ID   ZNF57_HUMAN             Reviewed;         555 AA.
AC   Q68EA5; Q8N6R9;
DT   06-FEB-2007, integrated into UniProtKB/Swiss-Prot.
DT   03-APR-2007, sequence version 3.
DT   03-AUG-2022, entry version 150.
DE   RecName: Full=Zinc finger protein 57;
DE   AltName: Full=Zinc finger protein 424;
GN   Name=ZNF57; Synonyms=ZNF424;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Endometrium;
RX   PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA   Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA   Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D.,
RA   Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A.,
RA   Wiemann S., Schupp I.;
RT   "The full-ORF clone resource of the German cDNA consortium.";
RL   BMC Genomics 8:399-399(2007).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Cervix;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: May be involved in transcriptional regulation.
CC   -!- INTERACTION:
CC       Q68EA5; Q9NPB3: CABP2; NbExp=3; IntAct=EBI-8490788, EBI-12011224;
CC       Q68EA5; G5E9A7: DMWD; NbExp=3; IntAct=EBI-8490788, EBI-10976677;
CC       Q68EA5; O95967: EFEMP2; NbExp=3; IntAct=EBI-8490788, EBI-743414;
CC       Q68EA5; Q53GS7: GLE1; NbExp=3; IntAct=EBI-8490788, EBI-1955541;
CC       Q68EA5; P28799: GRN; NbExp=3; IntAct=EBI-8490788, EBI-747754;
CC       Q68EA5; P42858: HTT; NbExp=15; IntAct=EBI-8490788, EBI-466029;
CC       Q68EA5; O60333-2: KIF1B; NbExp=3; IntAct=EBI-8490788, EBI-10975473;
CC       Q68EA5; Q96A72: MAGOHB; NbExp=3; IntAct=EBI-8490788, EBI-746778;
CC       Q68EA5; Q9GZM8: NDEL1; NbExp=3; IntAct=EBI-8490788, EBI-928842;
CC       Q68EA5; P07196: NEFL; NbExp=3; IntAct=EBI-8490788, EBI-475646;
CC       Q68EA5; D3DTS7: PMP22; NbExp=3; IntAct=EBI-8490788, EBI-25882629;
CC       Q68EA5; P60891: PRPS1; NbExp=3; IntAct=EBI-8490788, EBI-749195;
CC       Q68EA5; Q9Y3C5: RNF11; NbExp=3; IntAct=EBI-8490788, EBI-396669;
CC       Q68EA5; P37840: SNCA; NbExp=3; IntAct=EBI-8490788, EBI-985879;
CC       Q68EA5; Q7Z699: SPRED1; NbExp=3; IntAct=EBI-8490788, EBI-5235340;
CC       Q68EA5; P26368-2: U2AF2; NbExp=3; IntAct=EBI-8490788, EBI-11097439;
CC       Q68EA5; O76024: WFS1; NbExp=3; IntAct=EBI-8490788, EBI-720609;
CC       Q68EA5; P15622-3: ZNF250; NbExp=3; IntAct=EBI-8490788, EBI-10177272;
CC       Q68EA5; Q7Z3I7: ZNF572; NbExp=3; IntAct=EBI-8490788, EBI-10172590;
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC       family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; BX537601; CAH18455.2; -; mRNA.
DR   EMBL; BC028974; AAH28974.1; -; mRNA.
DR   CCDS; CCDS12098.1; -.
DR   PIR; B45193; B45193.
DR   RefSeq; NP_001306012.1; NM_001319083.1.
DR   RefSeq; NP_775751.1; NM_173480.2.
DR   AlphaFoldDB; Q68EA5; -.
DR   SMR; Q68EA5; -.
DR   BioGRID; 125974; 16.
DR   IntAct; Q68EA5; 25.
DR   MINT; Q68EA5; -.
DR   STRING; 9606.ENSP00000303696; -.
DR   GlyGen; Q68EA5; 1 site, 1 O-linked glycan (1 site).
DR   iPTMnet; Q68EA5; -.
DR   PhosphoSitePlus; Q68EA5; -.
DR   BioMuta; ZNF57; -.
DR   DMDM; 143811479; -.
DR   jPOST; Q68EA5; -.
DR   MassIVE; Q68EA5; -.
DR   MaxQB; Q68EA5; -.
DR   PaxDb; Q68EA5; -.
DR   PeptideAtlas; Q68EA5; -.
DR   PRIDE; Q68EA5; -.
DR   ProteomicsDB; 66128; -.
DR   Antibodypedia; 10870; 110 antibodies from 16 providers.
DR   DNASU; 126295; -.
DR   Ensembl; ENST00000306908.10; ENSP00000303696.5; ENSG00000171970.14.
DR   GeneID; 126295; -.
DR   KEGG; hsa:126295; -.
DR   MANE-Select; ENST00000306908.10; ENSP00000303696.5; NM_173480.3; NP_775751.1.
DR   UCSC; uc002lwr.3; human.
DR   CTD; 126295; -.
DR   DisGeNET; 126295; -.
DR   GeneCards; ZNF57; -.
DR   HGNC; HGNC:13125; ZNF57.
DR   HPA; ENSG00000171970; Tissue enhanced (testis).
DR   neXtProt; NX_Q68EA5; -.
