ZNF71_HUMAN
ID ZNF71_HUMAN Reviewed; 489 AA.
AC Q9NQZ8; Q15919; Q9UC09; Q9UQD3;
DT 27-MAY-2002, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2000, sequence version 1.
DT 03-AUG-2022, entry version 177.
DE RecName: Full=Endothelial zinc finger protein induced by tumor necrosis factor alpha;
DE AltName: Full=Zinc finger protein 71;
GN Name=ZNF71; Synonyms=EZFIT;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Umbilical vein endothelial cell;
RX PubMed=11426589; DOI=10.5551/jat1994.7.97;
RA Mataki C., Murakami T., Umetani M., Wada Y., Ishii M., Tsutsumi S.,
RA Aburatani H., Hamakubo T., Kodama T.;
RT "A novel zinc finger protein mRNA in human umbilical vein endothelial cells
RT is profoundly induced by tumor necrosis factor alpha.";
RL J. Atheroscler. Thromb. 7:97-103(2000).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15057824; DOI=10.1038/nature02399;
RA Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E.,
RA Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A.,
RA Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S.,
RA Carrano A.V., Caoile C., Chan Y.M., Christensen M., Cleland C.A.,
RA Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J.,
RA Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M.,
RA Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W.,
RA Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V.,
RA Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D.,
RA McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I.,
RA Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L.,
RA Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A.,
RA She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M.,
RA Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J.,
RA Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA Rubin E.M., Lucas S.M.;
RT "The DNA sequence and biology of human chromosome 19.";
RL Nature 428:529-535(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Placenta;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 151-235.
RX PubMed=1639391; DOI=10.1016/0888-7543(92)90135-f;
RA Aubry M., Marineau C., Zhang F.R., Zahed L., Figlewicz D., Delattre O.,
RA Thomas G., de Jong P.J., Julien J.-P., Rouleau G.A.;
RT "Cloning of six new genes with zinc finger motifs mapping to short and long
RT arms of human acrocentric chromosome 22 (p and q11.2).";
RL Genomics 13:641-648(1992).
RN [5]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 431-489.
RC TISSUE=Placenta;
RX PubMed=1505991; DOI=10.1016/0888-7543(92)90013-i;
RA Lichter P., Bray P., Ried T., Dawid I.B., Ward D.C.;
RT "Clustering of C2-H2 zinc finger motif sequences within telomeric and
RT fragile site regions of human chromosomes.";
RL Genomics 13:999-1007(1992).
CC -!- FUNCTION: May be involved in transcriptional regulation.
CC -!- INTERACTION:
CC Q9NQZ8; Q13895: BYSL; NbExp=3; IntAct=EBI-7138235, EBI-358049;
CC Q9NQZ8; Q92997: DVL3; NbExp=3; IntAct=EBI-7138235, EBI-739789;
CC Q9NQZ8; P51114-2: FXR1; NbExp=3; IntAct=EBI-7138235, EBI-11022345;
