLAKPKAGI SRSSSQGKAY ENKRKTGRQR QKWGMTIRFD SSFSRLRRSL DDKPYKCTEC
     EKSFSQSSTL FQHQKIHTGK KSHKCADCGK SFFQSSNLIQ HRRIHTGEKP YKCDECGESF
     KQSSNLIQHQ RIHTGEKPYQ CDECGRCFSQ SSHLIQHQRT HTGEKPYQCS ECGKCFSQSS
     HLRQHMKVHK EEKPRKTRGK NIRVKTHLPS WKAGTGRKSV AGLR