ZNF43_HUMAN
ID ZNF43_HUMAN Reviewed; 809 AA.
AC P17038; A8K5N8; P28160; Q53XQ2; Q5H9T3; Q96DG1;
DT 01-AUG-1990, integrated into UniProtKB/Swiss-Prot.
DT 24-MAR-2009, sequence version 4.
DT 03-AUG-2022, entry version 212.
DE RecName: Full=Zinc finger protein 43;
DE AltName: Full=Zinc finger protein 39;
DE AltName: Full=Zinc finger protein HTF6;
DE AltName: Full=Zinc finger protein KOX27;
GN Name=ZNF43; Synonyms=KOX27, ZNF39, ZNF39L1;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), AND VARIANT PRO-718.
RC TISSUE=T-cell;
RX PubMed=1711675; DOI=10.1093/nar/19.11.2921;
RA Lovering R., Trowsdale J.;
RT "A gene encoding 22 highly related zinc fingers is expressed in lymphoid
RT cell lines.";
RL Nucleic Acids Res. 19:2921-2927(1991).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RA Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S.,
RA Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y.,
RA Phelan M., Farmer A.;
RT "Cloning of human full-length CDSs in BD Creator(TM) system donor vector.";
RL Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Brain;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Endometrium;
RX PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D.,
RA Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A.,
RA Wiemann S., Schupp I.;
RT "The full-ORF clone resource of the German cDNA consortium.";
RL BMC Genomics 8:399-399(2007).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15057824; DOI=10.1038/nature02399;
RA Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E.,
RA Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A.,
RA Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S.,
RA Carrano A.V., Caoile C., Chan Y.M., Christensen M., Cleland C.A.,
RA Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J.,
RA Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M.,
RA Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W.,
RA Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V.,
RA Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D.,
RA McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I.,
RA Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L.,
RA Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A.,
RA She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M.,
RA Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J.,
RA Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA Rubin E.M., Lucas S.M.;
RT "The DNA sequence and biology of human chromosome 19.";
RL Nature 428:529-535(2004).
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [7]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Lymph;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [8]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 43-196 (ISOFORMS 1/2).
RX PubMed=2023909; DOI=10.1073/pnas.88.9.3608;
RA Bellefroid E.J., Poncelet D.A., Lecocq P.J., Revelant O., Martial J.A.;
RT "The evolutionarily conserved Kruppel-associated box domain defines a
RT subfamily of eukaryotic multifingered proteins.";
RL Proc. Natl. Acad. Sci. U.S.A. 88:3608-3612(1991).
RN [9]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 482-537 (ISOFORMS 1/2).
RC TISSUE=Lymphoid tissue;
RX PubMed=2288909;
RA Thiesen H.-J.;
RT "Multiple genes encoding zinc finger domains are expressed in human T
RT cells.";
RL New Biol. 2:363-374(1990).
RN [10]
RP VARIANT [LARGE SCALE ANALYSIS] CYS-244.
RX PubMed=16959974; DOI=10.1126/science.1133427;
RA Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D.,
RA Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P.,
RA Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V.,
RA Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H.,
RA Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W.,
RA Velculescu V.E.;
RT "The consensus coding sequences of human breast and colorectal cancers.";
RL Science 314:268-274(2006).
CC -!- FUNCTION: May be involved in transcriptional regulation.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=P17038-1; Sequence=Displayed;
CC Name=2;
CC IsoId=P17038-2; Sequence=VSP_036734;
CC -!- TISSUE SPECIFICITY: T- and B-cell lines.
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. {ECO:0000305}.
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DR EMBL; X59244; CAA41932.1; -; mRNA.
DR EMBL; BT009756; AAP88758.1; -; mRNA.
DR EMBL; AK291353; BAF84042.1; -; mRNA.
DR EMBL; CR933640; CAI45941.1; -; mRNA.
DR EMBL; AC010617; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC092364; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471106; EAW84908.1; -; Genomic_DNA.
DR EMBL; BC006528; AAH06528.2; -; mRNA.
DR EMBL; M61869; AAA58674.1; -; mRNA.
DR EMBL; X52358; CAA36584.1; -; mRNA.
DR CCDS; CCDS12413.2; -. [P17038-1]
DR CCDS; CCDS59367.1; -. [P17038-2]
DR PIR; D39384; D39384.
DR PIR; S26823; S26823.
