ZNF66_HUMAN
ID ZNF66_HUMAN Reviewed; 573 AA.
AC Q6ZN08; I3L4P5; Q15939;
DT 02-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT 26-JUN-2013, sequence version 3.
DT 03-AUG-2022, entry version 145.
DE RecName: Full=Putative zinc finger protein 66;
DE AltName: Full=Zinc finger protein 66 pseudogene;
GN Name=ZNF66; Synonyms=ZNF66P;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15057824; DOI=10.1038/nature02399;
RA Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E.,
RA Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A.,
RA Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S.,
RA Carrano A.V., Caoile C., Chan Y.M., Christensen M., Cleland C.A.,
RA Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J.,
RA Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M.,
RA Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W.,
RA Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V.,
RA Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D.,
RA McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I.,
RA Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L.,
RA Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A.,
RA She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M.,
RA Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J.,
RA Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA Rubin E.M., Lucas S.M.;
RT "The DNA sequence and biology of human chromosome 19.";
RL Nature 428:529-535(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 297-351.
RX PubMed=1946370; DOI=10.1073/pnas.88.21.9563;
RA Bray P.L., Lichter P., Thiesen H.-J., Ward D.C., Dawid I.B.;
RT "Characterization and mapping of human genes encoding zinc finger
RT proteins.";
RL Proc. Natl. Acad. Sci. U.S.A. 88:9563-9567(1991).
CC -!- FUNCTION: May be involved in transcriptional regulation. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. {ECO:0000305}.
CC -!- CAUTION: Could be the product of a pseudogene. {ECO:0000305}.
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DR EMBL; AC010329; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; M88375; AAA61333.1; -; Genomic_DNA.
DR PIR; I45193; I45193.
DR AlphaFoldDB; Q6ZN08; -.
DR SMR; Q6ZN08; -.
DR IntAct; Q6ZN08; 6.
DR STRING; 9606.ENSP00000461425; -.
DR iPTMnet; Q6ZN08; -.
DR PhosphoSitePlus; Q6ZN08; -.
DR BioMuta; ZNF66; -.
DR DMDM; 519668683; -.
DR EPD; Q6ZN08; -.
DR jPOST; Q6ZN08; -.
DR MassIVE; Q6ZN08; -.
DR PaxDb; Q6ZN08; -.
DR PeptideAtlas; Q6ZN08; -.
DR PRIDE; Q6ZN08; -.
DR ProteomicsDB; 47557; -.
DR ProteomicsDB; 67953; -.
DR Ensembl; ENST00000344519.10; ENSP00000461425.1; ENSG00000160229.13.
DR MANE-Select; ENST00000344519.10; ENSP00000461425.1; NM_001355197.2; NP_001342126.2.
DR UCSC; uc060wfa.1; human.
DR GeneCards; ZNF66; -.
DR HGNC; HGNC:13135; ZNF66.
DR HPA; ENSG00000160229; Tissue enhanced (brain).
DR neXtProt; NX_Q6ZN08; -.
DR OpenTargets; ENSG00000160229; -.
DR VEuPathDB; HostDB:ENSG00000160229; -.
DR eggNOG; KOG1721; Eukaryota.
DR GeneTree; ENSGT01050000244908; -.
DR HOGENOM; CLU_002678_44_5_1; -.
DR InParanoid; Q6ZN08; -.
DR OMA; IHMGGNP; -.
DR PhylomeDB; Q6ZN08; -.
DR TreeFam; TF342117; -.
DR PathwayCommons; Q6ZN08; -.
DR ChiTaRS; ZNF66; human.
DR Pharos; Q6ZN08; Tdark.
DR PRO; PR:Q6ZN08; -.
DR Proteomes; UP000005640; Chromosome 19.
DR RNAct; Q6ZN08; protein.
DR Bgee; ENSG00000160229; Expressed in sural nerve and 108 other tissues.
DR ExpressionAtlas; Q6ZN08; baseline and differential.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IBA:GO_Central.
DR CDD; cd07765; KRAB_A-box; 1.
DR InterPro; IPR001909; KRAB.
DR InterPro; IPR036051; KRAB_dom_sf.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF01352; KRAB; 1.
DR Pfam; PF00096; zf-C2H2; 12.
DR SMART; SM00349; KRAB; 1.
DR SMART; SM00355; ZnF_C2H2; 15.
DR SUPFAM; SSF109640; SSF109640; 1.
DR SUPFAM; SSF57667; SSF57667; 8.
DR PROSITE; PS50805; KRAB; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 14.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 15.
DR PROSITE; PS00142; ZINC_PROTEASE; 1.
PE 5: Uncertain;
KW DNA-binding; Metal-binding; Nucleus; Reference proteome; Repeat;
KW Transcription; Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1..573
FT /note="Putative zinc finger protein 66"
FT /id="PRO_0000304992"
FT DOMAIN 4..75
FT /note="KRAB"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00119"
FT ZN_FING 145..167
FT /note="C2H2-type 1; atypical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 171..195
FT /note="C2H2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 201..223
FT /note="C2H2-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 229..251
FT /note="C2H2-type 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 257..279
FT /note="C2H2-type 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 285..307
FT /note="C2H2-type 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 313..335
FT /note="C2H2-type 7"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 341..363
FT /note="C2H2-type 8"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 369..391
FT /note="C2H2-type 9"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 397..419
FT /note="C2H2-type 10"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 425..447
FT /note="C2H2-type 11"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 453..475
FT /note="C2H2-type 12"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 481..503
FT /note="C2H2-type 13"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 509..531
FT /note="C2H2-type 14"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 537..559
FT /note="C2H2-type 15"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT CONFLICT 349
FT /note="G -> S (in Ref. 2; AAA61333)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 573 AA; 65874 MW; FE7D5305F21F9D62 CRC64;
MGPLQFRDVA IEFSLEEWHC LDMAQRNLYR DVMLENYRNL VFLGIVVSKP DLITHLEQGK
KPSTMQRHEM VANPSVLCSH FNQDLWPEQS IKDSFQKLIL RRHKKCGHDN LQLKKGCESV
DKCKVHKRGY NGLNQCLTTT QSKMFQCDKH GKVFHQFSNT NRHKIRHTGK NPCKFTECGK
AFNRSSTFTT HKKIHTGEKP YKCIECGKAF NRSSHLTTHK IIHTGEKRYK CEDCGKAFNR
SSNLTTHKKI HTGEKPYKCE ECGKAFKRSS ILTTHKRIHT GEKPYKCEEC GKVFKYLSSL
STHKIIHTGE KPYKCEECGK AFNWSSHLTT HKRIHTGEKP YKCEECGKGF KYSSTLTKHK
IIHTGEKPYK CEECGEAFKY SCSLTAHKII HTGKKPYKCE ECGKVFKHSS PLSKHKRIHT
GEKPYKCEEC GKAFSRSSIL TTHKIIHTGE KPYECEDCGK AFNRSSNLTK HKKIHTGEKP
YKCEECGKAF KCSSILTTHK RIHTADKPYK CEECGKDFKY SSTLTRHKKI HTGGKPHKCN
KCGKAFISSS NLSRHEIIHM GGNPYKCENV AKP
