ZNF22_RAT
ID ZNF22_RAT Reviewed; 237 AA.
AC Q9ERU2; Q5EAN1;
DT 15-MAR-2004, integrated into UniProtKB/Swiss-Prot.
DT 24-JAN-2006, sequence version 2.
DT 03-AUG-2022, entry version 146.
DE RecName: Full=Zinc finger protein 22;
DE AltName: Full=Zinc finger protein Krox-25;
GN Name=Znf22; Synonyms=Krox25, Zfp422;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116 {ECO:0000312|EMBL:AAG12467.1};
RN [1] {ECO:0000305}
RP NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, TISSUE SPECIFICITY, AND
RP DEVELOPMENTAL STAGE.
RC STRAIN=Sprague-Dawley {ECO:0000312|EMBL:AAG12467.1};
RX PubMed=14706453; DOI=10.1016/j.ygeno.2003.08.006;
RA Lee S.K., Kim Y.S., Lee S.S., Lee Y.J., Song I.S., Park S.C., Kozak C.,
RA Yamada Y.;
RT "Molecular cloning, chromosomal mapping, and characteristic expression in
RT tooth organ of rat and mouse Krox-25.";
RL Genomics 83:243-253(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Binds DNA through the consensus sequence 5'-CAATG-3'. May be
CC involved in transcriptional regulation and may play a role in tooth
CC formation (By similarity). {ECO:0000250|UniProtKB:Q9ERU3}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:14706453}.
CC -!- TISSUE SPECIFICITY: Highly expressed in the ameloblast layer of
CC mandibular incisors, moderately expressed in submandibular gland,
CC calvaria, kidney and lung, and expressed at low levels in brain and
CC thymus. {ECO:0000269|PubMed:14706453}.
CC -!- DEVELOPMENTAL STAGE: Highly expressed in presecretory ameloblasts with
CC very high expression in secretory ameloblasts. Expression decreases in
CC the maturation stage and is very low in the late maturation stage.
CC {ECO:0000269|PubMed:14706453}.
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAG12467.1; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; AF281635; AAG12467.1; ALT_FRAME; mRNA.
DR EMBL; BC090354; AAH90354.1; -; mRNA.
DR RefSeq; NP_001012763.1; NM_001012745.1.
DR RefSeq; XP_006237249.1; XM_006237187.3.
DR RefSeq; XP_006237251.1; XM_006237189.3.
DR RefSeq; XP_006237252.1; XM_006237190.3.
DR RefSeq; XP_008761471.1; XM_008763249.1.
DR AlphaFoldDB; Q9ERU2; -.
DR SMR; Q9ERU2; -.
DR STRING; 10116.ENSRNOP00000018050; -.
DR iPTMnet; Q9ERU2; -.
DR PhosphoSitePlus; Q9ERU2; -.
DR PaxDb; Q9ERU2; -.
DR PRIDE; Q9ERU2; -.
DR Ensembl; ENSRNOT00000018050; ENSRNOP00000018050; ENSRNOG00000013379.
DR Ensembl; ENSRNOT00000097804; ENSRNOP00000076367; ENSRNOG00000013379.
DR Ensembl; ENSRNOT00000105818; ENSRNOP00000085999; ENSRNOG00000013379.
DR GeneID; 360389; -.
DR KEGG; rno:360389; -.
DR UCSC; RGD:620229; rat.
DR CTD; 67255; -.
DR RGD; 620229; Zfp422.
DR eggNOG; KOG1721; Eukaryota.
DR GeneTree; ENSGT01050000244959; -.
DR HOGENOM; CLU_002678_21_0_1; -.
DR InParanoid; Q9ERU2; -.
DR OMA; QKWGVTI; -.
DR OrthoDB; 1318335at2759; -.
DR PhylomeDB; Q9ERU2; -.
DR TreeFam; TF350836; -.
DR PRO; PR:Q9ERU2; -.
DR Proteomes; UP000002494; Chromosome 4.
DR Bgee; ENSRNOG00000013379; Expressed in thymus and 20 other tissues.
DR Genevisible; Q9ERU2; RN.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0005634; C:nucleus; IDA:UniProtKB.
DR GO; GO:0003677; F:DNA binding; ISS:UniProtKB.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0042476; P:odontogenesis; NAS:UniProtKB.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; NAS:UniProtKB.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF00096; zf-C2H2; 5.
DR SMART; SM00355; ZnF_C2H2; 5.
DR SUPFAM; SSF57667; SSF57667; 3.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 5.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 5.
PE 2: Evidence at transcript level;
KW Acetylation; DNA-binding; Metal-binding; Nucleus; Reference proteome;
KW Repeat; Transcription; Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1..237
FT /note="Zinc finger protein 22"
FT /id="PRO_0000047350"
FT ZN_FING 55..82
FT /note="C2H2-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 83..110
FT /note="C2H2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 111..138
FT /note="C2H2-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 139..166
FT /note="C2H2-type 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 167..194
FT /note="C2H2-type 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT REGION 1..33
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 188..218
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 18
FT /note="N6-acetyllysine"
FT /evidence="ECO:0000250|UniProtKB:Q9ERU3"
FT MOD_RES 23
FT /note="N6-acetyllysine"
FT /evidence="ECO:0000250|UniProtKB:Q9ERU3"
FT CONFLICT 6
FT /note="P -> PQ (in Ref. 1; AAG12467)"
FT /evidence="ECO:0000305"
FT CONFLICT 15
FT /note="S -> T (in Ref. 1; AAG12467)"
FT /evidence="ECO:0000305"
FT CONFLICT 23
FT /note="K -> R (in Ref. 1; AAG12467)"
FT /evidence="ECO:0000305"
FT CONFLICT 140
FT /note="C -> Y (in Ref. 1; AAG12467)"
FT /evidence="ECO:0000305"
FT CONFLICT 179
FT /note="S -> N (in Ref. 1; AAG12467)"
FT /evidence="ECO:0000305"
FT CONFLICT 190
FT /note="K -> Q (in Ref. 1; AAG12467)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 237 AA; 27286 MW; 9945E6C00AEC6624 CRC64;
MRLGKPKGGI SRSASQGKTY ESKRKTARQR QKWGVAIRFD SGLSRRRRNV DEKPYKCTKC
SKSFSQSSTL FQHKKIHTGK KSHKCADCGK SFFQSSNLIQ HRRIHTGEKP YKCDECGERF
KQSSNLIQHQ RIHTGEKPYC CDECGRCFSQ SSHLIQHQRT HTGEKPYQCE ECDKCFSQSS
HLRQHMKVHK EKKSHKRGKN ARAKTHPVSW KRGKGRKAVA GLRQVKGAAS GLFKKKK