DR RefSeq; NP_001243577.1; NM_001256648.1. [P17038-2]
DR RefSeq; NP_001243578.1; NM_001256649.1. [P17038-2]
DR RefSeq; NP_001243579.1; NM_001256650.1. [P17038-2]
DR RefSeq; NP_003414.2; NM_003423.3. [P17038-1]
DR RefSeq; XP_011526559.1; XM_011528257.2. [P17038-2]
DR RefSeq; XP_011526561.1; XM_011528259.2. [P17038-2]
DR RefSeq; XP_016882696.1; XM_017027207.1. [P17038-2]
DR RefSeq; XP_016882697.1; XM_017027208.1. [P17038-2]
DR RefSeq; XP_016882698.1; XM_017027209.1. [P17038-2]
DR RefSeq; XP_016882699.1; XM_017027210.1. [P17038-2]
DR RefSeq; XP_016882700.1; XM_017027211.1. [P17038-2]
DR RefSeq; XP_016882701.1; XM_017027212.1. [P17038-2]
DR RefSeq; XP_016882702.1; XM_017027213.1. [P17038-2]
DR RefSeq; XP_016882703.1; XM_017027214.1. [P17038-2]
DR RefSeq; XP_016882704.1; XM_017027215.1. [P17038-2]
DR RefSeq; XP_016882705.1; XM_017027216.1. [P17038-2]
DR AlphaFoldDB; P17038; -.
DR SMR; P17038; -.
DR BioGRID; 113420; 1.
DR iPTMnet; P17038; -.
DR PhosphoSitePlus; P17038; -.
DR BioMuta; ZNF43; -.
DR DMDM; 229485311; -.
DR EPD; P17038; -.
DR jPOST; P17038; -.
DR MassIVE; P17038; -.
DR MaxQB; P17038; -.
DR PaxDb; P17038; -.
DR PeptideAtlas; P17038; -.
DR PRIDE; P17038; -.
DR ProteomicsDB; 53440; -. [P17038-1]
DR ProteomicsDB; 53441; -. [P17038-2]
DR Antibodypedia; 28707; 85 antibodies from 17 providers.
DR DNASU; 7594; -.
DR Ensembl; ENST00000354959.9; ENSP00000347045.4; ENSG00000198521.12. [P17038-1]
DR Ensembl; ENST00000594012.5; ENSP00000469578.1; ENSG00000198521.12. [P17038-2]
DR Ensembl; ENST00000595461.5; ENSP00000469645.1; ENSG00000198521.12. [P17038-2]
DR Ensembl; ENST00000598381.5; ENSP00000470275.1; ENSG00000198521.12. [P17038-2]
DR GeneID; 7594; -.
DR KEGG; hsa:7594; -.
DR MANE-Select; ENST00000354959.9; ENSP00000347045.4; NM_003423.4; NP_003414.2.
DR UCSC; uc002nqj.5; human. [P17038-1]
DR CTD; 7594; -.
DR DisGeNET; 7594; -.
DR GeneCards; ZNF43; -.
DR HGNC; HGNC:13109; ZNF43.
DR HPA; ENSG00000198521; Low tissue specificity.
DR MIM; 603972; gene.
DR neXtProt; NX_P17038; -.
DR OpenTargets; ENSG00000198521; -.
DR PharmGKB; PA37684; -.
DR VEuPathDB; HostDB:ENSG00000198521; -.
DR eggNOG; KOG1721; Eukaryota.
DR GeneTree; ENSGT00940000163744; -.
DR HOGENOM; CLU_002678_17_1_1; -.
DR InParanoid; P17038; -.
DR PhylomeDB; P17038; -.
DR TreeFam; TF343410; -.
DR PathwayCommons; P17038; -.
DR Reactome; R-HSA-212436; Generic Transcription Pathway.
DR BioGRID-ORCS; 7594; 15 hits in 1028 CRISPR screens.
DR ChiTaRS; ZNF43; human.
DR GeneWiki; ZNF43; -.
DR GenomeRNAi; 7594; -.
DR Pharos; P17038; Tdark.
DR PRO; PR:P17038; -.
DR Proteomes; UP000005640; Chromosome 19.
DR RNAct; P17038; protein.
DR Bgee; ENSG00000198521; Expressed in calcaneal tendon and 111 other tissues.
DR ExpressionAtlas; P17038; baseline and differential.
DR Genevisible; P17038; HS.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0003677; F:DNA binding; TAS:ProtInc.
DR GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd07765; KRAB_A-box; 1.
DR InterPro; IPR001909; KRAB.
DR InterPro; IPR036051; KRAB_dom_sf.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF01352; KRAB; 1.
DR Pfam; PF00096; zf-C2H2; 17.
DR SMART; SM00349; KRAB; 1.
DR SMART; SM00355; ZnF_C2H2; 22.
DR SUPFAM; SSF109640; SSF109640; 1.
DR SUPFAM; SSF57667; SSF57667; 12.
DR PROSITE; PS50805; KRAB; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 19.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 22.
PE 2: Evidence at transcript level;
KW Alternative splicing; DNA-binding; Metal-binding; Nucleus;
KW Reference proteome; Repeat; Transcription; Transcription regulation; Zinc;
KW Zinc-finger.