CC Q9NQZ8; Q8TCE9: LGALS14; NbExp=3; IntAct=EBI-7138235, EBI-10274069;
CC Q9NQZ8; Q9NYL2-2: MAP3K20; NbExp=4; IntAct=EBI-7138235, EBI-10255081;
CC Q9NQZ8; P55081: MFAP1; NbExp=3; IntAct=EBI-7138235, EBI-1048159;
CC Q9NQZ8; O00264: PGRMC1; NbExp=5; IntAct=EBI-7138235, EBI-1045534;
CC Q9NQZ8; O43189: PHF1; NbExp=3; IntAct=EBI-7138235, EBI-530034;
CC Q9NQZ8; Q9NRD5: PICK1; NbExp=3; IntAct=EBI-7138235, EBI-79165;
CC Q9NQZ8; Q8WWY3: PRPF31; NbExp=3; IntAct=EBI-7138235, EBI-1567797;
CC Q9NQZ8; Q15020: SART3; NbExp=3; IntAct=EBI-7138235, EBI-308619;
CC Q9NQZ8; Q8WV44: TRIM41; NbExp=8; IntAct=EBI-7138235, EBI-725997;
CC Q9NQZ8; P26368-2: U2AF2; NbExp=3; IntAct=EBI-7138235, EBI-11097439;
CC Q9NQZ8; O43167: ZBTB24; NbExp=4; IntAct=EBI-7138235, EBI-744471;
CC Q9NQZ8; Q96C00: ZBTB9; NbExp=3; IntAct=EBI-7138235, EBI-395708;
CC Q9NQZ8; Q8N5A5-2: ZGPAT; NbExp=3; IntAct=EBI-7138235, EBI-10183064;
CC Q9NQZ8; Q8TAU3: ZNF417; NbExp=3; IntAct=EBI-7138235, EBI-740727;
CC Q9NQZ8; Q6ZNH5: ZNF497; NbExp=5; IntAct=EBI-7138235, EBI-10486136;
CC Q9NQZ8; Q96C55: ZNF524; NbExp=3; IntAct=EBI-7138235, EBI-10283126;
CC Q9NQZ8; Q5T619: ZNF648; NbExp=3; IntAct=EBI-7138235, EBI-11985915;
CC Q9NQZ8; Q3KQV3: ZNF792; NbExp=3; IntAct=EBI-7138235, EBI-10240849;
CC Q9NQZ8; Q9Y2P0: ZNF835; NbExp=3; IntAct=EBI-7138235, EBI-5667516;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- TISSUE SPECIFICITY: Highly expressed in placenta, followed by brain,
CC testis, pancreas, heart, small intestine, muscle, uterus, prostate and
CC peripheral blood leukocytes. Not detected in liver, lung, colon,
CC stomach, salivary and thyroid gland.
CC -!- INDUCTION: By TNF.
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAD23608.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AF269249; AAF88036.1; -; mRNA.
DR EMBL; AC007228; AAD23608.1; ALT_INIT; Genomic_DNA.
DR EMBL; BC014280; AAH14280.1; -; mRNA.
DR EMBL; X60074; CAC16174.1; -; Genomic_DNA.
DR EMBL; M88357; AAA61315.1; -; Genomic_DNA.
DR CCDS; CCDS12947.1; -.
DR PIR; A42825; A42825.
DR PIR; A43284; A43284.
DR RefSeq; NP_067039.1; NM_021216.4.
DR RefSeq; XP_016882569.1; XM_017027080.1.
DR AlphaFoldDB; Q9NQZ8; -.
DR SMR; Q9NQZ8; -.
DR BioGRID; 121821; 81.
DR IntAct; Q9NQZ8; 58.
DR MINT; Q9NQZ8; -.
DR STRING; 9606.ENSP00000328245; -.
DR iPTMnet; Q9NQZ8; -.
DR PhosphoSitePlus; Q9NQZ8; -.
DR BioMuta; ZNF71; -.
DR DMDM; 21263627; -.
DR EPD; Q9NQZ8; -.
DR MassIVE; Q9NQZ8; -.
DR MaxQB; Q9NQZ8; -.
DR PaxDb; Q9NQZ8; -.
DR PeptideAtlas; Q9NQZ8; -.
DR PRIDE; Q9NQZ8; -.
DR ProteomicsDB; 82239; -.
DR Antibodypedia; 19623; 171 antibodies from 29 providers.
DR DNASU; 58491; -.
DR Ensembl; ENST00000328070.10; ENSP00000328245.5; ENSG00000197951.10.
DR GeneID; 58491; -.
DR KEGG; hsa:58491; -.
DR UCSC; uc002qnm.5; human.
DR CTD; 58491; -.
DR DisGeNET; 58491; -.
DR GeneCards; ZNF71; -.
DR HGNC; HGNC:13141; ZNF71.
DR HPA; ENSG00000197951; Low tissue specificity.
DR MIM; 194545; gene.
DR neXtProt; NX_Q9NQZ8; -.
DR OpenTargets; ENSG00000197951; -.
DR PharmGKB; PA37715; -.
DR VEuPathDB; HostDB:ENSG00000197951; -.
