ZNF69_HUMAN
ID ZNF69_HUMAN Reviewed; 566 AA.
AC Q9UC07; Q86VA7;
DT 19-SEP-2002, integrated into UniProtKB/Swiss-Prot.
DT 24-JUL-2007, sequence version 2.
DT 03-AUG-2022, entry version 166.
DE RecName: Full=Zinc finger protein 69;
DE AltName: Full=hZNF3;
GN Name=ZNF69;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=10591208; DOI=10.1038/990031;
RA Dunham I., Hunt A.R., Collins J.E., Bruskiewich R., Beare D.M., Clamp M.,
RA Smink L.J., Ainscough R., Almeida J.P., Babbage A.K., Bagguley C.,
RA Bailey J., Barlow K.F., Bates K.N., Beasley O.P., Bird C.P., Blakey S.E.,
RA Bridgeman A.M., Buck D., Burgess J., Burrill W.D., Burton J., Carder C.,
RA Carter N.P., Chen Y., Clark G., Clegg S.M., Cobley V.E., Cole C.G.,
RA Collier R.E., Connor R., Conroy D., Corby N.R., Coville G.J., Cox A.V.,
RA Davis J., Dawson E., Dhami P.D., Dockree C., Dodsworth S.J., Durbin R.M.,
RA Ellington A.G., Evans K.L., Fey J.M., Fleming K., French L., Garner A.A.,
RA Gilbert J.G.R., Goward M.E., Grafham D.V., Griffiths M.N.D., Hall C.,
RA Hall R.E., Hall-Tamlyn G., Heathcott R.W., Ho S., Holmes S., Hunt S.E.,
RA Jones M.C., Kershaw J., Kimberley A.M., King A., Laird G.K., Langford C.F.,
RA Leversha M.A., Lloyd C., Lloyd D.M., Martyn I.D., Mashreghi-Mohammadi M.,
RA Matthews L.H., Mccann O.T., Mcclay J., Mclaren S., McMurray A.A.,
RA Milne S.A., Mortimore B.J., Odell C.N., Pavitt R., Pearce A.V., Pearson D.,
RA Phillimore B.J.C.T., Phillips S.H., Plumb R.W., Ramsay H., Ramsey Y.,
RA Rogers L., Ross M.T., Scott C.E., Sehra H.K., Skuce C.D., Smalley S.,
RA Smith M.L., Soderlund C., Spragon L., Steward C.A., Sulston J.E.,
RA Swann R.M., Vaudin M., Wall M., Wallis J.M., Whiteley M.N., Willey D.L.,
RA Williams L., Williams S.A., Williamson H., Wilmer T.E., Wilming L.,
RA Wright C.L., Hubbard T., Bentley D.R., Beck S., Rogers J., Shimizu N.,
RA Minoshima S., Kawasaki K., Sasaki T., Asakawa S., Kudoh J., Shintani A.,
RA Shibuya K., Yoshizaki Y., Aoki N., Mitsuyama S., Roe B.A., Chen F., Chu L.,
RA Crabtree J., Deschamps S., Do A., Do T., Dorman A., Fang F., Fu Y., Hu P.,
RA Hua A., Kenton S., Lai H., Lao H.I., Lewis J., Lewis S., Lin S.-P., Loh P.,
RA Malaj E., Nguyen T., Pan H., Phan S., Qi S., Qian Y., Ray L., Ren Q.,
RA Shaull S., Sloan D., Song L., Wang Q., Wang Y., Wang Z., White J.,
RA Willingham D., Wu H., Yao Z., Zhan M., Zhang G., Chissoe S., Murray J.,
RA Miller N., Minx P., Fulton R., Johnson D., Bemis G., Bentley D.,
RA Bradshaw H., Bourne S., Cordes M., Du Z., Fulton L., Goela D., Graves T.,
RA Hawkins J., Hinds K., Kemp K., Latreille P., Layman D., Ozersky P.,
RA Rohlfing T., Scheet P., Walker C., Wamsley A., Wohldmann P., Pepin K.,
RA Nelson J., Korf I., Bedell J.A., Hillier L.W., Mardis E., Waterston R.,
RA Wilson R., Emanuel B.S., Shaikh T., Kurahashi H., Saitta S., Budarf M.L.,
RA McDermid H.E., Johnson A., Wong A.C.C., Morrow B.E., Edelmann L., Kim U.J.,
RA Shizuya H., Simon M.I., Dumanski J.P., Peyrard M., Kedra D., Seroussi E.,
RA Fransson I., Tapia I., Bruder C.E., O'Brien K.P., Wilkinson P.,
RA Bodenteich A., Hartman K., Hu X., Khan A.S., Lane L., Tilahun Y.,
RA Wright H.;
RT "The DNA sequence of human chromosome 22.";
RL Nature 402:489-495(1999).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 246-373 (ISOFORM 1).
