ZNF25_HUMAN
ID ZNF25_HUMAN Reviewed; 456 AA.
AC P17030; A9Z1X5; Q8IYE3; Q8NDD6; Q96MU2;
DT 01-AUG-1990, integrated into UniProtKB/Swiss-Prot.
DT 25-JUL-2003, sequence version 2.
DT 03-AUG-2022, entry version 200.
DE RecName: Full=Zinc finger protein 25;
DE AltName: Full=Zinc finger protein KOX19;
GN Name=ZNF25; Synonyms=KOX19;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RA Hearn T.;
RT "Organisation, expression and evolution of Kruppel-type zinc finger genes
RT in human chromosomal region 10p11.2-q11.2.";
RL Thesis (2000), University of Newcastle, United Kingdom.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Teratocarcinoma;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Hippocampus;
RX PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D.,
RA Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A.,
RA Wiemann S., Schupp I.;
RT "The full-ORF clone resource of the German cDNA consortium.";
RL BMC Genomics 8:399-399(2007).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15164054; DOI=10.1038/nature02462;
RA Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L.,
RA Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K.,
RA Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L.,
RA Taylor A., Battles J., Bird C.P., Ainscough R., Almeida J.P.,
RA Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J.,
RA Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y.,
RA Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P.,
RA Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N.,
RA Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A.,
RA Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C.,
RA Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D.,
RA Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C.,
RA Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K.,
RA Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A.,
RA Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S.,
RA McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S.,
RA Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V.,
RA Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A.,
RA Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M.,
RA Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A.,
RA Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P.,
RA Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y.,
RA Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D.,
RA Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.;
RT "The DNA sequence and comparative analysis of human chromosome 10.";
RL Nature 429:375-381(2004).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 6-456 (ISOFORM 1), AND VARIANT
RP LYS-453.
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [6]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 230-285.
RC TISSUE=Lymphoid tissue;
RX PubMed=2288909;
RA Thiesen H.-J.;
RT "Multiple genes encoding zinc finger domains are expressed in human T
RT cells.";
RL New Biol. 2:363-374(1990).
RN [7]
RP VARIANTS [LARGE SCALE ANALYSIS] LYS-21 AND GLY-81.
RX PubMed=16959974; DOI=10.1126/science.1133427;
RA Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D.,
RA Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P.,
RA Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V.,
RA Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H.,
RA Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W.,
RA Velculescu V.E.;
RT "The consensus coding sequences of human breast and colorectal cancers.";
RL Science 314:268-274(2006).
CC -!- FUNCTION: May be involved in transcriptional regulation.
CC -!- INTERACTION:
CC P17030; Q12765-2: SCRN1; NbExp=3; IntAct=EBI-7934204, EBI-12027936;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=P17030-1; Sequence=Displayed;
CC Name=2;
CC IsoId=P17030-2; Sequence=VSP_007846, VSP_007847;
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH36038.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AJ491696; CAD36955.1; -; mRNA.
DR EMBL; AK056452; BAB71187.1; -; mRNA.
DR EMBL; AL834125; CAD38845.1; -; mRNA.
DR EMBL; AL117337; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC036038; AAH36038.1; ALT_INIT; mRNA.
DR EMBL; X52350; CAA36576.1; -; mRNA.
DR CCDS; CCDS7195.1; -. [P17030-1]
DR PIR; I37958; I37958.
DR RefSeq; NP_001316579.1; NM_001329650.1. [P17030-1]
DR RefSeq; NP_001316580.1; NM_001329651.1. [P17030-1]
DR RefSeq; NP_001316581.1; NM_001329652.1. [P17030-1]
DR RefSeq; NP_001316582.1; NM_001329653.1. [P17030-1]
DR RefSeq; NP_001316583.1; NM_001329654.1. [P17030-1]
DR RefSeq; NP_659448.1; NM_145011.3. [P17030-1]
DR AlphaFoldDB; P17030; -.
DR SMR; P17030; -.
DR BioGRID; 128572; 3.
DR IntAct; P17030; 3.
DR MINT; P17030; -.
DR STRING; 9606.ENSP00000302222; -.
DR GlyGen; P17030; 1 site, 2 O-linked glycans (1 site).
DR iPTMnet; P17030; -.
DR PhosphoSitePlus; P17030; -.
DR BioMuta; ZNF25; -.
DR DMDM; 33302620; -.
DR jPOST; P17030; -.
DR MassIVE; P17030; -.
DR MaxQB; P17030; -.
DR PaxDb; P17030; -.
DR PeptideAtlas; P17030; -.
DR PRIDE; P17030; -.
DR ProteomicsDB; 53432; -. [P17030-1]
DR ProteomicsDB; 53433; -. [P17030-2]
DR Antibodypedia; 13332; 122 antibodies from 22 providers.
DR DNASU; 219749; -.
DR Ensembl; ENST00000302609.8; ENSP00000302222.7; ENSG00000175395.16. [P17030-1]
DR GeneID; 219749; -.
DR KEGG; hsa:219749; -.
DR MANE-Select; ENST00000302609.8; ENSP00000302222.7; NM_145011.4; NP_659448.1.
DR UCSC; uc001ize.2; human. [P17030-1]
DR CTD; 219749; -.