DR eggNOG; KOG1721; Eukaryota.
DR GeneTree; ENSGT00940000163774; -.
DR HOGENOM; CLU_002678_44_0_1; -.
DR InParanoid; Q9NQZ8; -.
DR OMA; CVEKKTY; -.
DR PhylomeDB; Q9NQZ8; -.
DR TreeFam; TF350858; -.
DR PathwayCommons; Q9NQZ8; -.
DR Reactome; R-HSA-212436; Generic Transcription Pathway.
DR SignaLink; Q9NQZ8; -.
DR BioGRID-ORCS; 58491; 14 hits in 1098 CRISPR screens.
DR ChiTaRS; ZNF71; human.
DR GeneWiki; ZNF71; -.
DR GenomeRNAi; 58491; -.
DR Pharos; Q9NQZ8; Tbio.
DR PRO; PR:Q9NQZ8; -.
DR Proteomes; UP000005640; Chromosome 19.
DR RNAct; Q9NQZ8; protein.
DR Bgee; ENSG00000197951; Expressed in ganglionic eminence and 117 other tissues.
DR ExpressionAtlas; Q9NQZ8; baseline and differential.
DR Genevisible; Q9NQZ8; HS.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF00096; zf-C2H2; 13.
DR SMART; SM00355; ZnF_C2H2; 13.
DR SUPFAM; SSF57667; SSF57667; 7.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 13.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 13.
PE 1: Evidence at protein level;
KW DNA-binding; Metal-binding; Nucleus; Reference proteome; Repeat;
KW Transcription; Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1..489
FT /note="Endothelial zinc finger protein induced by tumor
FT necrosis factor alpha"
FT /id="PRO_0000047381"
FT ZN_FING 130..152
FT /note="C2H2-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 158..180
FT /note="C2H2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 186..208
FT /note="C2H2-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 214..236
FT /note="C2H2-type 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 242..264
FT /note="C2H2-type 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 270..292
FT /note="C2H2-type 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 298..320
FT /note="C2H2-type 7"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 326..348
FT /note="C2H2-type 8"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 354..376
FT /note="C2H2-type 9"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 382..404
FT /note="C2H2-type 10"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 410..432
FT /note="C2H2-type 11"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 438..460
FT /note="C2H2-type 12"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 466..488
FT /note="C2H2-type 13"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT REGION 1..61
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 98..122
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VARIANT 27
FT /note="R -> G (in dbSNP:rs10405299)"
FT /id="VAR_052762"
FT VARIANT 105
FT /note="V -> I (in dbSNP:rs2072501)"
FT /id="VAR_024196"
FT VARIANT 121
FT /note="P -> L (in dbSNP:rs35392779)"
FT /id="VAR_052763"
SQ SEQUENCE 489 AA; 54498 MW; 6B1156D21FF9295C CRC64;
MKELDPKNDI SEDKLSVVGE ATGGPTRNGA RGPGSEGVWE PGSWPERPRG DAGAEWEPLG
IPQGNKLLGG SVPACHELKA FANQGCVLVP PRLDDPTEKG ACPPVRRGKN FSSTSDLSKP
PMPCEEKKTY DCSECGKAFS RSSSLIKHQR IHTGEKPFEC DTCGKHFIER SSLTIHQRVH
TGEKPYACGD CGKAFSQRMN LTVHQRTHTG EKPYVCDVCG KAFRKTSSLT QHERIHTGEK
PYACGDCGKA FSQNMHLIVH QRTHTGEKPY VCPECGRAFS QNMHLTEHQR THTGEKPYAC
KECGKAFNKS SSLTLHQRNH TGEKPYVCGE CGKAFSQSSY LIQHQRFHIG VKPFECSECG
KAFSKNSSLT QHQRIHTGEK PYECYICKKH FTGRSSLIVH QIVHTGEKPY VCGECGKAFS
QSAYLIEHQR IHTGEKPYRC GQCGKSFIKN SSLTVHQRIH TGEKPYRCGE CGKTFSRNTN
LTRHLRIHT