RX PubMed=1639391; DOI=10.1016/0888-7543(92)90135-f;
RA Aubry M., Marineau C., Zhang F.R., Zahed L., Figlewicz D., Delattre O.,
RA Thomas G., de Jong P.J., Julien J.-P., Rouleau G.A.;
RT "Cloning of six new genes with zinc finger motifs mapping to short and long
RT arms of human acrocentric chromosome 22 (p and q11.2).";
RL Genomics 13:641-648(1992).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 329-566 (ISOFORM 1).
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
CC -!- FUNCTION: May be involved in transcriptional regulation.
CC -!- INTERACTION:
CC Q9UC07; Q9BW62: KATNAL1; NbExp=3; IntAct=EBI-10320266, EBI-743591;
CC Q9UC07; Q15323: KRT31; NbExp=3; IntAct=EBI-10320266, EBI-948001;
CC Q9UC07-2; Q9H5Z6-2: FAM124B; NbExp=3; IntAct=EBI-12310821, EBI-11986315;
CC Q9UC07-2; O43559: FRS3; NbExp=3; IntAct=EBI-12310821, EBI-725515;
CC Q9UC07-2; Q969Y2: GTPBP3; NbExp=3; IntAct=EBI-12310821, EBI-740290;
CC Q9UC07-2; Q9BW62: KATNAL1; NbExp=6; IntAct=EBI-12310821, EBI-743591;
CC Q9UC07-2; Q15323: KRT31; NbExp=3; IntAct=EBI-12310821, EBI-948001;
CC Q9UC07-2; Q8TAP4-4: LMO3; NbExp=3; IntAct=EBI-12310821, EBI-11742507;
CC Q9UC07-2; Q6FHY5: MEOX2; NbExp=3; IntAct=EBI-12310821, EBI-16439278;
CC Q9UC07-2; P07237: P4HB; NbExp=3; IntAct=EBI-12310821, EBI-395883;
CC Q9UC07-2; Q96GM5: SMARCD1; NbExp=3; IntAct=EBI-12310821, EBI-358489;
CC Q9UC07-2; Q8TAU3: ZNF417; NbExp=3; IntAct=EBI-12310821, EBI-740727;
CC Q9UC07-2; Q9UC07-2: ZNF69; NbExp=3; IntAct=EBI-12310821, EBI-12310821;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q9UC07-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q9UC07-2; Sequence=VSP_026927, VSP_026928;
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AK001669; Type=Frameshift; Evidence={ECO:0000305};
CC Sequence=CAC16147.1; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; BC051309; AAH51309.1; -; mRNA.
DR EMBL; AC008770; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; X60076; CAC16147.1; ALT_FRAME; Genomic_DNA.
DR EMBL; AK001669; -; NOT_ANNOTATED_CDS; mRNA.
DR CCDS; CCDS32914.1; -. [Q9UC07-2]
DR PIR; C42825; C42825.
DR RefSeq; NP_068734.1; NM_021915.3. [Q9UC07-2]
DR AlphaFoldDB; Q9UC07; -.
DR SMR; Q9UC07; -.
DR BioGRID; 113440; 16.
DR IntAct; Q9UC07; 10.
DR iPTMnet; Q9UC07; -.
DR PhosphoSitePlus; Q9UC07; -.
DR BioMuta; ZNF69; -.
DR DMDM; 158520002; -.
DR EPD; Q9UC07; -.
DR jPOST; Q9UC07; -.
DR MassIVE; Q9UC07; -.
DR MaxQB; Q9UC07; -.
DR PeptideAtlas; Q9UC07; -.
DR PRIDE; Q9UC07; -.
DR ProteomicsDB; 84109; -. [Q9UC07-1]
DR ProteomicsDB; 84110; -. [Q9UC07-2]
DR Antibodypedia; 25964; 177 antibodies from 17 providers.
DR DNASU; 7620; -.
DR Ensembl; ENST00000340180.5; ENSP00000345333.5; ENSG00000198429.10. [Q9UC07-2]
DR Ensembl; ENST00000429654.7; ENSP00000402985.2; ENSG00000198429.10. [Q9UC07-1]
DR GeneID; 7620; -.
DR KEGG; hsa:7620; -.
DR MANE-Select; ENST00000429654.7; ENSP00000402985.2; NM_001364730.1; NP_001351659.1.
DR UCSC; uc002mst.5; human. [Q9UC07-1]
DR CTD; 7620; -.
DR DisGeNET; 7620; -.
DR GeneCards; ZNF69; -.
DR HGNC; HGNC:13138; ZNF69.
