ZNF32_HUMAN
ID ZNF32_HUMAN Reviewed; 273 AA.
AC P17041; Q92951;
DT 01-AUG-1990, integrated into UniProtKB/Swiss-Prot.
DT 10-JAN-2006, sequence version 2.
DT 03-AUG-2022, entry version 195.
DE RecName: Full=Zinc finger protein 32;
DE AltName: Full=C2H2-546;
DE AltName: Full=Zinc finger protein KOX30;
GN Name=ZNF32; Synonyms=KOX30;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=9475118; DOI=10.3109/13550289709031192;
RA Drew P.D., Gado A.M., Canning R.D., Nagle J.W., Dehejia A.M.,
RA Polymeropoulos M.H., Biddison W.E., Jacobson S., Becker K.G.;
RT "C2H2-546: a zinc finger protein differentially expressed in HTLV-1
RT infected T cells.";
RL J. Neurovirol. 3:455-459(1997).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15164054; DOI=10.1038/nature02462;
RA Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L.,
RA Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K.,
RA Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L.,
RA Taylor A., Battles J., Bird C.P., Ainscough R., Almeida J.P.,
RA Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J.,
RA Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y.,
RA Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P.,
RA Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N.,
RA Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A.,
RA Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C.,
RA Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D.,
RA Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C.,
RA Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K.,
RA Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A.,
RA Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S.,
RA McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S.,
RA Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V.,
RA Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A.,
RA Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M.,
RA Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A.,
RA Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P.,
RA Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y.,
RA Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D.,
RA Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.;
RT "The DNA sequence and comparative analysis of human chromosome 10.";
RL Nature 429:375-381(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 77-128.
RC TISSUE=Lymphoid tissue;
RX PubMed=2288909;
RA Thiesen H.-J.;
RT "Multiple genes encoding zinc finger domains are expressed in human T
RT cells.";
RL New Biol. 2:363-374(1990).
RN [5]
RP STRUCTURE BY NMR OF 74-269.
RG RIKEN structural genomics initiative (RSGI);
RT "Solution structure of zinc finger domain 7 in zinc finger protein 32.";
RL Submitted (OCT-2007) to the PDB data bank.
CC -!- FUNCTION: May be involved in transcriptional regulation.
CC -!- INTERACTION:
CC P17041; Q9BWT7: CARD10; NbExp=3; IntAct=EBI-1965483, EBI-3866279;
CC P17041; Q86Z20: CCDC125; NbExp=3; IntAct=EBI-1965483, EBI-11977221;
CC P17041; A6NEM1: GOLGA6L9; NbExp=3; IntAct=EBI-1965483, EBI-5916454;
CC P17041; Q0VD86: INCA1; NbExp=3; IntAct=EBI-1965483, EBI-6509505;
CC P17041; P60372: KRTAP10-4; NbExp=3; IntAct=EBI-1965483, EBI-10178153;
CC P17041; P60370: KRTAP10-5; NbExp=3; IntAct=EBI-1965483, EBI-10172150;
CC P17041; P60409: KRTAP10-7; NbExp=3; IntAct=EBI-1965483, EBI-10172290;
CC P17041; P60410: KRTAP10-8; NbExp=3; IntAct=EBI-1965483, EBI-10171774;
CC P17041; Q7Z3S9: NOTCH2NLA; NbExp=3; IntAct=EBI-1965483, EBI-945833;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. {ECO:0000305}.
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DR EMBL; U69645; AAB09561.1; -; mRNA.
DR EMBL; AL645634; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC022842; AAH22842.1; -; mRNA.
DR EMBL; X52361; CAA36587.1; -; mRNA.
DR CCDS; CCDS7206.1; -.
DR PIR; I37971; I37971.
DR RefSeq; NP_001005368.1; NM_001005368.2.
DR RefSeq; NP_001311094.1; NM_001324165.1.
DR RefSeq; NP_001311097.1; NM_001324168.1.
DR RefSeq; NP_008904.1; NM_006973.2.
DR RefSeq; XP_016872105.1; XM_017016616.1.
DR PDB; 2EPC; NMR; -; A=241-269.
DR PDB; 2EPT; NMR; -; A=74-101.
DR PDB; 2EPU; NMR; -; A=100-131.
DR PDB; 2YTA; NMR; -; A=130-157.
DR PDB; 2YTB; NMR; -; A=185-213.
DR PDBsum; 2EPC; -.
DR PDBsum; 2EPT; -.
DR PDBsum; 2EPU; -.
DR PDBsum; 2YTA; -.
DR PDBsum; 2YTB; -.
DR AlphaFoldDB; P17041; -.
DR SMR; P17041; -.
DR BioGRID; 113409; 26.
DR IntAct; P17041; 13.
DR STRING; 9606.ENSP00000379143; -.
DR iPTMnet; P17041; -.
DR PhosphoSitePlus; P17041; -.
DR BioMuta; ZNF32; -.
DR DMDM; 85681868; -.
DR jPOST; P17041; -.
DR MassIVE; P17041; -.
DR MaxQB; P17041; -.
DR PaxDb; P17041; -.
DR PeptideAtlas; P17041; -.
DR PRIDE; P17041; -.
DR ProteomicsDB; 53449; -.
DR Antibodypedia; 26938; 64 antibodies from 13 providers.
DR DNASU; 7580; -.
DR Ensembl; ENST00000374433.7; ENSP00000363556.2; ENSG00000169740.14.