DR DisGeNET; 219749; -.
DR GeneCards; ZNF25; -.
DR HGNC; HGNC:13043; ZNF25.
DR HPA; ENSG00000175395; Low tissue specificity.
DR MIM; 194528; gene.
DR neXtProt; NX_P17030; -.
DR OpenTargets; ENSG00000175395; -.
DR PharmGKB; PA37621; -.
DR VEuPathDB; HostDB:ENSG00000175395; -.
DR eggNOG; KOG1721; Eukaryota.
DR GeneTree; ENSGT00940000159981; -.
DR HOGENOM; CLU_002678_0_5_1; -.
DR InParanoid; P17030; -.
DR OMA; ECKETFF; -.
DR OrthoDB; 1318335at2759; -.
DR PhylomeDB; P17030; -.
DR TreeFam; TF337898; -.
DR PathwayCommons; P17030; -.
DR Reactome; R-HSA-212436; Generic Transcription Pathway.
DR SignaLink; P17030; -.
DR BioGRID-ORCS; 219749; 9 hits in 1084 CRISPR screens.
DR ChiTaRS; ZNF25; human.
DR GenomeRNAi; 219749; -.
DR Pharos; P17030; Tdark.
DR PRO; PR:P17030; -.
DR Proteomes; UP000005640; Chromosome 10.
DR RNAct; P17030; protein.
DR Bgee; ENSG00000175395; Expressed in endothelial cell and 183 other tissues.
DR Genevisible; P17030; HS.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0001227; F:DNA-binding transcription repressor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000977; F:RNA polymerase II transcription regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd07765; KRAB_A-box; 1.
DR InterPro; IPR001909; KRAB.
DR InterPro; IPR036051; KRAB_dom_sf.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF01352; KRAB; 1.
DR Pfam; PF00096; zf-C2H2; 12.
DR SMART; SM00349; KRAB; 1.
DR SMART; SM00355; ZnF_C2H2; 12.
DR SUPFAM; SSF109640; SSF109640; 1.
DR SUPFAM; SSF57667; SSF57667; 7.
DR PROSITE; PS50805; KRAB; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 12.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 12.
PE 1: Evidence at protein level;
KW Alternative splicing; DNA-binding; Metal-binding; Nucleus;
KW Reference proteome; Repeat; Transcription; Transcription regulation; Zinc;
KW Zinc-finger.
FT CHAIN 1..456
FT /note="Zinc finger protein 25"
FT /id="PRO_0000047354"
FT DOMAIN 8..79
FT /note="KRAB"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00119"
FT ZN_FING 118..140
FT /note="C2H2-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 146..168
FT /note="C2H2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 174..196
FT /note="C2H2-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 202..224
FT /note="C2H2-type 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 230..252
FT /note="C2H2-type 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 258..280
FT /note="C2H2-type 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 286..308
FT /note="C2H2-type 7"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 314..336
FT /note="C2H2-type 8"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 342..364
FT /note="C2H2-type 9"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 370..392
FT /note="C2H2-type 10"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 398..420
FT /note="C2H2-type 11"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 426..448
FT /note="C2H2-type 12"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT VAR_SEQ 1..94
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:17974005"
FT /id="VSP_007846"
FT VAR_SEQ 95..99
FT /note="SQAGN -> MWNFL (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:17974005"
FT /id="VSP_007847"
FT VARIANT 21
FT /note="E -> K (in a breast cancer sample; somatic
FT mutation)"
FT /evidence="ECO:0000269|PubMed:16959974"
FT /id="VAR_035567"
FT VARIANT 81
FT /note="D -> G (in a breast cancer sample; somatic
FT mutation)"
FT /evidence="ECO:0000269|PubMed:16959974"
FT /id="VAR_035568"
FT VARIANT 453
FT /note="N -> K (in dbSNP:rs1208606)"
FT /evidence="ECO:0000269|PubMed:15489334"
FT /id="VAR_052748"
SQ SEQUENCE 456 AA; 53545 MW; 9B65561962CBD85D CRC64;
MNKFQGPVTL KDVIVEFTKE EWKLLTPAQR TLYKDVMLEN YSHLVSVGYH VNKPNAVFKL
KQGKEPWILE VEFPHRGFPE DLWSIHDLEA RYQESQAGNS RNGELTKHQK THTTEKACEC
KECGKFFCQK SALIVHQHTH SKGKSYDCDK CGKSFSKNED LIRHQKIHTR DKTYECKECK
KIFYHLSSLS RHLRTHAGEK PYECNQCEKS FYQKPHLTEH QKTHTGEKPF ECTECGKFFY
VKAYLMVHQK THTGEKPYEC KECGKAFSQK SHLTVHQRMH TGEKPYKCKE CGKFFSRNSH
LKTHQRSHTG EKPYECKECR KCFYQKSALT VHQRTHTGEK PFECNKCGKT FYYKSDLTKH
QRKHTGEKPY ECTECGKSFA VNSVLRLHQR THTGEKPYAC KECGKSFSQK SHFIIHQRKH
TGEKPYECQE CGETFIQKSQ LTAHQKTHTK KRNAEK