DR HPA; ENSG00000198429; Low tissue specificity.
DR MIM; 194543; gene.
DR neXtProt; NX_Q9UC07; -.
DR OpenTargets; ENSG00000198429; -.
DR PharmGKB; PA37712; -.
DR VEuPathDB; HostDB:ENSG00000198429; -.
DR GeneTree; ENSGT00940000163273; -.
DR HOGENOM; CLU_002678_44_5_1; -.
DR InParanoid; Q9UC07; -.
DR OMA; CYRRHER; -.
DR OrthoDB; 1318335at2759; -.
DR PhylomeDB; Q9UC07; -.
DR TreeFam; TF340042; -.
DR PathwayCommons; Q9UC07; -.
DR SignaLink; Q9UC07; -.
DR BioGRID-ORCS; 7620; 55 hits in 1000 CRISPR screens.
DR ChiTaRS; ZNF69; human.
DR GenomeRNAi; 7620; -.
DR Pharos; Q9UC07; Tbio.
DR PRO; PR:Q9UC07; -.
DR Proteomes; UP000005640; Chromosome 19.
DR RNAct; Q9UC07; protein.
DR Bgee; ENSG00000198429; Expressed in colonic epithelium and 100 other tissues.
DR ExpressionAtlas; Q9UC07; baseline and differential.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0001227; F:DNA-binding transcription repressor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0042802; F:identical protein binding; IPI:IntAct.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000977; F:RNA polymerase II transcription regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd07765; KRAB_A-box; 1.
DR InterPro; IPR001909; KRAB.
DR InterPro; IPR036051; KRAB_dom_sf.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF01352; KRAB; 1.
DR Pfam; PF00096; zf-C2H2; 8.
DR SMART; SM00349; KRAB; 1.
DR SMART; SM00355; ZnF_C2H2; 13.
DR SUPFAM; SSF109640; SSF109640; 1.
DR SUPFAM; SSF57667; SSF57667; 8.
DR PROSITE; PS50805; KRAB; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 13.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 14.
PE 1: Evidence at protein level;
KW Alternative splicing; DNA-binding; Metal-binding; Nucleus;
KW Reference proteome; Repeat; Transcription; Transcription regulation; Zinc;
KW Zinc-finger.
FT CHAIN 1..566
FT /note="Zinc finger protein 69"
FT /id="PRO_0000295545"
FT DOMAIN 24..106
FT /note="KRAB"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00119"
FT ZN_FING 164..186
FT /note="C2H2-type 1; degenerate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 192..214
FT /note="C2H2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 220..242
FT /note="C2H2-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 248..270
FT /note="C2H2-type 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 276..298
FT /note="C2H2-type 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 304..326
FT /note="C2H2-type 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 332..354
FT /note="C2H2-type 7"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 360..382
FT /note="C2H2-type 8"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 388..410
FT /note="C2H2-type 9"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 416..438
FT /note="C2H2-type 10"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 444..472
FT /note="C2H2-type 11"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 478..500
FT /note="C2H2-type 12"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 506..528
FT /note="C2H2-type 13"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 534..556
FT /note="C2H2-type 14"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT VAR_SEQ 22..35
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_026927"
FT VAR_SEQ 164..566
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_026928"
SQ SEQUENCE 566 AA; 65761 MW; DA1D46CBFD266AD6 CRC64;
MPCCSHRRCR EDPGTSESQE MDPVAFDDVA VNFTQEEWAL LDISQRKLYK EVMLETFRNL
TSVGKSWKDQ NIEYEYQNPR RNFRSLIEKK VNEIKDDSHC GETFTQVPDD RLNFQEKKAS
PEIKSCDSFV CGEVGLGNSS FNMNIRGDIG HKAYEYQEYG PKPCKCQQPK KAFRYHPSFR
TPQRDHTGEK PYACKECGKT FISHSSIQRH VVMHSGDGPY KCKFCGKAFH CLSLYLIHER
IHTGEKPYEC KQCGKSFSYS ATLRIHERTH TGEKPYECQQ CGKAFHSPRC YRRHERIHTG
EKAYQCKECG KAFTCPQYVR IHERTHSRKK PYECTQCGKA LSSLTSFQTH IRMHSGERPY
ECKICGKGFC SANSFQRHEK THSGEKPYKC KQCGKAFIHS SSLRYHERIH TGEKPYECKQ
CGKAFRSSSH LQLHGRTHTG EKPYECQECG KAFRSMKNLQ SHERTQTHVR IHSGERPYKC
KLCGKGFYCP KSLQRHEKTH TGEKLYECKQ CGEAFSSSSS FRYHERTHTG EKPYKCKQCG
KAFRAASVLR MHGRTHPEDK PYECKQ