DR   OpenTargets; ENSG00000171970; -.
DR   PharmGKB; PA37699; -.
DR   VEuPathDB; HostDB:ENSG00000171970; -.
DR   eggNOG; KOG1721; Eukaryota.
DR   GeneTree; ENSGT00950000182755; -.
DR   HOGENOM; CLU_002678_44_0_1; -.
DR   InParanoid; Q68EA5; -.
DR   OrthoDB; 1318335at2759; -.
DR   PhylomeDB; Q68EA5; -.
DR   TreeFam; TF338854; -.
DR   PathwayCommons; Q68EA5; -.
DR   SignaLink; Q68EA5; -.
DR   BioGRID-ORCS; 126295; 14 hits in 1098 CRISPR screens.
DR   GenomeRNAi; 126295; -.
DR   Pharos; Q68EA5; Tdark.
DR   PRO; PR:Q68EA5; -.
DR   Proteomes; UP000005640; Chromosome 19.
DR   RNAct; Q68EA5; protein.
DR   Bgee; ENSG00000171970; Expressed in sperm and 140 other tissues.
DR   ExpressionAtlas; Q68EA5; baseline and differential.
DR   Genevisible; Q68EA5; HS.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0000977; F:RNA polymerase II transcription regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   CDD; cd07765; KRAB_A-box; 1.
DR   InterPro; IPR001909; KRAB.
DR   InterPro; IPR036051; KRAB_dom_sf.
DR   InterPro; IPR036236; Znf_C2H2_sf.
DR   InterPro; IPR013087; Znf_C2H2_type.
DR   Pfam; PF01352; KRAB; 1.
DR   Pfam; PF00096; zf-C2H2; 9.
DR   SMART; SM00349; KRAB; 1.
DR   SMART; SM00355; ZnF_C2H2; 13.
DR   SUPFAM; SSF109640; SSF109640; 1.
DR   SUPFAM; SSF57667; SSF57667; 9.
DR   PROSITE; PS50805; KRAB; 1.
DR   PROSITE; PS00028; ZINC_FINGER_C2H2_1; 13.
DR   PROSITE; PS50157; ZINC_FINGER_C2H2_2; 13.
PE   1: Evidence at protein level;
KW   DNA-binding; Metal-binding; Nucleus; Reference proteome; Repeat;
KW   Transcription; Transcription regulation; Zinc; Zinc-finger.
FT   CHAIN           1..555
FT                   /note="Zinc finger protein 57"
FT                   /id="PRO_0000274878"
FT   DOMAIN          4..76
FT                   /note="KRAB"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00119"
FT   ZN_FING         140..162
FT                   /note="C2H2-type 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         196..218
FT                   /note="C2H2-type 2; degenerate"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         224..246
FT                   /note="C2H2-type 3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         252..274
FT                   /note="C2H2-type 4"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         280..302
FT                   /note="C2H2-type 5"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         308..330
FT                   /note="C2H2-type 6"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         336..358
FT                   /note="C2H2-type 7"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         364..386
FT                   /note="C2H2-type 8"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         392..414
FT                   /note="C2H2-type 9"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         420..442
FT                   /note="C2H2-type 10"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         448..470
FT                   /note="C2H2-type 11"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         476..498
FT                   /note="C2H2-type 12"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         504..526
FT                   /note="C2H2-type 13"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   VARIANT         223
FT                   /note="T -> N (in dbSNP:rs2288958)"
FT                   /id="VAR_052760"
FT   VARIANT         230
FT                   /note="R -> W (in dbSNP:rs2288957)"
FT                   /id="VAR_052761"
FT   VARIANT         357
FT                   /note="T -> M (in dbSNP:rs55682587)"
FT                   /id="VAR_061931"
FT   CONFLICT        198
FT                   /note="C -> R (in Ref. 1; CAH18455)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   555 AA;  64428 MW;  295DD933C850397F CRC64;
     MDSVVFEDVA VDFTLEEWAL LDSAQRDLYR DVMLETFRNL ASVDDGTQFK ANGSVSLQDM
     YGQEKSKEQT IPNFTGNNSC AYTLEKNCEG YGTEDHHKNL RNHMVDRFCT HNEGNQYGEA
     IHQMPDLTLH KKVSAGEKPY ECTKCRTVFT HLSSLKRHVK SHCGRKAPPG EECKQACICP
     SHLHSHGRTD TEEKPYKCQA CGQTFQHPRY LSHHVKTHTA EKTYKCEQCR MAFNGFASFT
     RHVRTHTKDR PYKCQECGRA FIYPSTFQRH MTTHTGEKPY KCQHCGKAFT YPQAFQRHEK
     THTGEKPYEC KQCGKTFSWS ETLRVHMRIH TGDKLYKCEH CGKAFTSSRS FQGHLRTHTG
     EKPYECKQCG KAFTWSSTFR EHVRIHTQEQ LYKCEQCGKA FTSSRSFRGH LRTHTGEKPY
     ECKQCGKTFT WSSTFREHVR IHTQEQLHKC EHCGKAFTSS RAFQGHLRMH TGEKPYECKQ
     CGKTFTWSST LHNHVRMHTG EKPHKCKQCG MSFKWHSSFR NHLRMHTGQK SHECQSYSKA
     FSCQVILSKT SESTH