ID   ZNF2_BOVIN              Reviewed;         425 AA.
AC   Q29RZ4;
DT   23-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT   04-APR-2006, sequence version 1.
DT   25-MAY-2022, entry version 93.
DE   RecName: Full=Zinc finger protein 2 {ECO:0000250|UniProtKB:Q9BSG1};
GN   Name=ZNF2 {ECO:0000250|UniProtKB:Q9BSG1};
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Uterus;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (FEB-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May be involved in transcriptional regulation.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC       family. {ECO:0000305}.
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DR   EMBL; BC113303; AAI13304.1; -; mRNA.
DR   RefSeq; NP_001039911.1; NM_001046446.2.
DR   RefSeq; XP_010808051.1; XM_010809749.2.
DR   AlphaFoldDB; Q29RZ4; -.
DR   SMR; Q29RZ4; -.
DR   STRING; 9913.ENSBTAP00000002533; -.
DR   PaxDb; Q29RZ4; -.
DR   GeneID; 539022; -.
DR   KEGG; bta:539022; -.
DR   CTD; 7549; -.
DR   eggNOG; KOG1721; Eukaryota.
DR   InParanoid; Q29RZ4; -.
DR   OrthoDB; 1318335at2759; -.
DR   Proteomes; UP000009136; Unplaced.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   CDD; cd07765; KRAB_A-box; 1.
DR   InterPro; IPR001909; KRAB.
DR   InterPro; IPR036051; KRAB_dom_sf.
DR   InterPro; IPR036236; Znf_C2H2_sf.
DR   InterPro; IPR013087; Znf_C2H2_type.
DR   Pfam; PF01352; KRAB; 1.
DR   Pfam; PF00096; zf-C2H2; 7.
DR   SMART; SM00349; KRAB; 1.
DR   SMART; SM00355; ZnF_C2H2; 9.
DR   SUPFAM; SSF109640; SSF109640; 1.
DR   SUPFAM; SSF57667; SSF57667; 5.
DR   PROSITE; PS50805; KRAB; 1.
DR   PROSITE; PS00028; ZINC_FINGER_C2H2_1; 8.
DR   PROSITE; PS50157; ZINC_FINGER_C2H2_2; 9.
PE   2: Evidence at transcript level;
KW   DNA-binding; Metal-binding; Nucleus; Reference proteome; Repeat;
KW   Transcription; Transcription regulation; Zinc; Zinc-finger.
FT   CHAIN           1..425
FT                   /note="Zinc finger protein 2"
FT                   /id="PRO_0000274048"
FT   DOMAIN          14..85
FT                   /note="KRAB"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00119"
FT   ZN_FING         173..195
FT                   /note="C2H2-type 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         201..223
FT                   /note="C2H2-type 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         229..251
FT                   /note="C2H2-type 3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         257..279
FT                   /note="C2H2-type 4"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         285..307
FT                   /note="C2H2-type 5"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         313..335
FT                   /note="C2H2-type 6"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         341..363
FT                   /note="C2H2-type 7"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         369..391
FT                   /note="C2H2-type 8"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         397..419
FT                   /note="C2H2-type 9; degenerate"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   REGION          97..124
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        97..113
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   425 AA;  48223 MW;  E7220404A4E1FB91 CRC64;
     MAAVSPTRCQ DPVTFEDVAV VFTDEEWRRL VPTQRDLYKE VMLENYKSIV SLGLPVPGPD
     VIFQLKRGDE PWLVEFHGFE GKEGAENVSL DWETKPEIQG ASEEEKSEGS LKENLGRKGP
     PSPKVEVYVL DGRLGTEKES PTVEACKKPP SLEESLRHRA TPPKKFLTKE RDQECSNCGK
     TFFDHSSLIR HQRTHTGEKP YDCPECGKAF SHRSSLSRHL MSHTGESPYE CNACGKAFFD
     RSSLTVHQRI HTGEKPFKCS ECGKAFFDRS SLTRHQRIHT GESPYECNQC GKAFSQKSIL
     TRHQLIHTGR KPYECNECGK AFYGVSSLNR HQKAHAGEPR YQCSECGKAF FDRSSLTQHQ
     KIHTGDKPYE CSECGKAFSQ RCRLTRHQRV HTGEKPFECS VCGKVFSSKS SVIQHQRRYA
     KQGID