ZNF32_MOUSE
ID ZNF32_MOUSE Reviewed; 272 AA.
AC Q80V23; Q3UIS3;
DT 10-JAN-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2003, sequence version 1.
DT 03-AUG-2022, entry version 136.
DE RecName: Full=Zinc finger protein 32;
DE AltName: Full=Zinc finger protein 637;
GN Name=Znf32; Synonyms=Zfp637;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC STRAIN=C57BL/6J; TISSUE=Heart;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC STRAIN=C57BL/6J, and FVB/N; TISSUE=Mammary tumor;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: May be involved in transcriptional regulation.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q80V23-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q80V23-2; Sequence=VSP_016954;
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. {ECO:0000305}.
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DR EMBL; AK146789; BAE27433.1; -; mRNA.
DR EMBL; BC048843; AAH48843.1; -; mRNA.
DR CCDS; CCDS39607.1; -. [Q80V23-1]
DR CCDS; CCDS85139.1; -. [Q80V23-2]
DR RefSeq; NP_001333576.1; NM_001346647.1. [Q80V23-2]
DR RefSeq; NP_001333577.1; NM_001346648.1. [Q80V23-2]
DR RefSeq; NP_001333578.1; NM_001346649.1. [Q80V23-1]
DR RefSeq; NP_001333579.1; NM_001346650.1. [Q80V23-1]
DR RefSeq; NP_001333580.1; NM_001346651.1.
DR RefSeq; NP_001333581.1; NM_001346652.1.
DR RefSeq; NP_001333582.1; NM_001346653.1.
DR RefSeq; NP_808352.1; NM_177684.3. [Q80V23-1]
DR RefSeq; XP_006506080.1; XM_006506017.3. [Q80V23-2]
DR AlphaFoldDB; Q80V23; -.
DR SMR; Q80V23; -.
DR iPTMnet; Q80V23; -.
DR PhosphoSitePlus; Q80V23; -.
DR MaxQB; Q80V23; -.
DR PaxDb; Q80V23; -.
DR PRIDE; Q80V23; -.
DR ProteomicsDB; 275303; -. [Q80V23-1]
DR ProteomicsDB; 275304; -. [Q80V23-2]
DR Antibodypedia; 26938; 64 antibodies from 13 providers.
DR DNASU; 232337; -.
DR Ensembl; ENSMUST00000112860; ENSMUSP00000108481; ENSMUSG00000059689. [Q80V23-2]
DR Ensembl; ENSMUST00000112861; ENSMUSP00000108482; ENSMUSG00000059689. [Q80V23-1]
DR Ensembl; ENSMUST00000164472; ENSMUSP00000130144; ENSMUSG00000059689. [Q80V23-1]
DR Ensembl; ENSMUST00000223041; ENSMUSP00000152569; ENSMUSG00000059689. [Q80V23-2]
DR GeneID; 232337; -.
DR KEGG; mmu:232337; -.
DR UCSC; uc009dky.1; mouse. [Q80V23-1]
DR UCSC; uc009dkz.1; mouse. [Q80V23-2]
DR CTD; 232337; -.
DR MGI; MGI:2448537; Zfp637.
DR VEuPathDB; HostDB:ENSMUSG00000059689; -.
DR eggNOG; KOG1721; Eukaryota.
DR GeneTree; ENSGT00940000153582; -.
DR HOGENOM; CLU_002678_18_0_1; -.
DR InParanoid; Q80V23; -.
DR OMA; WDFQNAF; -.
DR OrthoDB; 1318335at2759; -.
DR PhylomeDB; Q80V23; -.
DR TreeFam; TF337055; -.
DR BioGRID-ORCS; 232337; 0 hits in 72 CRISPR screens.
DR ChiTaRS; Zfp637; mouse.
DR PRO; PR:Q80V23; -.
DR Proteomes; UP000000589; Chromosome 6.
DR RNAct; Q80V23; protein.
DR Bgee; ENSMUSG00000059689; Expressed in cortical plate and 237 other tissues.
DR ExpressionAtlas; Q80V23; baseline and differential.
DR Genevisible; Q80V23; MM.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:1990837; F:sequence-specific double-stranded DNA binding; ISO:MGI.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF00096; zf-C2H2; 6.
DR SMART; SM00355; ZnF_C2H2; 7.
DR SUPFAM; SSF57667; SSF57667; 4.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 6.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 7.
PE 2: Evidence at transcript level;
KW Alternative splicing; Metal-binding; Nucleus; Reference proteome; Repeat;
KW Zinc; Zinc-finger.
FT CHAIN 1..272
FT /note="Zinc finger protein 32"
FT /id="PRO_0000047362"
FT ZN_FING 76..98
FT /note="C2H2-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 104..126
FT /note="C2H2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 132..154
FT /note="C2H2-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 160..182
FT /note="C2H2-type 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 188..210
FT /note="C2H2-type 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 216..238
FT /note="C2H2-type 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 244..265
FT /note="C2H2-type 7; degenerate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT REGION 50..69
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 23..24
FT /note="FN -> FTYWCILHDFPLVLPD (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_016954"
SQ SEQUENCE 272 AA; 30773 MW; F28BD2DF43BF418E CRC64;
MFGFPTATLL DCHGRYAQNV AFFNVMTEAH KYDPSEATGS SSWDFQSSFR REKLEQKSPE
SKALQEDSPG VRQKVYDCQE CGKSFRQKGS LTLHERIHTG QKPFECTQCG KSFRAKGNLV
THQRIHTGEK PYQCKECGKS FSQRGSLAVH ERLHTGQKPY ECAICQRSFR NQSNLAVHRR
VHSGEKPYRC DQCGKAFSQK GSLIVHIRVH TGLKPYACSH CRKSFHTRGN CLLHGKVHTG
ETPYLCGQCG KSFTQRGSLA VHQRSCSQRL TL
