ID   ZNF2_PONAB              Reviewed;         425 AA.
AC   Q5RBY9;
DT   23-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT   21-DEC-2004, sequence version 1.
DT   25-MAY-2022, entry version 92.
DE   RecName: Full=Zinc finger protein 2 {ECO:0000250|UniProtKB:Q9BSG1};
GN   Name=ZNF2 {ECO:0000250|UniProtKB:Q9BSG1};
OS   Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pongo.
OX   NCBI_TaxID=9601;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Kidney;
RG   The German cDNA consortium;
RL   Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May be involved in transcriptional regulation.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC       family. {ECO:0000305}.
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DR   EMBL; CR858493; CAH90721.1; -; mRNA.
DR   RefSeq; NP_001125401.1; NM_001131929.1.
DR   AlphaFoldDB; Q5RBY9; -.
DR   SMR; Q5RBY9; -.
DR   STRING; 9601.ENSPPYP00000013439; -.
DR   GeneID; 100172306; -.
DR   KEGG; pon:100172306; -.
DR   CTD; 7549; -.
DR   eggNOG; KOG1721; Eukaryota.
DR   InParanoid; Q5RBY9; -.
DR   Proteomes; UP000001595; Unplaced.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR   CDD; cd07765; KRAB_A-box; 1.
DR   InterPro; IPR001909; KRAB.
DR   InterPro; IPR036051; KRAB_dom_sf.
DR   InterPro; IPR036236; Znf_C2H2_sf.
DR   InterPro; IPR013087; Znf_C2H2_type.
DR   Pfam; PF01352; KRAB; 1.
DR   Pfam; PF00096; zf-C2H2; 7.
DR   SMART; SM00349; KRAB; 1.
DR   SMART; SM00355; ZnF_C2H2; 9.
DR   SUPFAM; SSF109640; SSF109640; 1.
DR   SUPFAM; SSF57667; SSF57667; 5.
DR   PROSITE; PS50805; KRAB; 1.
DR   PROSITE; PS00028; ZINC_FINGER_C2H2_1; 8.
DR   PROSITE; PS50157; ZINC_FINGER_C2H2_2; 9.
PE   2: Evidence at transcript level;
KW   DNA-binding; Metal-binding; Nucleus; Reference proteome; Repeat;
KW   Transcription; Transcription regulation; Zinc; Zinc-finger.
FT   CHAIN           1..425
FT                   /note="Zinc finger protein 2"
FT                   /id="PRO_0000274051"
FT   DOMAIN          14..85
FT                   /note="KRAB"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00119"
FT   ZN_FING         173..195
FT                   /note="C2H2-type 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         201..223
FT                   /note="C2H2-type 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         229..251
FT                   /note="C2H2-type 3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         257..279
FT                   /note="C2H2-type 4"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         285..307
FT                   /note="C2H2-type 5"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         313..335
FT                   /note="C2H2-type 6"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         341..363
FT                   /note="C2H2-type 7"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         369..391
FT                   /note="C2H2-type 8"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         397..419
FT                   /note="C2H2-type 9; degenerate"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   REGION          125..160
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        140..160
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   425 AA;  48409 MW;  DCF2A9608183AD17 CRC64;
     MAAVSPTTRC QESVTFEDVA VVFTDEEWSH LVPTQRDLYK EVMLENYNSI VSLGLPVPQP
     DVIFQLKRGD KPWMVDLHGS EEREWPESVS LDWETKPEIH DASNEKSEGS LRECLGRQSP
     LCPKFEVHTP DGRMGTEKQS SSGETHKKSL SQDKGLRRGS ALPREILTKE RHQECSDCGK
     TFFDHSSLTR HQRTHTGEKP YDCHECGKAF SHRSSLSRHL MSHTGESPYG CSVCAKAFFD
     RSSLTVHQRI HTGEKPFQCN ECGKAFFDRS SLTRHQRIHT GESPYECHQC GKAFSQKSIL
     TRHQLIHTGR KPYECNECGK AFYGVSSLNR HQKAHAGDPR YQCNECGKAF FDRSSLTQHQ
     KIHTGDKPYE CSECGKAFSQ RCRLTRHQRV HTGEKPFECS VCGKVFSSKS SVIQHQRRYA
     KQGID