FT CHAIN 1..809
FT /note="Zinc finger protein 43"
FT /id="PRO_0000047376"
FT DOMAIN 7..75
FT /note="KRAB"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00119"
FT ZN_FING 174..196
FT /note="C2H2-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 202..224
FT /note="C2H2-type 2; degenerate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 230..252
FT /note="C2H2-type 3; degenerate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 258..280
FT /note="C2H2-type 4; degenerate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 286..308
FT /note="C2H2-type 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 314..336
FT /note="C2H2-type 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 342..364
FT /note="C2H2-type 7"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 370..392
FT /note="C2H2-type 8"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 398..420
FT /note="C2H2-type 9"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 426..448
FT /note="C2H2-type 10"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 454..476
FT /note="C2H2-type 11"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 482..504
FT /note="C2H2-type 12"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 510..532
FT /note="C2H2-type 13"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 538..560
FT /note="C2H2-type 14"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 566..588
FT /note="C2H2-type 15"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 594..616
FT /note="C2H2-type 16"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 622..644
FT /note="C2H2-type 17"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 650..672
FT /note="C2H2-type 18"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 678..700
FT /note="C2H2-type 19"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 706..728
FT /note="C2H2-type 20"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 734..756
FT /note="C2H2-type 21"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 762..784
FT /note="C2H2-type 22"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT VAR_SEQ 1..7
FT /note="MGPLTFM -> M (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039,
FT ECO:0000303|PubMed:1711675, ECO:0000303|PubMed:17974005,
FT ECO:0000303|Ref.2"
FT /id="VSP_036734"
FT VARIANT 244
FT /note="R -> C (in a colorectal cancer sample; somatic
FT mutation; dbSNP:rs200399581)"
FT /evidence="ECO:0000269|PubMed:16959974"
FT /id="VAR_035569"
FT VARIANT 718
FT /note="S -> P (in dbSNP:rs1063327)"
FT /evidence="ECO:0000269|PubMed:1711675"
FT /id="VAR_054794"
FT CONFLICT 43
FT /note="L -> M (in Ref. 8; AAA58674)"
FT /evidence="ECO:0000305"
FT CONFLICT 187
FT /note="P -> S (in Ref. 8; AAA58674)"
FT /evidence="ECO:0000305"
FT CONFLICT 573
FT /note="K -> R (in Ref. 3; BAF84042)"
FT /evidence="ECO:0000305"
FT CONFLICT 622
FT /note="Y -> H (in Ref. 4; CAI45941)"
FT /evidence="ECO:0000305"
FT CONFLICT 738
FT /note="E -> G (in Ref. 4; CAI45941)"
FT /evidence="ECO:0000305"
FT CONFLICT 797
FT /note="V -> M (in Ref. 3; BAF84042)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 809 AA; 94124 MW; 03386F299D6794C4 CRC64;
MGPLTFMDVA IEFCLEEWQC LDIAQQNLYR NVMLENYRNL VFLGIAVSKP DLITCLEQEK
EPWEPMRRHE MVAKPPVMCS HFTQDFWPEQ HIKDPFQKAT LRRYKNCEHK NVHLKKDHKS
VDECKVHRGG YNGFNQCLPA TQSKIFLFDK CVKAFHKFSN SNRHKISHTE KKLFKCKECG
KSFCMLPHLA QHKIIHTRVN FCKCEKCGKA FNCPSIITKH KRINTGEKPY TCEECGKVFN
WSSRLTTHKK NYTRYKLYKC EECGKAFNKS SILTTHKIIR TGEKFYKCKE CAKAFNQSSN
LTEHKKIHPG EKPYKCEECG KAFNWPSTLT KHKRIHTGEK PYTCEECGKA FNQFSNLTTH
KRIHTAEKFY KCTECGEAFS RSSNLTKHKK IHTEKKPYKC EECGKAFKWS SKLTEHKLTH
TGEKPYKCEE CGKAFNWPST LTKHNRIHTG EKPYKCEVCG KAFNQFSNLT THKRIHTAEK
PYKCEECGKA FSRSSNLTKH KKIHIEKKPY KCEECGKAFK WSSKLTEHKI THTGEKPYKC
EECGKAFNHF SILTKHKRIH TGEKPYKCEE CGKAFTQSSN LTTHKKIHTG EKFYKCEECG
KAFTQSSNLT THKKIHTGGK PYKCEECGKA FNQFSTLTKH KIIHTEEKPY KCEECGKAFK
WSSTLTKHKI IHTGEKPYKC EECGKAFKLS STLSTHKIIH TGEKPYKCEK CGKAFNRSSN
LIEHKKIHTG EQPYKCEECG KAFNYSSHLN THKRIHTKEQ PYKCKECGKA FNQYSNLTTH
NKIHTGEKLY KPEDVTVILT TPQTFSNIK
