ID   ZNF34_BOVIN             Reviewed;         543 AA.
AC   A3KN32;
DT   13-NOV-2007, integrated into UniProtKB/Swiss-Prot.
DT   03-APR-2007, sequence version 1.
DT   03-AUG-2022, entry version 92.
DE   RecName: Full=Zinc finger protein 34;
GN   Name=ZNF34;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Uterus;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (FEB-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May be involved in transcriptional regulation.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC       family. {ECO:0000305}.
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DR   EMBL; BC133534; AAI33535.1; -; mRNA.
DR   RefSeq; NP_001076989.1; NM_001083520.1.
DR   RefSeq; XP_015329850.1; XM_015474364.1.
DR   AlphaFoldDB; A3KN32; -.
DR   SMR; A3KN32; -.
DR   STRING; 9913.ENSBTAP00000046669; -.
DR   PaxDb; A3KN32; -.
DR   PRIDE; A3KN32; -.
DR   Ensembl; ENSBTAT00000016390; ENSBTAP00000016390; ENSBTAG00000012353.
DR   GeneID; 615905; -.
DR   KEGG; bta:615905; -.
DR   CTD; 80778; -.
DR   VEuPathDB; HostDB:ENSBTAG00000012353; -.
DR   VGNC; VGNC:37252; ZNF34.
DR   eggNOG; KOG1721; Eukaryota.
DR   GeneTree; ENSGT00940000153104; -.
DR   InParanoid; A3KN32; -.
DR   OMA; NVFQHQR; -.
DR   OrthoDB; 1318335at2759; -.
DR   Proteomes; UP000009136; Chromosome 14.
DR   Bgee; ENSBTAG00000012353; Expressed in retina and 105 other tissues.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   CDD; cd07765; KRAB_A-box; 1.
DR   InterPro; IPR001909; KRAB.
DR   InterPro; IPR036051; KRAB_dom_sf.
DR   InterPro; IPR036236; Znf_C2H2_sf.
DR   InterPro; IPR013087; Znf_C2H2_type.
DR   Pfam; PF01352; KRAB; 1.
DR   Pfam; PF00096; zf-C2H2; 12.
DR   SMART; SM00349; KRAB; 1.
DR   SMART; SM00355; ZnF_C2H2; 12.
DR   SUPFAM; SSF109640; SSF109640; 1.
DR   SUPFAM; SSF57667; SSF57667; 7.
DR   PROSITE; PS50805; KRAB; 1.
DR   PROSITE; PS00028; ZINC_FINGER_C2H2_1; 12.
DR   PROSITE; PS50157; ZINC_FINGER_C2H2_2; 12.
PE   2: Evidence at transcript level;
KW   DNA-binding; Metal-binding; Nucleus; Reference proteome; Repeat;
KW   Transcription; Transcription regulation; Zinc; Zinc-finger.
FT   CHAIN           1..543
FT                   /note="Zinc finger protein 34"
FT                   /id="PRO_0000310415"
FT   DOMAIN          14..87
FT                   /note="KRAB"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00119"
FT   ZN_FING         179..201
FT                   /note="C2H2-type 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         234..256
FT                   /note="C2H2-type 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         262..284
FT                   /note="C2H2-type 3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         290..312
FT                   /note="C2H2-type 4"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         318..340
FT                   /note="C2H2-type 5"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         346..368
FT                   /note="C2H2-type 6"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         374..396
FT                   /note="C2H2-type 7"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         402..424
FT                   /note="C2H2-type 8"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         430..452
FT                   /note="C2H2-type 9"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         458..480
FT                   /note="C2H2-type 10"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         486..508
FT                   /note="C2H2-type 11"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         514..536
FT                   /note="C2H2-type 12"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   REGION          84..151
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        89..103
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        123..145
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   543 AA;  61997 MW;  92B27BB7B1DEF549 CRC64;
     MAALDLCALP QAEVTFEDVA VFLSQEEWGL LGPAQKGLYR EVMLETYRNL VSLGAGLAGP
     KPEVIAQLEQ GDELWVLDMH GAEQPSVDGS AHGTRTENQE VTSGEMLFGR ELDPLRGSVL
     RGPEPGEVHE RVREPEGRLD RPGEQRGPRL VTLANEECGL ESGGNLRSRS RPVPDQRPHK
     CDICEQSFEQ RSYLNNHKRV HRCKKTNIVH DSGEIFAANL VKEDQKIPVG KRLYYCGCCG
     KAFRYSANLV KHQRLHSEEK PYKCEECGKA FHQSCELISH RRMHSGEIPY RCDECGKTFN
     QRPNLMKHQR IHTGEKPYKC SECGKHFSAY SSLIYHQRIH TGEKPYKCSD CGKAFSDGSI
     LIRHRRTHTG EKPYECKECG KGFTQSSNLI QHQRIHTGEK PYKCNECEKA FIQKTKLVEH
     QRSHTGEKPY ECNDCGKVFS QSTHLIQHQR IHTGEKPYKC SECGKAFHNS SRLIHHQRSH
     HGEKPYKCAD CKKAFSQGTY LLQHRRIHTG EKPYTCGECG KAFRHSSNMS QHQRIHLRED
     FSL