DR Ensembl; ENST00000395797.1; ENSP00000379143.1; ENSG00000169740.14.
DR GeneID; 7580; -.
DR KEGG; hsa:7580; -.
DR MANE-Select; ENST00000374433.7; ENSP00000363556.2; NM_006973.3; NP_008904.1.
DR UCSC; uc001jbb.4; human.
DR CTD; 7580; -.
DR DisGeNET; 7580; -.
DR GeneCards; ZNF32; -.
DR HGNC; HGNC:13095; ZNF32.
DR HPA; ENSG00000169740; Low tissue specificity.
DR MIM; 194539; gene.
DR neXtProt; NX_P17041; -.
DR OpenTargets; ENSG00000169740; -.
DR PharmGKB; PA37670; -.
DR VEuPathDB; HostDB:ENSG00000169740; -.
DR eggNOG; KOG1721; Eukaryota.
DR GeneTree; ENSGT00940000153582; -.
DR HOGENOM; CLU_002678_18_0_1; -.
DR InParanoid; P17041; -.
DR OMA; WDFQNAF; -.
DR OrthoDB; 1318335at2759; -.
DR PhylomeDB; P17041; -.
DR TreeFam; TF337055; -.
DR PathwayCommons; P17041; -.
DR SignaLink; P17041; -.
DR BioGRID-ORCS; 7580; 10 hits in 1104 CRISPR screens.
DR ChiTaRS; ZNF32; human.
DR EvolutionaryTrace; P17041; -.
DR GenomeRNAi; 7580; -.
DR Pharos; P17041; Tdark.
DR PRO; PR:P17041; -.
DR Proteomes; UP000005640; Chromosome 10.
DR RNAct; P17041; protein.
DR Bgee; ENSG00000169740; Expressed in skeletal muscle tissue of rectus abdominis and 201 other tissues.
DR ExpressionAtlas; P17041; baseline and differential.
DR Genevisible; P17041; HS.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:1990837; F:sequence-specific double-stranded DNA binding; IDA:ARUK-UCL.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF00096; zf-C2H2; 6.
DR SMART; SM00355; ZnF_C2H2; 7.
DR SUPFAM; SSF57667; SSF57667; 4.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 6.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 7.
PE 1: Evidence at protein level;
KW 3D-structure; DNA-binding; Metal-binding; Nucleus; Reference proteome;
KW Repeat; Transcription; Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1..273
FT /note="Zinc finger protein 32"
FT /id="PRO_0000047361"
FT ZN_FING 77..99
FT /note="C2H2-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 105..127
FT /note="C2H2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 133..155
FT /note="C2H2-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 161..183
FT /note="C2H2-type 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 189..211
FT /note="C2H2-type 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 217..239
FT /note="C2H2-type 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 245..266
FT /note="C2H2-type 7; degenerate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT CONFLICT 118
FT /note="G -> A (in Ref. 4; CAA36587)"
FT /evidence="ECO:0000305"
FT STRAND 80..82
FT /evidence="ECO:0007829|PDB:2EPT"
FT STRAND 85..88
FT /evidence="ECO:0007829|PDB:2EPT"
FT HELIX 89..95
FT /evidence="ECO:0007829|PDB:2EPT"
FT HELIX 96..98
FT /evidence="ECO:0007829|PDB:2EPT"
FT STRAND 104..106
FT /evidence="ECO:0007829|PDB:2EPU"
FT TURN 108..110
FT /evidence="ECO:0007829|PDB:2EPU"
FT STRAND 113..116
FT /evidence="ECO:0007829|PDB:2EPU"
FT HELIX 117..124
FT /evidence="ECO:0007829|PDB:2EPU"
FT TURN 125..127
FT /evidence="ECO:0007829|PDB:2EPU"
FT STRAND 136..138
FT /evidence="ECO:0007829|PDB:2YTA"
FT HELIX 145..153
FT /evidence="ECO:0007829|PDB:2YTA"
FT TURN 192..195
FT /evidence="ECO:0007829|PDB:2YTB"
FT STRAND 198..200
FT /evidence="ECO:0007829|PDB:2YTB"
FT HELIX 201..205
FT /evidence="ECO:0007829|PDB:2YTB"
FT HELIX 208..210
FT /evidence="ECO:0007829|PDB:2YTB"
FT STRAND 248..250
FT /evidence="ECO:0007829|PDB:2EPC"
FT STRAND 253..256
FT /evidence="ECO:0007829|PDB:2EPC"
FT HELIX 257..266
FT /evidence="ECO:0007829|PDB:2EPC"
SQ SEQUENCE 273 AA; 31029 MW; 91E7148C665C4734 CRC64;
MFGFPTATLL DCHGRYAQNV AFFNVMTEAH HKYDHSEATG SSSWDIQNSF RREKLEQKSP
DSKTLQEDSP GVRQRVYECQ ECGKSFRQKG SLTLHERIHT GQKPFECTHC GKSFRAKGNL
VTHQRIHTGE KPYQCKECGK SFSQRGSLAV HERLHTGQKP YECAICQRSF RNQSNLAVHR
RVHSGEKPYR CDQCGKAFSQ KGSLIVHIRV HTGLKPYACT QCRKSFHTRG NCILHGKIHT
GETPYLCGQC GKSFTQRGSL AVHQRSCSQR LTL
