ZNF70_HUMAN
ID ZNF70_HUMAN Reviewed; 446 AA.
AC Q9UC06;
DT 27-MAR-2002, integrated into UniProtKB/Swiss-Prot.
DT 27-MAR-2002, sequence version 2.
DT 03-AUG-2022, entry version 173.
DE RecName: Full=Zinc finger protein 70;
DE AltName: Full=Zinc finger protein N27C7-1;
GN Name=ZNF70;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Shimizu N., Minosima S., Kawasaki K., Sasaki T., Hosono K.;
RT "Molecular cloning of N27C7-1 gene.";
RL Submitted (NOV-2000) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15461802; DOI=10.1186/gb-2004-5-10-r84;
RA Collins J.E., Wright C.L., Edwards C.A., Davis M.P., Grinham J.A.,
RA Cole C.G., Goward M.E., Aguado B., Mallya M., Mokrab Y., Huckle E.J.,
RA Beare D.M., Dunham I.;
RT "A genome annotation-driven approach to cloning the human ORFeome.";
RL Genome Biol. 5:R84.1-R84.11(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Eye;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 245-335.
RX PubMed=1639391; DOI=10.1016/0888-7543(92)90135-f;
RA Aubry M., Marineau C., Zhang F.R., Zahed L., Figlewicz D., Delattre O.,
RA Thomas G., de Jong P.J., Julien J.-P., Rouleau G.A.;
RT "Cloning of six new genes with zinc finger motifs mapping to short and long
RT arms of human acrocentric chromosome 22 (p and q11.2).";
RL Genomics 13:641-648(1992).
CC -!- FUNCTION: May be involved in transcriptional regulation.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. {ECO:0000305}.
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DR EMBL; AB050771; BAB83033.1; -; Genomic_DNA.
DR EMBL; CR456615; CAG30501.1; -; mRNA.
DR EMBL; BC040161; AAH40161.1; -; mRNA.
DR EMBL; X60077; CAC16148.1; -; Genomic_DNA.
DR CCDS; CCDS13812.1; -.
DR PIR; D42825; D42825.
DR RefSeq; NP_068735.1; NM_021916.3.
DR AlphaFoldDB; Q9UC06; -.
DR SMR; Q9UC06; -.
DR BioGRID; 113441; 33.
DR IntAct; Q9UC06; 8.
DR STRING; 9606.ENSP00000339314; -.
DR iPTMnet; Q9UC06; -.
DR PhosphoSitePlus; Q9UC06; -.
DR BioMuta; ZNF70; -.
DR DMDM; 20141062; -.
DR jPOST; Q9UC06; -.
DR MassIVE; Q9UC06; -.
DR MaxQB; Q9UC06; -.
DR PaxDb; Q9UC06; -.
DR PeptideAtlas; Q9UC06; -.
DR PRIDE; Q9UC06; -.
DR ProteomicsDB; 84108; -.
DR Antibodypedia; 9369; 94 antibodies from 22 providers.
DR DNASU; 7621; -.
DR Ensembl; ENST00000341976.5; ENSP00000339314.3; ENSG00000187792.5.
DR GeneID; 7621; -.
DR KEGG; hsa:7621; -.
DR MANE-Select; ENST00000341976.5; ENSP00000339314.3; NM_021916.4; NP_068735.1.
DR UCSC; uc002zxs.4; human.
DR CTD; 7621; -.
DR DisGeNET; 7621; -.
DR GeneCards; ZNF70; -.
DR HGNC; HGNC:13140; ZNF70.
DR HPA; ENSG00000187792; Low tissue specificity.
DR MIM; 194544; gene.
DR neXtProt; NX_Q9UC06; -.
DR OpenTargets; ENSG00000187792; -.
DR PharmGKB; PA37714; -.
DR VEuPathDB; HostDB:ENSG00000187792; -.
DR eggNOG; KOG1721; Eukaryota.
DR GeneTree; ENSGT00940000163200; -.
DR HOGENOM; CLU_002678_44_13_1; -.
DR InParanoid; Q9UC06; -.
DR OMA; PVQHQST; -.
DR OrthoDB; 1318335at2759; -.
DR PhylomeDB; Q9UC06; -.
DR TreeFam; TF337055; -.
DR PathwayCommons; Q9UC06; -.
DR Reactome; R-HSA-212436; Generic Transcription Pathway.
DR SignaLink; Q9UC06; -.
DR BioGRID-ORCS; 7621; 16 hits in 1087 CRISPR screens.
DR ChiTaRS; ZNF70; human.
DR GenomeRNAi; 7621; -.
DR Pharos; Q9UC06; Tdark.
DR PRO; PR:Q9UC06; -.
DR Proteomes; UP000005640; Chromosome 22.
DR RNAct; Q9UC06; protein.
DR Bgee; ENSG00000187792; Expressed in tibia and 139 other tissues.
DR Genevisible; Q9UC06; HS.
DR GO; GO:0005737; C:cytoplasm; IDA:UniProtKB.
DR GO; GO:0043076; C:megasporocyte nucleus; IDA:UniProtKB.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000977; F:RNA polymerase II transcription regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF00096; zf-C2H2; 10.
DR SMART; SM00355; ZnF_C2H2; 11.
DR SUPFAM; SSF57667; SSF57667; 6.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 10.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 11.
PE 2: Evidence at transcript level;
KW DNA-binding; Metal-binding; Nucleus; Reference proteome; Repeat;
KW Transcription; Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1..446
FT /note="Zinc finger protein 70"
FT /id="PRO_0000047380"
FT ZN_FING 140..162
FT /note="C2H2-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 168..190
FT /note="C2H2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 196..218
FT /note="C2H2-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 224..246
FT /note="C2H2-type 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 252..274
FT /note="C2H2-type 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 280..302
FT /note="C2H2-type 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 308..330
FT /note="C2H2-type 7"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 336..358
FT /note="C2H2-type 8"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 364..386
FT /note="C2H2-type 9"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 392..413
FT /note="C2H2-type 10"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 419..441
FT /note="C2H2-type 11"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT REGION 114..138
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 446 AA; 50802 MW; E79A25ED2BD816D9 CRC64;
MEVPPATKFG ETFAFENRLE SQQGLFPGED LGDPFLQERG LEQMAVIYKE IPLGEQDEEN
DDYEGNFSLC SSPVQHQSIP PGTRPQDDEL FGQTFLQKSD LSMCQIIHSE EPSPCDCAET
DRGDSGPNAP HRTPQPAKPY ACRECGKAFS QSSHLLRHLV IHTGEKPYEC CECGKAFSQS
SHLLRHQIIH TGEKPYECRE CGKAFRQSSA LTQHQKIHTG KRPYECRECG KDFSRSSSLR
KHERIHTGER PYQCKECGKS FNQSSGLSQH RKIHTLKKPH ECDLCGKAFC HRSHLIRHQR
IHTGKKPYKC DECGKAFSQS SNLIEHRKTH TGEKPYKCQK CGKAFSQSSS LIEHQRIHTG
EKPYECCQCG KAFCHSSALI QHQRIHTGKK PYTCECGKAF RHRSALIEHY KTHTREKPYV
CNLCGKSFRG SSHLIRHQKI HSGEKL
